Udaykumar Ranga

Summary

Affiliation: Jawaharlal Nehru Centre for Advanced Scientific Research
Country: India

Publications

  1. ncbi request reprint Characterization of human immunodeficiency virus (HIV)-infected cells in infiltrates associated with CNS opportunistic infections in patients with HIV clade C infection
    Anita Mahadevan
    Departments of Neuropathology, National Institute of Mental Health and Neurological Sciences, Bangalore, India
    J Neuropathol Exp Neurol 66:799-808. 2007
  2. pmc Evident stabilization of the clinical profile in HIV/AIDS as evaluated in an open label clinical trial using a polyherbal formulation
    Mangaiarkarasi Asokan
    HIV AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
    Indian J Med Res 137:1128-44. 2013
  3. pmc Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence
    Vasudev R Rao
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Retrovirology 10:61. 2013
  4. pmc Development of a liposomal nanodelivery system for nevirapine
    Lakshmi N Ramana
    Centre for Nanotechnology and Advanced Biomaterials, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, India
    J Biomed Sci 17:57. 2010
  5. pmc Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India
    Ujjwal Neogi
    Department of Pediatrics, St, John s Medical College and Hospital, St, John s National Academy of Health Sciences, Sarjapur Road, Bangalore 560034, India
    AIDS Res Ther 7:24. 2010
  6. pmc Tat protein of human immunodeficiency virus type 1 subtype C strains is a defective chemokine
    Udaykumar Ranga
    Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
    J Virol 78:2586-90. 2004
  7. doi request reprint HIV-1 infection induces acetylation of NPM1 that facilitates Tat localization and enhances viral transactivation
    Shrikanth S Gadad
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India
    J Mol Biol 410:997-1007. 2011
  8. ncbi request reprint Gene expression analysis from human immunodeficiency virus type 1 subtype C promoter and construction of bicistronic reporter vectors
    Nagadenahalli Byrareddy Siddappa
    Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
    AIDS Res Hum Retroviruses 23:1268-78. 2007
  9. pmc Multiple NF-κB sites in HIV-1 subtype C long terminal repeat confer superior magnitude of transcription and thereby the enhanced viral predominance
    Mahesh Bachu
    HIV AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru 560064, India
    J Biol Chem 287:44714-35. 2012
  10. doi request reprint HIV-1 Tat-specific IgG antibodies in high-responders target a B-cell epitope in the cysteine-rich domain and block extracellular Tat efficiently
    Venkatesh Prasanna Kashi
    Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560 064, India
    Vaccine 27:6739-47. 2009

