Ahmed Kamal

Summary

Affiliation: Indian Institute of Chemical Technology
Country: India

Publications

  1. doi request reprint Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Academy of Scientific and Innovative Research, CSIR Indian Institute of Chemical Technology, Hyderabad, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Catalytic Chemistry Chair, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia Electronic address
    Bioorg Chem 65:126-36. 2016
  2. doi request reprint Silver catalyzed domino aza-annulation/Diels-Alder cyclization of 2-ene-yne anilines: a facile one-pot access to carbazole, dihydrocarbazole and tetrahydrocarbazole frameworks
    Namballa Hari Krishna
    Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500037, India and Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India
    Chem Commun (Camb) 52:4581-4. 2016
  3. doi request reprint Investigation of the mechanism and apoptotic pathway induced by 4β cinnamido linked podophyllotoxins against human lung cancer cells A549
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad, 500 007, India
    Apoptosis 20:1518-29. 2015
  4. doi request reprint PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Org Biomol Chem 13:8652-62. 2015
  5. doi request reprint Embracing synthetic lethality of novel anticancer therapies
    Ahmed Kamal
    a 1 CSIR Indian Institute of Chemical Technology, Medicinal Chemistry and Pharmacology, Hyderabad 500007, India 91 40 2719 3157 91 40 2719 3189
    Expert Opin Drug Discov 10:1119-32. 2015
  6. doi request reprint Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Electronic address
    Bioorg Med Chem 23:5511-26. 2015
  7. doi request reprint Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Catalytic Chemistry Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia Electronic address
    Eur J Med Chem 108:476-85. 2016
  8. doi request reprint Synthesis and biological evaluation of phaitanthrin congeners as anti-mycobacterial agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Hyderabad 500 037, India Electronic address
    Bioorg Med Chem Lett 25:3867-72. 2015
  9. doi request reprint Podophyllotoxin derivatives: a patent review (2012 - 2014)
    Ahmed Kamal
    a 1 CSIR Indian Institute of Chemical Technology, Medicinal Chemistry and Pharmacology, Hyderabad 500007, India 91 40 27193157 91 40 27193189
    Expert Opin Ther Pat 25:1025-34. 2015
  10. ncbi request reprint Recent developments towards podophyllotoxin congeners as potential apoptosis inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India
    Anticancer Agents Med Chem 15:565-74. 2015

Detail Information

Publications151 found, 100 shown here

  1. doi request reprint Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Academy of Scientific and Innovative Research, CSIR Indian Institute of Chemical Technology, Hyderabad, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Catalytic Chemistry Chair, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia Electronic address
    Bioorg Chem 65:126-36. 2016
    ..Further, DNA fragmentation and Hoecst staining assays confirm that 5m induces apoptosis. Molecular docking studies and competitive binding assay indicated that 5m effectively bind at the colchicine binding site of the tubulin. ..
  2. doi request reprint Silver catalyzed domino aza-annulation/Diels-Alder cyclization of 2-ene-yne anilines: a facile one-pot access to carbazole, dihydrocarbazole and tetrahydrocarbazole frameworks
    Namballa Hari Krishna
    Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500037, India and Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India
    Chem Commun (Camb) 52:4581-4. 2016
    ..A series of symmetrical, unsymmetrical and base sensitive dienophiles provide the corresponding carbazoles under mild conditions in excellent yields with high regioselectivity. ..
  3. doi request reprint Investigation of the mechanism and apoptotic pathway induced by 4β cinnamido linked podophyllotoxins against human lung cancer cells A549
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad, 500 007, India
    Apoptosis 20:1518-29. 2015
    ..Moreover, these compounds did not significantly inhibit the noncancerous human embryonic kidney cells, HEK-293. ..
  4. doi request reprint PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Org Biomol Chem 13:8652-62. 2015
    ..The utility of this protocol has been demonstrated in the synthesis of β-carboline alkaloids norharmane (2o), harmane (2p), eudistomin U (9) and eudistomin I (12). ..
