Ganesh Chandra Jagetia
Affiliation: Kasturba Medical College
- Jagetia G, Baliga M. Induction of developmental toxicity in mice treated with Alstonia scholaris (Sapthaparna) In utero. Birth Defects Res B Dev Reprod Toxicol. 2003;68:472-8 pubmed..Our study indicates clearly that ASE treatment caused teratogenic effect only at doses above 240 mg/kg (>20% of LD(50)). Lower doses had no developmental toxicity. ..
- Jagetia G, Shirwaikar A, Rao S, Bhilegaonkar P. Evaluation of the radioprotective effect of Ageratum conyzoides Linn. extract in mice exposed to different doses of gamma radiation. J Pharm Pharmacol. 2003;55:1151-8 pubmed..ACE was found to scavenge DPPH radicals in a concentration-dependent manner, indicating that the radioprotection afforded by ACE may be in part due to the scavenging of reactive oxygen species induced by ionizing radiation. ..
- Chandra Jagetia G, Rajanikant G, Rao S, Shrinath Baliga M. Alteration in the glutathione, glutathione peroxidase, superoxide dismutase and lipid peroxidation by ascorbic acid in the skin of mice exposed to fractionated gamma radiation. Clin Chim Acta. 2003;332:111-21 pubmed
- Jagetia G, Baliga M, Venkatesh P, Ulloor J. Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation. Radiat Res. 2003;160:584-92 pubmed..ZOE also had a dose-dependent antimicrobial activity against Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli and Candida albicans. ..
- Jagetia G, Rao S, Baliga M, S Babu K. The evaluation of nitric oxide scavenging activity of certain herbal formulations in vitro: a preliminary study. Phytother Res. 2004;18:561-5 pubmed
- Jagetia G, Baliga M, Venkatesh P. Ginger (Zingiber officinale Rosc.), a dietary supplement, protects mice against radiation-induced lethality: mechanism of action. Cancer Biother Radiopharm. 2004;19:422-35 pubmed..Ginger was found to scavenge *OH, O2*- and ABTS*+ radicals in a dose-dependent manner in vitro. The drug was nontoxic up to a dose of 1500 mg/kg body weight, the highest drug dose that could be tested for acute toxicity. ..
- Jagetia G, Baliga M. Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study. Phytomedicine. 2005;12:209-15 pubmed..The administration of 400 mg/kg MGN induced 50% mortality, therefore LD50 of the drug was considered to be 400 mg/kg. ..
- Jagetia G, Venkatesh P, Baliga M. Evaluation of the radioprotective effect of bael leaf (Aegle marmelos) extract in mice. Int J Radiat Biol. 2004;80:281-90 pubmed..To investigate the radioprotective activity of a leaf extract of bael leaf (Aegle marmelos) (AME) in mice exposed to different doses of gamma-radiation...
- Jagetia G, Venkatesh P, Baliga M. Evaluation of the radioprotective effect of Aegle marmelos (L.) Correa in cultured human peripheral blood lymphocytes exposed to different doses of gamma-radiation: a micronucleus study. Mutagenesis. 2003;18:387-93 pubmed
- Jagetia G, Venkatesh P, Baliga M. Aegle marmelos (L.) Correa inhibits the proliferation of transplanted Ehrlich ascites carcinoma in mice. Biol Pharm Bull. 2005;28:58-64 pubmed..The acute toxicity study of AME showed that the drug was non-toxic up to a dose of 1750 mg/kg b. wt. The LD10 and LD50 was found to be 2000 and 2250 mg/kg...
- Jagetia G, Baliga M. Influence of the leaf extract of Mentha arvensis Linn. (mint) on the survival of mice exposed to different doses of gamma radiation. Strahlenther Onkol. 2002;178:91-8 pubmed..The aim of the present study was to evaluate the radioprotective effect of Mentha arvensis (mint) on the survival of mice exposed to various doses of whole-body gamma radiation...