Akhilesh C Mishra

Summary

Country: India

Publications

  1. pmc A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India
    Akhilesh C Mishra
    Microbial Containment Complex, National Institute of Virology, Pashan, Pune 411021, Maharashtra, India
    Virol J 6:26. 2009
  2. pmc Chikungunya outbreaks caused by African genotype, India
    Prasanna N Yergolkar
    National Institute of Virology, Pune, India
    Emerg Infect Dis 12:1580-3. 2006
  3. pmc Genetic characterization of the influenza A pandemic (H1N1) 2009 virus isolates from India
    Varsha A Potdar
    National Institute of Virology, Pune, India
    PLoS ONE 5:e9693. 2010
  4. pmc Characterization of the influenza A H5N1 viruses of the 2008-09 outbreaks in India reveals a third introduction and possible endemicity
    Alok K Chakrabarti
    Microbial Containment Complex, National Institute of Virology, Pune, India
    PLoS ONE 4:e7846. 2009
  5. pmc Avian influenza H9N2 seroprevalence among poultry workers in Pune, India, 2010
    Shailesh D Pawar
    National Institute of Virology, Microbial Containment Complex, Pashan, Pune, India
    PLoS ONE 7:e36374. 2012
  6. pmc Antigen-Antibody docking reveals the molecular basis for cross-reactivity of the 1918 and 2009 Influenza A/H1N1 pandemic viruses
    Sarah Cherian
    Bioinformatics and Data management Division, National Institute of Virology, 20 A, Dr Ambedkar Road, Pune 411001, India
    Bioinformation 6:35-8. 2011
  7. pmc Burden of seasonal and pandemic influenza-associated hospitalization during and after 2009 A(H1N1)pdm09 pandemic in a rural community in India
    Mandeep S Chadha
    National Institute of Virology, Indian Council of Medical Research, Pune, India
    PLoS ONE 8:e55918. 2013
  8. pmc Surveillance in Eastern India (2007-2009) revealed reassortment event involving NS and PB1-F2 gene segments among co-circulating influenza A subtypes
    Mehuli Sarkar
    Division of Virology, National Institute of Cholera and Enteric Diseases, P 33, CIT, Road, Scheme XM, Beliaghata, Kolkata 700 010, West Bengal, India
    Virol J 9:3. 2012
  9. pmc An avian influenza A(H11N1) virus from a wild aquatic bird revealing a unique Eurasian-American genetic reassortment
    Shailesh Pawar
    National Institute of Virology, Microbial Containment Complex, 130 1, Sus Road, Pashan, Pune, 411021, India
    Virus Genes 41:14-22. 2010
  10. pmc Immune response during acute Chandipura viral infection in experimentally infected susceptible mice
    Anukumar Balakrishnan
    Chandipura Virus Group, National Institute of Virology, 20 A Dr Ambedkar Road, Post Box 11, Pune 411001, Maharashtra, India
    Virol J 5:121. 2008

Collaborators

Detail Information

Publications48

  1. pmc A unique influenza A (H5N1) virus causing a focal poultry outbreak in 2007 in Manipur, India
    Akhilesh C Mishra
    Microbial Containment Complex, National Institute of Virology, Pashan, Pune 411021, Maharashtra, India
    Virol J 6:26. 2009
    ..The aim of this study was to genetically characterize the Manipur isolate to understand the relationship with other H5N1 isolates and to trace the possible source of introduction of the virus into the country...
  2. pmc Chikungunya outbreaks caused by African genotype, India
    Prasanna N Yergolkar
    National Institute of Virology, Pune, India
    Emerg Infect Dis 12:1580-3. 2006
    ..Phylogenic analysis based on partial sequences of NS4 and E1 genes showed that all earlier isolates (1963-1973) were Asian genotype, whereas the current and Yawat (2000) isolates were African genotype...