  5. doi request reprint Embracing synthetic lethality of novel anticancer therapies
    Ahmed Kamal
    a 1 CSIR Indian Institute of Chemical Technology, Medicinal Chemistry and Pharmacology, Hyderabad 500007, India 91 40 2719 3157 91 40 2719 3189
    Expert Opin Drug Discov 10:1119-32. 2015
    ..This concept is specifically being exploited in cancer research for selectively targeting specific tumor cells...
  6. doi request reprint Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Electronic address
    Bioorg Med Chem 23:5511-26. 2015
    ..Overall, the present study emphasizes the importance of linking a dithiocarbamate moiety to the β-carboline scaffold for exhibiting profound activity...
  7. doi request reprint Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Catalytic Chemistry Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia Electronic address
    Eur J Med Chem 108:476-85. 2016
    ..Furthermore, it was observed that there is an increase in expression levels of cyclin dependent kinase inhibitors like Cip1/p21 and Kip1/p27. ..
  8. doi request reprint Synthesis and biological evaluation of phaitanthrin congeners as anti-mycobacterial agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Hyderabad 500 037, India Electronic address
    Bioorg Med Chem Lett 25:3867-72. 2015
    ..Phaitanthrin derivatives are prepared by modifying the keto functionality of tryptanthrin. These phaitanthrin congeners are found to display promising anti-tubercular activity. ..
  9. doi request reprint Podophyllotoxin derivatives: a patent review (2012 - 2014)
    Ahmed Kamal
    a 1 CSIR Indian Institute of Chemical Technology, Medicinal Chemistry and Pharmacology, Hyderabad 500007, India 91 40 27193157 91 40 27193189
    Expert Opin Ther Pat 25:1025-34. 2015
    ..Some of the compounds obtained are under clinical investigations and are anticipated to reach the market...
  10. ncbi request reprint Recent developments towards podophyllotoxin congeners as potential apoptosis inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India
    Anticancer Agents Med Chem 15:565-74. 2015
    ..Therefore the present review focuses on the studies carried out in the design and synthesis of new podophyllotoxin derivatives and their evaluation as apoptosis inducers. ..
  11. doi request reprint Synthesis of 2-aryl-1,2,4-oxadiazolo-benzimidazoles: Tubulin polymerization inhibitors and apoptosis inducing agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Electronic address
    Bioorg Med Chem 23:4608-23. 2015
    ..Molecular docking studies of compounds 5l and 5x into the colchicine-binding site of the tubulin, revealed the possible mode of interaction by these compounds...
  12. doi request reprint Synthesis and antimicrobial potential of nitrofuran-triazole congeners
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Org Biomol Chem 13:9388-97. 2015
    ..Most of these compounds exhibited ten times lower cytotoxicity toward the normal cells compared to the antimicrobial activity. ..
  13. doi request reprint Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India
    Org Biomol Chem 13:10162-78. 2015
    ....
  14. doi request reprint Synthesis and biological evaluation of benzimidazole-oxindole conjugates as microtubule-targeting agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Electronic address
    Bioorg Chem 63:72-84. 2015
    ..By and large, the results demonstrated that these benzimidazole-oxindole conjugates possess cytotoxic property by inhibiting the tubulin polymerization...
  15. doi request reprint Design, synthesis and antiproliferative activity of the new conjugates of E7010 and resveratrol as tubulin polymerization inhibitors
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India
    Org Biomol Chem 14:1382-94. 2016
    ..Structure based studies, western blotting and immunofluorescence experiments demonstrated that RSV-1 and RSV-11 depolymerize microtubules in the HepG2 cell line, resulting in an accumulation of G2/M cells. ..
  16. doi request reprint Sulfamic acid promoted one-pot three-component synthesis and cytotoxic evaluation of spirooxindoles
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India Catalytic Chemistry Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia Electronic address
    Bioorg Med Chem Lett 25:2199-202. 2015
    ..Some of the compounds like 4o and 4p exhibited remarkable cytotoxicities with IC50 values of 0.35μM and 1.92μM against MDA-MB-231 cell line. ..
  17. doi request reprint Synthesis of arylpyrazole linked benzimidazole conjugates as potential microtubule disruptors
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, Hyderabad 500007, India Electronic address
    Bioorg Med Chem 23:1082-95. 2015
    ..These investigations reveal that such conjugates having pyrazole and benzimidazole moieties have the potential in the development of newer chemotherapeutic agents. ..
