Alok Srivastava

Summary

Affiliation: Christian Medical College
Country: India

Publications

  1. ncbi von Willebrand disease in the developing world
    Alok Srivastava
    Department of Medicine, Christian Medical College, Vellore, India
    Semin Hematol 42:36-41. 2005
  2. ncbi Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients
    Sharat Damodar
    Department of Haematology, Christian Medical College, Vellore 632004, Tamil Nadu, India
    Eur J Haematol 75:328-31. 2005
  3. ncbi Optimizing clotting factor replacement therapy in hemophilia: a global need
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore, 632004, India
    Hematology 10:229-30. 2005
  4. ncbi Epidemiology of von Willebrand disease in developing countries
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore, India
    Semin Thromb Hemost 31:569-76. 2005
  5. ncbi Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity
    Vikram Mathews
    Department of Haematology, Christian Medical College and Hospital, Vellore 632004, India
    Blood 107:2627-32. 2006
  6. doi Guidelines for the management of hemophilia
    A Srivastava
    Department of Hematology, Christian Medical College, Vellore, India
    Haemophilia 19:e1-47. 2013
  7. ncbi Factor replacement therapy in haemophilia--are there models for developing countries?
    A Srivastava
    Christian Medical College Hospital, Vellore, India
    Haemophilia 9:391-6. 2003
  8. ncbi Prenatal diagnosis of Glanzmann thrombasthenia
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore 632004, Tamil Nadu, India
    Natl Med J India 16:207-8. 2003
  9. ncbi Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore 632 004, India
    Blood 104:1574-7. 2004
  10. ncbi Dose and response in haemophilia--optimization of factor replacement therapy
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore, India
    Br J Haematol 127:12-25. 2004

