Atchayaram Nalini

Summary

Country: India

Publications

  1. doi request reprint Rosai Dorfman disease: case with extensive dural involvement and cerebrospinal fluid pleocytosis
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 314:152-4. 2012
  2. doi request reprint Madras motor neuron disease (MMND): clinical description and survival pattern of 116 patients from Southern India seen over 36 years (1971-2007)
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 269:65-73. 2008
  3. doi request reprint Mitochondrial neurogastrointestinal encephalopathy in an Indian family with possible manifesting carriers of heterozygous TYMP mutation
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 309:131-5. 2011
  4. doi request reprint Sarcoglycanopathy: clinical and histochemical characteristics in 66 patients
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 58:691-6. 2010
  5. ncbi request reprint Ullrich congenital muscular dystrophy: report of nine cases from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 57:41-5. 2009
  6. doi request reprint Clinical characteristics and survival pattern of 1,153 patients with amyotrophic lateral sclerosis: experience over 30 years from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 272:60-70. 2008
  7. doi request reprint Clinical, pathological and molecular findings in two siblings with giant axonal neuropathy (GAN): report from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560 029, India
    Eur J Med Genet 51:426-35. 2008
  8. doi request reprint Marchiafava-Bignami disease: Two cases with magnetic resonance imaging and positron emission tomography scan findings
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    Neurol India 57:644-8. 2009
  9. ncbi request reprint Multichannel somato sensory evoked potential study demonstrated abnormalities in cervical cord function in brachial monomelic amyotrophy
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 56:368-73. 2008
  10. ncbi request reprint Dysferlinopathy: a clinical and histopathological study of 28 patients from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
    Neurol India 56:379-85; discussion 386-7. 2008

Collaborators

Detail Information

Publications51

  1. doi request reprint Rosai Dorfman disease: case with extensive dural involvement and cerebrospinal fluid pleocytosis
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 314:152-4. 2012
    ..Histiocytes were strongly positive for CD-68 and S-100 proteins. The illness relentlessly progressed with patient developing total deafness and near total blindness at last follow-up...
  2. doi request reprint Madras motor neuron disease (MMND): clinical description and survival pattern of 116 patients from Southern India seen over 36 years (1971-2007)
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 269:65-73. 2008
    ..Studies to look for environmental and genetic basis of this intriguing disease are necessary to find the causation of this rare disorder...
  3. doi request reprint Mitochondrial neurogastrointestinal encephalopathy in an Indian family with possible manifesting carriers of heterozygous TYMP mutation
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 309:131-5. 2011
    ..Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a distinctive autosomal recessive disorder with mitochondrial alterations due to mutations TYMP gene encoding thymidine phosphorylase...
  4. doi request reprint Sarcoglycanopathy: clinical and histochemical characteristics in 66 patients
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 58:691-6. 2010
    ..Sarcoglycanopathies are a group or autosomal recessive muscular dystrophies designated as α, β, γ, or δ sarcogycanopathy...
  5. ncbi request reprint Ullrich congenital muscular dystrophy: report of nine cases from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 57:41-5. 2009
    ....
  6. doi request reprint Clinical characteristics and survival pattern of 1,153 patients with amyotrophic lateral sclerosis: experience over 30 years from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 272:60-70. 2008
    ..Thus, Indians appear to have a relatively younger age of onset and prolonged survival suggesting the relatively slow course of ALS among Indian patients...
  7. doi request reprint Clinical, pathological and molecular findings in two siblings with giant axonal neuropathy (GAN): report from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560 029, India
    Eur J Med Genet 51:426-35. 2008
    ..Here, we report a family originating in India with two patients showing typical clinical signs suggestive of GAN...
  8. doi request reprint Marchiafava-Bignami disease: Two cases with magnetic resonance imaging and positron emission tomography scan findings
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    Neurol India 57:644-8. 2009
    ..Functional brain imaging may help to understand the pathogenesis of acute MBD and possibly the behavioral manifestations...