  18. doi request reprint Synthesis of phenstatin/isocombretastatin-chalcone conjugates as potent tubulin polymerization inhibitors and mitochondrial apoptotic inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India
    Org Biomol Chem 13:3963-81. 2015
    ..Molecular docking studies indicated that compounds like 3e occupy the colchicine binding site of tubulin...
  19. doi request reprint Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Org Biomol Chem 13:3416-31. 2015
    ..These investigations reveal that such conjugates containing pyrazole with a trimethoxy phenyl ring and indole moieties have potential for the development of newer chemotherapeutic agents...
  20. doi request reprint Therapeutic potential of benzothiazoles: a patent review (2010 - 2014)
    Ahmed Kamal
    CSIR Indian Institute of Chemical Technology, Medicinal Chemistry and Pharmacology, Hyderabad 500007, India 91 40 27193157 91 40 27193189
    Expert Opin Ther Pat 25:335-49. 2015
    ..Some of the compounds containing benzothiazole ring system are in clinical usage for the treatment of various diseases/disorders...
  21. doi request reprint Design and synthesis of pyrazole-oxindole conjugates targeting tubulin polymerization as new anticancer agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India Electronic address
    Eur J Med Chem 92:501-13. 2015
    ..Zebrafish screening revealed that 12b, and 12d caused developmental defects. Docking analysis demonstrated that the congeners occupy the colchicine binding pocket of tubulin. ..
  22. doi request reprint Regioselective synthesis, antimicrobial evaluation and theoretical studies of 2-styryl quinolines
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India
    Org Biomol Chem 13:1347-57. 2015
    ..luteus and S. aureus MLS16. Further, theoretical studies such as those on druggable properties and PMI plot have been carried out...
  23. doi request reprint Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Electronic address
    Bioorg Med Chem 22:5466-75. 2014
    ..Molecular docking studies of these compounds into the colchicine-binding site of tubulin, revealed possible mode of inhibition by these compounds...
  24. ncbi request reprint Tankyrase inhibitors as therapeutic targets for cancer
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad, 500 007, India
    Curr Top Med Chem 14:1967-76. 2014
    ..The current review covers the progress, mechanism and binding modes of recently known Tankyrase inhibitors and discusses the rational approaches that were used to identify the tankyrase inhibitors...
  25. doi request reprint Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Electronic address
    Bioorg Med Chem 22:5155-67. 2014
    ..Further, mitochondrial membrane potential, ROS generation, caspase-3 activation assay, Hoechst staining and DNA fragmentation analysis revealed that these conjugates induce cell death by apoptosis...
  26. doi request reprint Pyrazole-oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Org Biomol Chem 12:7993-8007. 2014
    ..Elucidation of zebrafish embryos revealed that the conjugates cause developmental defects. Molecular docking simulations determined the binding modes of these potent conjugates at the colchicine site of tubulin...
  27. doi request reprint Design and synthesis of aminostilbene-arylpropenones as tubulin polymerization inhibitors
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology Hyderabad, 500 007 India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037 India
    ChemMedChem 9:2565-79. 2014
    ..79 μM. Moreover, dot-blot analysis of cyclin B1 demonstrated that some of the congeners strongly induced cyclin B1 protein levels. Molecular docking studies indicated that these compounds occupy the colchicine binding site of tubulin...
  28. doi request reprint Asymmetric Michael addition of ketones to nitroolefins: pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Org Biomol Chem 12:8008-18. 2014
    ..These results support the preferential formation of syn-products by the approach of trans-β-nitrostyrene through the re-face of anti-enamine. ..
  29. doi request reprint Design and synthesis of imidazo[2,1-b]thiazole-chalcone conjugates: microtubule-destabilizing agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, Council of Science and Industrial Research, Indian Institute of Chemical Technology CSIR IICT, Hyderabad 500 007 India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037 India
    ChemMedChem 9:2766-80. 2014
    ..Moreover, molecular docking studies indicated that this conjugate (11 x) interacts and binds efficiently with the tubulin protein...
