Affiliation: Indian Institute of Chemical Biology
Niyogi S, Ghosh M, Adak M, Chakrabarti P. PEDF promotes nuclear degradation of ATGL through COP1. Biochem Biophys Res Commun. 2019;512:806-811 pubmed publisher
..PEDF also controls cell autonomous hepatocyte lipid accumulation and mobilization through COP1-ATGL axis, thereby unraveling a novel pathway for hepatic lipid metabolism. ..
Khan M, Layden B, Chakrabarti P. Inhibition of mTOR complexes protects cancer cells from glutamine starvation induced cell death by restoring Akt stability. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2040-2052 pubmed publisher
..Thus, our data uncovers a novel molecular link between glutamine metabolism, autophagy and stability of Akt with cancer cell survival. ..
Nargis T, Kumar K, Ghosh A, Sharma A, Rudra D, Sen D, et al
. KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes. Mol Metab. 2017;6:1529-1539 pubmed publisher
..Thus, our study uncovers a hitherto unknown cellular source and mechanism behind enhanced plasma DPP4 activity in T2DM. ..