  3. pmc Genetic characterization of the influenza A pandemic (H1N1) 2009 virus isolates from India
    Varsha A Potdar
    National Institute of Virology, Pune, India
    PLoS ONE 5:e9693. 2010
    ..Continuous monitoring of the genetic makeup of the virus is essential to understand its evolution within the country in relation to global diversification and to track the mutations that may affect the behavior of the virus...
  4. pmc Characterization of the influenza A H5N1 viruses of the 2008-09 outbreaks in India reveals a third introduction and possible endemicity
    Alok K Chakrabarti
    Microbial Containment Complex, National Institute of Virology, Pune, India
    PLoS ONE 4:e7846. 2009
    ....
  5. pmc Avian influenza H9N2 seroprevalence among poultry workers in Pune, India, 2010
    Shailesh D Pawar
    National Institute of Virology, Microbial Containment Complex, Pashan, Pune, India
    PLoS ONE 7:e36374. 2012
    ..8% poultry workers were positive for antibodies against AI H9N2 by HI and MN assay respectively using 40 as cut-off antibody titre. This is the first report of seroprevalence of antibodies against AI H9N2 among poultry workers in India...
  6. pmc Antigen-Antibody docking reveals the molecular basis for cross-reactivity of the 1918 and 2009 Influenza A/H1N1 pandemic viruses
    Sarah Cherian
    Bioinformatics and Data management Division, National Institute of Virology, 20 A, Dr Ambedkar Road, Pune 411001, India
    Bioinformation 6:35-8. 2011
    ..However, 2D1 failed to bind to the known antigenic sites in the HAs of seasonal strains. Our study thus reveals the molecular basis for pre-existing immunity in elderly people to the 2009 pandemic virus...
  7. pmc Burden of seasonal and pandemic influenza-associated hospitalization during and after 2009 A(H1N1)pdm09 pandemic in a rural community in India
    Mandeep S Chadha
    National Institute of Virology, Indian Council of Medical Research, Pune, India
    PLoS ONE 8:e55918. 2013
    ..We conducted a population-based study to estimate the incidence of laboratory confirmed influenza-associated hospitalizations in a rural community in western India...
  8. pmc Surveillance in Eastern India (2007-2009) revealed reassortment event involving NS and PB1-F2 gene segments among co-circulating influenza A subtypes
    Mehuli Sarkar
    Division of Virology, National Institute of Cholera and Enteric Diseases, P 33, CIT, Road, Scheme XM, Beliaghata, Kolkata 700 010, West Bengal, India
    Virol J 9:3. 2012
    ..Thus, in addition to the HA and NA gene segments, monitoring diversity of NS1 and PB1-F2 is also important...
  9. pmc An avian influenza A(H11N1) virus from a wild aquatic bird revealing a unique Eurasian-American genetic reassortment
    Shailesh Pawar
    National Institute of Virology, Microbial Containment Complex, 130 1, Sus Road, Pashan, Pune, 411021, India
    Virus Genes 41:14-22. 2010
    ..Such a genetic reassortment is unique and interesting, though the pathways leading to its emergence and its future persistence in the avian reservoir is yet to be fully established...
  10. pmc Immune response during acute Chandipura viral infection in experimentally infected susceptible mice
    Anukumar Balakrishnan
    Chandipura Virus Group, National Institute of Virology, 20 A Dr Ambedkar Road, Post Box 11, Pune 411001, Maharashtra, India
    Virol J 5:121. 2008
    ..As Chandipura virus infects both young and adult mice brain through intracerebral route the role of immune system during peripheral infection in young susceptible mice needs to be studied...
  11. pmc Development and evaluation of a real-time one step reverse-transcriptase PCR for quantitation of Chandipura virus
    Satyendra Kumar
    National Institute of Virology, Pashan, Pune, India
    BMC Infect Dis 8:168. 2008
    ....
  12. pmc Pandemic influenza (H1N1) 2009 is associated with severe disease in India
    Akhilesh C Mishra
    National Institute of Virology, Pune, India
    PLoS ONE 5:e10540. 2010
    ..Pandemic influenza A (H1N1) 2009 has posed a serious public health challenge world-wide. In absence of reliable information on severity of the disease, the nations are unable to decide on the appropriate response against this disease...
