Abhay Pande

Summary

Affiliation: National Institute of Pharmaceutical Education and Research
Location: SAS Nagar (Mohali), India
Publications:
1.A therapeutic chemical chaperone inhibits cholera intoxication and unfolding/translocation of the cholera toxin A1 subunit.

Taylor M, Banerjee T, Navarro-Garcia F, Huerta J, Massey S, Burlingame M, Pande AH, Tatulian SA, Teter K.

PLoS One. 2011 Apr 19;6(4):e18825.

PMID:[PubMed - in process] Free PMC Article
Free full text Related citations

2.Closely related oxidized phospholipids differentially modulate the physicochemical properties of lipid particles.

Kar S, Tillu VA, Meena SC, Pande AH.

Chem Phys Lipids. 2011 Jan;164(1):54-61. Epub 2010 Nov 11.

PMID:[PubMed - indexed for MEDLINE]
Related citations

3.Membrane lipid composition differentially modulates the function of human plasma platelet activating factor-acetylhydrolase.

Pande AH, Tillu VA.

Biochim Biophys Acta. 2011 Jan;1811(1):46-56. Epub 2010 Sep 30.

PMID:[PubMed - indexed for MEDLINE]
Related citations

4.Oxidatively modified fatty acyl chain determines physicochemical properties of aggregates of oxidized phospholipids.

Pande AH, Kar S, Tripathy RK.

Biochim Biophys Acta. 2010 Mar;1798(3):442-52. Epub 2010 Jan 7.

PMID:[PubMed - indexed for MEDLINE]
Related citations

5.Stabilization of the tertiary structure of the cholera toxin A1 subunit inhibits toxin dislocation and cellular intoxication.

Massey S, Banerjee T, Pande AH, Taylor M, Tatulian SA, Teter K.

J Mol Biol. 2009 Nov 13;393(5):1083-96. Epub 2009 Sep 11.

PMID:[PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations

6.Peptide derived from the lipid binding domain of Group IB human pancreatic phospholipase A(2) possesses antibacterial activity.

Limbachiya MS, Pande AH.

Biochimie. 2009 Nov-Dec;91(11-12):1387-93. Epub 2009 Jul 18.

PMID:[PubMed - indexed for MEDLINE]
Related citations

7.Membrane surface charge modulates lipoprotein complex forming capability of peptides derived from the C-terminal domain of apolipoprotein E.

Pande AH, Tripathy RK, Nankar SA.

Biochim Biophys Acta. 2009 Jun;1788(6):1366-76. Epub 2009 Apr 8.

PMID:[PubMed - indexed for MEDLINE]
Related citations

8.Preferential binding of apolipoprotein E derived peptides with oxidized phospholipid.

Pande AH, Tripathy RK.

Biochem Biophys Res Commun. 2009 Feb 27;380(1):71-5. Epub 2009 Jan 19.

PMID:[PubMed - indexed for MEDLINE]
Related citations

9.Conformational instability of the cholera toxin A1 polypeptide.

Pande AH, Scaglione P, Taylor M, Nemec KN, Tuthill S, Moe D, Holmes RK, Tatulian SA, Teter K.

J Mol Biol. 2007 Dec 7;374(4):1114-28. Epub 2007 Oct 16.

PMID:[PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations

10.The pertussis toxin S1 subunit is a thermally unstable protein susceptible to degradation by the 20S proteasome.

Pande AH, Moe D, Jamnadas M, Tatulian SA, Teter K.

Biochemistry. 2006 Nov 21;45(46):13734-40.

PMID:[PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations

11.Structural and functional effects of tryptophans inserted into the membrane-binding and substrate-binding sites of human group IIA phospholipase A2.

Nemec KN, Pande AH, Qin S, Bieber Urbauer RJ, Tan S, Moe D, Tatulian SA.

Biochemistry. 2006 Oct 17;45(41):12448-60.

PMID:[PubMed - indexed for MEDLINE]
Related citations

12.Isoform-specific membrane insertion of secretory phospholipase A2 and functional implications.

Pande AH, Qin S, Nemec KN, He X, Tatulian SA.

Biochemistry. 2006 Oct 17;45(41):12436-47.

PMID:[PubMed - indexed for MEDLINE]
Related citations

13.Carbohydrate-induced modulation of cell membrane. VIII. Agglutination with mammalian lectin galectin-1 increases osmofragility and membrane fluidity of trypsinized erythrocytes.

Gupta RK, Pande AH, Gulla KC, Gabius HJ, Hajela K.

FEBS Lett. 2006 Mar 6;580(6):1691-5. Epub 2006 Feb 17.

PMID:[PubMed - indexed for MEDLINE]
Related citations

14.Evidence for the regulatory role of the N-terminal helix of secretory phospholipase A(2) from studies on native and chimeric proteins.

