Ahmed Kamal

Summary

Affiliation: Indian Institute of Chemical Technology
Country: India

Publications

  1. ncbi request reprint Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 13:2021-9. 2005
  2. ncbi request reprint Synthesis and biological evaluation of imidazo[2,1-b][1,3,4]thiadiazole-linked oxindoles as potent tubulin polymerization inhibitors
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007 India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037 India
    ChemMedChem 9:1463-75. 2014
  3. ncbi request reprint Synthesis and biological evaluation of cinnamido linked benzophenone hybrids as tubulin polymerization inhibitors and apoptosis inducing agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India Electronic address
    Bioorg Med Chem Lett 24:2309-14. 2014
  4. ncbi request reprint Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Electronic address
    Bioorg Med Chem 22:2714-23. 2014
  5. doi request reprint Apoptosis-inducing agents: a patent review (2010 - 2013)
    Ahmed Kamal
    CSIR Indian Institute of Chemical Technology, Medicinal Chemistry and Pharmacology, Tarnaka, Hyderabad 500007, India 91 402 719 3157 91 402 719 3189
    Expert Opin Ther Pat 24:339-54. 2014
  6. ncbi request reprint Synthesis and biological evaluation of benzo[b]furans as inhibitors of tubulin polymerization and inducers of apoptosis
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007 India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037 India
    ChemMedChem 9:117-28. 2014
  7. ncbi request reprint Synthesis and anticancer potential of benzothiazole linked phenylpyridopyrimidinones and their diones as mitochondrial apoptotic inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India Electronic address
    Bioorg Med Chem Lett 24:147-51. 2014
  8. ncbi request reprint Synthesis and Biological Evaluation of Diaryl Ether Linked DC-81 Conjugates as Potential Antitumor Agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, Chemical Biology Laboratory, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Anticancer Agents Med Chem 13:1590-600. 2013
  9. ncbi request reprint Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India Electronic address
    Bioorg Med Chem Lett 23:6842-6. 2013
  10. ncbi request reprint Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Electronic address
    Bioorg Med Chem Lett 23:5733-9. 2013

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 13:2021-9. 2005
    ..These PBD conjugates have exhibited good DNA binding affinity, and a representative compound shows promising in vitro anticancer activity...
  2. ncbi request reprint Synthesis and biological evaluation of imidazo[2,1-b][1,3,4]thiadiazole-linked oxindoles as potent tubulin polymerization inhibitors
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007 India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037 India
    ChemMedChem 9:1463-75. 2014
    ..15 μM) lower than that of combretastatin A-4 (1.16 μM). Docking studies reveal that compounds 7 and 11 bind with αAsn101, βThr179, and βCys241 in the colchicine binding site of tubulin. ..
  3. ncbi request reprint Synthesis and biological evaluation of cinnamido linked benzophenone hybrids as tubulin polymerization inhibitors and apoptosis inducing agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India Electronic address
    Bioorg Med Chem Lett 24:2309-14. 2014
    ..Overall, the current study demonstrates that the synthesis of benzophenone linked cinnamide subunit conjugates as promising anticancer agents with G2/M arrest and apoptotic-inducing ability via targeting tubulin. ..
  4. ncbi request reprint Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Electronic address
    Bioorg Med Chem 22:2714-23. 2014
    ....
  5. doi request reprint Apoptosis-inducing agents: a patent review (2010 - 2013)
    Ahmed Kamal
    CSIR Indian Institute of Chemical Technology, Medicinal Chemistry and Pharmacology, Tarnaka, Hyderabad 500007, India 91 402 719 3157 91 402 719 3189
    Expert Opin Ther Pat 24:339-54. 2014
    ..Therefore, it has become one of the prime molecular target for drug discovery and development particularly for diseases like cancer...
  6. ncbi request reprint Synthesis and biological evaluation of benzo[b]furans as inhibitors of tubulin polymerization and inducers of apoptosis
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007 India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037 India
    ChemMedChem 9:117-28. 2014
    ..Molecular docking studies indicated that compound 36 interacts and binds efficiently with the tubulin protein...