  30. doi request reprint Design and synthesis of C3-pyrazole/chalcone-linked beta-carboline hybrids: antitopoisomerase I, DNA-interactive, and apoptosis-inducing anticancer agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007 India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037 India
    ChemMedChem 9:2084-98. 2014
    ..Further, an in silico study of these β-carboline hybrids revealed their drug-like properties...
  31. doi request reprint Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Org Biomol Chem 12:9864-80. 2014
    ..The molecular docking simulations predicted the binding interactions of 5d and 5l with colchicine binding site of the tubulin, which is in compliance with the antiproliferative activity data...
  32. doi request reprint Synthesis of β-carboline-benzimidazole conjugates using lanthanum nitrate as a catalyst and their biological evaluation
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Org Biomol Chem 12:2370-87. 2014
    ..Moreover, an in silico study of these β-carboline-benzimidazole conjugates reveals that they possess drug-like properties...
  33. ncbi request reprint Synthesis of benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines as DNA-binding and potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Centre for Chemical Biology, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Med Chem 9:177-92. 2013
    ..A series of twelve benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized. They exhibit significant DNA-binding activity and excellent cytotoxic activity against various human cancer cell lines...
  34. doi request reprint Quinazolino linked 4β-amidopodophyllotoxin conjugates regulate angiogenic pathway and control breast cancer cell proliferation
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India Electronic address
    Bioorg Med Chem 21:6414-26. 2013
    ..Thus these conjugates have the potential to control breast cancer cell growth by effecting tumor angiogenesis and invasion. ..
  35. doi request reprint Synthesis of pyrazolo[1,5-a]pyrimidine linked aminobenzothiazole conjugates as potential anticancer agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 23:3208-15. 2013
    ..This was further confirmed by staining as well as DNA fragmentation analysis...
  36. doi request reprint 4β-[4'-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 21:5198-208. 2013
    ..In addition, a brief structure-activity relationship studies within the series along with docking results of representative compounds 11a, 11h, 11k, 11l were presented. ..
  37. doi request reprint Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad, 500 007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037, India Electronic address
    Bioorg Med Chem Lett 24:3356-60. 2014
    ..The flow cytometry analysis confirmed that the synthesized compounds led to cell cycle arrest at the G2/M phase. Moreover, the structure activity relationship studies in this series are also discussed...
  38. doi request reprint Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India
    Bioorg Med Chem Lett 22:571-8. 2012
    ..The apoptotic nature of these compounds was further evidenced by increased expression of cleaved-PARP and active caspase-7 in MCF-7 cells...
  39. doi request reprint Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents
    Ahmed Kamal
    Division of Organic Chemistry, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India
    Eur J Med Chem 62:661-9. 2013
    ..These compounds also showed activity against Candida albicans, with a MIC value of 4.0 μg/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented...
  40. doi request reprint Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues
    Ahmed Kamal
    Division of Organic Chemistry, CSIR Indian Institute of Chemical Technology, Hyderabad 500607, India
    Bioorg Med Chem Lett 22:4891-5. 2012
    ..Interestingly, some of these synthesized compounds also showed moderate antioxidant property...
  41. doi request reprint Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500037, India Electronic address
    Bioorg Med Chem 22:3465-77. 2014
    ..Overall, the results demonstrate that N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamide scaffold possess anticancer property by inhibiting the tubulin polymerization. ..
  42. ncbi request reprint Solid-phase synthesis of a library of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones with potential antitubercular activity
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    J Comb Chem 9:29-42. 2007
    ..Further, from a generated library of 210 compounds, 142 compounds have been selected and evaluated for in vitro activity against Mycobacterium tuberculosis, and some of these compounds have exhibited promising activity...
  43. doi request reprint Synthesis and biological evaluation of imidazo[2,1-b][1,3,4]thiadiazole-linked oxindoles as potent tubulin polymerization inhibitors
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007 India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037 India
    ChemMedChem 9:1463-75. 2014
    ..15 μM) lower than that of combretastatin A-4 (1.16 μM). Docking studies reveal that compounds 7 and 11 bind with αAsn101, βThr179, and βCys241 in the colchicine binding site of tubulin. ..
