Affiliation: Indian Institute of Chemical Biology
Rahaman O, Bhattacharya R, Liu C, Raychaudhuri D, Ghosh A, Bandopadhyay P, et al
. Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype. J Immunol. 2019;202:1674-1679 pubmed publisher
..We also identified an ABHD6High SLE endophenotype wherein reduced local abundance of 2-AG relieves the CB2-mediated steady-state resistive tuning on IFN-α induction by pDCs, thereby contributing to SLE pathogenesis. ..
Paul B, Rahaman O, Roy S, Pal S, Satish S, Mukherjee A, et al
. Activity-guided development of potent and selective toll-like receptor 9 antagonists. Eur J Med Chem. 2018;159:187-205 pubmed publisher
Ghosh A, Bhattacharya R, Bhattacharya S, Nargis T, Rahaman O, Duttagupta P, et al
. Adipose Recruitment and Activation of Plasmacytoid Dendritic Cells Fuel Metaflammation. Diabetes. 2016;65:3440-3452 pubmed
..Thus, this study reveals a pathway that drives adipose tissue inflammation and consequent IR in obesity. ..
Liu C, Raychaudhuri D, Paul B, Chakrabarty Y, Ghosh A, Rahaman O, et al
. Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation. J Immunol. 2018;200:1255-1260 pubmed publisher
..Thus, we discovered a hitherto unknown regulatory mechanism for human T cell activation and provide the first evidence, to our knowledge, for the involvement of Piezo1 mechanosensors in immune regulation. ..
Roy S, Mukherjee A, Paul B, Rahaman O, Roy S, Maithri G, et al
. Design and development of benzoxazole derivatives with toll-like receptor 9 antagonism. Eur J Med Chem. 2017;134:334-347 pubmed publisher
Ganguly D. Do Type I Interferons Link Systemic Autoimmunities and Metabolic Syndrome in a Pathogenetic Continuum?. Trends Immunol. 2018;39:28-43 pubmed publisher
..This concurrence of autoimmunities and metabolic disorders may be explained by a single pathogenetic continuum, and suggests shared targets for potential new therapies. ..
Nargis T, Kumar K, Ghosh A, Sharma A, Rudra D, Sen D, et al
. KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes. Mol Metab. 2017;6:1529-1539 pubmed publisher
..Thus, our study uncovers a hitherto unknown cellular source and mechanism behind enhanced plasma DPP4 activity in T2DM. ..