  7. ncbi request reprint Synthesis and anticancer potential of benzothiazole linked phenylpyridopyrimidinones and their diones as mitochondrial apoptotic inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India Electronic address
    Bioorg Med Chem Lett 24:147-51. 2014
    ..DNA fragmentation and Hoechst staining reveals that this compound induced cell death by apoptosis. Further caspase-3 and loss of mitochondrial membrane potential suggested that the compound induces cell death by apoptosis. ..
  8. ncbi request reprint Synthesis and Biological Evaluation of Diaryl Ether Linked DC-81 Conjugates as Potential Antitumor Agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, Chemical Biology Laboratory, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Anticancer Agents Med Chem 13:1590-600. 2013
    ..Further conjugates 4b, 4h and 6b induce the activation of caspase and PARP proteins, followed by apoptotic cell death in MCF7 cell line. ..
  9. ncbi request reprint Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India Electronic address
    Bioorg Med Chem Lett 23:6842-6. 2013
    ..Compound 8e showed promising antitubercular activity with MIC value of 0.25 μg/ml. Most of these compounds are less toxic to normal mammalian cells than the widely used antibacterial drug Ciprofloxacin...
  10. ncbi request reprint Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Electronic address
    Bioorg Med Chem Lett 23:5733-9. 2013
    ..Hence these small molecules have the potential to control both the cell proliferation as well as the invasion process in the highly malignant breast cancers...
  11. ncbi request reprint Synthesis and biological evaluation of imidazopyridine-oxindole conjugates as microtubule-targeting agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad 500007 India
    ChemMedChem 8:2015-25. 2013
    ..Docking of compound 10 f with tubulin protein suggested that the imidazo[1,2-a]pyridine moiety occupies the colchicine binding site of tubulin. ..
  12. doi request reprint Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India
    Eur J Med Chem 64:239-51. 2013
    ..The docking studies have been carried out to provide some insight into the mechanism of action for this class of compounds...
  13. ncbi request reprint Synthesis, DNA binding ability and anticancer activity of 2-heteroaryl substituted benzimidazoles linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Med Chem 9:651-9. 2013
    ..Further, these compounds also showed significant DNA-binding affinity by thermal denaturation study using duplex form of calf thymus (CT) DNA...
  14. doi request reprint The first total synthesis of nhatrangin A
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad, 500007, India
    Org Biomol Chem 11:4442-8. 2013
    ..The first total synthesis of nhatrangin A has been achieved. Pivotal bond forming events in the synthesis include Brown crotylboration, olefin cross-metathesis, Sharpless asymmetric dihydroxylation and Yamaguchi esterification...
  15. ncbi request reprint The design and development of imidazothiazole-chalcone derivatives as potential anticancer drugs
    Ahmed Kamal
    CSIR Indian Institute of Chemical Technology, Division of Organic Chemistry, Tarnaka, Hyderabad, India
    Expert Opin Drug Discov 8:289-304. 2013
    ..Their promising biological profile and easy synthetic accessibility have triggered investigations directed at the design and development of new imidazothiazole-chalcone conjugate derivatives as potential chemotherapeutics...
  16. ncbi request reprint Naphthalimide derivatives with therapeutic characteristics: a patent review
    Ahmed Kamal
    CSIR, Indian Institute of Chemical Technology, Natural Product Chemistry Division, Tarnaka, Hyderabad 500007, India
    Expert Opin Ther Pat 23:299-317. 2013
    ..Few of such molecules are currently under preclinical and clinical evaluations...
  17. doi request reprint Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents
    Ahmed Kamal
    Division of Organic Chemistry, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 23:273-80. 2013
    ..Further, Hoechst 33258 staining and DNA fragmentation assay also suggests that 17g induces cell death by apoptosis...
  18. doi request reprint Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, CSIR Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Eur J Med Chem 56:166-78. 2012
    ..Docking experiments have shown that the active molecules interact and bind well in the ATP binding pocket of ERK protein...