  44. doi request reprint Synthesis and biological evaluation of cinnamido linked benzophenone hybrids as tubulin polymerization inhibitors and apoptosis inducing agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India Electronic address
    Bioorg Med Chem Lett 24:2309-14. 2014
    ..Overall, the current study demonstrates that the synthesis of benzophenone linked cinnamide subunit conjugates as promising anticancer agents with G2/M arrest and apoptotic-inducing ability via targeting tubulin. ..
  45. doi request reprint Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Electronic address
    Bioorg Med Chem 22:2714-23. 2014
    ....
  46. doi request reprint Apoptosis-inducing agents: a patent review (2010 - 2013)
    Ahmed Kamal
    CSIR Indian Institute of Chemical Technology, Medicinal Chemistry and Pharmacology, Tarnaka, Hyderabad 500007, India 91 402 719 3157 91 402 719 3189
    Expert Opin Ther Pat 24:339-54. 2014
    ..Therefore, it has become one of the prime molecular target for drug discovery and development particularly for diseases like cancer...
  47. doi request reprint Synthesis and biological evaluation of benzo[b]furans as inhibitors of tubulin polymerization and inducers of apoptosis
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007 India Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Hyderabad 500 037 India
    ChemMedChem 9:117-28. 2014
    ..Molecular docking studies indicated that compound 36 interacts and binds efficiently with the tubulin protein...
  48. doi request reprint Synthesis and anticancer potential of benzothiazole linked phenylpyridopyrimidinones and their diones as mitochondrial apoptotic inducers
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India Electronic address
    Bioorg Med Chem Lett 24:147-51. 2014
    ..DNA fragmentation and Hoechst staining reveals that this compound induced cell death by apoptosis. Further caspase-3 and loss of mitochondrial membrane potential suggested that the compound induces cell death by apoptosis. ..
  49. ncbi request reprint Synthesis and biological evaluation of diaryl ether linked DC-81 conjugates as potential antitumor agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, Chemical Biology Laboratory, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Anticancer Agents Med Chem 13:1590-600. 2013
    ..Further conjugates 4b, 4h and 6b induce the activation of caspase and PARP proteins, followed by apoptotic cell death in MCF7 cell line. ..
  50. doi request reprint Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India Electronic address
    Bioorg Med Chem Lett 23:6842-6. 2013
    ..Compound 8e showed promising antitubercular activity with MIC value of 0.25 μg/ml. Most of these compounds are less toxic to normal mammalian cells than the widely used antibacterial drug Ciprofloxacin...
  51. doi request reprint Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India Electronic address
    Bioorg Med Chem Lett 23:5733-9. 2013
    ..Hence these small molecules have the potential to control both the cell proliferation as well as the invasion process in the highly malignant breast cancers...
  52. doi request reprint Synthesis and biological evaluation of imidazopyridine-oxindole conjugates as microtubule-targeting agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad 500007 India
    ChemMedChem 8:2015-25. 2013
    ..Docking of compound 10 f with tubulin protein suggested that the imidazo[1,2-a]pyridine moiety occupies the colchicine binding site of tubulin. ..
  53. doi request reprint The first total synthesis of nhatrangin A
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad, 500007, India
    Org Biomol Chem 11:4442-8. 2013
    ..The first total synthesis of nhatrangin A has been achieved. Pivotal bond forming events in the synthesis include Brown crotylboration, olefin cross-metathesis, Sharpless asymmetric dihydroxylation and Yamaguchi esterification...
  54. ncbi request reprint Synthesis, DNA binding ability and anticancer activity of 2-heteroaryl substituted benzimidazoles linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Med Chem 9:651-9. 2013
    ..Further, these compounds also showed significant DNA-binding affinity by thermal denaturation study using duplex form of calf thymus (CT) DNA...
  55. doi request reprint Anti-tubercular agents. Part 7: a new class of diarylpyrrole-oxazolidinone conjugates as antimycobacterial agents
    Ahmed Kamal
    Medicinal Chemistry and Pharmacology, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India
    Eur J Med Chem 64:239-51. 2013
    ..The docking studies have been carried out to provide some insight into the mechanism of action for this class of compounds...
