C Mandal

Summary

Affiliation: Indian Institute of Chemical Biology
Country: India

Publications

  1. ncbi request reprint Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia
    Shyamasree Ghosh
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata, India
    Br J Haematol 128:35-41. 2005
  2. ncbi request reprint Detection of immune-complexed 9-O-acetylated sialoglycoconjugates in the sera of patients with pediatric acute lymphoblastic leukemia
    Suman Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    J Immunol Methods 297:13-26. 2005
  3. ncbi request reprint Glycobiology of Leishmania donovani
    Sumi Mukhopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, Kolkata, India
    Indian J Med Res 123:203-20. 2006
  4. pmc Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition
    Biswajit Khatua
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata, India
    FEBS Lett 584:555-61. 2010
  5. pmc Flow-cytometric monitoring of disease-associated expression of 9-O-acetylated sialoglycoproteins in combination with known CD antigens, as an index for MRD in children with acute lymphoblastic leukaemia: a two-year longitudinal follow-up study
    Suchandra Chowdhury
    Immunobiology Division, Indian Institute of Chemical Biology, 4, Raja S, C, Mullick Road, Kolkata 700032, Kothari Medical Centre 8 3, Alipore Road, Kolkata 700027, India
    BMC Cancer 8:40. 2008
  6. pmc Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
    Susmita Mondal
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, A Unit of Council of Scientific and Industrial Research, Govt, of India 4, Raja S, C, Mullick Road, Kolkata 700032, India
    Mol Cancer 9:239. 2010
  7. ncbi request reprint Identification and characterization of adsorbed serum sialoglycans on Leishmania donovani promastigotes
    Mitali Chatterjee
    Immunobiology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Calcutta 700032, India
    Glycobiology 13:351-61. 2003
  8. doi request reprint 9- O-acetylated sialic acids enhance entry of virulent Leishmania donovani promastigotes into macrophages
    A Ghoshal
    Infectious Disease and Immunology Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India
    Parasitology 136:159-73. 2009
  9. ncbi request reprint Identification of sialic acids on Leishmania donovani amastigotes
    Anil K Chava
    Immunobiology Division, Indian Institute of Chemical Biology, 4, S C Mullick Road, Jadavpur, 700 032 Kolkata, India
    Biol Chem 385:59-66. 2004
  10. ncbi request reprint Identification of 9-O-acetylated sialoglycans on peripheral blood mononuclear cells in Indian Visceral Leishmaniasis
    Sumi Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700 032, India
    Glycoconj J 20:531-6. 2004

Collaborators

  • Shyam Sundar
  • R Schauer
  • P R Crocker
  • S Sinha
  • Reinhard Schwartz-Albiez
  • Rajender Sangwan
  • Stephan Hinderlich
  • Niranjan P Sahu
  • Suman Bandyopadhyay
  • Mitali Chatterjee
  • Avijit Dutta
  • Santanu Pal
  • Angana Ghoshal
  • Suchandra Chowdhury
  • Shyamasree Ghosh
  • Waliza Ansar
  • Kankana Mukherjee
  • Sumi Bandyopadhyay
  • Tanusree Das
  • Sarmila Chandra
  • Sumi Mukhopadhyay
  • Dilip K Bhattacharya
  • Anil K Chava
  • Anil Kumar Chava
  • Bibhuti Saha
  • Susmita Mondal
  • Sumi Mukhopadhyay Nee Bandyopadhyay
  • Asish Mallick
  • Gerrit J Gerwig
  • Johannis P Kamerling
  • Dilip Kumar Bhattacharya
  • Biswajit Khatua
  • Rajdeep Chowdhury
  • S K Hasan Habib
  • A Ghoshal
  • Asish Kumar Sen
  • Jagnyeswar Ratha
  • M Chatterjee
  • Guido Kohla
  • Anette Merling
  • S Pal
  • Keya Chaudhuri
  • Raghunath Chatterjee
  • Kaushik Bhattacharya
  • Ashok K Giri
  • Rodion Demine
  • Saulius Jarmalavicius
  • Shyamasree Basu
  • J P Kamerling
  • G J Gerwig
  • Michael Forgber
  • A K Chava
  • Peter Walden
  • S Mukhopadhyay
  • Samir Roy
  • Debjani Sarkar
  • Ameenah Gurib-Fakim
  • Sukdeb Banerjee
  • Rupak K Bhadra
  • Goutam Mandal
  • Nirup B Mondal
  • Debayan Mandal
  • Ranjan Bhadra
  • Krishna Das Saha
  • Chandrika N Nair
  • Kajal Nayan Majumdar
  • Shripad D Banavali
  • Sushil Kumar Mandal
  • Chinmoy Sarkar
  • Bidisha Saha
  • Sk Hasan Habib
  • Suresh H Advani
  • Rabindranath Bera
  • Benubrata Das
  • Arindam Bhattacharyya
  • Tanya Das
  • Gayatri Tripathi
  • Gaurisankar Sa
  • Samiran Bandyopadhyay
  • Vineeta Sharma
  • Reinhard Brossmer
  • Malcolm J McConville
  • Rainer Isecke
  • Lynne Minto
  • Andrew G Hall
  • Ross F Waller
  • Santu Bandhyopadhyay
  • Tore Kempf
  • Ulrike Unger
  • Peter Strasser