  19. doi request reprint Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells
    Ahmed Kamal
    Division of Organic Chemistry, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India
    ChemMedChem 7:1453-64. 2012
    ....
  20. doi request reprint Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents
    Ahmed Kamal
    Division of Organic Chemistry, CSIR Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Bioorg Med Chem 20:3480-92. 2012
    ..Overall, the current study demonstrates that the synthesis of chalcone-amidobenzothiazole conjugates as promising anticancer agents with potent G2/M arrest and apoptotic-inducing activities via targeting tubulin...
  21. doi request reprint 2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India
    Bioorg Med Chem 19:7136-50. 2011
    ..The cytotoxicity of 4i correlated with induction of apoptosis, caspases activation and DNA damage and thus indicating the apoptotic pathway of anticancer effect of these compounds...
  22. doi request reprint Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500607, India
    Eur J Med Chem 50:9-17. 2012
    ..Compounds 3t and 3ad are the most promising candidates amongst the series and has the potential to be taken up for further detailed studies either alone or in combination with the existing therapies...
  23. doi request reprint Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Bioorg Med Chem 20:2054-66. 2012
    ..Moreover activation of caspase-3, p21, p16, NF-kB and down regulation of Bcl-2 protein suggests that this compound (11e) has apoptotic cell death inducing ability, apart from acting as a topo-IIα inhibitor...
  24. ncbi request reprint Recent advances on structural modifications of benzothiazoles and their conjugate systems as potential chemotherapeutics
    Kamal Ahmed
    Indian Institute of Chemical Technology, Division of Organic Chemistry, Tarnaka, Hyderabad, India
    Expert Opin Investig Drugs 21:619-35. 2012
    ..The promising biological profile and synthetic accessibility have been attractive in the design and development of new benzothiazoles and their conjugate systems as potential chemotherapeutics...
  25. ncbi request reprint Metabolic profiling and biological activities of bioactive compounds produced by Pseudomonas sp. strain ICTB-745 isolated from Ladakh, India
    Ahmed Kamal
    Chemical Biology Laboratory, Division of Organic Chemistry, IndianInstitute of Chemical Technology, Uppal Road, Hyderabad 500 607, India
    J Microbiol Biotechnol 22:69-79. 2012
    ..The metabolites from Pseudomonas sp. strain ICTB-745 have interesting potential for use as a biopesticide in pest control programs...
  26. doi request reprint Synthesis and apoptosis inducing ability of new anilino substituted pyrimidine sulfonamides as potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Eur J Med Chem 46:5817-24. 2011
    ..One of the representative compound 3e could be considered as the potential lead for its development as a new anticancer agent...
  27. doi request reprint Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Eur J Med Chem 47:530-45. 2012
    ..Further, Hoechst 33258 staining and DNA fragmentation assay also suggested that 17a and 17f induced cell death by apoptosis...
  28. doi request reprint Design and synthesis of benzo[c,d]indolone-pyrrolobenzodiazepine conjugates as potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Bioorg Med Chem 20:789-800. 2012
    ..This is confirmed by Annexin V-FITC, Hoechst staining, caspase-3 activity as well as DNA fragmentation analysis...
  29. doi request reprint Anti-tubercular agents. Part 5: synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners
    Ahmed Kamal
    Division of Organic Chemistry I, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Eur J Med Chem 45:4545-53. 2010
    ..Further, to understand structural requirements for exploring the structure activity relationship of BTDs, cytotoxicity and in vivo study of recently reported potent molecule 4 (MIC = 1 microg/mL) is also discussed...
  30. ncbi request reprint Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates
    Ahmed Kamal
    Chemical Biology Laboratory, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Bioorg Med Chem 18:6666-77. 2010
    ..Some detailed biological assays relating to the cell cycle aspects associated to Bax and caspases have been examined with a view to understand the mechanism of action of these conjugates...