  9. ncbi request reprint Multichannel somato sensory evoked potential study demonstrated abnormalities in cervical cord function in brachial monomelic amyotrophy
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 56:368-73. 2008
    ..Brachial monomelic amyotrophy (BMMA) is known to affect the central cervical cord gray matter resulting in single upper limb atrophy and weakness...
  10. ncbi request reprint Dysferlinopathy: a clinical and histopathological study of 28 patients from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
    Neurol India 56:379-85; discussion 386-7. 2008
    ..We describe the clinical features in 28 patients with dysferlin deficiency confirmed by muscle immunohistochemistry (IHC)...
  11. ncbi request reprint Distal myopathy with rimmed vacuoles: report on clinical characteristics in 23 cases
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 58:235-41. 2010
    ..Distal myopathy with rimmed vacuoles (DMRV) is an autosomal recessive (AR) myopathy characterized clinically by the preferential involvement of the tibialis anterior and has been reported predominantly in the Japanese population...
  12. ncbi request reprint Madras motor neuron disease variant, clinical features of seven patients
    M Gourie-Devi
    Department of Neurology, National Institute of Mental Health and Neurosciences, 506 029, Bangalore, India
    J Neurol Sci 209:13-7. 2003
    ..3% of MMND and the difference was statistically significant (p=0.003). This clinical profile may be considered to be a variant of Madras motor neuron disease (MMNDV)...
  13. ncbi request reprint Familial monomelic amyotrophy: a case report from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India
    J Neurol Sci 220:95-8. 2004
    ..A total of 190 patients were diagnosed to have MMA in our institute over the last 27 years and this is the first case of familial MMA...
  14. doi request reprint GNE myopathy in India
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
    Neurol India 61:371-4. 2013
    ..GNE myopathy is a clinicopathologically distinct distal myopathy with autosomal-recessive inheritance. The GNE gene mutations are known to cause this form of distal myopathy..
  15. doi request reprint Congenital myopathy with tubular aggregates: report on two siblings from India
    Gayathri Narayanappa
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Child Neurol 24:874-8. 2009
    ..To the best of our knowledge, association of seizures and mental subnormality in familial tubular aggregates has not been described. Muscle biopsy helped in establishing the diagnosis of this rare familial disorder...
  16. doi request reprint Spectrum of magnetic resonance imaging findings in a family with giant axonal neuropathy confirmed by genetic studies
    S Ravishankar
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 57:181-4. 2009
    ..MRS showed elevated choline peaks and reduced N-acetylaspartate peaks as well as presence of lactate peaks. Diffusion weighted images showed restricted diffusion...
  17. doi request reprint Biotin-responsive basal ganglia disease: a treatable and reversible neurological disorder of childhood
    P S Bindu
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Child Neurol 24:750-2. 2009
    ..Only few cases have been reported earlier in literature. We report a case of biotin-responsive basal ganglia disease suspected clinically, corroborated by neuroimaging and a dramatic response to biotin therapy...
  18. pmc Early or late appearance of "dropped head syndrome" in amyotrophic lateral sclerosis
    M Gourie-Devi
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Neurosurg Psychiatry 74:683-6. 2003
    ..Investigations were undertaken to exclude malignancy, lymphoproliferative disorders, thyroid dysfunction, and collagen vascular disease...
  19. ncbi request reprint Familial Madras motor neuron disease (FMMND): study of 15 families from southern India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560 029, India
    J Neurol Sci 250:140-6. 2006
    ..6+/-74.0 months. Notably, the occurrence of MMNDV in the familial group (15 of 25 patients) was significantly more as compared to occurrence in the group with sporadic MMND (SMMND) [12 of 79 patients] (p=0.0002)...
  20. ncbi request reprint Quantitative serial t2 relaxometry: a prospective evaluation in solitary cerebral cysticercosis
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences Bangalore, India
    Neuroradiol J 27:339-49. 2014
    ..A mild increase after six months may be due to the initiation of gliosis. T2R values appear to decline faster in patients who receive albendazole. ..