Detail Information

Publications46

  1. ncbi request reprint Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia
    Shyamasree Ghosh
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata, India
    Br J Haematol 128:35-41. 2005
    ..Controlled expression of these molecules may be exploited as potential targets for therapy, promising beneficial effects to children with ALL...
  2. ncbi request reprint Detection of immune-complexed 9-O-acetylated sialoglycoconjugates in the sera of patients with pediatric acute lymphoblastic leukemia
    Suman Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    J Immunol Methods 297:13-26. 2005
    ....
  3. ncbi request reprint Glycobiology of Leishmania donovani
    Sumi Mukhopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, Kolkata, India
    Indian J Med Res 123:203-20. 2006
    ....
  4. pmc Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition
    Biswajit Khatua
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata, India
    FEBS Lett 584:555-61. 2010
    ..Therefore, Sia may be acquired by PA in the host and contribute to bacterial pathogenicity and host-cell interactions via reduction of complement deposition and siglec-dependent recognition...
  5. pmc Flow-cytometric monitoring of disease-associated expression of 9-O-acetylated sialoglycoproteins in combination with known CD antigens, as an index for MRD in children with acute lymphoblastic leukaemia: a two-year longitudinal follow-up study
    Suchandra Chowdhury
    Immunobiology Division, Indian Institute of Chemical Biology, 4, Raja S, C, Mullick Road, Kolkata 700032, Kothari Medical Centre 8 3, Alipore Road, Kolkata 700027, India
    BMC Cancer 8:40. 2008
    ....
  6. pmc Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
    Susmita Mondal
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, A Unit of Council of Scientific and Industrial Research, Govt, of India 4, Raja S, C, Mullick Road, Kolkata 700032, India
    Mol Cancer 9:239. 2010
    ..Manipulation in ceramide production by physiological and pharmacological modulators therefore will give additive effect in leukemia chemotherapy...
  7. ncbi request reprint Identification and characterization of adsorbed serum sialoglycans on Leishmania donovani promastigotes
    Mitali Chatterjee
    Immunobiology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Calcutta 700032, India
    Glycobiology 13:351-61. 2003
    ..Our results indicate that sialic acids (alpha2-->6 and alpha2-->3 linked) and 9-O-acetyl derivatives constitute components of the parasite cell surface...
  8. doi request reprint 9- O-acetylated sialic acids enhance entry of virulent Leishmania donovani promastigotes into macrophages
    A Ghoshal
    Infectious Disease and Immunology Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India
    Parasitology 136:159-73. 2009
    ....
  9. ncbi request reprint Identification of sialic acids on Leishmania donovani amastigotes
    Anil K Chava
    Immunobiology Division, Indian Institute of Chemical Biology, 4, S C Mullick Road, Jadavpur, 700 032 Kolkata, India
    Biol Chem 385:59-66. 2004
    ..Our results indicate that Neu5Ac [(alpha2 --> 6)- and (alpha2 --> 3)-linked], as well as Neu5Gc and their 9-O-acetyl derivatives, constitute components of the amastigote cell surface of L. donovani...
  10. ncbi request reprint Identification of 9-O-acetylated sialoglycans on peripheral blood mononuclear cells in Indian Visceral Leishmaniasis
    Sumi Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700 032, India
    Glycoconj J 20:531-6. 2004
    ....
  11. ncbi request reprint Acute phase response of C-reactive protein of Labeo rohita to aquatic pollutants is accompanied by the appearance of distinct molecular forms
    S Sinha
    Immunobiology Division, Protein Design and Engineering Division, Indian Institute of Chemical Biology, Raja S.C. Mullick Road, Calcutta, 700 032, India
    Arch Biochem Biophys 396:139-50. 2001
    ....
  12. ncbi request reprint Variable degree of alternative complement pathway-mediated hemolysis in Indian visceral leishmaniasis induced by differential expression of 9-O-acetylated sialoglycans
    Anil Kumar Chava
    Immunobiology Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India
    J Infect Dis 189:1257-64. 2004
    ..We assessed the capacity of this glycotope to influence hemolysis via activation of the alternative complement pathway in patients with VL, compared with that in healthy control subjects...
  13. ncbi request reprint Purification, characterization of O-acetylated sialoglycoconjugates-specific IgM, and development of an enzyme-linked immunosorbent assay for diagnosis and follow-up of indian visceral leishmaniasis patients
    Sumi Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India
    Diagn Microbiol Infect Dis 50:15-24. 2004
    ....
  14. ncbi request reprint Differential expression of 9-O-acetylated sialoglycoconjugates on leukemic blasts: a potential tool for long-term monitoring of children with acute lymphoblastic leukemia
