R Tuteja

Summary

Affiliation: International Centre for Genetic Engineering and Biotechnology
Country: India

Publications

  1. ncbi request reprint DNA vaccine against malaria: a long way to go
    Renu Tuteja
    International Centre for Genetic Engineering and Biotechnology, New Delhi
    Crit Rev Biochem Mol Biol 37:29-54. 2002
  2. ncbi request reprint Unraveling the 'DEAD-box' helicases of Plasmodium falciparum
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Gene 376:1-12. 2006
  3. pmc In silico analysis of Plasmodium species specific UvrD helicase
    Renu Tuteja
    Malaria Group International Centre for Genetic Engineering and Biotechnology New Delhi, India
    Commun Integr Biol 6:e23125. 2013
  4. pmc Genome wide comparative comprehensive analysis of Plasmodium falciparum MCM family with human host
    Abulaish Ansari
    Malaria Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi India
    Commun Integr Biol 5:607-15. 2012
  5. pmc Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression
    Moaz Ahmad
    Malaria Group International Centre for Genetic Engineering and Biotechnology New Delhi, India
    Commun Integr Biol 5:350-61. 2012
  6. pmc Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction
    Moaz Ahmad
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    PLoS ONE 7:e49385. 2012
  7. doi request reprint Genetically engineered synthetic miniaturized versions of Plasmodium falciparum UvrD helicase are catalytically active
    Abulaish Ansari
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    PLoS ONE 9:e90951. 2014
  8. doi request reprint Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth
    Mohammed Tarique
    International Centre for Genetic Engineering and Biotechnology, P, O, Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    BMC Biochem 15:9. 2014
  9. doi request reprint Analysis of DNA repair helicase UvrD from Arabidopsis thaliana and Oryza sativa
    Renu Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India Electronic address
    Plant Physiol Biochem 71:254-60. 2013
  10. doi request reprint Genome wide computational analysis of Brugia malayi helicases: a comparison with human host
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Gene 499:202-8. 2012

Collaborators

  • Pawan Malhotra
  • A Falaschi
  • P L Bhalla
  • P J Shaw
  • Ping Song
  • Narendra Tuteja
  • Arun Pradhan
  • Abulaish Ansari
  • Moaz Ahmad
  • Mohammed Tarique
  • Jay Shankar
  • Virander S Chauhan
  • Ngoc Quang Tran
  • Pavan Umate
  • Krishna Prakash
  • Neeti Sanan Mishra
  • Ajay Amar Vashisht
  • Khondaker M Nasirudin
  • Nasreen Z Ehtesham
  • Tuan Nghia Phan
  • Farha Tabassum
  • Akash Tripathi Satsangi
  • Hung Quang Dang
  • Ejaz M Hussain
  • B P Nayak
  • Sudhir K Sopory
  • K V Rao
  • R P Roy
  • V Manivel
  • R A Vishwakarma

