Research Topics

Srikrishna Subramanian


Affiliation: Institute of Microbial Technology
Country: India


  1. Agrawal Y, Khatri I, Subramanian S, Shenoy B. Genome sequence, comparative analysis, and evolutionary insights into chitinases of entomopathogenic fungus Hirsutella thompsonii. Genome Biol Evol. 2015;7:916-30 pubmed publisher
    ..We further identify and classify putative chitinases that may function as virulence factors in fungal entomopathogens due to their role in degradation of arthropod cuticle. ..
  2. Kaur G, Subramanian S. The insertion domain 1 of class IIA dimeric glycyl-tRNA synthetase is a rubredoxin-like zinc ribbon. J Struct Biol. 2015;190:38-46 pubmed publisher
  3. Kaur G, Subramanian S. The Ku-Mar zinc finger: A segment-swapped zinc ribbon in MarR-like transcription regulators related to the Ku bridge. J Struct Biol. 2015;191:281-9 pubmed publisher
    ..However, unlike Ku where the segment-swapped zinc ribbons play a role in DNA-binding and obligate dimerization, their primary role in MarR appears to be in dimerization and strengthening of inter-subunit contacts. ..
  4. Kaur G, Iyer L, Subramanian S, Aravind L. Evolutionary convergence and divergence in archaeal chromosomal proteins and Chromo-like domains from bacteria and eukaryotes. Sci Rep. 2018;8:6196 pubmed publisher
  5. Kaur G, Subramanian S. Repurposing TRASH: emergence of the enzyme organomercurial lyase from a non-catalytic zinc finger scaffold. J Struct Biol. 2014;188:16-21 pubmed publisher
    ..The emergence of MerB from a zinc finger ancestor serves as a rare example of how a novel enzyme may emerge from a non-catalytic scaffold with a related binding function. ..
  6. Kaur G, Subramanian S. The UBR-box and its relationship to binuclear RING-like treble clef zinc fingers. Biol Direct. 2015;10:36 pubmed publisher
    ..The UBR-box appears to have emerged during the expansion of ubiquitin system pathway-related functions in eukaryotes, but is also likely to have other non-N-recognin functions as well. ..
  7. Kaur G, Subramanian S. A novel RING finger in the C-terminal domain of the coatomer protein α-COP. Biol Direct. 2015;10:70 pubmed publisher
    ..This RING-like domain is possibly related to those of other vesicle membrane-associated complexes, such as CORVET, HOPS and SEA, and likely mediates interactions with Dsl1p and assist in coat oligomerization. ..
  8. Sharma G, Khatri I, Subramanian S. Complete Genome of the Starch-Degrading Myxobacteria Sandaracinus amylolyticus DSM 53668T. Genome Biol Evol. 2016;8:2520-9 pubmed publisher
    ..However, the absence of cellobiohydrolases/exoglucanases corroborates with the lack of cellulose degradation by this bacteria. ..
  9. Acharya G, Kaur G, Subramanian S. Evolutionary relationships between heme-binding ferredoxin ? + ? barrels. BMC Bioinformatics. 2016;17:168 pubmed publisher
    ..Our study offers insights into the plausible evolutionary relationships between the two distinct barrel packing topologies and relate the observed heme-binding sites to these topologies. ..

More Information


  1. Agrawal Y, Narwani T, Subramanian S. Genome sequence and comparative analysis of clavicipitaceous insect-pathogenic fungus Aschersonia badia with Metarhizium spp. BMC Genomics. 2016;17:367 pubmed publisher
    ..The variation in association of CBMs, being higher in generalists (MR) and lower in specialists (Ab and MAC) fungi may further be responsible for the differences in host affiliation. ..
  2. Acharya G, Kaur G, Subramanian S. An atypical segment swap in the DN and DC domains of the Acr_tran family resistance-nodulation-cell division pump. J Struct Biol. 2016;196:358-363 pubmed publisher
    ..This exemplifies the role of functional constraints including oligomerization that determine the interplay between sequence and the three-dimensional structure of proteins. ..
  3. Khatri I, Tomar R, Ganesan K, Prasad G, Subramanian S. Complete genome sequence and comparative genomics of the probiotic yeast Saccharomyces boulardii. Sci Rep. 2017;7:371 pubmed publisher
    ..We find the introgression of five genes from Z. bailii into the chromosome IV of Sb and wine strains of Sc. Intriguingly, genes involved in conferring known probiotic properties to Sb are conserved in most Sc strains. ..
  4. Sharma G, Khatri I, Subramanian S. Comparative Genomics of Myxobacterial Chemosensory Systems. J Bacteriol. 2018;200: pubmed publisher
    ..We are interested in understanding the distribution of CSS within all known myxobacteria and their probable evolution. ..