  31. doi request reprint Synthesis of imidazothiazole-chalcone derivatives as anticancer and apoptosis inducing agents
    Ahmed Kamal
    Chemical Biology Laboratory, Indian Institute of Chemical Technology, Hyderabad 500607, India
    ChemMedChem 5:1937-47. 2010
    ..One of these chalcone derivatives, 3 d, is potentially well suited for detailed biological studies, either alone or in combination with existing therapies...
  32. doi request reprint Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Bioorg Med Chem 18:8493-500. 2010
    ..The ease of synthesis and interesting biological activities make the present series of polyaromatic-podophyllotoxin congeners as a promising new structure for the development of new anticancer agents based on podophyllotoxin scaffold...
  33. doi request reprint An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Bioorg Med Chem Lett 21:350-3. 2011
    ..Some of the representative compounds have been evaluated for their cytotoxicity against selected human cancer cell lines and DNA topoisomerase-II inhibition activity...
  34. doi request reprint Synthesis of 3,3-diindolyl oxyindoles efficiently catalysed by FeCl3 and their in vitro evaluation for anticancer activity
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, India
    Bioorg Med Chem Lett 20:5229-31. 2010
    ..2, 1.2, 3.6 and 3.6 microM, respectively, against DU-145 cell line. Interestingly, some of the compounds are selectively potent in prostate cancer (DU-145) with IC(50) values of 1.2-19.6 microM...
  35. doi request reprint Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India
    Bioorg Med Chem Lett 20:5232-6. 2010
    ..These compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP...
  36. ncbi request reprint Synthesis and anti-cancer activity of chalcone linked imidazolones
    Ahmed Kamal
    Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Bioorg Med Chem Lett 20:4865-9. 2010
    ..Surprisingly, the increased concentration of the same compound to 30 microM caused accumulation of cells in G0/G1 phase of the cell cycle...
  37. doi request reprint Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates
    Ahmed Kamal
    Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500607, India
    Bioorg Med Chem 18:4747-61. 2010
    ..Further, the compound 17d was evaluated for in vivo efficacy studies in human colon cancer HT29 xenograft mice...
  38. doi request reprint Omega-3 polyunsaturated acids and cardiovascular disease: notable ethnic differences or unfulfilled promise?
    J V Patel
    Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, England, UK
    J Thromb Haemost 8:2095-104. 2010
    ..Future epidemiological research into the efficacy of omega-3 PUFA in cardiovascular disease should consider the influence of ethnicity...
  39. doi request reprint Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Eur J Med Chem 45:3924-37. 2010
    ..Hence these PBD conjugates with 6a being the most potent one could be be taken up for preclinical studies either alone or in combination with existing therapies...
  40. doi request reprint Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents
    Ahmed Kamal
    Division of Organic Chemistry I, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Eur J Med Chem 45:3870-84. 2010
    ..Interestingly, compounds 5b and 6b have been identified as a new class of inhibitors of tubulin polymerization and their action has been rationalized by the cell cycle arrest in G0 and G2/M phase...
  41. doi request reprint Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India
    Eur J Med Chem 46:691-703. 2011
    ..Further some detailed biological assays relating to the cell cycle aspects and tubulin depolymerization activity have been examined with a view to understand the mechanism of action of this conjugate...
  42. doi request reprint Anti-tubercular agents. Part 6: synthesis and antimycobacterial activity of novel arylsulfonamido conjugated oxazolidinones
    Ahmed Kamal
    Division of Organic Chemistry I, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Eur J Med Chem 46:893-900. 2011
    ..Finally, these studies suggest that compounds 7c and 9a may serve as promising lead scaffolds for further generation of new as anti-TB agents...
  43. ncbi request reprint Bioconversion of acrylonitrile to acrylic acid by rhodococcus ruber strain AKSH-84
    Ahmed Kamal
    Chemical Biology Laboratory, Indian Institute of Chemical Technology, Hyderabad 500607, India
    J Microbiol Biotechnol 21:37-42. 2011
    ..ruber AKSH-84, which can be used in green biosynthesis of acrylic acid for biotechnological processes. The nitrilase produced by the isolate was purified and characterized...