Detail Information

Publications57

  1. ncbi request reprint DNA vaccine against malaria: a long way to go
    Renu Tuteja
    International Centre for Genetic Engineering and Biotechnology, New Delhi
    Crit Rev Biochem Mol Biol 37:29-54. 2002
    ..This review presents an update of the studies carried out in malaria using DNA vaccine approach, the challenges, and the future prospects...
  2. ncbi request reprint Unraveling the 'DEAD-box' helicases of Plasmodium falciparum
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Gene 376:1-12. 2006
    ..These detailed studies may help to identify a parasite-specific enzyme, which could be a potential drug target to treat malaria. The various steps at which this probable drug can act are also discussed...
  3. pmc In silico analysis of Plasmodium species specific UvrD helicase
    Renu Tuteja
    Malaria Group International Centre for Genetic Engineering and Biotechnology New Delhi, India
    Commun Integr Biol 6:e23125. 2013
    ..The results suggest that among all the species of Plasmodium, P. falciparum contains the largest UvrD and this enzyme is variable at the sequence and structural level...
  4. pmc Genome wide comparative comprehensive analysis of Plasmodium falciparum MCM family with human host
    Abulaish Ansari
    Malaria Group International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi India
    Commun Integr Biol 5:607-15. 2012
    ..This article will focus on members of this important family of proteins from the malaria parasite Plasmodium falciparum and their comparison with the human host...
  5. pmc Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression
    Moaz Ahmad
    Malaria Group International Centre for Genetic Engineering and Biotechnology New Delhi, India
    Commun Integr Biol 5:350-61. 2012
    ..Thus PfRuvBs can serve as potential drug target if they show an essential role in the survival of parasite...
  6. pmc Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction
    Moaz Ahmad
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    PLoS ONE 7:e49385. 2012
    ..These studies will make an important contribution in understanding the nucleic acid transaction in the malaria parasite...
  7. doi request reprint Genetically engineered synthetic miniaturized versions of Plasmodium falciparum UvrD helicase are catalytically active
    Abulaish Ansari
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    PLoS ONE 9:e90951. 2014
    ..These studies show that for helicase activity only the conserved domains are essentially required and intervening sequences have almost no role. These observations will aid in understanding the unwinding mechanism by a helicase...
  8. doi request reprint Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth
    Mohammed Tarique
    International Centre for Genetic Engineering and Biotechnology, P, O, Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    BMC Biochem 15:9. 2014
    ..Genome wide analysis revealed that Plasmodium falciparum possesses UvrD helicase, which is absent in the human host...
  9. doi request reprint Analysis of DNA repair helicase UvrD from Arabidopsis thaliana and Oryza sativa
    Renu Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India Electronic address
    Plant Physiol Biochem 71:254-60. 2013
    ..coli UvrD because they contain a longer N-terminal extension. In order to decipher the role of plant UvrD in various stresses it will be important to study the biochemical and functional properties of this enzyme...
  10. doi request reprint Genome wide computational analysis of Brugia malayi helicases: a comparison with human host
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Gene 499:202-8. 2012
    ..Further characterization of these helicases will help in understanding physiological significance of these helicases in filarial parasites, which in future can be utilized for chemotherapy of parasitic infection...
  11. ncbi request reprint Helicases - feasible antimalarial drug target for Plasmodium falciparum
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    FEBS J 274:4699-704. 2007
    ..One feasible target might be helicases, which are important unwinding enzymes and required for almost all the nucleic acid metabolism in the malaria parasite...
  12. ncbi request reprint Malaria - an overview
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    FEBS J 274:4670-9. 2007
    ....
  13. ncbi request reprint Type I signal peptidase: an overview
    Renu Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Arch Biochem Biophys 441:107-11. 2005
    ..Type I signal peptidases have been found in bacteria, archaea, fungi, plants, and animals. In this review, I present an overview of bacterial type I signal peptidases and describe some of their properties in detail...
  14. ncbi request reprint Serial analysis of gene expression (SAGE): application in cancer research
    Renu Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Med Sci Monit 10:RA132-40. 2004