    Santanu Pal
    Immunobiology Division, Indian Institute of Chemical Biology, Kolkata, India
    Int J Cancer 111:270-7. 2004
    ..We propose that close monitoring of 90 and 120 kDa 9-O-AcSGs may serve as a reliable index for long-term management of childhood ALL and merits therapeutic consideration...
  15. ncbi request reprint Protein A--a new ligand for human C-reactive protein
    Tanusree Das
    Immunobiology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700 032, India
    FEBS Lett 576:107-13. 2004
    ..We have demonstrated that Protein A is another ligand in addition to PC establishing an extended definition of CRP. Protein A binding may impart immunomodulatory roles of CRP in combating microorganisms or other foreign materials...
  16. ncbi request reprint O-acetyl sialic acid specific IgM in childhood acute lymphoblastic leukaemia
    S Pal
    Immunobiology Division, Indian Institute of Chemical Biology, Calcutta 700032, India
    Glycoconj J 18:529-37. 2001
    ..Taken together, the data indicates that carbohydrate epitopes having terminal O-AcSA alpha2 --> 6 GalNAc determinants induce disease specific IgG and IgM, potentially useful molecular markers for childhood ALL...
  17. pmc Induction of glycosylation in human C-reactive protein under different pathological conditions
    Tanusree Das
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Calcutta 700 032, India
    Biochem J 373:345-55. 2003
    ..Thus we have convincingly demonstrated that human CRP is glycosylated in some pathological conditions...
  18. ncbi request reprint Sialoglycotherapeutics in protozoal diseases
    Angana Ghoshal
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata, India
    Mini Rev Med Chem 8:358-69. 2008
    ..This review focuses on the development of novel glycobiological therapeutic strategies in the field of protozoan infections...
  19. ncbi request reprint Development of an assay for quantification of linkage-specific O-acetylated sialoglycans on erythrocytes; its application in Indian visceral leishmaniasis
    Anil Kumar Chava
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Calcutta 700 032, India
    J Immunol Methods 270:1-10. 2002
    ..Taken together, we conclude that this antigen-based assay is a specific and reproducible method for monitoring the disease status of VL patients and could be used in retrospective and prospective trials...
  20. doi request reprint Co-expression of 9-O-acetylated sialoglycoproteins and their binding proteins on lymphoblasts of childhood acute lymphoblastic leukemia: an anti-apoptotic role
    Kankana Mukherjee
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
    Biol Chem 390:325-35. 2009
    ....
  21. doi request reprint Detection and characterization of a sialoglycosylated bacterial ABC-type phosphate transporter protein from patients with visceral leishmaniasis
    Angana Ghoshal
    Department of Infectious Disease and Immunology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata, 700032, India
    Glycoconj J 26:675-89. 2009
    ..This is the first reported glycosylation as well as sialylation of the periplasmic component of an ABC-type phosphate transporter protein and of one of few identified bacterial glycoproteins...
  22. ncbi request reprint Sialoglycans in protozoal diseases: their detection, modes of acquisition and emerging biological roles
    Anil K Chava
    Immunobiology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    Glycoconj J 20:199-206. 2004
    ....
  23. doi request reprint Unraveling the C-reactive protein complement-cascade in destruction of red blood cells: potential pathological implications in Plasmodium falciparum malaria
    Waliza Ansar
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata, India
    Cell Physiol Biochem 23:175-90. 2009
    ..Here, we sought to determine the role of affinity-purified C-reactive protein from patients (CRP(Mal)), in modulating the complement-regulatory proteins and downstream effect on complement-cascade...
  24. doi request reprint O-acetylated sialic acids: multifaceted role in childhood acute lymphoblastic leukaemia
    Suchandra Chowdhury
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, Kolkata, India
    Biotechnol J 4:361-74. 2009
    ..Taken together, monitoring these molecules helps not only in unravelling the biology of this paediatric malignancy but also in personalizing the treatment strategies for the betterment of the patient population...
  25. ncbi request reprint Over-expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia
    Suman Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    Int Immunol 17:177-91. 2005
    ..These findings justify further evaluation of the mechanism for functional unresponsiveness of antibodies and production of 9-OAcSA-specific chimeric antibodies with normal Fc domain for therapeutic applications...