  21. doi request reprint New mutation of the desmin gene identified in an extended Indian pedigree presenting with distal myopathy and cardiac disease
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
    Neurol India 61:622-6. 2013
    ..At 40 years, he had a pacemaker implanted. The 9 exons and intronic boundaries of the desmin gene were sequenced and a heterozygous nucleotide change c. 734A > G in exon 3 was identified. ..
  22. doi request reprint Duchenne muscular dystrophy: a clinical, histopathological and genetic study at a neurology tertiary care center in Southern India
    Bhairavi Swaminathan
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 57:734-8. 2009
    ..Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy that affects young boys and the dystrophin gene on the X chromosome has been found to be associated with the disorder...
  23. ncbi request reprint Paternal inheritance or a de novo mutation in a Duchenne Muscular Dystrophy pedigree from South India
    Meera Purushottam
    Molecular Genetics Laboratory, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 268:179-82. 2008
    ..Molecular genetics analysis by PCR of the exons showed a deletion in exon 45 in two affected individuals. Microsatellite analysis showed that though the deletion was observed in the same locus in exon 45 it is a new independent mutation...
  24. ncbi request reprint Cerebrospinal fluid from amyotrophic lateral sclerosis patients preferentially elevates intracellular calcium and toxicity in motor neurons via AMPA/kainate receptor
    Indrani Sen
    Department of Biophysics, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
    J Neurol Sci 235:45-54. 2005
    ..Our data demonstrate that the exposure of spinal cord neurons to ALS-CSF differentially elevates [Ca(2+)](i) and neurotoxicity in motor neurons by activation of glutamate receptors, the AMPA/kainate receptor playing the major role...
  25. ncbi request reprint Sympathetic skin response in monomelic amyotrophy
    M Gourie-Devi
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, Karnataka, India
    Acta Neurol Scand 104:162-6. 2001
    ..Symptoms of increased sweating, coldness and cyanosis have been observed in a few patients. The objective was to evaluate the involvement of the sympathetic nervous system in MMA by measuring sympathetic skin response...
  26. doi request reprint Major histocompatibility complex and inflammatory cell subtype expression in inflammatory myopathies and muscular dystrophies
    Madhu Nagappa
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
    Neurol India 61:614-21. 2013
    ..In inflammatory myopathies muscle biopsy is a crucial diagnostic test. Misinterpretation between inflammatory myopathies and muscular dystrophies with inflammation is known...
  27. ncbi request reprint Madras motor neuron disease (MMND) is distinct from the riboflavin transporter genetic defects that cause Brown-Vialetto-Van Laere syndrome
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India Electronic address
    J Neurol Sci 334:119-22. 2013
    ..Recently a number of BVVL cases and families have been described with mutations in two riboflavin transporter genes SLC52A2 and SLC52A3 (solute carrier family 52, riboflavin transporter, member 2 and 3 respectively)...
  28. doi request reprint Vascular endothelial growth factor attenuates neurodegenerative changes in the NSC-34 motor neuron cell line induced by cerebrospinal fluid of sporadic amyotrophic lateral sclerosis patients
    Dinkar Kulshreshtha
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurodegener Dis 8:322-30. 2011
    ..Recently, vascular endothelial growth factor (VEGF) has been identified as a neurotrophic factor in animal models of familial ALS and other neurological diseases...
  29. doi request reprint Perilesional gliosis around solitary cerebral parenchymal cysticerci and long-term seizure outcome: a prospective study using serial magnetization transfer imaging
    Aaron de Souza
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Epilepsia 52:1918-27. 2011
    ..This study aims to describe development of gliosis around SCC by prospective serial MTI and to correlate this gliosis with long-term seizure outcome...
  30. ncbi request reprint Cerebral glycolipidoses: clinical characteristics of 41 pediatric patients
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Child Neurol 19:447-52. 2004
    ..The case with multiple sulfatase deficiency had low levels of arylsulfatase A and B. This study indicates that these autosomal recessive inherited disorders are indeed prevalent in India...