  13. pmc Seroepidemiology of pandemic influenza A (H1N1) 2009 virus infections in Pune, India
    Babasaheb V Tandale
    National Institute of Virology, 20 A, Dr, Ambedkar Road, Pune 411001, India
    BMC Infect Dis 10:255. 2010
    ..We undertook serosurveys among the risk groups and general population to determine the extent of pandemic influenza A (H1N1) 2009 virus infections...
  14. doi request reprint Evolutionary rates and timescale comparison of Chikungunya viruses inferred from the whole genome/E1 gene with special reference to the 2005-07 outbreak in the Indian subcontinent
    Sarah S Cherian
    National Institute of Virology, Pune, Maharashtra State, India
    Infect Genet Evol 9:16-23. 2009
    ..The study confirms the epidemiological data, specifically with regard to the re-emergence of CHIKV and throws light on the evolutionary dynamics of CHIK viruses...
  15. ncbi request reprint Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007
    Yogesh K Gurav
    National Institute of Virology ICMR, Pune, India
    Indian J Med Res 132:395-9. 2010
    ..An outbreak of acute encephalitis syndrome (AES) among children from Nagpur division, Maharashtra was investigated to confirm the aetiology and to describe clinico-epidemiological features...
  16. pmc Recent ancestry of Kyasanur Forest disease virus
    Rajeev Mehla
    National Institute of Virology, Pune, India
    Emerg Infect Dis 15:1431-7. 2009
    ..Recent common ancestry of KFDVs from India and Saudi Arabia, despite their large geographic separation, indicates long-range movement of virus, possibly by birds...
  17. doi request reprint Evolution, dispersal and replacement of American genotype dengue type 2 viruses in India (1956-2005): selection pressure and molecular clock analyses
    Sandeep R P Kumar
    National Institute of Virology, Pashan, Pune 411021, Maharashtra, India
    J Gen Virol 91:707-20. 2010
    ..Overall, the present study increases our understanding of the events leading to the establishment and dispersal of the two genotypes in India...
  18. doi request reprint Characterization of the complete genome of influenza A (H5N1) virus isolated during the 2006 outbreak in poultry in India
    Koninika Ray
    Microbial Containment Complex, National Institute of Virology, Sus Road, Pashan, Pune 411021, India
    Virus Genes 36:345-53. 2008
    ....
  19. pmc Avian influenza surveillance reveals presence of low pathogenic avian influenza viruses in poultry during 2009-2011 in the West Bengal State, India
    Shailesh D Pawar
    National Institute of Virology, Microbial Containment Complex, 130 1, Sus Road, Pashan, Pune, 411021, India
    Virol J 9:151. 2012
    ..Therefore, in view of the recent HPAI H5N1 outbreaks in poultry, active AI surveillance encompassing wild, resident, migratory birds and poultry was undertaken during 2009-2011 in the State of West Bengal...
  20. doi request reprint Diagnosis of Kyasanur forest disease by nested RT-PCR, real-time RT-PCR and IgM capture ELISA
    Devendra T Mourya
    Microbial Containment Complex, National Institute of Virology, 130 1 Sus Road, Pashan, Pune 411021, Maharashtra, India
    J Virol Methods 186:49-54. 2012
    ..In addition, early laboratory diagnosis of KFDV infection will help in the application of appropriate control measures and management of KFD cases...
  21. doi request reprint Systemic involvements and fatalities during Chikungunya epidemic in India, 2006
    Babasaheb V Tandale
    National Institute of Virology, Pune, India
    J Clin Virol 46:145-9. 2009
    ..In addition to classical manifestations of Chikungunya infection, severe infections requiring hospitalization were reported during outbreaks in India in 2006...