Qin S, Pande AH, Nemec KN, He X, Tatulian SA.

J Biol Chem. 2005 Nov 4;280(44):36773-83. Epub 2005 Aug 15.

PMID:[PubMed - indexed for MEDLINE] Free Article
Related citations

15.Positioning membrane proteins by novel protein engineering and biophysical approaches.

Tatulian SA, Qin S, Pande AH, He X.

J Mol Biol. 2005 Sep 2;351(5):939-47.

PMID:[PubMed - indexed for MEDLINE]
Related citations

16.Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase.

Pande AH, Qin S, Tatulian SA.

Biophys J. 2005 Jun;88(6):4084-94. Epub 2005 Mar 18.

PMID:[PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations

17.Modulation of human 5-lipoxygenase activity by membrane lipids.

Pande AH, Moe D, Nemec KN, Qin S, Tan S, Tatulian SA.

Biochemistry. 2004 Nov 23;43(46):14653-66. Erratum in: Biochemistry. 2005 Jan 11;44(1):440.

PMID:[PubMed - indexed for MEDLINE]
Related citations

18.The N-terminal alpha-helix of pancreatic phospholipase A2 determines productive-mode orientation of the enzyme at the membrane surface.

Qin S, Pande AH, Nemec KN, Tatulian SA.

J Mol Biol. 2004 Nov 12;344(1):71-89.

PMID:[PubMed - indexed for MEDLINE]
Related citations

19.Oxidation of goat hepatic galectin-1 induces change in secondary structure.

Pande AH, Gupta RK, Sumati, Hajela K.

Protein Pept Lett. 2003 Jun;10(3):265-75.

PMID:[PubMed - indexed for MEDLINE]
Related citations

20.Involvement of a nine-residue loop of streptokinase in the generation of macromolecular substrate specificity by the activator complex through interaction with substrate kringle domains.

Dhar J, Pande AH, Sundram V, Nanda JS, Mande SC, Sahni G.

J Biol Chem. 2002 Apr 12;277(15):13257-67. Epub 2002 Jan 30.

PMID:[PubMed - indexed for MEDLINE] Free Article
Related citations
Carbohydrate induced modulation of cell membrane VII. Binding of exogenous lectin increases osmofragility of erythrocytes.

Pande AH, Sumati N, Hajela N, Hajela K.

FEBS Lett. 1998 May 1;427(1):21-4.

PMID:9613592[PubMed - indexed for MEDLINE]
Related citations

22.Carbohydrate induced modulation of cell membrane. VI. Binding of exogenous lectin induces susceptibility of erythrocytes to free radical damage: a spin label study.

Hajela K, Pande AH, Sumati.

FEBS Lett. 1997 Apr 14;406(3):255-8.

PMID:9136896[PubMed - indexed for MEDLINE]
Related citations

Publications

  1. doi request reprint Oxidatively modified fatty acyl chain determines physicochemical properties of aggregates of oxidized phospholipids
    Abhay H Pande
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar Mohali 160062, Punjab, India
    Biochim Biophys Acta 1798:442-52. 2010
  2. ncbi request reprint Carbohydrate induced modulation of cell membrane. VI. Binding of exogenous lectin induces susceptibility of erythrocytes to free radical damage: a spin label study
    K Hajela
    School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, India
    FEBS Lett 406:255-8. 1997
  3. pmc The pertussis toxin S1 subunit is a thermally unstable protein susceptible to degradation by the 20S proteasome
    Abhay H Pande
    Department of Molecular Biology and Microbiology, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, USA
    Biochemistry 45:13734-40. 2006
  4. pmc Conformational instability of the cholera toxin A1 polypeptide
    Abhay H Pande
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, FL 32826, USA
    J Mol Biol 374:1114-28. 2007
  5. doi request reprint Preferential binding of apolipoprotein E derived peptides with oxidized phospholipid
    Abhay H Pande
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Biochem Biophys Res Commun 380:71-5. 2009
  6. doi request reprint Membrane surface charge modulates lipoprotein complex forming capability of peptides derived from the C-terminal domain of apolipoprotein E
    Abhay H Pande
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali 160062, Punjab, India
    Biochim Biophys Acta 1788:1366-76. 2009
  7. doi request reprint Peptide derived from the lipid binding domain of Group IB human pancreatic phospholipase A(2) possesses antibacterial activity
    Mehulkumar S Limbachiya
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Biochimie 91:1387-93. 2009
  8. pmc Stabilization of the tertiary structure of the cholera toxin A1 subunit inhibits toxin dislocation and cellular intoxication
    Shane Massey
    Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL 32826, USA
    J Mol Biol 393:1083-96. 2009
  9. doi request reprint Membrane lipid composition differentially modulates the function of human plasma platelet activating factor-acetylhydrolase
    Abhay H Pande
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Biochim Biophys Acta 1811:46-56. 2011
  10. doi request reprint Closely related oxidized phospholipids differentially modulate the physicochemical properties of lipid particles
    Subhabrata Kar
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Mohali, 160062 Punjab, India
    Chem Phys Lipids 164:54-61. 2011