  44. ncbi request reprint 3-substituted 2-phenylimidazo[2,1-b]benzothiazoles: synthesis, anticancer activity, and inhibition of tubulin polymerization
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500607, India
    ChemMedChem 7:292-300. 2012
    ..Molecular modeling studies provided a molecular basis for the favorable binding of compounds 3 a, 3 e, and 3 h to the colchicine binding pocket of tubulin...
  45. ncbi request reprint Design, synthesis, biological evaluation and QSAR studies of novel bisepipodophyllotoxins as cytotoxic agents
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 12:4197-209. 2004
    ..QSAR models developed in these studies will be helpful in the future to design novel potent bispodophyllotoxin analogues by minor structural modifications...
  46. doi request reprint Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India
    Bioorg Med Chem 19:4589-600. 2011
    ....
  47. doi request reprint Synthesis of aryl-substituted naphthalene-linked pyrrolobenzodiazepine conjugates as potential anticancer agents with apoptosis-inducing ability
    Ahmed Kamal
    Chemical Biology Laboratory, Indian Institute of Chemical Technology, Hyderabad 500607, India
    ChemMedChem 6:1665-79. 2011
    ..One conjugate in particular is the most promising candidate of the series, with the potential to be selected for further studies, either alone or in combination with existing anticancer therapies...
  48. doi request reprint Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Eur J Med Chem 46:3820-31. 2011
    ..These findings suggest that one of the compound 4d among this series is most effective and has potential for detailed investigations...
  49. doi request reprint Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Eur J Med Chem 46:3274-81. 2011
    ..Further, the DNA binding ability by thermal denaturation studies and antimicrobial activities of these compounds are also discussed...
  50. pmc Chalcone-imidazolone conjugates induce apoptosis through DNA damage pathway by affecting telomeres
    M Janaki Ramaiah
    Division of Chemical Biology, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India
    Cancer Cell Int 11:11. 2011
    ..abstract:..
  51. doi request reprint Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Bioorg Med Chem 19:2975-9. 2011
    ..Further, compounds 6g and 6i are also evaluated for their DNA topoisomerase-II (topo-II) inhibition activity and they exhibited significant inhibition of topo-II catalytic activity comparable to etoposide...
  52. ncbi request reprint Synthesis and anticancer activities of new Benzothiadiazinyl Hydrazinecarboxamides and Anilino[1,2,4]triazolo[1,5-b][1,2,4]thiadiazine 5,5-diones
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, India
    Med Chem 7:165-72. 2011
    ..Further studies showed that cancer cell growth inhibition by compounds 22 and 23 could be in part due to the inhibition of tubulin polymerization, with the IC50 values of 4.70 and 5.25 µM, respectively...
  53. doi request reprint Synthesis and anticancer activity of oxindole derived imidazo[1,5-a]pyrazines
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Eur J Med Chem 46:2427-35. 2011
    ..5 μM (IC50) concentration of compound 7l and induced apoptosis. This was confirmed by Annexin V-FITC as well as DNA fragmentation analysis and interestingly this compound (7l) did not affect the normal cells...
  54. doi request reprint Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, India
    Bioorg Med Chem 19:2565-81. 2011
    ..Among all these conjugates, one of the compound 5c could be considered as the most effective compound particularly against MCF-7 breast cancer cell line...
  55. doi request reprint Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Bioorg Med Chem 19:2349-58. 2011
    ..Flow cytometric analysis showed that these compounds (11a, 11k and 11p) arrested the cell cycle in the G2/M phase of cell cycle leading to caspase-3 dependent apoptotic cell death...
  56. ncbi request reprint Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates
    Ahmed Kamal
    Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Bioorg Med Chem Lett 20:3310-3. 2010
    ..These promising compounds showed the characteristic features of apoptosis like enhancement in the levels of p53 and activation of caspase-3...
  57. ncbi request reprint DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 14:385-94. 2006
    ..Interestingly, these dimers 6a-d are significantly more cytotoxic than 4 in a number of human cancer cell lines, in particular, compound 6c is highly potent for almost all the nine human cancer cell lines...
