N R Jana

Summary

Affiliation: National Brain Research Centre
Country: India

Publications

  1. ncbi request reprint BAG-1 associates with the polyglutamine-expanded huntingtin aggregates
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122050, India
    Neurosci Lett 378:171-5. 2005
  2. doi request reprint NSAIDs and apoptosis
    N R Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon, India
    Cell Mol Life Sci 65:1295-301. 2008
  3. pmc Understanding the pathogenesis of Angelman syndrome through animal models
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122 050, India
    Neural Plast 2012:710943. 2012
  4. doi request reprint Protein homeostasis and aging: role of ubiquitin protein ligases
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122050, India
    Neurochem Int 60:443-7. 2012
  5. ncbi request reprint Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122 050, India
    J Biol Chem 280:11635-40. 2005
  6. ncbi request reprint Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway
    Nihar Ranjan Jana
    National Brain Research Centre, SCO 5, 6 and 7, Sector 15, Part II, 122 001 Gurgaon, India
    J Chem Neuroanat 26:95-101. 2003
  7. ncbi request reprint Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122050, India
    J Biol Chem 279:11680-5. 2004
  8. ncbi request reprint Misfolding promotes the ubiquitination of polyglutamine-expanded ataxin-3, the defective gene product in SCA3/MJD
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122 050, India
    Neurotox Res 6:523-33. 2004
  9. pmc Dysregulation of core components of SCF complex in poly-glutamine disorders
    S Bhutani
    Department of Cellular and Molecular Neurosciences, National Brain Research Centre, Gurgaon 122 050, India
    Cell Death Dis 3:e428. 2012
  10. doi request reprint Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome
    A Mishra
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon, 122 050, India
    Cell Mol Life Sci 65:656-66. 2008

Collaborators

Detail Information

Publications13

  1. ncbi request reprint BAG-1 associates with the polyglutamine-expanded huntingtin aggregates
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122050, India
    Neurosci Lett 378:171-5. 2005
    ..Since, BAG-1 is essential for cell survival, its association with tNhtt aggregates might disrupt its normal function and thereby promote polyglutamine-expanded tNhtt-induced cell death...
  2. doi request reprint NSAIDs and apoptosis
    N R Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon, India
    Cell Mol Life Sci 65:1295-301. 2008
    ..Both COX-2-dependent and COX-2-independent mechanisms are involved in NSAIDs-induced neoplastic growth. This article reviews the recent literature that has revealed various important mechanisms of NSAIDs-induced apoptosis...
  3. pmc Understanding the pathogenesis of Angelman syndrome through animal models
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122 050, India
    Neural Plast 2012:710943. 2012
    ..This paper mainly discusses various animal models of AS and how these models provide fundamental insight into understanding the disease biology for potential therapeutic intervention...
  4. doi request reprint Protein homeostasis and aging: role of ubiquitin protein ligases
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122050, India
    Neurochem Int 60:443-7. 2012
    ..This review mainly focuses on our current understanding of the importance of UPS function in the regulation of normal aging process...
  5. ncbi request reprint Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122 050, India
    J Biol Chem 280:11635-40. 2005
    ..Finally, we show that overexpression of CHIP suppresses the aggregation and cell death mediated by expanded polyglutamine proteins and the suppressive effect is more prominent when CHIP is overexpressed along with Hsc70...
  6. ncbi request reprint Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway
    Nihar Ranjan Jana
    National Brain Research Centre, SCO 5, 6 and 7, Sector 15, Part II, 122 001 Gurgaon, India
    J Chem Neuroanat 26:95-101. 2003
    ..Here we review the recent studies that have revealed a critical role for molecular chaperones and ubiquitin-proteasome pathway in the pathogenesis of polyglutamine diseases...
  7. ncbi request reprint Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122050, India
    J Biol Chem 279:11680-5. 2004
    ..Addition of curcumin to neuro 2a cells induces a rapid decrease in mitochondrial membrane potential and the release of cytochrome c into cytosol, followed by activation of caspase-9 and caspase-3...
  8. ncbi request reprint Misfolding promotes the ubiquitination of polyglutamine-expanded ataxin-3, the defective gene product in SCA3/MJD
    Nihar Ranjan Jana
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122 050, India
    Neurotox Res 6:523-33. 2004
    ....
  9. pmc Dysregulation of core components of SCF complex in poly-glutamine disorders
    S Bhutani
    Department of Cellular and Molecular Neurosciences, National Brain Research Centre, Gurgaon 122 050, India
    Cell Death Dis 3:e428. 2012
    ..Our results imply that reduced levels of SCF complex might contribute to polyQ disease pathology...
  10. doi request reprint Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome
    A Mishra
    Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon, 122 050, India
    Cell Mol Life Sci 65:656-66. 2008
    ..Partial knockdown also increased neuronal cell death, which may be mediated partly via p53. Our result suggests that E6-AP not only enhances the degradation of p53 but also regulates the neuronal cell growth...
  11. ncbi request reprint Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
    N R Jana
    Laboratory for CAG Repeat Diseases, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
    Hum Mol Genet 10:1049-59. 2001
    ..These results suggest that the impaired proteasomal function plays an important role in polyglutamine protein-induced cell death...
  12. ncbi request reprint Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity
    N R Jana
    Laboratory for CAG Repeat Diseases, RIKEN Brain Science Institute, Hirosawa, Japan
    Hum Mol Genet 9:2009-18. 2000
    ..Overexpression of Hdj-1 and Hsc70 is also able to protect cell death caused by polyglutamine-expanded tNhtt and their combination proved to be most effective...
  13. ncbi request reprint Abundant secretory lipocalins displaying male and lactation-specific expression in adult hamster submandibular gland. cDNA cloning and sex hormone-regulated repression
    E Thavathiru
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Eur J Biochem 266:467-76. 1999
    ..The results of homology search and the male- and lactation-specific pressure of the SMG proteins in adult saliva and urine suggests a possibility of their involvement in olfaction-mediated chemical communication between hamsters...