Collaborators

  • Suren A Tatulian
  • Fernando Navarro-Garcia
  • Shan Qin
  • Kathleen N Nemec
  • Michael Taylor
  • Shane Massey
  • Subhabrata Kar
  • Tuhina Banerjee
  • Ken Teter
  • Mehulkumar S Limbachiya
  • Rajesh K Gupta
  • Jayeeta Dhar
  • Shiv Charan Meena
  • Jazmin Huerta
  • Mansfield Burlingame
  • Vikas A Tillu
  • Shuhua Tan
  • Ramona J Bieber Urbauer
  • Krishnan Hajela
  • Hans J Gabius
  • David Moe
  • Krishana C Gulla
  • Xiaomei He
  • K Hajela
  • Girish Sahni
  • Vasudha Sundram
  • Shekhar C Mande
  • Jagpreet S Nanda
  • - Sumati

Detail Information

Publications22

  1. doi request reprint Oxidatively modified fatty acyl chain determines physicochemical properties of aggregates of oxidized phospholipids
    Abhay H Pande
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar Mohali 160062, Punjab, India
    Biochim Biophys Acta 1798:442-52. 2010
    ..Our result provides first direct evidence that because of the specific chemical composition of the sn-2 fatty acyl chain aggregates of particular tOx-PL possess a distinctive set of physicochemical properties...
  2. ncbi request reprint Carbohydrate induced modulation of cell membrane. VI. Binding of exogenous lectin induces susceptibility of erythrocytes to free radical damage: a spin label study
    K Hajela
    School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Indore, India
    FEBS Lett 406:255-8. 1997
    ....
  3. pmc The pertussis toxin S1 subunit is a thermally unstable protein susceptible to degradation by the 20S proteasome
    Abhay H Pande
    Department of Molecular Biology and Microbiology, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, USA
    Biochemistry 45:13734-40. 2006
    ..These observations support a model of intoxication in which toxin translocation, degradation, and activity are all influenced by the heat-labile nature of the isolated toxin A chain...
  4. pmc Conformational instability of the cholera toxin A1 polypeptide
    Abhay H Pande
    Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, FL 32826, USA
    J Mol Biol 374:1114-28. 2007
    ..Thermal instability in the reduced CTA1 polypeptide has not been reported before, yet both the translocation and degradation of CTA1 may depend upon this physical property...
  5. doi request reprint Preferential binding of apolipoprotein E derived peptides with oxidized phospholipid
    Abhay H Pande
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Biochem Biophys Res Commun 380:71-5. 2009
    ..These observations suggest that the preferential binding of apoE to oxidized phospholipid containing membrane may play a role in the anti-oxidative properties of apoE...
  6. doi request reprint Membrane surface charge modulates lipoprotein complex forming capability of peptides derived from the C-terminal domain of apolipoprotein E
    Abhay H Pande
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali 160062, Punjab, India
    Biochim Biophys Acta 1788:1366-76. 2009
    ..The results suggest that surface charge of lipoprotein regulates its metabolism possibly by modulating the recruitment of apoE on its surface...
  7. doi request reprint Peptide derived from the lipid binding domain of Group IB human pancreatic phospholipase A(2) possesses antibacterial activity
    Mehulkumar S Limbachiya
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Biochimie 91:1387-93. 2009
    ..coli and at subinhibitory concentration and can potentiate the antibacterial activity of membrane active enzyme. These observations suggest that N10 peptide may play an important role in the antimicrobial activity of pancreatic juice...
  8. pmc Stabilization of the tertiary structure of the cholera toxin A1 subunit inhibits toxin dislocation and cellular intoxication
    Shane Massey
    Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL 32826, USA
    J Mol Biol 393:1083-96. 2009
    ..Collectively, these findings indicate that toxin thermal instability plays a key role in the intoxication process. They also suggest the stabilization of CTA1 tertiary structure is a potential goal for novel antitoxin therapeutic agents...
  9. doi request reprint Membrane lipid composition differentially modulates the function of human plasma platelet activating factor-acetylhydrolase
    Abhay H Pande
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Biochim Biophys Acta 1811:46-56. 2011
    ....
  10. doi request reprint Closely related oxidized phospholipids differentially modulate the physicochemical properties of lipid particles
    Subhabrata Kar
    Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Mohali, 160062 Punjab, India
    Chem Phys Lipids 164:54-61. 2011
    ....
  11. ncbi request reprint Structural and functional effects of tryptophans inserted into the membrane-binding and substrate-binding sites of human group IIA phospholipase A2
    Kathleen N Nemec