  22. ncbi request reprint Genetic divergence of Chikungunya viruses in India (1963-2006) with special reference to the 2005-2006 explosive epidemic
    Vidya A Arankalle
    National Institute of Virology, 130 1 Sus Road, Pashan, Pune 411021, India
    J Gen Virol 88:1967-76. 2007
    ..The results may help in understanding the association, if any, of the unique mutations with the explosive nature of the CHIK outbreak...
  23. doi request reprint Buffalopox outbreak in humans and animals in Western Maharashtra, India
    Yogesh K Gurav
    National Institute of Virology, 20 A, Dr Ambedkar Road, Pune 411001, India
    Prev Vet Med 100:242-7. 2011
    ..Considering the productivity losses caused by buffalopox infection and its zoonotic impact, the importance of control measures in reducing the economic and public health impact cannot be underestimated...
  24. pmc Detection of Nipah virus RNA in fruit bat (Pteropus giganteus) from India
    Pragya D Yadav
    Microbial Containment Complex, National Institute of Virology, Pune, India
    Am J Trop Med Hyg 87:576-8. 2012
    ..This is the first report on confirmation of Nipah viral RNA in Pteropus bat from India and suggests the possible role of this species in transmission of NiV in India...
  25. pmc Detection, isolation and confirmation of Crimean-Congo hemorrhagic fever virus in human, ticks and animals in Ahmadabad, India, 2010-2011
    Devendra T Mourya
    National Institute of Virology, Pashan, Pune, India
    PLoS Negl Trop Dis 6:e1653. 2012
    ..This paper reports a detailed epidemiological investigation of nosocomial outbreak from the affected area of Ahmadabad, Gujarat, India...
  26. pmc Receptor specificity and erythrocyte binding preferences of avian influenza viruses isolated from India
    Shailesh D Pawar
    National Institute of Virology NIV Microbial Containment Complex MCC, 130 1, Sus Road, Pashan, Pune 411021, India
    Virol J 9:251. 2012
    ..With this background, the present study was undertaken to study erythrocyte binding preferences and receptor specificities of AI viruses isolated from India...
  27. pmc Non structural protein of avian influenza A (H11N1) virus is a weaker suppressor of immune responses but capable of inducing apoptosis in host cells
    Sanjay Mukherjee
    Microbial Containment Complex, National Institute of Virology, Pashan, Pune, India
    Virol J 9:149. 2012
    ..Interactions of NS1 protein with host factors, role of NS1 protein in regulating cellular responses and apoptosis are quite complicated and further studies are still needed to understand it completely...
  28. ncbi request reprint Chandipura virus: a major cause of acute encephalitis in children in North Telangana, Andhra Pradesh, India
    Babasaheb V Tandale
    National Institute of Virology, Pune, India
    J Med Virol 80:118-24. 2008
    ..05) than in contacts (75/77, 97.4%) and non-contacts (302/321, 94.1%) more than 15 years respectively. CHPV appears to be the major cause of acute viral encephalitis in children in endemic areas during early monsoon months...
  29. ncbi request reprint Genetic characterization of Bagaza virus (BAGV) isolated in India and evidence of anti-BAGV antibodies in sera collected from encephalitis patients
    Vijay P Bondre
    National Institute of Virology, Pashan, Pune 411 021, India
    J Gen Virol 90:2644-9. 2009
    ..This is the first report of the isolation of BAGV from India. The presence of anti-BAGV neutralizing antibodies suggests that the human population has been exposed to BAGV...
  30. ncbi request reprint Pandemic influenza A(H1N1) 2009 outbreak in a residential school at Panchgani, Maharashtra, India
    Yogesh K Gurav
    National Institute of Virology ICMR, Pune, India
    Indian J Med Res 132:67-71. 2010
    ..The nature of public health response and effectiveness of the control measures were also evaluated...
  31. doi request reprint Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010-2011
    Pragya D Yadav
    Microbial Containment Complex, National Institute of Virology, Sus Road, Pashan, Pune 410021, India
    Infect Genet Evol 14:223-31. 2013
    ..The study thus warrants the need for continued surveillance and increased sampling of CCHFV in different parts of the country...