    ..In this review we present an outline of the method and updated information on the applications of SAGE technology to various cancers...
  15. doi request reprint Isolation and functional characterization of eIF4F components and poly(A)-binding protein from Plasmodium falciparum
    Renu Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Parasitol Int 58:481-5. 2009
    ..These studies demonstrate that these factors are structurally and functionally conserved. These studies will contribute to understand the important process and components of translation complex in the malaria parasite...
  16. ncbi request reprint DNA vaccines: a ray of hope
    R Tuteja
    Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    Crit Rev Biochem Mol Biol 34:1-24. 1999
    ..These include the technical challenges of improving delivery and/or potency so that low doses of DNA can achieve the efficacy of conventional vaccines...
  17. ncbi request reprint Ku autoantigen: a multifunctional DNA-binding protein
    R Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi
    Crit Rev Biochem Mol Biol 35:1-33. 2000
    ..The mechanism underlying the regulation of all the diverse functions of Ku is still obscure...
  18. ncbi request reprint Augmentation of immune responses to hepatitis E virus ORF2 DNA vaccination by codelivery of cytokine genes
    R Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Viral Immunol 13:169-78. 2000
    ..We further show that the immune responses generated by plasmid pcDNA-ORF2 can be boosted with virus-like particles composed of the ORF2 protein expressed through a baculovirus expression system...
  19. ncbi request reprint Plasmodium falciparum signal peptidase is regulated by phosphorylation and required for intra-erythrocytic growth
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Mol Biochem Parasitol 157:137-47. 2008
    ..These studies demonstrate the characterization of a functional subunit of SPC from P. falciparum and should make an important contribution in our better understanding of the complex process of protein translocation in the parasite...
  20. ncbi request reprint Genome wide identification of Plasmodium falciparum helicases: a comparison with human host
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Cell Cycle 9:104-20. 2010
    ..falciparum. The detailed studies of these helicases will help in identifying a specific enzyme, which could be used as potential target to control the replication and transmission of the malaria parasite...
  21. ncbi request reprint Isolation and characterization of an eIF-4A homologue from Plasmodium cynomolgi
    Renu Tuteja
    International Center for Genetic Engineering and Biotechnology, PO Box 10504, Aruna Asaf Ali Marg, New Delhi, India
    Mol Biochem Parasitol 124:79-83. 2002
  22. ncbi request reprint Replication fork-stimulated eIF-4A from Plasmodium cynomolgi unwinds DNA in the 3' to 5' direction and is inhibited by DNA-interacting compounds
    Renu Tuteja
    International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Arch Biochem Biophys 414:108-14. 2003
    ....
  23. ncbi request reprint Serial analysis of gene expression (SAGE): unraveling the bioinformatics tools
    Renu Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Bioessays 26:916-22. 2004
    ..In this review, we present an outline of the method, various bioinformatics methods for data analysis and general applications of this important technology...
  24. doi request reprint Helicases involved in splicing from malaria parasite Plasmodium falciparum
    Renu Tuteja
    International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    Parasitol Int 60:335-40. 2011
    ..This article will focus on members of the DExD/H-box proteins involved specially in splicing in the malaria parasite Plasmodium falciparum...
  25. pmc Emerging functions of transcription factors in malaria parasite
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Biomed Biotechnol 2011:461979. 2011
    ..These studies show that these TFs are slowly emerging to have defined roles in the regulation of gene expression in the parasite...
  26. ncbi request reprint Unraveling DNA repair in human: molecular mechanisms and consequences of repair defect
    N Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Crit Rev Biochem Mol Biol 36:261-90. 2001
    ..This review describes the biochemistry of various repair processes and summarizes the clinical features and molecular mechanisms underlying these disorders...
  27. ncbi request reprint Molecular mechanisms of DNA damage and repair: progress in plants
    N Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Crit Rev Biochem Mol Biol 36:337-97. 2001
    ....
  28. ncbi request reprint Bipolar, Dual Plasmodium falciparum helicase 45 expressed in the intraerythrocytic developmental cycle is required for parasite growth
    Arun Pradhan