    Biomolecular Science Center, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, USA
    Biochemistry 45:12448-60. 2006
    ....
  12. ncbi request reprint Isoform-specific membrane insertion of secretory phospholipase A2 and functional implications
    Abhay H Pande
    Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826, USA
    Biochemistry 45:12436-47. 2006
    ....
  13. ncbi request reprint Carbohydrate induced modulation of cell membrane VII. Binding of exogenous lectin increases osmofragility of erythrocytes
    A H Pande
    School of Life Sciences, Devi Ahilya Vishwavidyalaya Vigyan Bhawan, Khandwa Road Campus, Indore, M P, India
    FEBS Lett 427:21-4. 1998
    ..It was also found that agglutination per se does not increase osmofragility but the binding of legume lectin is essential since human Rh+ cells agglutinated by a monoclonal antibody do not exhibit hemolysis...
  14. ncbi request reprint Involvement of a nine-residue loop of streptokinase in the generation of macromolecular substrate specificity by the activator complex through interaction with substrate kringle domains
    Jayeeta Dhar
    Institute of Microbial Technology, Sector 39 A, Chandigarh 160036, India
    J Biol Chem 277:13257-67. 2002
    ..HPG activator complex and demonstrate that it promotes the binding of substrate HPG to the activator via the kringle(s) during the HPG activation process...
  15. ncbi request reprint Oxidation of goat hepatic galectin-1 induces change in secondary structure
    Abhay H Pande
    School of Life Sciences, Devi Ahilya Vishwavidyalaya, Vigyan Bhawan, Khandwa Road Campus, Indore 452 001 MP, India
    Protein Pept Lett 10:265-75. 2003
    ..Conformational changes in goat hepatic galectin-1 due to oxidation were investigated by absorption, fluorescence and circular dichroism measurements...
  16. ncbi request reprint The N-terminal alpha-helix of pancreatic phospholipase A2 determines productive-mode orientation of the enzyme at the membrane surface
    Shan Qin
    Biomolecular Science Center, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826, USA
    J Mol Biol 344:71-89. 2004
    ....
  17. ncbi request reprint Modulation of human 5-lipoxygenase activity by membrane lipids
    Abhay H Pande
    Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826, USA
    Biochemistry 43:14653-66. 2004
    ..Our results provide insight into the understanding of the effects of membrane surface properties on 5-LO-membrane interactions and the interfacial activation of 5-LO...
  18. pmc Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase
    Abhay H Pande
    Biomolecular Science Center, University of Central Florida, Orlando, 32826, USA
    Biophys J 88:4084-94. 2005
    ..The data presented in this article and earlier data allow construction of a model for membrane-bound 5-LO, including the angular orientation and membrane insertion of the protein...
  19. ncbi request reprint Positioning membrane proteins by novel protein engineering and biophysical approaches
    Suren A Tatulian
    Biomolecular Science Center, University of Central Florida, 12722 Research Parkway, Orlando, FL 32826, USA
    J Mol Biol 351:939-47. 2005
    ..Given the functional significance of the orientation and location of membrane-bound proteins with respect to the membrane, we propose to specify this structural feature as the "quinary" structure of membrane proteins...
  20. ncbi request reprint Evidence for the regulatory role of the N-terminal helix of secretory phospholipase A(2) from studies on native and chimeric proteins
    Shan Qin
    Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826, USA
    J Biol Chem 280:36773-83. 2005
    ..Altogether, the data provide evidence that the N-terminal helix of group I/II PLA(2)s acts as a regulatory domain that mediates interfacial activation of these enzymes...
  21. ncbi request reprint Carbohydrate-induced modulation of cell membrane. VIII. Agglutination with mammalian lectin galectin-1 increases osmofragility and membrane fluidity of trypsinized erythrocytes
    Rajesh K Gupta
    School of Life Sciences, Devi Ahilya Vishwavidyalaya, Khandwa Road, Indore 452017, India
    FEBS Lett 580:1691-5. 2006
    ..Moreover, it increases susceptibility of erythrocytes to radical damage. These observations indicate the potential of this endogenous lectin to affect membrane properties beyond the immediate interaction with cell surface epitopes...
  22. pmc A therapeutic chemical chaperone inhibits cholera intoxication and unfolding/translocation of the cholera toxin A1 subunit
    Michael Taylor
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America
    PLoS ONE 6:e18825. 2011
    ..PBA is currently used as a therapeutic agent to treat urea cycle disorders. Our data suggest PBA could also be used in a new application to prevent or possibly treat cholera...