Govindasamy Mugesh

Summary

Country: India

Publications

  1. request reprint
    Mondal S, Mugesh G. Biomimetic deiodination of thyroid hormones and iodothyronamines - a structure-activity relationship study. Org Biomol Chem. 2016;14:9490-9500 pubmed
  2. Lamani D, Bhowmick D, Mugesh G. Substituent effects on the stability and antioxidant activity of spirodiazaselenuranes. Molecules. 2015;20:12959-78 pubmed publisher
    ..The experimental observations suggest that the antioxidant activity is increased considerably upon substitution of the aromatic group with the benzylic/aliphatic substituents on the nitrogen atoms. ..
  3. Mondal S, Mugesh G. Structure Elucidation and Characterization of Different Thyroxine Polymorphs. Angew Chem Int Ed Engl. 2015;54:10833-7 pubmed publisher
    ..Conformational changes were also discovered to have a remarkable effect on the strength of halogen bonding and the reactivity of the C-I bonds, which could have a significant effect on the hormone activity. ..
  4. Bhowmick D, Mugesh G. Introduction of a catalytic triad increases the glutathione peroxidase-like activity of diaryl diselenides. Org Biomol Chem. 2015;13:9072-82 pubmed publisher
    ..Although the amino moiety increases the nucleophilicity of the thiol, it does not prevent the thiol exchange reactions that take place in the selenenyl sulfide intermediates. ..
  5. Raja K, Mugesh G. Remarkable effect of chalcogen substitution on an enzyme mimetic for deiodination of thyroid hormones. Angew Chem Int Ed Engl. 2015;54:7674-8 pubmed publisher
  6. Mondal S, Manna D, Mugesh G. Selenium-Mediated Dehalogenation of Halogenated Nucleosides and its Relevance to the DNA Repair Pathway. Angew Chem Int Ed Engl. 2015;54:9298-302 pubmed publisher
    ..The results described herein should help in understanding the metabolism of halogenated nucleosides in DNA and RNA. ..
  7. Bhowmick D, Mugesh G. Insights into the catalytic mechanism of synthetic glutathione peroxidase mimetics. Org Biomol Chem. 2015;13:10262-72 pubmed publisher
    ..The catalytic cycle of small GPx mimics is also dependent on the nature of peroxides and thiols used in the study. In this review, we discuss how the catalytic mechanism varies with the substituents attached to the selenium atom. ..
  8. Vernekar A, Das T, Ghosh S, Mugesh G. A Remarkably Efficient MnFe2 O4 -based Oxidase Nanozyme. Chem Asian J. 2016;11:72-6 pubmed publisher
    ..Interestingly, the activity is morphology-dependent, with nanooctahedra (NOh) exhibiting a catalytic efficiency of 2.21×10(9)  m(-1)  s(-1) , the highest activity ever reported for a nanozyme. ..
  9. Bhowmick D, Srivastava S, D Silva P, Mugesh G. Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage. Angew Chem Int Ed Engl. 2015;54:8449-53 pubmed publisher
    ..The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species. ..

More Information

Publications13

  1. Vernekar A, Das T, Mugesh G. Vacancy-Engineered Nanoceria: Enzyme Mimetic Hotspots for the Degradation of Nerve Agents. Angew Chem Int Ed Engl. 2016;55:1412-6 pubmed publisher
    ..Furthermore, the catalysis by nanoceria overcomes the product inhibition generally observed for PTE and small molecule-based PTE mimetics. ..
  2. Mondal S, Raja K, Schweizer U, Mugesh G. Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones. Angew Chem Int Ed Engl. 2016;55:7606-30 pubmed publisher
    ..We also discuss thyroid hormone receptors and their mechanism of action to regulate gene expression, as well as various thyroid-related disorders and the available treatments. ..
  3. Mondal S, Mugesh G. Novel thyroid hormone analogues, enzyme inhibitors and mimetics, and their action. Mol Cell Endocrinol. 2017;458:91-104 pubmed publisher
    ..We also discuss on the development of small-molecule deiodinase mimetics and their mechanism of deiodination, as these compounds have the potential to regulate the thyroid hormone levels. ..
  4. Mahata S, Maru S, Shukla S, Pandey A, Mugesh G, Das B, et al. Anticancer property of Bryophyllum pinnata (Lam.) Oken. leaf on human cervical cancer cells. BMC Complement Altern Med. 2012;12:15 pubmed publisher
    ..In view of broad spectrum therapeutic potential of B. pinnata we designed a study to examine anti-cancer and anti-Human Papillomavirus (HPV) activities in its leaf extracts and tried to isolate its active principle...