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, PO Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Mol Biol 373:268-81. 2007
    ..These studies indicate that PfH45 is an indispensable enzyme that is essential for growth, and probably survival, of P. falciparum...
  29. ncbi request reprint A novel 'DEAD-box' DNA helicase from Plasmodium falciparum is homologous to p68
    Arun Pradhan
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Mol Biochem Parasitol 140:55-60. 2005
  30. doi request reprint Isolation and characterization of Plasmodium falciparum UAP56 homolog: evidence for the coupling of RNA binding and splicing activity by site-directed mutations
    Jay Shankar
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, PO Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Arch Biochem Biophys 478:143-53. 2008
    ..In the present study we have reported the detailed characterization of PfU52 from P. falciparum and these results advance the knowledge regarding the function of UAP56 in general...
  31. ncbi request reprint A pea homologue of human DNA helicase I is localized within the dense fibrillar component of the nucleolus and stimulated by phosphorylation with CK2 and cdc2 protein kinases
    N Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110 070, India
    Plant J 25:9-17. 2001
    ..These observations suggest that PDH65 may be involved both in rDNA transcription and in the early stages of pre-rRNA processing...
  32. ncbi request reprint Nucleolin: a multifunctional major nucleolar phosphoprotein
    R Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Crit Rev Biochem Mol Biol 33:407-36. 1998
    ..In plants it is developmentally, cell-cycle, and light regulated. The regulation of all these functions of a single protein seems to be a challenging puzzle...
  33. ncbi request reprint Plasmodium falciparum DNA helicase 60 is a schizont stage specific, bipolar and dual helicase stimulated by PKC phosphorylation
    Arun Pradhan
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Mol Biochem Parasitol 144:133-41. 2005
    ....
  34. ncbi request reprint Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents
    N Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Biochem Biophys Res Commun 236:636-40. 1997
    ..This inhibition could be due to binding of these drugs to DNA, thereby impeding the movement of the helicase for unwinding action which may be their most important pharmacological function against cancer cells...
  35. doi request reprint Genotoxic stress in plants: shedding light on DNA damage, repair and DNA repair helicases
    Narendra Tuteja
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Mutat Res 681:134-49. 2009
    ..This article describes the insight underlying the DNA damage and repair pathways in plants. The comet assay to measure the DNA damage and the role of DNA repair helicases such as XPD and XPB are also covered...
  36. ncbi request reprint 'DEAD-box' helicase from Plasmodium falciparum is active at wide pH and is schizont stage-specific
    Arun Pradhan
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    J Vector Borne Dis 44:12-22. 2007
    ..In the present study, we report some of the important activities of the encoded protein...
  37. ncbi request reprint Prokaryotic and eukaryotic DNA helicases. Essential molecular motor proteins for cellular machinery
    Narendra Tuteja
    International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi, India
    Eur J Biochem 271:1835-48. 2004
    ..The properties of most of the known DNA helicases from prokaryotic and eukaryotic systems, including viruses and bacteriophages, are summarized in tables...
  38. pmc Conserved thioredoxin fold is present in Pisum sativum L. sieve element occlusion-1 protein
    Narendra Tuteja
    International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi, India
    Plant Signal Behav 5:623-8. 2010
    ..Motif 1 (EVF) is conserved in Ps.SEO1, Vicia faba (Vf.For1) and Medicago truncatula (Mt.SEO3); motif 2 (KKED) is well conserved across all forisomes proteins and motif 3 (IGYIGNP) is conserved in Ps.SEO1 and Vf.For1...
  39. doi request reprint Genome-wide analysis of helicase gene family from rice and Arabidopsis: a comparison with yeast and human
    Pavan Umate
    Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology ICGEB, Aruna Asaf Ali Marg, New Delhi 110067, India
    Plant Mol Biol 73:449-65. 2010
    ..Our results revealed that expression of helicase genes is profoundly regulated under various stress conditions. The helicases identified in this study lay a foundation for the in depth characterization of each helicase type...
  40. doi request reprint A novel DEAD box helicase Has1p from Plasmodium falciparum: N-terminal is essential for activity
    Krishna Prakash
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Parasitol Int 59:271-7. 2010
    ..These studies suggest that besides the conserved helicase domain the highly variable N-terminal region also contributes in the activity of the protein...