  56. doi request reprint Naphthalimide derivatives with therapeutic characteristics: a patent review
    Ahmed Kamal
    CSIR, Indian Institute of Chemical Technology, Natural Product Chemistry Division, Tarnaka, Hyderabad 500007, India
    Expert Opin Ther Pat 23:299-317. 2013
    ..Few of such molecules are currently under preclinical and clinical evaluations...
  57. doi request reprint The design and development of imidazothiazole-chalcone derivatives as potential anticancer drugs
    Ahmed Kamal
    CSIR Indian Institute of Chemical Technology, Division of Organic Chemistry, Tarnaka, Hyderabad, India
    Expert Opin Drug Discov 8:289-304. 2013
    ..Their promising biological profile and easy synthetic accessibility have triggered investigations directed at the design and development of new imidazothiazole-chalcone conjugate derivatives as potential chemotherapeutics...
  58. doi request reprint Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents
    Ahmed Kamal
    Division of Organic Chemistry, CSIR Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 23:273-80. 2013
    ..Further, Hoechst 33258 staining and DNA fragmentation assay also suggests that 17g induces cell death by apoptosis...
  59. doi request reprint Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, CSIR Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Eur J Med Chem 56:166-78. 2012
    ..Docking experiments have shown that the active molecules interact and bind well in the ATP binding pocket of ERK protein...
  60. doi request reprint Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells
    Ahmed Kamal
    Division of Organic Chemistry, CSIR Indian Institute of Chemical Technology, Hyderabad 500007, India
    ChemMedChem 7:1453-64. 2012
    ....
  61. doi request reprint Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents
    Ahmed Kamal
    Division of Organic Chemistry, CSIR Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Bioorg Med Chem 20:3480-92. 2012
    ..Overall, the current study demonstrates that the synthesis of chalcone-amidobenzothiazole conjugates as promising anticancer agents with potent G2/M arrest and apoptotic-inducing activities via targeting tubulin...
  62. doi request reprint 2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India
    Bioorg Med Chem 19:7136-50. 2011
    ..The cytotoxicity of 4i correlated with induction of apoptosis, caspases activation and DNA damage and thus indicating the apoptotic pathway of anticancer effect of these compounds...
  63. doi request reprint Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500607, India
    Eur J Med Chem 50:9-17. 2012
    ..Compounds 3t and 3ad are the most promising candidates amongst the series and has the potential to be taken up for further detailed studies either alone or in combination with the existing therapies...
  64. doi request reprint Recent advances on structural modifications of benzothiazoles and their conjugate systems as potential chemotherapeutics
    Kamal Ahmed
    Indian Institute of Chemical Technology, Division of Organic Chemistry, Tarnaka, Hyderabad, India
    Expert Opin Investig Drugs 21:619-35. 2012
    ..The promising biological profile and synthetic accessibility have been attractive in the design and development of new benzothiazoles and their conjugate systems as potential chemotherapeutics...
  65. doi request reprint Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Bioorg Med Chem 20:2054-66. 2012
    ..Moreover activation of caspase-3, p21, p16, NF-kB and down regulation of Bcl-2 protein suggests that this compound (11e) has apoptotic cell death inducing ability, apart from acting as a topo-IIα inhibitor...
  66. ncbi request reprint Metabolic profiling and biological activities of bioactive compounds produced by Pseudomonas sp. strain ICTB-745 isolated from Ladakh, India
    Ahmed Kamal
    Chemical Biology Laboratory, Division of Organic Chemistry, IndianInstitute of Chemical Technology, Uppal Road, Hyderabad 500 607, India
    J Microbiol Biotechnol 22:69-79. 2012
    ..The metabolites from Pseudomonas sp. strain ICTB-745 have interesting potential for use as a biopesticide in pest control programs...
  67. doi request reprint Synthesis and apoptosis inducing ability of new anilino substituted pyrimidine sulfonamides as potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Eur J Med Chem 46:5817-24. 2011
    ..One of the representative compound 3e could be considered as the potential lead for its development as a new anticancer agent...
  68. doi request reprint Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Eur J Med Chem 47:530-45. 2012
    ..Further, Hoechst 33258 staining and DNA fragmentation assay also suggested that 17a and 17f induced cell death by apoptosis...
