Ganesh Chandra Jagetia


Affiliation: Kasturba Medical College
Country: India


  1. Jagetia G, Baliga M, Venkatesh P. Effect of Sapthaparna (Alstonia scholaris Linn) in modulating the benzo(a)pyrene-induced forestomach carcinogenesis in mice. Toxicol Lett. 2003;144:183-93 pubmed
    ..The pre or post-treatment of mice with 4 mg/ml ASE also significantly reduced the frequency of BaP-induced MN in the splenocytes of treated animals. ..
  2. Jagetia G, Baliga M. Treatment of mice with a herbal preparation (mentat) protects against radiation-induced mortality. Phytother Res. 2003;17:876-81 pubmed
    ..wt., where no drug-induced mortality was observed. The LD50 dose of mentat was found to be 1.75 g/kg b. wt. Our study demonstrates that mentat can provide good radioprotection at a dose of 80 mg/kg, which is far below its toxic dose. ..
  3. Jagetia G, Baliga M. Modulation of antineoplastic activity of cyclophosphamide by Alstonia scholaris in the Ehrlich ascites carcinoma-bearing mice. J Exp Ther Oncol. 2003;3:272-82 pubmed
    ..The administration of 120 mg/kg of ASE 6 h before the administration of 25 mg/kg of CPA resulted in a drastic decline in the glutathione levels and increased the lipid peroxidation considerably when compared with either drug alone. ..
  4. Jagetia G, Baliga M. Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes: a preliminary study. Toxicol Lett. 2002;132:19-25 pubmed
    ..Our study demonstrates that the leaf extract of S. cumini, a plant traditionally used to treat diabetic disorders protects against the radiation-induced DNA damage. ..
  5. Jagetia G, Baliga M, Venkatesh P. Influence of seed extract of Syzygium Cumini (Jamun) on mice exposed to different doses of gamma-radiation. J Radiat Res. 2005;46:59-65 pubmed
    ..The SCE treatment protected mice against the gastrointestinal as well as bone marrow deaths and the DRF was found to be 1.24. ..
  6. Jagetia G, Venkatesh P, Baliga M. Fruit extract of Aegle marmelos protects mice against radiation-induced lethality. Integr Cancer Ther. 2004;3:323-32 pubmed
  7. Jagetia G, Baliga M. Polyherbal extract of septilin protects mice against whole body lethal dose of gamma radiation. Phytother Res. 2004;18:619-23 pubmed
    ..33%) which was used as a positive control. The LD(50) of Septilin was 1250 mg/kg as against the optimum protective dose of 100 mg/kg. Our study demonstrates Septilin as a good radioprotective agent. ..
  8. Jagetia G, Baliga M. Effect of Alstonia scholaris in enhancing the anticancer activity of berberine in the Ehrlich ascites carcinoma-bearing mice. J Med Food. 2004;7:235-44 pubmed
  9. Jagetia G, Rajanikant G. Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of gamma-radiation. J Surg Res. 2004;120:127-38 pubmed
    ..This study demonstrates that curcumin pretreatment has a conducive effect on the irradiated wound and could be a substantial therapeutic strategy in initiating and supporting the cascade of tissue repair processes in irradiated wounds. ..

More Information


  1. Jagetia G, Baliga M. Induction of developmental toxicity in mice treated with Alstonia scholaris (Sapthaparna) In utero. Birth Defects Res B Dev Reprod Toxicol. 2003;68:472-8 pubmed
    ..Our study indicates clearly that ASE treatment caused teratogenic effect only at doses above 240 mg/kg (>20% of LD(50)). Lower doses had no developmental toxicity. ..
  2. Jagetia G, Shirwaikar A, Rao S, Bhilegaonkar P. Evaluation of the radioprotective effect of Ageratum conyzoides Linn. extract in mice exposed to different doses of gamma radiation. J Pharm Pharmacol. 2003;55:1151-8 pubmed
    ..ACE was found to scavenge DPPH radicals in a concentration-dependent manner, indicating that the radioprotection afforded by ACE may be in part due to the scavenging of reactive oxygen species induced by ionizing radiation. ..
  3. Chandra Jagetia G, Rajanikant G, Rao S, Shrinath Baliga M. Alteration in the glutathione, glutathione peroxidase, superoxide dismutase and lipid peroxidation by ascorbic acid in the skin of mice exposed to fractionated gamma radiation. Clin Chim Acta. 2003;332:111-21 pubmed
  4. Jagetia G, Baliga M, Venkatesh P, Ulloor J. Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation. Radiat Res. 2003;160:584-92 pubmed
    ..ZOE also had a dose-dependent antimicrobial activity against Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli and Candida albicans. ..
  5. Jagetia G, Rao S, Baliga M, S Babu K. The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro: a preliminary study. Phytother Res. 2004;18:561-5 pubmed
  6. Jagetia G, Baliga M, Venkatesh P. Ginger (Zingiber officinale Rosc.), a dietary supplement, protects mice against radiation-induced lethality: mechanism of action. Cancer Biother Radiopharm. 2004;19:422-35 pubmed
    ..Ginger was found to scavenge *OH, O2*- and ABTS*+ radicals in a dose-dependent manner in vitro. The drug was nontoxic up to a dose of 1500 mg/kg body weight, the highest drug dose that could be tested for acute toxicity. ..
  7. Jagetia G, Baliga M. Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study. Phytomedicine. 2005;12:209-15 pubmed
    ..The administration of 400 mg/kg MGN induced 50% mortality, therefore LD50 of the drug was considered to be 400 mg/kg. ..
  8. Jagetia G, Venkatesh P, Baliga M. Evaluation of the radioprotective effect of bael leaf (Aegle marmelos) extract in mice. Int J Radiat Biol. 2004;80:281-90 pubmed
    ..To investigate the radioprotective activity of a leaf extract of bael leaf (Aegle marmelos) (AME) in mice exposed to different doses of gamma-radiation...
  9. Jagetia G, Venkatesh P, Baliga M. Evaluation of the radioprotective effect of Aegle marmelos (L.) Correa in cultured human peripheral blood lymphocytes exposed to different doses of gamma-radiation: a micronucleus study. Mutagenesis. 2003;18:387-93 pubmed
  10. Jagetia G, Venkatesh P, Baliga M. Aegle marmelos (L.) Correa inhibits the proliferation of transplanted Ehrlich ascites carcinoma in mice. Biol Pharm Bull. 2005;28:58-64 pubmed
    ..The acute toxicity study of AME showed that the drug was non-toxic up to a dose of 1750 mg/kg b. wt. The LD10 and LD50 was found to be 2000 and 2250 mg/kg...
  11. Jagetia G, Baliga M. Influence of the leaf extract of Mentha arvensis Linn. (mint) on the survival of mice exposed to different doses of gamma radiation. Strahlenther Onkol. 2002;178:91-8 pubmed
    ..The aim of the present study was to evaluate the radioprotective effect of Mentha arvensis (mint) on the survival of mice exposed to various doses of whole-body gamma radiation...