S M Hadi

Summary

Country: India

Publications

  1. ncbi Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties
    S M Hadi
    Department of Biochemistry, Faculty of Life Sciences, A M U, Aligarh 202002, UP, India
    Semin Cancer Biol 17:370-6. 2007
  2. doi Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer
    S M Hadi
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India
    Pharm Res 27:979-88. 2010
  3. doi Catalytic therapy of cancer by ascorbic acid involves redox cycling of exogenous/endogenous copper ions and generation of reactive oxygen species
    S M Hadi
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India
    Chemotherapy 56:280-4. 2010
  4. ncbi The prooxidant action of dietary antioxidants leading to cellular DNA breakage and anticancer effects: implications for chemotherapeutic action against cancer
    M F Ullah
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, India
    Cell Biochem Biophys 67:431-8. 2013
  5. ncbi Prooxidant and antioxidant activities of bilirubin and its metabolic precursor biliverdin: a structure-activity study
    S F Asad
    Department of Biochemistry, Aligarh Muslim University, Aligarh-202 002, India
    Chem Biol Interact 137:59-74. 2001
  6. ncbi Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: implications for an anticancer mechanism
    Uzma Shamim
    Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh, UP, India
    Free Radic Res 42:764-72. 2008
  7. pmc Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants
    H Zubair
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India
    Cell Death Dis 4:e660. 2013
  8. ncbi Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties
    Asfar Sohail Azmi
    Department of Biochemistry, Faculty of Life Sciences, A M U, Aligarh 202002, UP, India
    FEBS Lett 580:533-8. 2006
  9. ncbi Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties
    S Azam
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, U P, India
    Toxicol In Vitro 18:555-61. 2004
  10. ncbi Ascorbic acid mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties
    Showket Hussain Bhat
    Department of Biochemistry, Faculty of Life Sciences, A M U, Aligarh 202002, UP, India
    Int J Biochem Cell Biol 38:2074-81. 2006