  69. doi request reprint Design and synthesis of benzo[c,d]indolone-pyrrolobenzodiazepine conjugates as potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Bioorg Med Chem 20:789-800. 2012
    ..This is confirmed by Annexin V-FITC, Hoechst staining, caspase-3 activity as well as DNA fragmentation analysis...
  70. doi request reprint Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India
    Eur J Med Chem 45:3924-37. 2010
    ..Hence these PBD conjugates with 6a being the most potent one could be be taken up for preclinical studies either alone or in combination with existing therapies...
  71. doi request reprint 3-substituted 2-phenylimidazo[2,1-b]benzothiazoles: synthesis, anticancer activity, and inhibition of tubulin polymerization
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500607, India
    ChemMedChem 7:292-300. 2012
    ..Molecular modeling studies provided a molecular basis for the favorable binding of compounds 3 a, 3 e, and 3 h to the colchicine binding pocket of tubulin...
  72. doi request reprint Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India
    Bioorg Med Chem 19:4589-600. 2011
    ....
  73. doi request reprint Synthesis of aryl-substituted naphthalene-linked pyrrolobenzodiazepine conjugates as potential anticancer agents with apoptosis-inducing ability
    Ahmed Kamal
    Chemical Biology Laboratory, Indian Institute of Chemical Technology, Hyderabad 500607, India
    ChemMedChem 6:1665-79. 2011
    ..One conjugate in particular is the most promising candidate of the series, with the potential to be selected for further studies, either alone or in combination with existing anticancer therapies...
  74. doi request reprint Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Eur J Med Chem 46:3820-31. 2011
    ..These findings suggest that one of the compound 4d among this series is most effective and has potential for detailed investigations...
  75. doi request reprint Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Eur J Med Chem 46:3274-81. 2011
    ..Further, the DNA binding ability by thermal denaturation studies and antimicrobial activities of these compounds are also discussed...
  76. pmc Chalcone-imidazolone conjugates induce apoptosis through DNA damage pathway by affecting telomeres
    M Janaki Ramaiah
    Division of Chemical Biology, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India
    Cancer Cell Int 11:11. 2011
    ..abstract:..
  77. doi request reprint Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Bioorg Med Chem 19:2975-9. 2011
    ..Further, compounds 6g and 6i are also evaluated for their DNA topoisomerase-II (topo-II) inhibition activity and they exhibited significant inhibition of topo-II catalytic activity comparable to etoposide...
  78. ncbi request reprint Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 14:4107-11. 2004
    ..Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity...
  79. ncbi request reprint Recent advances in the solid-phase combinatorial synthetic strategies for the quinoxaline, quinazoline and benzimidazole based privileged structures
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Mini Rev Med Chem 6:71-89. 2006
    ..Further, benzothiadiazinone, thioxoquinazolinone, cinnoline and indazole are also examined in this review...
  80. ncbi request reprint Synthesis of a new class of 2-anilino substituted nicotinyl arylsulfonylhydrazides as potential anticancer and antibacterial agents
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 15:1004-13. 2007
    ..Most of these compounds showed better inhibitory activity in comparison to the standard drugs...
  81. ncbi request reprint Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 17:803-6. 2007
    ..8 degrees C after incubation of 36 h at 37 degrees C...
  82. ncbi request reprint Efficient solid-phase synthesis of a library of imidazo[1,2-a]pyridine-8-carboxamides
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    J Comb Chem 9:267-74. 2007
    ..The final crude products were purified from excess amines by solid-supported liquid-liquid extraction (SLE)...
  83. ncbi request reprint Anti-tubercular agents. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1,2,4-benzothiadiazines
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 17:5419-22. 2007
    ..One of the compounds 2f has shown good in vitro antimycobacterial activity. All the synthesized compounds have shown moderate to good antibacterial activity...
  84. ncbi request reprint 1,2,4-benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 17:5345-8. 2007
    ..Their DNA thermal denaturation studies have been carried out and one of the compounds (4b) elevates the DNA helix melting temperature of the CT-DNA by 6.7 degrees C after incubation for 36 h...
  85. ncbi request reprint Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 15:6868-75. 2007
    ..Some of these molecules have shown significant anticancer activity in a number of cancer cell lines...