  31. doi request reprint Randomized controlled trial of albendazole in new onset epilepsy and MRI confirmed solitary cerebral cysticercal lesion: effect on long-term seizure outcome
    Aaron de Souza
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 276:108-14. 2009
    ..05). Thus, albendazole did not alter the long-term seizure outcome in patients with SCCL and epilepsy. However, albendazole hastened resolution of SCCL on MRI, but interestingly 23% of lesions were still active 12 months after treatment...
  32. ncbi request reprint Deletion analysis of spinal muscular atrophy in southern Indian population
    Bhairavi Swaminathan
    Molecular Genetics Laboratory, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 56:348-51. 2008
    ..The C-->T transition (at Codon 280) within Exon 7 of SMN2 causes disruption of an exonic splicing enhancer (ESE) and/or creates an exonic splicing silencer (ESS) leading to abnormal splicing and a truncated protein...
  33. ncbi request reprint Long-term follow-up of 44 patients with brachial monomelic amyotrophy
    M Gourie-Devi
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Acta Neurol Scand 107:215-20. 2003
    ..The aim of the study was to determine whether (i) atrophy and weakness in the affected limb progresses beyond 5 years; (ii) the illness spreads to the other limbs; and (iii) the disease progresses to amyotrophic lateral sclerosis...
  34. doi request reprint Severe form of radiculo - myelo - neuropathy with meningo - encephalitis secondary to Angiostrongylus cantonensis infection: unusual corpus callosal lesions and serial magnetic resonance imaging findings
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
    Neurol India 61:414-8. 2013
    ..Diffusion showed no restriction of corpus callosal lesions. Patient was treated with the high dose parenteral steroids with albendazole and at 6-month follow-up and had a remarkable recovery. ..
  35. ncbi request reprint Assessment of cardiac autonomic function in patients with Duchenne muscular dystrophy using short term heart rate variability measures
    Pradnya Dhargave
    National Institute of Mental Health and Neurosciences, Bangalore, India
    Eur J Paediatr Neurol 18:317-20. 2014
    ..Early diagnostic markers of cardiac involvement might help in timely intervention. In this study we compared the short term HRV measures of DMD children with that of healthy subjects...
  36. ncbi request reprint Central nervous system norcardiosis with granulomatous pachymeningitis and osteomyelitis of skull vault
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
    Indian J Pathol Microbiol 57:332-4. 2014
    ..Patient was treated with three drug regime with good recovery at 3 months follow-up. This is a rare case of central nervous system nocardiosis with skull vault osteomyelitis and a protracted clinical course. ..
  37. ncbi request reprint Assessment of pulmonary function in amyotrophic lateral sclerosis
    Sathyaprabha Talakad N
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bengaluru, India
    Indian J Chest Dis Allied Sci 51:87-91. 2009
    ..At diagnosis most patients with ALS usually do not have any respiratory complaints. However, sub-clinical pulmonary dysfunction is known...
  38. ncbi request reprint Altered in-vitro and in-vivo expression of glial glutamate transporter-1 following exposure to cerebrospinal fluid of amyotrophic lateral sclerosis patients
    K Shobha
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore 560 029, India
    J Neurol Sci 254:9-16. 2007
    ..This could lead to an increased level of glutamate in the synaptic pool causing excitotoxicity to motor neurons, possibly by triggering the 'glutamate-mediated toxicity-pathway'...
  39. ncbi request reprint Cerebrospinal fluid from amyotrophic lateral sclerosis patients causes fragmentation of the Golgi apparatus in the neonatal rat spinal cord
    Priti Y Ramamohan
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    Amyotroph Lateral Scler 8:79-82. 2007
    ..Thus, we suggest that the putative toxin(s) present in ALS-CSF may cause impairment in the protein processing leading to motor neuron death...
  40. ncbi request reprint Familial amyotrophic lateral sclerosis: first report from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 54:304-5. 2006
    ..In the first instance the mother had a duration of illness of 8 years while in the second the father lived for 15 years after the onset of illness...
