Tapas K Kundu

Summary

Affiliation: Jawaharlal Nehru Centre for Advanced Scientific Research
Country: India

Publications

  1. Chatterjee S, Cassel R, Schneider Anthony A, Merienne K, Cosquer B, Tzeplaeff L, et al. Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator. EMBO Mol Med. 2018;10: pubmed publisher
  2. Kaypee S, Sahadevan S, Patil S, Ghosh P, Roy N, Roy S, et al. Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation. iScience. 2018;4:260-272 pubmed publisher
    ..Reversal of gain-of-function properties of mutant p53 suggests that molecules targeting the p53-p300 interface may be good candidates for anti-tumor drugs. ..
  3. Singh A, Halder Sinha S, Clement J, Kundu T. Epigenetic modulation by small molecule compounds for neurodegenerative disorders. Pharmacol Res. 2018;132:135-148 pubmed publisher
    ..A few small molecule modulators which have been shown to possess promising results in the animal model system of neurological disorders will also be discussed with future perspectives. ..
  4. Kaypee S, Sahadevan S, Sudarshan D, Halder Sinha S, Patil S, Senapati P, et al. Oligomers of human histone chaperone NPM1 alter p300/KAT3B folding to induce autoacetylation. Biochim Biophys Acta Gen Subj. 2018;1862:1729-1741 pubmed publisher
    ..NPM1 is overexpressed in several solid cancers, the significance of which is unknown. Induction of p300 autoacetylation could be the cause of NPM1-mediated tumorigenicity. ..
  5. Chaturbedy P, Kumar M, Salikolimi K, Das S, Sinha S, Chatterjee S, et al. Shape-directed compartmentalized delivery of a nanoparticle-conjugated small-molecule activator of an epigenetic enzyme in the brain. J Control Release. 2015;217:151-9 pubmed publisher
  6. Kaypee S, Sudarshan D, Shanmugam M, Mukherjee D, Sethi G, Kundu T. Aberrant lysine acetylation in tumorigenesis: Implications in the development of therapeutics. Pharmacol Ther. 2016;162:98-119 pubmed publisher
  7. Babu A, Kamaraj M, Basu M, Mukherjee D, Kapoor S, Ranjan S, et al. Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi Syndrome in zebrafish. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1203-1215 pubmed publisher
    ..Thus, modeling rare human genetic disorders in zebrafish allows for functional understanding of the genes involved and can also yield small molecule candidates towards therapeutic goals. ..
  8. request reprint
    Behera A, Swamy M, Natesh N, Kundu T. Garcinol and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:435-452 pubmed
    ..though seem favourable, are very recent and require in depth scientific investigation. ..
  9. Shandilya J, Senapati P, Dhanasekaran K, Bangalore S, Kumar M, Kishore A, et al. Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression. FEBS Lett. 2014;588:2198-205 pubmed publisher
    ..These data suggest that Aurora kinase B-mediated phosphorylation of NPM1 plays a critical role during mitosis, which could have wider implications in oncogenesis. ..

More Information

Publications11

  1. Selvi B, Swaminathan A, Maheshwari U, Nagabhushana A, Mishra R, Kundu T. CARM1 regulates astroglial lineage through transcriptional regulation of Nanog and posttranscriptional regulation by miR92a. Mol Biol Cell. 2015;26:316-26 pubmed publisher
    ..This study thus establishes the functional cooperation between arginine methylation and microRNA expression in the neuronal developmental process, with potential implications in sensory development pathways. ..
  2. Swaminathan A, Delage H, Chatterjee S, Belgarbi Dutron L, Cassel R, Martinez N, et al. Transcriptional Coactivator and Chromatin Protein PC4 Is Involved in Hippocampal Neurogenesis and Spatial Memory Extinction. J Biol Chem. 2016;291:20303-14 pubmed publisher
    ..These observations indicate that non-histone chromatin-associated proteins like PC4 play a significant role in neuronal plasticity. ..