  26. doi request reprint Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells
    Chandan Mandal
    Indian Institute of Chemical Biology, Kolkata, India
    Int J Cancer 126:337-49. 2010
    ..Consequently, Neu3 could represent a new potent biomarker in childhood ALL, to assess the efficacy of therapeutic protocols and to rapidly identify an eventual relapse...
  27. ncbi request reprint Aloe vera leaf exudate induces a caspase-independent cell death in Leishmania donovani promastigotes
    Avijit Dutta
    Department of Immunobiology, Indian Institute of Chemical Biology, 4 Raja SC Mullick Road, Kolkata 700 032, India
    J Med Microbiol 56:629-36. 2007
    ....
  28. ncbi request reprint O-acetylation of sialic acids is required for the survival of lymphoblasts in childhood acute lymphoblastic leukemia (ALL)
    Shyamasree Ghosh
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700 032, India
    Glycoconj J 24:17-24. 2007
    ..Taken together, it may be hypothesized that Neu5,9Ac(2)-GPs and their antibodies play a prominent role in promoting the survival of lymphoblasts in ALL...
  29. ncbi request reprint Variations in binding characteristics of glycosylated human C-reactive proteins in different pathological conditions
    Tanusree Das
    Immunobiology, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700 032, India
    Glycoconj J 20:537-43. 2004
    ..Thus, we have convincingly demonstrated that differentially induced CRPs exhibited variable binding characteristics. These results may have far reaching practical applications for understanding acute phase responses...
  30. ncbi request reprint Antibodies directed against O-acetylated sialoglycoconjugates accelerate complement activation in Leishmania donovani promastigotes
    Sumi Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    J Infect Dis 190:2010-9. 2004
    ..Antibodies directed against these epitopes are present in high titers. The biological relevance of these antibodies, with regard to activation of the classical pathway (CP), was investigated...
  31. doi request reprint Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression
    Rajdeep Chowdhury
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
    Toxicol Lett 198:263-71. 2010
    ..N-Acetyl-l-cysteine, a ROS quencher, blocked the arsenic-induced effects. Our study underlines a previously undefined mechanism by which arsenic imparts its toxicity and results in uncontrolled cell proliferation...
  32. doi request reprint Sialic acids in different Leishmania sp., its correlation with nitric oxide resistance and host responses
    Angana Ghoshal
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, A Unit of Council of Scientific and Industrial Research C S I R, Govt of India, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    Glycobiology 20:553-66. 2010
    ..Hence, enhanced levels of 9-O-AcSA serve as one of the potential determinants responsible for increased NO resistance and survivability of parasites by inhibition of host responses...
  33. ncbi request reprint Purification and characterization of 9-O-acetylated sialoglycoproteins from leukemic cells and their potential as immunological tool for monitoring childhood acute lymphoblastic leukemia
    Santanu Pal
    Immunobiology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
    Glycobiology 14:859-70. 2004
    ..This study demonstrated the potential of purified Neu5,9Ac(2)-GPs(ALL) as an alternate tool for detection of anti-Neu5,9Ac(2)-GP antibodies to be helpful for diagnosis and monitoring of childhood ALL patients...
  34. ncbi request reprint Altered erythrocyte membrane characteristics during anemia in childhood acute lymphoblastic leukemia
    Shyamasree Ghosh
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata, 700032, India
    Ann Hematol 84:76-84. 2005
    ..Taken together, our results are suggestive of their interplay in the contribution to the observed anemia in these patients, which may be exploited for better management of the disease...
  35. ncbi request reprint Antibodies against 9-O-acetylated sialoglycans: a potent marker to monitor clinical status in childhood acute lymphoblastic leukemia
    Santanu Pal
    Immunobiology Division, Indian Institute of Chemical Biology, Jadavpur 700 032, India
    Clin Biochem 37:395-403. 2004
    ..In ALL, the cell surface over expression of 9-O-acetylated sialoglycans (9-OAcSGs) on lymphoblasts and concomitant high antibody titers in patients' sera was reported...
  36. ncbi request reprint Development of a modified MTT assay for screening antimonial resistant field isolates of Indian visceral leishmaniasis
    Avijit Dutta
    Dept of Immunobiology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700 032, India
    Parasitol Int 54:119-22. 2005
    ..Considering the growing problem of antimonial unresponsiveness in the Indian subcontinent, this modified MTT assay is a useful tool for Leishmania research...
  37. ncbi request reprint Role of C-reactive protein in complement-mediated hemolysis in Malaria