  41. doi request reprint Exposure to cerebrospinal fluid of sporadic amyotrophic lateral sclerosis patients alters Nav1.6 and Kv1.6 channel expression in rat spinal motor neurons
    R Gunasekaran
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Post Box no 2900, Hosur Road, Bangalore 560 029, India
    Brain Res 1255:170-9. 2009
    ..Altered expression of these voltage-gated channels may interfere with the electrical activity of motor neurons, and thereby lead to the degeneration of neurons...
  42. ncbi request reprint Late onset glycogen storage disease type II with reducing body-like inclusions
    N Gayathri
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Clin Neuropathol 29:36-40. 2010
    ..There are only two reports in the literature describing similar inclusions in late onset GSD II. We report morphological findings of this rare disorder and compare the findings with earlier two reports...
  43. doi request reprint Natural history of solitary cerebral cysticercosis on serial magnetic resonance imaging and the effect of albendazole therapy on its evolution
    A De Souza
    Departments of Neurology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India
    J Neurol Sci 288:135-41. 2010
    ..To describe the evolution of imaging characteristics of solitary cerebral cysticercal lesions (SCCL) on serial MRI, and to study the effect of treatment with albendazole...
  44. doi request reprint Cerebrospinal fluid from sporadic amyotrophic lateral sclerosis patients induces degeneration of a cultured motor neuron cell line
    K Vijayalakshmi
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    Brain Res 1263:122-33. 2009
    ..Unlimited supply of NSC-34 cells and their vulnerability to SALS-CSF render them to be a good bioassay system to identify new therapeutic agents conferring protection to motor neurons...
  45. doi request reprint Altered neuronal activities in the motor cortex with impaired motor performance in adult rats observed after infusion of cerebrospinal fluid from amyotrophic lateral sclerosis patients
    R Sankaranarayani
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore 560029, India
    Behav Brain Res 206:109-19. 2010
    ..In the current study, we have shown that, ALS-CSF has the potential to perturb neuronal activity of the rat motor cortex which was associated with poor performance on motor function tests...
  46. doi request reprint Exposure to CSF from sporadic amyotrophic lateral sclerosis patients induces morphological transformation of astroglia and enhances GFAP and S100beta expression
    K Shobha
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore 560029, Karnataka, India
    Neurosci Lett 473:56-61. 2010
    ..The above changes could possibly alter the microenvironment hastening the motor neuron degeneration...
  47. doi request reprint Pulmonary function tests and diaphragmatic compound muscle action potential in patients with sporadic amyotrophic lateral sclerosis
    T N Sathyaprabha
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    Acta Neurol Scand 121:400-5. 2010
    ..Respiratory failure is the primary cause of death in patients with amyotrophic lateral sclerosis (ALS). Diaphragmatic compound muscle action potentials (DCMAP) are valid parameters to assess the respiratory muscle innervation...
  48. ncbi request reprint Cyclophosphamide attenuates the degenerative changes induced by CSF from patients with amyotrophic lateral sclerosis in the neonatal rat spinal cord
    N Shahani
    Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS) P.O. Box 2900, Hosur Road, 560 029, Bangalore, India
    J Neurol Sci 185:109-18. 2001
    ..These results suggest that cyclophosphamide could exert a neuroprotective effect against the neurotoxic action of factor(s) present in the ALS-CSF...
  49. pmc "Dropped head syndrome" in syringomyelia: report of two cases
    A Nalini
    J Neurol Neurosurg Psychiatry 76:290-1. 2005
  50. ncbi request reprint (-)-Deprenyl alleviates the degenerative changes induced in the neonatal rat spinal cord by CSF from amyotrophic lateral sclerosis patients
    Neelam Shahani
    Department of Neurobiology, University of Osnabrueck, D 49076 Osnabrueck, Germany
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:172-9. 2004
    ..There was also a significant (35%) decrease in the LDH activity following (-)-deprenyl treatment. These results suggest that (-)-deprenyl may confer neuroprotection against the toxic factor(s) present in ALS CSF...