Verma V, Sharma V, Singh V, Sharma S, Bishnoi A, Chandra V, et al
. Designed modulation of sex steroid signaling inhibits telomerase activity and proliferation of human prostate cancer cells. Toxicol Appl Pharmacol. 2014;280:323-34 pubmed publisher
..Its unique molecular design can serve as a lead structure for generation of potent agents against endocrine malignancies like the CaP. ..
Gupta G, Jangir S, Sharma V. Targeting post-ejaculation sperm for value-added contraception. Curr Mol Pharmacol. 2014;7:167-74 pubmed
..We have reviewed here our recent endeavors in this important area of chemical contraception by using designed chemical synthesis approach to inhibit spermatozoa and infection. ..
Kumar R, Verma V, Sharma V, Jain A, Singh V, Sarswat A, et al
. A precisely substituted benzopyran targets androgen refractory prostate cancer cells through selective modulation of estrogen receptors. Toxicol Appl Pharmacol. 2015;283:187-97 pubmed publisher
..Its precise ER-subtype specific activity presents a unique lead structure for further optimization. ..
Yadav S, Pandey A, Kumar L, Devi A, Kushwaha B, Vishvkarma R, et al
. The thermo-sensitive gene expression signatures of spermatogenesis. Reprod Biol Endocrinol. 2018;16:56 pubmed publisher
Sharma V, Verma V, Lal N, Yadav S, Sarkar S, Mandalapu D, et al
. Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptor Î². Mol Carcinog. 2016;55:1843-1857 pubmed publisher
..Compound-339 presents a new lead for further study as an anti-prostate cancer agent. Â© 2015 Wiley Periodicals, Inc. ..
Kushwaha B, Mandalapu D, Bala V, Kumar L, Pandey A, Pandey D, et al
. Ammonium salts of carbamodithioic acid as potent vaginal trichomonacides and fungicides. Int J Antimicrob Agents. 2016;47:36-47 pubmed publisher
..vaginalis by the new compounds has been proposed. Thus, a unique scaffold of antimicrobial agents has been discovered that warrants further investigation for development as contraceptive vaginal microbicides. ..
Kumar L, Yadav S, Kushwaha B, Pandey A, Sharma V, Verma V, et al
. Energy Utilization for Survival and Fertilization-Parsimonious Quiescent Sperm Turn Extravagant on Motility Activation in Rat. Biol Reprod. 2016;94:96 pubmed publisher
..This study also presents a proof of concept for targeting sperm energy metabolism for contraception. ..
Sharma V, Kumar L, Mohanty S, Maikhuri J, Rajender S, Gupta G. Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcumin. Mol Cell Endocrinol. 2016;431:12-23 pubmed publisher
Singh V, Sharma V, Verma V, Pandey D, Yadav S, Maikhuri J, et al
. Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-Î² from degradation and induce apoptosis in prostate cancer cells. Eur J Nutr. 2015;54:1255-67 pubmed publisher
..Unlike bortezomib, apigenin's actions are subtle, precise, mechanistically distinct and capable of abstaining drug resistance. ..