  58. ncbi request reprint Efficient solid-phase synthesis of a library of imidazo[1,2-a]pyridine-8-carboxamides
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    J Comb Chem 9:267-74. 2007
    ..The final crude products were purified from excess amines by solid-supported liquid-liquid extraction (SLE)...
  59. ncbi request reprint Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 17:803-6. 2007
    ..8 degrees C after incubation of 36 h at 37 degrees C...
  60. ncbi request reprint Synthesis of a new class of 2-anilino substituted nicotinyl arylsulfonylhydrazides as potential anticancer and antibacterial agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 15:1004-13. 2007
    ..Most of these compounds showed better inhibitory activity in comparison to the standard drugs...
  61. ncbi request reprint Recent advances in the solid-phase combinatorial synthetic strategies for the quinoxaline, quinazoline and benzimidazole based privileged structures
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Mini Rev Med Chem 6:71-89. 2006
    ..Further, benzothiadiazinone, thioxoquinazolinone, cinnoline and indazole are also examined in this review...
  62. ncbi request reprint Recent advances in the solid-phase combinatorial synthetic strategies for the benzodiazepine based privileged structures
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Mini Rev Med Chem 6:53-69. 2006
    ..Further, the most relevant biological properties of these heterocycles have also been incorporated...
  63. ncbi request reprint Synthesis and DNA-binding ability of pyrrolo[2,1-c][1,4]benzodiazepine-azepane conjugates
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 16:1160-3. 2006
    ..One of the compound (4b), elevates the DNA helix melting temperature of the CT-DNA by 2.0 degrees C after incubation for 36 h at 37 degrees C...
  64. ncbi request reprint Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti-Mycobacterium activity
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 14:650-8. 2006
    ..However, the in vivo testing in a mouse model of tuberculosis infection did not show significant anti-tubercular activity, probably because of its poor bioavailability...
  65. ncbi request reprint Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, Andhra Pradesh, India
    Bioorg Med Chem 13:6218-25. 2005
    ..Some of these compounds have exhibited promising in vitro anticancer and topo-II inhibition activity...
  66. ncbi request reprint Antitubercular agents. Part 2: new thiolactomycin analogues active against Mycobacterium tuberculosis
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 15:1927-9. 2005
    ..Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis...
  67. ncbi request reprint Antitubercular agents. Part 1: synthesis of phthalimido- and naphthalimido-linked phenazines as new prototype antitubercular agents
    Ahmed Kamal
    Division of Organic Chemistry I, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 15:1923-6. 2005
    ..Some of these new compounds inhibited the growth of Mycobacterium tuberculosis ATCC 27294, Mycobacterium avium ATCC 49601, Mycobacterium intracellulare ATCC 13950 and some clinical isolates...
  68. ncbi request reprint A new facile chemoenzymatic synthesis of levamisole
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 15:613-5. 2005
    ..An efficient and facile chemoenzymatic synthesis of levamisole by employing lipase-mediated resolution of 3-hydroxy-3-phenylpropanenitrile followed by its conversion to beta-amino alcohol as the key intermediate is described...
  69. ncbi request reprint Design, synthesis, and evaluation of mixed imine-amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 12:5427-36. 2004
    ..0 degrees C) when compared to naturally occurring DC-81, 1 (DeltaTm=0.7 degrees C). The imine-amine PBD dimers exhibit promising in vitro antitumor activity in a number of human cancer cell lines...
  70. ncbi request reprint Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007
    Bioorg Med Chem Lett 14:4581-3. 2004
    ....
  71. ncbi request reprint Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity
    Ahmed Kamal
    Division of Organic Chemistry I, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 14:4907-9. 2004
    ..New pyrrolobenzodiazepine-anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many cancer cell lines..
  72. ncbi request reprint Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 14:4791-4. 2004
    ..These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity...
  73. ncbi request reprint Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem 12:4337-50. 2004
    ..The synthesis of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity...
  74. ncbi request reprint Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 14:4107-11. 2004
    ..Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity...