Collaborators

Detail Information

Publications26

  1. ncbi Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties
    S M Hadi
    Department of Biochemistry, Faculty of Life Sciences, A M U, Aligarh 202002, UP, India
    Semin Cancer Biol 17:370-6. 2007
    ..Thus, our results are in support of our hypothesis that anticancer mechanism of plant polyphenols involves mobilization of endogenous copper possibly chromatin bound copper and the consequent prooxidant action...
  2. doi Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer
    S M Hadi
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India
    Pharm Res 27:979-88. 2010
    ..Such a mechanism better explains the anti-cancer effects of resveratrol, as it accounts for the preferential cytotoxicity towards cancer cells...
  3. doi Catalytic therapy of cancer by ascorbic acid involves redox cycling of exogenous/endogenous copper ions and generation of reactive oxygen species
    S M Hadi
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India
    Chemotherapy 56:280-4. 2010
    ..In this review we cite evidence to indicate that in catalytic therapy cytotoxic action against cancer cells involves redox cycling of exogenous/endogenous copper ions...
  4. ncbi The prooxidant action of dietary antioxidants leading to cellular DNA breakage and anticancer effects: implications for chemotherapeutic action against cancer
    M F Ullah
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, India
    Cell Biochem Biophys 67:431-8. 2013
    ....
  5. ncbi Prooxidant and antioxidant activities of bilirubin and its metabolic precursor biliverdin: a structure-activity study
    S F Asad
    Department of Biochemistry, Aligarh Muslim University, Aligarh-202 002, India
    Chem Biol Interact 137:59-74. 2001
    ..Further it would appear that the structural features of the bilirubin molecule which are important for its prooxidant action are also the ones that render it a more effective antioxidant...
  6. ncbi Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: implications for an anticancer mechanism
    Uzma Shamim
    Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh, UP, India
    Free Radic Res 42:764-72. 2008
    ..These results indicate that the generation of ROS occurs through mobilization of nuclear copper resulting in oxidatively generated DNA breakage...
  7. pmc Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants
    H Zubair
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India
    Cell Death Dis 4:e660. 2013
    ..We believe that such a prooxidant cytotoxic mechanism better explains the anticancer activity of plant-derived antioxidants...
  8. ncbi Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties
    Asfar Sohail Azmi
    Department of Biochemistry, Faculty of Life Sciences, A M U, Aligarh 202002, UP, India
    FEBS Lett 580:533-8. 2006
    ..These results are in further support of our hypothesis that anticancer mechanism of plant polyphenols involves mobilization of endogenous copper, possibly chromatin bound copper, and the consequent prooxidant action...
  9. ncbi Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties
    S Azam
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, U P, India
    Toxicol In Vitro 18:555-61. 2004
    ..A model for binding of Cu(II) to EC has been presented where the formation of quinone and a quinone methide has been proposed...
  10. ncbi Ascorbic acid mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties
    Showket Hussain Bhat
    Department of Biochemistry, Faculty of Life Sciences, A M U, Aligarh 202002, UP, India
    Int J Biochem Cell Biol 38:2074-81. 2006
    ..This would account for the observation of several decades back by Pauling and co-workers where oral doses of ascorbic acid in gram quantities were found to be effective in treating some cancers...
  11. ncbi Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties
    S H Bhat
    Department of Biochemistry, Faculty of Life Sciences, A M U, Aligarh 202002 U P, India
    Toxicol Appl Pharmacol 218:249-55. 2007
    ..These results are in further support of our hypothesis that anticancer mechanism of plant polyphenols involves mobilization of endogenous copper, possibly chromatin bound copper, and the consequent prooxidant action...
  12. doi The anthocyanidin delphinidin mobilizes endogenous copper ions from human lymphocytes leading to oxidative degradation of cellular DNA
    Sarmad Hanif
    Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh 202002, UP, India
    Toxicology 249:19-25. 2008
    ..The results are in support of our hypothesis that the prooxidant activity of plant polyphenols may be an important mechanism for their anticancer properties...
  13. ncbi Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II)
    S Singh
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Uttar Pradesh 202002, Aligarh, India
    Cancer Lett 169:139-46. 2001
    ..This explains the greater activity of capsaicin and also leads to a model for copper binding to the capsaicins...
  14. doi The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer
    M F Ullah
    Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh, UP 202002, India
    Cancer Chemother Pharmacol 67:103-10. 2011
    ..In this study, we propose a putative molecular mechanism that accounts for the preferential cytotoxicity of ascorbic acid against cancer cells...
  15. doi Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage
    Haseeb Zubair
    Department of Biochemistry, Aligarh Muslim University, Aligarh 202002, India
    Eur J Pharm Sci 47:280-6. 2012
    ..This may account for the preferential cytotoxicity of apogossypolone towards tumor cells...
  16. doi Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells
    S Nazeem
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
    Mutagenesis 24:413-8. 2009
    ....
  17. ncbi The biflavonoid, amentoflavone degrades DNA in the presence of copper ions
    Qamar Uddin
    Department of Chemistry, Natural Product Research Lab, Aligarh Muslim University, Aligarh 202002, UP, India
    Toxicol In Vitro 18:435-40. 2004
    ..Amentoflavone and apigenin were isolated from Cycas rumphii and Trifolium alexandrinum, respectively. The results are discussed in relation to the putative chemopreventive mechanism of amentoflavone...
  18. ncbi Prooxidant activity of resveratrol in the presence of copper ions: mutagenicity in plasmid DNA
    Aamir Ahmad
    Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh, UP 202002, India
    Toxicol Lett 159:1-12. 2005
    ..Concentration of copper is reported to be elevated in various malignancies and the present studies might explain the reported anticancer activity of resveratrol in various cancer cell lines...
  19. ncbi Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds
    S M Hadi
    Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh, India
    IUBMB Life 50:167-71. 2000
    ..We propose a mechanism for the cytotoxic action of these compounds against cancer cells that involves mobilization of endogenous copper and the consequent prooxidant action...
  20. ncbi Inhibition of L-DOPA-Cu(II)-mediated DNA cleavage by bilirubin
    S F Asad
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligath (U. P.) 202 002, India
    Toxicol In Vitro 14:401-4. 2000
    ..Bilirubin was also shown to directly quench the generation of hydroxyl radicals by L-DOPA-Cu(II) to an extent of 30% at a concentration of 20 microM. The results support the putative antioxidant role of bilirubin in higher primates...
  21. ncbi DNA degradation by aqueous extract of Aloe vera in the presence of copper ions
    Shoa Naqvi
    Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh, India
    Indian J Biochem Biophys 47:161-5. 2010
    ..Thus, the study shows that in addition to antioxidant activity, Aloe vera extract also possess pro-oxidant properties, leading to oxidative DNA breakage...
  22. ncbi Resveratrol-Cu(II) induced DNA breakage in human peripheral lymphocytes: implications for anticancer properties
    Asfar Sohail Azmi
    Department of Biochemistry, Faculty of Life Sciences, A M U Aligarh 202 002, UP, India
    FEBS Lett 579:3131-5. 2005
    ..Our results are in partial support of our hypothesis that anticancer properties of various plant derived polyphenols may involve mobilization of endogenous copper and the consequent prooxidant action...
  23. ncbi Old wine in a new bottle: the Warburg effect and anticancer mechanisms of resveratrol
    Irfana Muqbil
    Department of Biochemistry, Aligarh Muslim University, India
    Curr Pharm Des 18:1645-54. 2012
    ..This review discusses the recent advancements in understanding the pro-oxidant anti-cancer behavior of resveratrol as a dietary chemopreventive agent, explained in the light of the Warburg effect...
  24. ncbi DNA degradation by water extract of green tea in the presence of copper ions: implications for anticancer properties
    Arshi Malik
    Department of Biochemistry, Faculty of Life Science, AMU, Aligarh, India
    Phytother Res 17:358-63. 2003
    ..The results are discussed in relation to the structural differences between polyphenols of green and black tea...
  25. ncbi Bilirubin/biliverdin-Cu(II) induced DNA breakage; reaction mechanism and biological significance
    S Farhan Asad
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, UP 202 002, India
    Toxicol Lett 131:181-9. 2002
    ..Our results, therefore are suggestive of one of the mechanisms through which endogenous DNA damage may occur...
  26. doi Synthesis, spectroscopic and electrochemical studies of N,N-bis[(E)-2-thienylmethylidene]-1,8-naphthalenediamine and its Cu(II) complex: DNA cleavage and generation of superoxide anion
    Mohammad Shakir
    Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India
    J Photochem Photobiol B 104:449-56. 2011
    ..Since it is known that various anticancer drugs act through induction of oxidative stress that is mediated by reactive oxygen species, our results suggest a putative role of Cu(II) complex similar to various anticancer drugs...