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Characterization of human immunodeficiency virus (HIV)-infected cells in infiltrates associated with CNS opportunistic infections in patients with HIV clade C infection
    Anita Mahadevan
    Departments of Neuropathology, National Institute of Mental Health and Neurological Sciences, Bangalore, India
    J Neuropathol Exp Neurol 66:799-808. 2007
    ..These findings suggest the possibility that patients, even if successfully treated for an opportunistic inflection, may be at high risk of developing HIV encephalitis and subsequent dementia...
  2. pmc Evident stabilization of the clinical profile in HIV/AIDS as evaluated in an open label clinical trial using a polyherbal formulation
    Mangaiarkarasi Asokan
    HIV AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
    Indian J Med Res 137:1128-44. 2013
    ..In a prospective, single-site, open-label, non-randomized, controlled, pilot trial, we evaluated a polyherbal formulation (PHF) for its safety and efficacy in treating subjects with HIV-AIDS...
  3. pmc Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence
    Vasudev R Rao
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Retrovirology 10:61. 2013
    ..HIV-1 Tat protein is a viral determinant of neurocognitive dysfunction. Therefore, we focused our study on the variations seen in tat gene and its contribution to HIV associated neuropathogenesis...
  4. pmc Development of a liposomal nanodelivery system for nevirapine
    Lakshmi N Ramana
    Centre for Nanotechnology and Advanced Biomaterials, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, India
    J Biomed Sci 17:57. 2010
    ..We propose that nevirapine-loaded liposomal formulations reported here could improve targeted delivery of the anti-retroviral drugs to select compartments and cells and alleviate systemic toxic side effects as a consequence...
  5. pmc Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India
    Ujjwal Neogi
    Department of Pediatrics, St, John s Medical College and Hospital, St, John s National Academy of Health Sciences, Sarjapur Road, Bangalore 560034, India
    AIDS Res Ther 7:24. 2010
    ..The objective of this study was to determine using in silico methods, HIV-1 tropism among a large number of Indian isolates both from primary clinical isolates as well as from database-derived sequences...
  6. pmc Tat protein of human immunodeficiency virus type 1 subtype C strains is a defective chemokine
    Udaykumar Ranga
    Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
    J Virol 78:2586-90. 2004
    ....
  7. doi request reprint HIV-1 infection induces acetylation of NPM1 that facilitates Tat localization and enhances viral transactivation
    Shrikanth S Gadad
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India
    J Mol Biol 410:997-1007. 2011
    ..These results shed further insights into the possible role of histone chaperone NPM1 acetylation in viral gene transcription, which could be a potential therapeutic target...
  8. ncbi request reprint Gene expression analysis from human immunodeficiency virus type 1 subtype C promoter and construction of bicistronic reporter vectors
    Nagadenahalli Byrareddy Siddappa
    Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
    AIDS Res Hum Retroviruses 23:1268-78. 2007
    ..The LTR reporters we developed could be of significant use in the study of viral transactivation, in the evaluation of biological properties of viral subtypes, and in the screening for antiviral inhibitors...
  9. pmc Multiple NF-κB sites in HIV-1 subtype C long terminal repeat confer superior magnitude of transcription and thereby the enhanced viral predominance
    Mahesh Bachu
    HIV AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru 560064, India
    J Biol Chem 287:44714-35. 2012
    ....
  10. doi request reprint HIV-1 Tat-specific IgG antibodies in high-responders target a B-cell epitope in the cysteine-rich domain and block extracellular Tat efficiently
    Venkatesh Prasanna Kashi
    Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560 064, India
    Vaccine 27:6739-47. 2009
    ..To the best of our knowledge this is the first report on immune responses to Tat from Indian populations and the data presented here could significantly contribute to HIV Tat vaccine design...
  11. pmc Exceptional molecular and coreceptor-requirement properties of molecular clones isolated from an Human Immunodeficiency Virus Type-1 subtype C infection
    Prasanta K Dash
    Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
    Retrovirology 5:25. 2008
    ..To isolate molecular clones from this virus, we devised a novel strategy based on anchor primers that target a sequence in the reverse transcriptase, highly conserved among diverse subtypes of HIV-1...
  12. pmc Codon optimization of the tat antigen of human immunodeficiency virus type 1 generates strong immune responses in mice following genetic immunization
    Lakshmi Ramakrishna
    Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India
    J Virol 78:9174-89. 2004
    ....
  13. pmc Sequence insertions in the HIV type 1 subtype C viral promoter predominantly generate an additional NF-κB binding site
    Mahesh Bachu
    HIV AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru, India