  41. doi request reprint UvrD helicase of Plasmodium falciparum
    Jay Shankar
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Gene 410:223-33. 2008
    ..In this manuscript we provide an overview of UvrD family of helicases and bioinformatics analysis of UvrD from P. falciparum...
  42. doi request reprint Characterization of replication fork and phosphorylation stimulated Plasmodium falciparum helicase 45
    Arun Pradhan
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Gene 420:66-75. 2008
    ..5 to 5.0 microM respectively. These compounds distinctively inhibit the helicase activity probably by forming complex with DNA and obstructing enzyme movement...
  43. ncbi request reprint Unraveling DNA helicases. Motif, structure, mechanism and function
    Narendra Tuteja
    International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi, India
    Eur J Biochem 271:1849-63. 2004
    ..The genes containing helicase motifs may have evolved from a common ancestor. In this review we cover the conserved motifs, structural information, mechanism of DNA unwinding and translocation, and functional aspects of DNA helicases...
  44. ncbi request reprint Unraveling the components of protein translocation pathway in human malaria parasite Plasmodium falciparum
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Arch Biochem Biophys 467:249-60. 2007
    ..We have also shown the various steps of translocation in a hypothetical model...
  45. ncbi request reprint Signaling through MAP kinase networks in plants
    Neeti Sanan Mishra
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Arch Biochem Biophys 452:55-68. 2006
    ..The cross-talk between plant MAP kinases is also discussed to bring out the complexity within this three-component module...
  46. ncbi request reprint Cold- and salinity stress-induced bipolar pea DNA helicase 47 is involved in protein synthesis and stimulated by phosphorylation with protein kinase C
    Ajay Amar Vashisht
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    Plant J 44:76-87. 2005
    ..Its bipolar helicase activities may also be involved in distinct cellular processes in stressed conditions...
  47. ncbi request reprint B cell responses to a peptide epitope. V. Kinetic regulation of repertoire discrimination and antibody optimization for epitope
    B P Nayak
    Immunology Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    J Immunol 161:3510-9. 1998
    ..Thus, it would appear that the kinetics of Ag recognition dominate over equilibrium binding criteria both in epitope-driven repertoire selection and Ab maturation in a humoral response...
  48. ncbi request reprint A novel nuclear DNA helicase with high specific activity from Pisum sativum catalytically translocates in the 3'-->5' direction
    Tuan Nghia Phan
    International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    Eur J Biochem 270:1735-45. 2003
    ..Isolation of this new DNA helicase should make an important contribution to our better understanding of DNA transaction in plants...
  49. ncbi request reprint The Gly-Arg-rich C-terminal domain of pea nucleolin is a DNA helicase that catalytically translocates in the 5'- to 3'-direction
    Khondaker M Nasirudin
    Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    Arch Biochem Biophys 434:306-15. 2005
    ..This study should make important contribution to our better understanding of DNA transaction in plants, mechanism of DNA unwinding, and the mechanism by which these ligands can disturb genome integrity...
  50. ncbi request reprint Plasmodium falciparum DNA helicase 60. dsRNA- and antibody-mediated inhibition of malaria parasite growth and downregulation of its enzyme activities by DNA-interacting compounds
    Arun Pradhan
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    FEBS J 273:3545-56. 2006
    ..These compounds also inhibited parasite growth in culture. This is the first study to show inhibition of growth of the parasite by the dsRNA of a helicase, and most probably this is due to interference with cognate mRNA expression...
  51. doi request reprint A single subunit MCM6 from pea forms homohexamer and functions as DNA helicase
    Ngoc Quang Tran
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India
    Plant Mol Biol 74:327-36. 2010
    ..This discovery should make an important contribution to a better understanding of DNA replication in plants...
  52. doi request reprint A method to inhibit the growth of Plasmodium falciparum by double-stranded RNA-mediated gene silencing of helicases
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    Methods Mol Biol 587:389-99. 2010
    ..Using this approach, we show that helicases are indispensable enzymes, which are required for growth and most probably survival of the malaria parasite...
  53. ncbi request reprint Malaria - the global disease
    Renu Tuteja
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    FEBS J 274:4669. 2007