  32. doi request reprint Multisite virological influenza surveillance in India: 2004-2008
    Mandeep S Chadha
    National Institute of Virology, Pune, India All India Institute of Medical Sciences, New Delhi, India
    Influenza Other Respir Viruses 6:196-203. 2012
    ..Influenza surveillance is important to identify circulating, emerging/reemerging strains and unusual epidemiological trends. With these objectives, a multisite human influenza surveillance network was initiated in India in 2004...
  33. doi request reprint Comprehensive global amino acid sequence analysis of PB1F2 protein of influenza A H5N1 viruses and the influenza A virus subtypes responsible for the 20th-century pandemics
    Gunisha Pasricha
    Microbial Containment Complex, National Institute of Virology, Pashan, Pune, India
    Influenza Other Respir Viruses 7:497-505. 2013
    ..Selection of PB1 gene segment in the pandemics, variable size and pleiotropic effect of PB1F2 intrigued us to analyze amino acid sequences of this protein in various influenza A viruses...
  34. ncbi request reprint Serologic evidence of avian influenza H9N2 and paramyxovirus type 1 infection in emus (Dromaius novaehollandiae) in India
    Prashant V Shinde
    Avian Influenza Group, National Institute of Virology Microbial Containment Complex, 131 1, Sus Road, Pashan, Pune 411 021, India
    Avian Dis 56:257-60. 2012
    ..Performance of both HI and MN assays was similar, suggesting the utility of using the MN assay along with HI assay for surveillance studies. This is the first report of the seroprevalence of AI H9N2 and APMV-1 in emus in India...
  35. pmc Antibody persistence after Pandemic H1N1 2009 influenza vaccination among healthcare workers in Pune, India
    Babasaheb V Tandale
    National Institute of Virology, Pashan, Pune India
    Hum Vaccin Immunother 9:125-7. 2013
    ..Seroprotection at 12 mo (60.2%) was significantly lower as compared with 3 weeks (74.7%), 3 mo (77.8%) and 6 mo (75.4%). The vaccine provided seroprotection up to one year...
  36. pmc Low Level of Cross-Reactive Antibodies to Pandemic Influenza (H1N1) 2009 Virus in Humans in Pre-Pandemic Period in Maharashtra, India
    Sadhana S Kode
    National Institute of Virology NIV Microbial Containment Complex MCC, 130 1, Sus Road, Pashan, Pune, 411021 India
    Indian J Virol 23:36-8. 2012
    ..Overall, low level of cross-reactive antibodies to H1N1pdm virus were found in humans in pre-pandemic period in Maharashtra, India...
  37. pmc Molecular characterization of Umbre virus (Bunyaviridae)
    Pragya D Yadav
    Microbial Containment Complex, National Institute of Virology, 130 1 Sus Road, Pashan, Pune 411021, India
    Virol J 5:115. 2008
    ..Twenty-six percent differences at nucleotide level while 17% differences at amino acid level were noted within different isolates. Phylogentic data shows that this virus represents a distinct group within the genus Orthobunyavirus...
  38. doi request reprint Evolutionary dynamics of the influenza A pandemic (H1N1) 2009 virus with emphasis on Indian isolates: evidence for adaptive evolution in the HA gene
    Jayati Mullick
    National Institute of Virology, 20 A, Ambedkar Road, Pune 411001, India
    Infect Genet Evol 11:997-1005. 2011
    ..The study thus warrants the need for continued surveillance and genetic characterization of whole genome sequences to detect any possible reassortment events that might further contribute to the viral fitness of the pH1N1 viruses...
  39. doi request reprint Genomic analysis reveals Nairobi sheep disease virus to be highly diverse and present in both Africa, and in India in the form of the Ganjam virus variant
    Pragya D Yadav
    Microbial Containement Complex, National Institute of Virology, Sus Road, Pashan, Pune 410021, India
    Infect Genet Evol 11:1111-20. 2011
    ..Surprisingly, NSD virus does not represent a distinct lineage, but appears as a variant with other Ganjam virus among NSD virus group...