  75. ncbi request reprint Anti-tubercular agents. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1,2,4-benzothiadiazines
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 17:5419-22. 2007
    ..One of the compounds 2f has shown good in vitro antimycobacterial activity. All the synthesized compounds have shown moderate to good antibacterial activity...
  76. ncbi request reprint An efficient synthesis of bis(indolyl)methanes and evaluation of their antimicrobial activities
    Ahmed Kamal
    Division of Organic Chemistry, Biotransformation Laboratory, Indian Institute of Chemical Technology, Hyderabad, India
    J Enzyme Inhib Med Chem 24:559-65. 2009
    ..5 mol%) as a novel catalyst. Further, some of the synthesized compounds were evaluated for their efficacy as antibacterial and antifungal activities. Most of the compounds have shown moderate to good inhibitory activity...
  77. ncbi request reprint Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Bioorg Med Chem 16:7218-24. 2008
    ..These new conjugates exhibit very high DNA binding affinity and cytotoxic activity against a number of cell lines...
  78. ncbi request reprint Pyrrolo[2,1-c][1,4]benzodiazepine-beta-glucuronide prodrugs with a potential for selective therapy of solid tumors by PMT and ADEPT strategies
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Bioorg Med Chem Lett 18:3769-73. 2008
    ..Enhanced water solubility and improved stability are the other important outcomes upon modifying these molecules as their prodrugs...
  79. doi request reprint Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 18:2594-8. 2008
    ..Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human cancer cell lines...
  80. doi request reprint Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential
    Ahmed Kamal
    Division of Organic Chemistry, Chemical Biology Laboratory, Indian Institute of Chemical Technology, Hyderabad, India
    Bioorg Med Chem 17:1557-72. 2009
    ..Some representative C2-fluoro substituted dimers (8a and 14a) have also exhibited significant anticancer activity in the 60 cancer cell line assay of the National Cancer Institute (NCI)...
  81. doi request reprint Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity
    Ahmed Kamal
    Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, Andra Pradesh 500 007, India
    Bioorg Med Chem Lett 18:2434-9. 2008
    ..Interestingly, some of these molecules have shown enhanced DNA-binding affinity and promising anticancer activity on a large number of human cancer cell lines...
  82. doi request reprint Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, Andhra Pradesh 500 007, India
    Bioorg Med Chem 16:3895-906. 2008
    ..These pyrrolobenzodiazepine conjugates have exhibited remarkable DNA-binding affinity and improved solubility in water, a representative compound 7d showing promising in vitro cytotoxicity...
  83. doi request reprint Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT
    Ahmed Kamal
    Department of Chemical Biology, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    ChemMedChem 3:794-802. 2008
    ..Another important property of these molecules is their enhanced water solubility and stability, which are essential for a molecule to be an effective drug...
  84. ncbi request reprint Efforts towards the development of new antitubercular agents: potential for thiolactomycin based compounds
    Ahmed Kamal
    Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, India
    J Pharm Pharm Sci 11:56s-80s. 2008
    ..We have also attempted to highlight the efforts that are being made in the development of new molecules based on thiolactomycin as lead compound, including studies from this laboratory...
  85. doi request reprint Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents
    Ahmed Kamal
    Chemical Biology Laboratory, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Bioorg Med Chem 18:526-42. 2010
    ..Therefore, the data generated suggests that these PBD conjugates activate p53 and inhibit NF-kappaB and thereby these compounds could be promising anticancer agents with better therapeutic potential for the suppression of tumours...
  86. ncbi request reprint Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 15:6868-75. 2007
    ..Some of these molecules have shown significant anticancer activity in a number of cancer cell lines...
  87. doi request reprint Synthesis and potential cytotoxic activity of new phenanthrylphenol-pyrrolobenzodiazepines
    Ahmed Kamal
    Chemical Biology Laboratory, Division of Organic Chemistry I, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Eur J Med Chem 45:2173-81. 2010
    ..Our findings suggested the phenanthrylphenol-PBD conjugate 4c, which is a cyclin D1 inhibitor could be considered as a promising lead compound against breast cancer for further investigation...
