Affiliation: National Centre for Biological Sciences
Manjila S, Kuruvilla M, Ferveur J, Sane S, Hasan G. Extended Flight Bouts Require Disinhibition from GABAergic Mushroom Body Neurons. Curr Biol. 2019;29:283-293.e5 pubmed publisher
..video abstract. ..
Jayakumar S, Richhariya S, Deb B, Hasan G. A Multicomponent Neuronal Response Encodes the Larval Decision to Pupariate upon Amino Acid Starvation. J Neurosci. 2018;38:10202-10219 pubmed publisher
..These glutamatergic interneurons require calcium-signaling-regulated expression of a host of neuronal channels to generate complex calcium signals essential for pupariation on a protein-deficient diet. ..
Chakraborty S, Hasan G. Store-Operated Ca2+ Entry in Drosophila Primary Neuronal Cultures. Methods Mol Biol. 2018;1843:125-136 pubmed publisher
..Protocols for measurement of IP3-mediated Ca2+ release, passive depletion of ER Ca2+ store, and SOCE in primary cultures of Drosophila neurons are described here. ..
Kumaran D, Balagopal K, Tharmaraj R, Aaron S, George K, Muliyil J, et al
. Genetic characterization of Spinocerebellar ataxia 1 in a South Indian cohort. BMC Med Genet. 2014;15:114 pubmed publisher
..Moreover, such undetected SCA1 cases could underscore the true prevalence of SCA1 in India. ..
Sadaf S, Reddy O, Sane S, Hasan G. Neural control of wing coordination in flies. Curr Biol. 2015;25:80-6 pubmed publisher
..Thus, independent central circuits function in the context of different natural behaviors to control the motor circuit for Drosophila wing movement. ..
Subramanian M, Jayakumar S, Richhariya S, Hasan G. Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila. BMC Neurosci. 2013;14:157 pubmed publisher
..Our results suggest that intracellular calcium signaling in peptidergic neurons affects lipid metabolism by both cell autonomous and non-autonomous mechanisms. ..
Pathak T, Agrawal T, Richhariya S, Sadaf S, Hasan G. Store-Operated Calcium Entry through Orai Is Required for Transcriptional Maturation of the Flight Circuit in Drosophila. J Neurosci. 2015;35:13784-99 pubmed publisher
..This cell-signaling mechanism is required to maintain optimal levels of a key enzyme for dopamine synthesis and may serve as a mechanism for restoring dopamine levels in relevant pathological conditions. ..
Pathak T, Trivedi D, Hasan G. CRISPR-Cas-Induced Mutants Identify a Requirement for dSTIM in Larval Dopaminergic Cells of Drosophila melanogaster. G3 (Bethesda). 2017;7:923-933 pubmed publisher
..Our data identify an essential role for STIM in larval dopaminergic cells. The molecular basis for this cell-specific requirement needs further investigation. ..
Megha -, Hasan G. IP3R-mediated Ca2+ release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress. Development. 2017;144:1484-1489 pubmed publisher
..Thus cell-specific regulation of protein synthesis by IP3R in NE cells influences protein metabolism. We propose that this regulation helps developing animals survive in poor nutritional conditions. ..