Genomes and Genes

Narayanan Manoj


Affiliation: Indian Institute of Technology
Country: India


  1. Singh M, Manoj N. An extended loop in CE7 carbohydrate esterase family is dispensable for oligomerization but required for activity and thermostability. J Struct Biol. 2016;194:434-45 pubmed publisher
    ..Rather, the loop extension event was evolutionarily selected to regulate activity, conformational flexibility and thermal stability. ..
  2. Krishnan A, Dnyansagar R, Almén M, Williams M, Fredriksson R, Manoj N, et al. The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals. BMC Evol Biol. 2014;14:270 pubmed publisher
    ..In summary, this study provides a framework to perform future experimental and comparative studies to further verify and understand the roles of GPCRs that predates the divergence of bilaterian and eumetazoan lineages. ..
  3. Singh M, Manoj N. Crystal structure of Thermotoga maritima acetyl esterase complex with a substrate analog: Insights into the distinctive substrate specificity in the CE7 carbohydrate esterase family. Biochem Biophys Res Commun. 2016;476:63-8 pubmed publisher
    ..The structure provides a template for focused attempts to engineer the CE7 enzymes for enhanced stability, selectivity or activity for biocatalytic applications. ..