Patrick D Silva
Bhowmick D, Srivastava S, D Silva P, Mugesh G. Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage. Angew Chem Int Ed Engl. 2015;54:8449-53 pubmed publisher
..The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species. ..
Samaddar M, Goswami A, Purushotham J, Hegde P, D Silva P. Role of the loop L4,5 in allosteric regulation in mtHsp70s: in vivo significance of domain communication and its implications in protein translocation. Mol Biol Cell. 2014;25:2129-42 pubmed publisher
Saha P, Srivastava S, Kumar S K P, Sinha D, D Silva P. Mapping Key Residues of ISD11 Critical for NFS1-ISD11 Subcomplex Stability: IMPLICATIONS IN THE DEVELOPMENT OF MITOCHONDRIAL DISORDER, COXPD19. J Biol Chem. 2015;290:25876-90 pubmed publisher
..Furthermore, the R68L ISD11 mutant displayed accumulation of mitochondrial iron and reactive oxygen species, leading to mitochondrial dysfunction, which correlates with the phenotype observed in COXPD19 patients. ..
Bankapalli K, Saladi S, Awadia S, Goswami A, Samaddar M, D Silva P. Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae. J Biol Chem. 2015;290:26491-507 pubmed publisher
Sinha D, Srivastava S, D Silva P. Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase. J Biol Chem. 2016;291:17345-59 pubmed publisher
..Our analysis indicates that the differential cellular phenotype displayed by human mitochondrial J-proteins is independent of their activity and association with Magmas at the translocation channel. ..
Matta S, Pareek G, Bankapalli K, Oblesha A, D Silva P. Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability. Mol Cell Biol. 2017;37: pubmed publisher
..We conclude that the integrity of Tim17 transmembrane regions is critical for mitochondrial function and protein turnover. ..
Saha P, Vishwanathan V, Bankapalli K, D Silva P. Iron-Sulfur Protein Assembly in Human Cells. Rev Physiol Biochem Pharmacol. 2018;174:25-65 pubmed publisher
..The current review highlights recent developments and understanding in the domain of Fe-S cluster assembly biology in higher eukaryotes, particularly in human cells. ..