  88. ncbi request reprint 1,2,4-benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 17:5345-8. 2007
    ..Their DNA thermal denaturation studies have been carried out and one of the compounds (4b) elevates the DNA helix melting temperature of the CT-DNA by 6.7 degrees C after incubation for 36 h...
  89. ncbi request reprint Search for new and novel chemotherapeutics for the treatment of human malignancies
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Mini Rev Med Chem 10:405-35. 2010
    ....
  90. ncbi request reprint Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4]benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates
    Ahmed Kamal
    Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 16:7804-10. 2008
    ..Their DNA thermal denaturation studies have also been carried out, and one of the compounds 5c elevates the DNA helix melting temperature of the CT-DNA by 2.6 degrees C after incubation for 36 h...
  91. ncbi request reprint Synthesis, structure analysis, and antibacterial activity of some novel 10-substituted 2-(4-piperidyl/phenyl)-5,5-dioxo[1,2,4]triazolo[1,5-b][1,2,4]benzothiadiazine derivatives
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 17:5400-5. 2007
    ..coli as well as Bacillus subtilis. Moreover, other compounds also showed potent inhibitory activity in comparison to the standard drugs...
  92. ncbi request reprint The effect of C2-fluoro group on the biological activity of DC-81 and its dimers
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 14:2669-72. 2004
    ..C2-Fluoro substituted pyrrolobenzodiazepines (PBDs) have been synthesized that exhibit potential anticancer activity in a number of human tumour cell lines. These C2-fluoro substituted PBDs also exhibit significant DNA-binding ability...
  93. ncbi request reprint Design and synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrids as anti-tumour agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 12:1933-5. 2002
    ..Some of these new hybrid compounds showed higher cytotoxic activity than the existing natural and synthetic pyrrolo[2,1-c][1,4]benzodiazepines...
  94. doi request reprint Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 18:1468-73. 2008
    ..These molecules have exhibited promising DNA-binding affinity and anticancer activity in selected human cancer cell lines...
  95. ncbi request reprint Recent developments in the design, synthesis and structure-activity relationship studies of pyrrolo[2,1-c][1,4]benzodiazepines as DNA-interactive antitumour antibiotics
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Curr Med Chem Anticancer Agents 2:215-54. 2002
    ..In this review both the synthetic strategies and the structure-activity relationships, particularly the DNA binding and cytotoxicity studies of PBDs have been discussed...
  96. ncbi request reprint Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    J Med Chem 45:4679-88. 2002
    ..The energy of interaction in all of the complexes studied is correlated to the DeltaT(m) values. Furthermore, this dimer 5c has significant cytotoxicity in a number of human cancer cell lines...
  97. ncbi request reprint Synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines as potential anti-cancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 12:1917-9. 2002
    ..These have been prepared by linking the amines at C-8 position with propane spacer to improve solubility in water, and their in vitro cytotoxicity studies have been carried out...
  98. ncbi request reprint Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 14:5699-702. 2004
    ..A series of C2-exo-fluorounsaturated pyrrolobenzodiazepines (PBDs) have been synthesized. These C2-exo-fluorounsaturated PBD dimers have exhibited remarkable DNA-binding affinity...
  99. ncbi request reprint Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 13:3955-8. 2003
    ..The synthesis of new A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]-benzodiazepine dimers have been described in this report. These dimers exhibit significant DNA-binding ability with moderate anticancer activity...
  100. ncbi request reprint Solid-phase synthesis of a library of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones with potential antitubercular activity
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    J Comb Chem 9:29-42. 2007
    ..Further, from a generated library of 210 compounds, 142 compounds have been selected and evaluated for in vitro activity against Mycobacterium tuberculosis, and some of these compounds have exhibited promising activity...
  101. ncbi request reprint Decolorization and biotransformation of triphenylmethane dye, methyl violet, by Aspergillus sp. isolated from Ladakh, India
    C Ganesh Kumar
    Chemical Biology Laboratory, Indian Institute of Chemical Technology, Hyderabad, India
    J Microbiol Biotechnol 21:267-73. 2011
    ....