  86. doi request reprint Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT
    Ahmed Kamal
    Department of Chemical Biology, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    ChemMedChem 3:794-802. 2008
    ..Another important property of these molecules is their enhanced water solubility and stability, which are essential for a molecule to be an effective drug...
  87. doi request reprint Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, Andhra Pradesh 500 007, India
    Bioorg Med Chem 16:3895-906. 2008
    ..These pyrrolobenzodiazepine conjugates have exhibited remarkable DNA-binding affinity and improved solubility in water, a representative compound 7d showing promising in vitro cytotoxicity...
  88. doi request reprint Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity
    Ahmed Kamal
    Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, Andra Pradesh 500 007, India
    Bioorg Med Chem Lett 18:2434-9. 2008
    ..Interestingly, some of these molecules have shown enhanced DNA-binding affinity and promising anticancer activity on a large number of human cancer cell lines...
  89. doi request reprint Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 18:2594-8. 2008
    ..Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human cancer cell lines...
  90. doi request reprint Pyrrolo[2,1-c][1,4]benzodiazepine-beta-glucuronide prodrugs with a potential for selective therapy of solid tumors by PMT and ADEPT strategies
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
    Bioorg Med Chem Lett 18:3769-73. 2008
    ..Enhanced water solubility and improved stability are the other important outcomes upon modifying these molecules as their prodrugs...
  91. ncbi request reprint Recent advances in the solid-phase combinatorial synthetic strategies for the benzodiazepine based privileged structures
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Mini Rev Med Chem 6:53-69. 2006
    ..Further, the most relevant biological properties of these heterocycles have also been incorporated...
  92. ncbi request reprint Synthesis and DNA-binding ability of pyrrolo[2,1-c][1,4]benzodiazepine-azepane conjugates
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 16:1160-3. 2006
    ..One of the compound (4b), elevates the DNA helix melting temperature of the CT-DNA by 2.0 degrees C after incubation for 36 h at 37 degrees C...
  93. ncbi request reprint Design, synthesis, biological evaluation and QSAR studies of novel bisepipodophyllotoxins as cytotoxic agents
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 12:4197-209. 2004
    ..QSAR models developed in these studies will be helpful in the future to design novel potent bispodophyllotoxin analogues by minor structural modifications...
  94. ncbi request reprint Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem 12:4337-50. 2004
    ..The synthesis of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity...
  95. ncbi request reprint Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 14:4791-4. 2004
    ..These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity...
  96. ncbi request reprint Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity
    Ahmed Kamal
    Division of Organic Chemistry I, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem Lett 14:4907-9. 2004
    ..New pyrrolobenzodiazepine-anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many cancer cell lines..
  97. ncbi request reprint Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007
    Bioorg Med Chem Lett 14:4581-3. 2004
    ....
  98. ncbi request reprint Design, synthesis, and evaluation of mixed imine-amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Bioorg Med Chem 12:5427-36. 2004
    ..0 degrees C) when compared to naturally occurring DC-81, 1 (DeltaTm=0.7 degrees C). The imine-amine PBD dimers exhibit promising in vitro antitumor activity in a number of human cancer cell lines...
  99. ncbi request reprint A new facile chemoenzymatic synthesis of levamisole
    Ahmed Kamal
    Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 15:613-5. 2005
    ..An efficient and facile chemoenzymatic synthesis of levamisole by employing lipase-mediated resolution of 3-hydroxy-3-phenylpropanenitrile followed by its conversion to beta-amino alcohol as the key intermediate is described...
  100. ncbi request reprint Antitubercular agents. Part 1: synthesis of phthalimido- and naphthalimido-linked phenazines as new prototype antitubercular agents
    Ahmed Kamal
    Division of Organic Chemistry I, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 15:1923-6. 2005
    ..Some of these new compounds inhibited the growth of Mycobacterium tuberculosis ATCC 27294, Mycobacterium avium ATCC 49601, Mycobacterium intracellulare ATCC 13950 and some clinical isolates...
  101. ncbi request reprint Antitubercular agents. Part 2: new thiolactomycin analogues active against Mycobacterium tuberculosis
    Ahmed Kamal
    Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
    Bioorg Med Chem Lett 15:1927-9. 2005
    ..Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis...