Ashis K Mukherjee


Country: India


  1. Patra A, Kalita B, Mukherjee A. Assessment of quality, safety, and pre-clinical toxicity of an equine polyvalent anti-snake venom (Pan Africa): Determination of immunological cross-reactivity of antivenom against venom samples of Elapidae and Viperidae snakes of Africa. Toxicon. 2018;: pubmed publisher
    ..CSVAPA at a dose of 3-12 times higher than the clinical dose did not cause deaths or adverse reaction of treated rabbits. The results suggest the satisfactory quality, safety, and efficacy of CSVAPA. ..
  2. Kalita B, Singh S, Patra A, Mukherjee A. Quantitative proteomic analysis and antivenom study revealing that neurotoxic phospholipase A2 enzymes, the major toxin class of Russell's viper venom from southern India, shows the least immuno-recognition and neutralization by commercial polyvalent. Int J Biol Macromol. 2018;118:375-385 pubmed publisher
  3. Mukherjee A, Dutta S, Mackessy S. A new C-type lectin (RVsnaclec) purified from venom of Daboia russelii russelii shows anticoagulant activity via inhibition of FXa and concentration-dependent differential response to platelets in a Ca²⁺-independent manner. Thromb Res. 2014;134:1150-6 pubmed publisher
    ..RVsnaclec (5.0 mg/kg body weight) was non-lethal to mice and showed no adverse pharmacological effects, suggesting that it has potential as a lead compound for future therapeutic applications in cardiovascular disorders. ..
  4. Dutta S, Gogoi D, Mukherjee A. Anticoagulant mechanism and platelet deaggregation property of a non-cytotoxic, acidic phospholipase A2 purified from Indian cobra (Naja naja) venom: inhibition of anticoagulant activity by low molecular weight heparin. Biochimie. 2015;110:93-106 pubmed publisher
    ..The future therapeutic application of NnPLA2-I for treatment and prevention of cardiovascular disorders is therefore suggested. ..
  5. Majumdar S, Dutta S, Das T, Chattopadhyay P, Mukherjee A. Antiplatelet and antithrombotic activity of a fibrin(ogen)olytic protease from Bacillus cereus strain FF01. Int J Biol Macromol. 2015;79:477-89 pubmed publisher
    ..Bacethrombase (10 mg/kg) did not show toxicity after i.v. administration in Wistar rats; however, it revealed an in vivo anticoagulant effect and significantly inhibited the carrageenan-induced in vivo thrombus formation in rats. ..
  6. Mukherjee A, Saviola A, Burns P, Mackessy S. Apoptosis induction in human breast cancer (MCF-7) cells by a novel venom L-amino acid oxidase (Rusvinoxidase) is independent of its enzymatic activity and is accompanied by caspase-7 activation and reactive oxygen species production. Apoptosis. 2015;20:1358-72 pubmed publisher
    ..Rusvinoxidase at a dose of 4 mg/kg was non-toxic in mice, indicating that it may be useful as a model for the development of peptide-based anticancer drugs. ..
  7. Mukherjee A, Rai S, Thakur R, Chattopadhyay P, Kar S. Bafibrinase: A non-toxic, non-hemorrhagic, direct-acting fibrinolytic serine protease from Bacillus sp. strain AS-S20-I exhibits in vivo anticoagulant activity and thrombolytic potency. Biochimie. 2012;94:1300-8 pubmed publisher
    ..Bafibrinase was also superior to human plasmin in degrading in vitro thrombus. The in vivo anticoagulant nature of Bafibrinase is being explored for the treatment and prevention of thrombosis and other cardiovascular diseases. ..
  8. Mukherjee A, Saviola A, Mackessy S. Cellular mechanism of resistance of human colorectal adenocarcinoma cells against apoptosis-induction by Russell's Viper venom l-amino acid oxidase (Rusvinoxidase). Biochimie. 2018;150:8-15 pubmed publisher
  9. Majumdar S, Chattopadhyay P, Mukherjee A. In Vivo Anticoagulant and Thrombolytic Activities of a Fibrinolytic Serine Protease (Brevithrombolase) With the k-Carrageenan-Induced Rat Tail Thrombosis Model. Clin Appl Thromb Hemost. 2016;22:594-8 pubmed publisher
    ..These findings unequivocally suggest that Brevithrombolase may serve a promising alternative to the commercial thrombolytic drugs. ..

More Information


  1. Thakur R, Chattopadhyay P, Ghosh S, Mukherjee A. Elucidation of procoagulant mechanism and pathophysiological significance of a new prothrombin activating metalloprotease purified from Daboia russelii russelii venom. Toxicon. 2015;100:1-12 pubmed publisher
    ..In conclusion, Rusviprotease is the first example of a prothrombin activator with fibrinogenolytic property purified from Daboia russelii russelii venom. ..
  2. Gogoi D, Arora N, Kalita B, Sarma R, Islam T, Ghosh S, et al. Anticoagulant mechanism, pharmacological activity, and assessment of preclinical safety of a novel fibrin(ogen)olytic serine protease from leaves of Leucas indica. Sci Rep. 2018;8:6210 pubmed publisher
    ..125-0.5 mg/kg) in vivo anticoagulant and plasma defibrinogenation activities in a rodent model. Lunathrombase (10 mg/kg) did not show toxicity or adverse pharmacological effects in treated animals. ..
  3. Mukherjee A, Dutta S, Kalita B, Jha D, Deb P, Mackessy S. Structural and functional characterization of complex formation between two Kunitz-type serine protease inhibitors from Russell's Viper venom. Biochimie. 2016;128-129:138-47 pubmed publisher
    ..This study may lay the foundation for understanding the basis of protein complexes in snake venoms and their role in pathophysiology of snakebite. ..
  4. Kalita B, Patra A, Jahan S, Mukherjee A. First report of the characterization of a snake venom apyrase (Ruviapyrase) from Indian Russell's viper (Daboia russelii) venom. Int J Biol Macromol. 2018;111:639-648 pubmed publisher
    ..The catalytic activity and platelet deaggregation property of Ruviapyrase was significantly inhibited by EDTA, DTT and IAA, and neutralized by commercial monovalent and polyvalent antivenom. ..
  5. Thakur R, Mukherjee A. Pathophysiological significance and therapeutic applications of snake venom protease inhibitors. Toxicon. 2017;131:37-47 pubmed publisher
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    Mukherjee A, Das K. Microbial surfactants and their potential applications: an overview. Adv Exp Med Biol. 2010;672:54-64 pubmed
    ..The present chapter reviews the biochemical properties of different classes of microbial surfactants and their potential application in different industrial sectors. ..
  7. Thakur R, Kini S, Kurkalang S, Banerjee A, Chatterjee P, Chanda A, et al. Mechanism of apoptosis induction in human breast cancer MCF-7 cell by Ruviprase, a small peptide from Daboia russelii russelii venom. Chem Biol Interact. 2016;258:297-304 pubmed publisher
    ..This is the first report on the characterization of the anticancer potential of a small, non-toxic and anticoagulant peptide purified from Russell's viper venom. ..
  8. Bora B, Gogoi D, Tripathy D, Kurkalang S, Ramani S, Chatterjee A, et al. The N-terminal-truncated recombinant fibrin(ogen)olytic serine protease improves its functional property, demonstrates in vivo anticoagulant and plasma defibrinogenation activity as well as pre-clinical safety in rodent model. Int J Biol Macromol. 2018;111:462-474 pubmed publisher
    ..We propose that [Bacifrinase (?N24)] may serve as prototype for the development of potent drug to prevent hyperfibrinogenemia related disorders. ..
  9. Mukherjee A, Bhagowati P, Biswa B, Chanda A, Kalita B. A comparative intracellular proteomic profiling of Pseudomonas aeruginosa strain ASP-53 grown on pyrene or glucose as sole source of carbon and identification of some key enzymes of pyrene biodegradation pathway. J Proteomics. 2017;167:25-35 pubmed publisher
    ..aeruginosa ASP-53 when grown in pyrene medium. This study identified some important pyrene biodegradation enzymes in Pseudomonas aeruginosa ASP-53 and highlights that the bacterium follows salicylate pathway for pyrene degradation. ..
  10. Patra A, Kalita B, Chanda A, Mukherjee A. Proteomics and antivenomics of Echis carinatus carinatus venom: Correlation with pharmacological properties and pathophysiology of envenomation. Sci Rep. 2017;7:17119 pubmed publisher
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    Mukherjee A, Das K. Correlation between diverse cyclic lipopeptides production and regulation of growth and substrate utilization by Bacillus subtilis strains in a particular habitat. FEMS Microbiol Ecol. 2005;54:479-89 pubmed
    ..subtilis strains in their parent ecological niche...
  12. Dutta S, Chanda A, Kalita B, Islam T, Patra A, Mukherjee A. Proteomic analysis to unravel the complex venom proteome of eastern India Naja naja: Correlation of venom composition with its biochemical and pharmacological properties. J Proteomics. 2017;156:29-39 pubmed publisher
    ..naja within the Indian sub-continent. In addition, this study has also identified several enzymes in EI N. naja venom which were previously uncharacterized by proteomic analysis of Naja venom. ..
  13. Mukherjee A, Kalita B, Mackessy S. A proteomic analysis of Pakistan Daboia russelii russelii venom and assessment of potency of Indian polyvalent and monovalent antivenom. J Proteomics. 2016;144:73-86 pubmed publisher
    ..Further, the proteomic findings will contribute to understand the variation in venom composition owing to different geographical location and identification of pharmacologically important proteins in Pakistan RVV. ..
  14. Mukherjee A, Bordoloi N. Biodegradation of benzene, toluene, and xylene (BTX) in liquid culture and in soil by Bacillus subtilis and Pseudomonas aeruginosa strains and a formulated bacterial consortium. Environ Sci Pollut Res Int. 2012;19:3380-8 pubmed publisher
    ..This study highlighted the role of hydrogen peroxide (H(2)O(2)), nitrate, and phosphate in stimulating the biodegradation of BTX compounds under hypoxic condition...
  15. Mukherjee A, Doley R, Saikia D. Isolation of a snake venom phospholipase A2 (PLA2) inhibitor (AIPLAI) from leaves of Azadirachta indica (Neem): mechanism of PLA2 inhibition by AIPLAI in vitro condition. Toxicon. 2008;51:1548-53 pubmed publisher
    ..kaouthia PLA(2) enzymes in a non-competitive manner. The AIPLAI is quite stable at room temperature. The present study shows that AIPLAI holds good promise for the development of novel anti-snake venom drug in future. ..