  40. doi request reprint Development of a multiplex one step RT-PCR that detects eighteen respiratory viruses in clinical specimens and comparison with real time RT-PCR
    Manohar L Choudhary
    Influenza Division, National Institute of Virology, Pune, India
    J Virol Methods 189:15-9. 2013
    ..4%), H1N1pdm09 (8.54%), parainfluenza virus-3 (5.8%) and metapneumovirus (5.2%). In conclusion, mRT-PCR is a rapid, cost effective, specific and highly sensitive method for detection of respiratory viruses...
  41. pmc Pandemic (H1N1) 2009 influenza virus induces weaker host immune responses in vitro: a possible mechanism of high transmissibility
    Sanjay Mukherjee
    Microbial Containment Complex, National Institute of Virology, Sus Road, Pashan, Pune 411021, India
    Virol J 8:140. 2011
    ..There is still a high morbidity and mortality of susceptible adult as well as young population without having underlying health issues due to the influenza infection...
  42. pmc Introduction of Japanese encephalitis virus genotype I, India
    Pradip V Fulmali
    National Institute of Virology, Pune, India P V Fulmali, G N Sapkal, S Athawale, A C Mishra, V P Bondre and National Institute of Virology, Gorakhpur, India M M Gore
    Emerg Infect Dis 17:319-21. 2011
    ..Currently, >2,000 patients with AES are admitted each year to Baba Raghav Das Medical College, Gorakhpur...
  43. pmc Host gene expression profiling in influenza A virus-infected lung epithelial (A549) cells: a comparative analysis between highly pathogenic and modified H5N1 viruses
    Alok K Chakrabarti
    Microbial Containment Complex, National Institute of Virology, Sus Road, Pashan, Pune 411021 India
    Virol J 7:219. 2010
    ....
  44. pmc Genomic characterization of Nipah virus, West Bengal, India
    Vidya A Arankalle
    National Institute of Virology, Pune, India
    Emerg Infect Dis 17:907-9. 2011
    ..Full-genome sequence of Nipah virus (18,252 nt) amplified from lung tissue showed 99.2% nt and 99.8% aa identity with the Bangladesh-2004 isolate, suggesting a common source of the virus...
  45. doi request reprint Establishment and characterization of a new Aedes aegypti (L.) (Diptera: Culicidae) cell line with special emphasis on virus susceptibility
    A B Sudeep
    Microbial Containment Complex, National Institute of Virology, Indian Council of Medical Research, Sus Road Pashan, Pune 411021, India
    In Vitro Cell Dev Biol Anim 45:491-5. 2009
    ..Due to its high susceptibility to a broad spectrum of viruses, the new cell line may find application in virus isolation during epidemics and in antigen production...
  46. doi request reprint Pathologic study of pandemic influenza A (H1N1) 2009 cases from India
    Vijay N Shelke
    Department of Electron Microscopy and Histopath, Byramjee Jeejeebhoy Medical College and Hospital, Pune, India
    Pathol Int 62:36-42. 2012
    ..This study also emphasizes the use of the postmortem needle biopsy technique whenever an autopsy is not possible...
  47. ncbi request reprint Experimental transmission of Chandipura virus by Phlebotomus argentipes (diptera: psychodidae)
    Mangala S Mavale
    National Institute of Virology, Pune, India
    Am J Trop Med Hyg 76:307-9. 2007
    ..The susceptibility of P. argentipes to CHPV and its potential to transmit the virus by bite has importance in epidemiology of CHPV...
  48. doi request reprint Validity of clinical case definitions for influenza surveillance among hospitalized patients: results from a rural community in North India
    Vivek Gupta
    AIIMS INCLEN collaborative influenza projects, The Inclen Trust International, New Delhi, India
    Influenza Other Respir Viruses 7:321-9. 2013
    ..Specimens were tested by rRT-PCR for influenza viruses...