    AIDS Res Hum Retroviruses 28:1362-8. 2012
    ..Further investigation is warranted to examine the significance of the sequence insertions for the replicative fitness of the variant viral strains...
  14. pmc Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV-1 subtype-C Tat protein
    Nagadenahalli Byrareddy Siddappa
    Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
    Retrovirology 3:53. 2006
    ..Keeping this limitation in view, we developed an efficient protein purification strategy for Tat...
  15. ncbi request reprint Identification of unique B/C recombinant strains of HIV-1 in the southern state of Karnataka, India
    Nagadenahalli Byrareddy Siddappa
    Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560 064, India
    AIDS 19:1426-9. 2005
    ..Unexpectedly, env sequences of two of the three B/C recombinants phylogenetically clustered with subtype B strains of the USA. The determination of the real incidence of the recombinant viruses is of importance...
  16. doi request reprint Molecular characterization of a full-length genome of a HIV-2 isolate from India
    Susmita R Gurjar
    Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Acquir Immune Defic Syndr 52:329-35. 2009
    ....
  17. ncbi request reprint Specific inhibition of p300-HAT alters global gene expression and represses HIV replication
    K Mantelingu
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P O Bangalore, India
    Chem Biol 14:645-57. 2007
    ..Remarkably, these inhibitors were found to be nontoxic to T cells, inhibit histone acetylation of HIV infected cells, and consequently inhibit the multiplication of HIV...
  18. pmc Identification of subtype C human immunodeficiency virus type 1 by subtype-specific PCR and its use in the characterization of viruses circulating in the southern parts of India
    Nagadenahalli B Siddappa
    Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India
    J Clin Microbiol 42:2742-51. 2004
    ..We propose the use of C-PCR to facilitate rapid molecular epidemiologic characterization to aid vaccine and therapeutic strategies...
  19. pmc Genetic characterization of HIV type 1 Tat exon 1 from a southern Indian clinical cohort: identification of unique epidemiological signature residues
    Ujjwal Neogi
    Clinical Virology, Department of Microbiology, St John s Medical College, St John s National Academy of Health Sciences, Bangalore, India
    AIDS Res Hum Retroviruses 28:1152-6. 2012
    ..Our data have direct relevance for subunit-based Tat HIV-1 vaccine development...
  20. ncbi request reprint Regeneration of commercial nucleic acid extraction columns without the risk of carryover contamination
    Nagadenahalli B Siddappa
    Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
    Biotechniques 42:186, 188-92. 2007
    ....
  21. doi request reprint The multifunctional protein nucleophosmin (NPM1) is a human linker histone H1 chaperone
    Shrikanth S Gadad
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India
    Biochemistry 50:2780-9. 2011
    ..These data identify NPM1 as an important member of the linker histone chaperone family in humans...
  22. ncbi request reprint Codon optimization and ubiquitin conjugation of human immunodeficiency virus-1 Tat lead to enhanced cell-mediated immune responses
    Lakshmi Ramakrishna
    Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur PO, Bangalore 560064, India
    Vaccine 22:2586-98. 2004
    ..Preliminary attempts at characterizing the immunodominant regions identified a novel T-helper epitope within the core domain of Tat...
  23. ncbi request reprint Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription
    Karanam Balasubramanyam
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India
    J Biol Chem 279:51163-71. 2004
    ..Thus, non-toxic curcumin, which targets p300/CBP, may serve as a lead compound in combinatorial HIV therapeutics...
  24. doi request reprint Neuropathological correlate of the "concentric target sign" in MRI of HIV-associated cerebral toxoplasmosis
    Anita Mahadevan
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Magn Reson Imaging 38:488-95. 2013
    ..The exclusive specificity of this sign in cerebral toxoplasmosis remains to be further elucidated...
  25. pmc HIV-1 clade-specific differences in the induction of neuropathogenesis
    Vasudev R Rao
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 28:10010-6. 2008
    ....
  26. ncbi request reprint Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: significance of dicysteine C30C31 motif
    Mamata Mishra
    National Brain Research Centre, Manesar Gurgaon, India
    Ann Neurol 63:366-76. 2008
    ..Whether clade-specific differences translate to varied neuropathogenesis is not known, and this uncertainty warrants an immediate investigation into neurotoxicity on human neurons of Tat derived from different viral clades..
  27. ncbi request reprint HIV-1 clade-C-associated "ALS"-like disorder: first report from India
    Sanjib Sinha
    Department of Neurology, NIMHANS, Hosur Road, Bangalore 560 029, India
    J Neurol Sci 224:97-100. 2004
    ..The reversibility of "ALS"-like features in this subgroup of patients might offer an insight into the pathogenesis of amyotrophic lateral sclerosis. This is a first report of ALS-like illness caused by subtype C of HIV-1 strain...