    Waliza Ansar
    Immunobiology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata, 700 032, India
    Glycoconj J 23:233-40. 2006
    ..Hemolysis as triggered by this pathway may be one of the causative factors of anemia, a common clinical manifestation of this disease...
  38. ncbi request reprint A sphingolipid rich lipid fraction isolated from attenuated Leishmania donovani promastigote induces apoptosis in mouse and human melanoma cells in vitro
    Jagnyeswar Ratha
    Cellular Biochemistry Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, India
    Mol Cell Biochem 290:113-23. 2006
    ..Further studies are thus necessary to identify these specific bioactive sphingolipid(s)/ceramide(s) and to establish their mechanism of action, in order to explore their use as anticancer agents...
  39. ncbi request reprint Antibodies against 9-O-acetylated sialic acids in childhood acute lymphoblastic leukemia: a two-year study with 186 samples following protocol MCP 943
    Suman Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, Kolkata, India
    Indian J Biochem Biophys 43:7-14. 2006
    ..We contend that these disease-specific antibodies could be considered as potential markers both for the initial diagnosis of ALL and possibly for longitudinal monitoring of the disease...
  40. ncbi request reprint Targeting glycoproteins or glycolipids and their metabolic pathways for antiparasite therapy
    Sumi Mukhopadhyay Nee Bandyopadhyay
    Immunobiology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    Adv Exp Med Biol 625:87-102. 2008
    ..This review intends to focus on such lines, which will give us an insight into the future hope for development of novel therapeutic strategies through glycobiological platform for combating kinetoplastid infections...
  41. ncbi request reprint Comparative analysis of differential expression of sialic acids and adhesion molecules on mononuclear cells of bone marrow and peripheral blood in childhood acute lymphoblastic leukaemia at diagnosis and clinical remission
    Suchandra Chowdhury
    Infectious Disease and Immunology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
    Indian J Biochem Biophys 44:357-65. 2007
    ..Hence, supervising these cell surface macromolecules at various stages of treatment might help in minimal residual disease detection, identifying mobilization factor(s) and in isolation of normal HPCs for autologous BM transplantation...
  42. doi request reprint In vitro and in vivo activity of Aloe vera leaf exudate in experimental visceral leishmaniasis
    Avijit Dutta
    Department of Infectious Disease and Immunology, Indian Institute of Chemical Biology, 4 Raja SC Mullick Road, Kolkata 700032, India
    Parasitol Res 102:1235-42. 2008
    ..Collectively, we conclude that AVL shows promising antileishmanial activity and may provide a new lead agent in the treatment of Leishmaniasis...
  43. ncbi request reprint In vitro antileishmanial activity of Aloe vera leaf exudate: a potential herbal therapy in leishmaniasis
    Avijit Dutta
    Department of Immunobiology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    Glycoconj J 24:81-6. 2007
    ..Collectively, our data indicates that AVL, via its direct leishmanicidal activity which can be further enhanced by activation of host macrophages, is an effective antileishmanial agent meriting further pharmacological investigations...
  44. ncbi request reprint Racemoside A, an anti-leishmanial, water-soluble, natural steroidal saponin, induces programmed cell death in Leishmania donovani
    Avijit Dutta
    Department of Infectious Disease and Immunology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700032, India
    J Med Microbiol 56:1196-204. 2007
    ..16 microg ml(-1), respectively, and was non-toxic to murine peritoneal macrophages up to a concentration of 10 microg ml(-1). Hence, racemoside A is a potent anti-leishmanial agent that merits further pharmacological investigation...
  45. ncbi request reprint 9-O-acetylated GD3 triggers programmed cell death in mature erythrocytes
    Kankana Mukherjee
    Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700032, India
    Biochem Biophys Res Commun 362:651-7. 2007
    ..This is the first report of a programmed cell death pathway in mature erythrocytes, triggered by 9-O-AcGD3 contrary to their anti-apoptotic role in lymphoblasts, which suggests a cell specific role of this O-acetyl ester of GD3...
  46. doi request reprint Disease-associated glycosylated molecular variants of human C-reactive protein activate complement-mediated hemolysis of erythrocytes in tuberculosis and Indian visceral leishmaniasis
    Waliza Ansar
    Infectious Disease and Immunology Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata, 700 032, India
    Glycoconj J 26:1151-69. 2009
    ..Thus, it may be postulated that CRP have a protective role towards the clearance of damaged-erythrocytes in these two diseases...