Collaborators

Detail Information

Publications80

  1. ncbi von Willebrand disease in the developing world
    Alok Srivastava
    Department of Medicine, Christian Medical College, Vellore, India
    Semin Hematol 42:36-41. 2005
    ..There is inadequate awareness of this condition and lack of support for these patients from the health care system in many developing countries. Concerted efforts are needed at the scientific and social levels to improve this situation...
  2. ncbi Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients
    Sharat Damodar
    Department of Haematology, Christian Medical College, Vellore 632004, Tamil Nadu, India
    Eur J Haematol 75:328-31. 2005
    ..These results demonstrate that dapsone is an effective, inexpensive and well-tolerated treatment for chronic ITP, in both children and adults and could be considered for patients who fail steroid therapy...
  3. ncbi Optimizing clotting factor replacement therapy in hemophilia: a global need
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore, 632004, India
    Hematology 10:229-30. 2005
  4. ncbi Epidemiology of von Willebrand disease in developing countries
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore, India
    Semin Thromb Hemost 31:569-76. 2005
    ..Efforts are needed to develop national registries and make at least basic services for diagnosis and treatment widely available...
  5. ncbi Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity
    Vikram Mathews
    Department of Haematology, Christian Medical College and Hospital, Vellore 632004, India
    Blood 107:2627-32. 2006
    ..Additionally, this regimen has minimal toxicity and can be administered on an outpatient basis after remission induction...
  6. doi Guidelines for the management of hemophilia
    A Srivastava
    Department of Hematology, Christian Medical College, Vellore, India
    Haemophilia 19:e1-47. 2013
    ....
  7. ncbi Factor replacement therapy in haemophilia--are there models for developing countries?
    A Srivastava
    Christian Medical College Hospital, Vellore, India
    Haemophilia 9:391-6. 2003
    ..This can be achieved by production of such concentrates locally or by importing them. Different models are possible depending on the circumstances in each country...
  8. ncbi Prenatal diagnosis of Glanzmann thrombasthenia
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore 632004, Tamil Nadu, India
    Natl Med J India 16:207-8. 2003
    ..Platelet transfusions are often needed to control the bleeding. Glanzmann thrombasthenia results from mutations in the genes located on chromosome 17q21-23, encoding the platelet glycoprotein (GP) IIb/IIIa receptor...
  9. ncbi Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore 632 004, India
    Blood 104:1574-7. 2004
    ..001, respectively). We conclude that the GSTM1-null genotype predisposes to HVOD, and the sinusoidal endothelial cells and hepatocyte damage may be mediated by metabolites of busulfan through depletion of the cellular GSH pool...
  10. ncbi Dose and response in haemophilia--optimization of factor replacement therapy
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore, India
    Br J Haematol 127:12-25. 2004
    ..Less intensive protocols could achieve similar outcomes. Large multi-centre prospective studies are needed to provide comparative data on unresolved issues so that factor replacement therapy can be optimized, based on evidence...
  11. doi Tests of global haemostasis and their applications in bleeding disorders
    S C Nair
    Christian Medical College, Vellore, India
    Haemophilia 16:85-92. 2010
    ..Furthermore, these tests need to be standardized with regard to their reagents, methodology and interpretation, and finally, much more data need to be collected regarding clinical correlations with the parameters measured...
  12. ncbi Choice of factor concentrates for haemophilia: a developing world perspective
    A Srivastava
    Department of Haematology, Christian Medical College Hospital, Vellore, India
    Haemophilia 7:117-22. 2001
    ..Until such time as these examples are widely emulated, less safe products will continue to be used in situations where a distinction frequent needs to be made between what is ideal and what is practical...
  13. ncbi Hemophilia treatment in developing countries: products and protocols
    Alok Srivastava
    Christian Medical College, Vellore, India
    Semin Thromb Hemost 31:495-500. 2005
    ..The combined experience in the developing world in providing hemophilia services should be used to define standards of care that are practical and to set achievable goals...
  14. ncbi Uncertain times for research on hemophilia and allied disorders
    A Srivastava
    Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India
    J Thromb Haemost 4:680; discussion 681-3. 2006
  15. pmc Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo
    Dwaipayan Sen
    Department of Hematology, Christian Medical College, Vellore 632004, Tamil Nadu, India
    Hum Gene Ther Methods 24:104-16. 2013
    ..FIX:Ag were higher in all the K137R-AAV8 treated groups up to 8 weeks post-hepatic gene transfer. These studies demonstrate the feasibility of the use of this novel AAV8 vectors for potential gene therapy of hemophilia B...
  16. ncbi Comparison of clinical outcomes of patients with relapsed acute promyelocytic leukemia induced with arsenic trioxide and consolidated with either an autologous stem cell transplant or an arsenic trioxide-based regimen
    Rajasekar Thirugnanam
    Department of Haematology, Christian Medical College, Vellore, India
    Biol Blood Marrow Transplant 15:1479-84. 2009
    ....
  17. doi Dendritic cell count in the graft predicts relapse in patients with hematologic malignancies undergoing an HLA-matched related allogeneic peripheral blood stem cell transplant
    Reena Rajasekar
    Department of Haematology, Christian Medical College, Vellore, India
    Biol Blood Marrow Transplant 16:854-60. 2010
    ..There is potential for pretransplant manipulation of this cellular subset in the graft...
  18. pmc Improved clinical outcomes of high risk β thalassemia major patients undergoing a HLA matched related allogeneic stem cell transplant with a treosulfan based conditioning regimen and peripheral blood stem cell grafts
    Vikram Mathews
    Department of Haematology, Christian Medical College, Vellore, India
    PLoS ONE 8:e61637. 2013
    ..BuCy (86.6 ± 7.3 Vs. 39.4 ± 6.8%; P = 0.002 and 77.8 ± 8.8 Vs. 32.4 ± 6.5%; P = 0.003 respectively). A TreoFluT conditioning regimen with a PBSC graft can significantly improve clinical outcomes of Class IIIHR patients...
  19. ncbi Fludarabine-based reduced intensity conditioning regimens for allogeneic hematopoietic stem cell transplantation in patients with aplastic anemia and fungal infections
    Biju George
    Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India
    Clin Transplant 23:228-32. 2009
    ..At a median follow up of 30 months, 11 patients (61.1%) were alive and well. Fludarabine-based conditioning regimens with PBSC transplantation can be used successfully in patients with aplastic anemia and fungal infections...
  20. doi Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: long-term follow-up data
    Vikram Mathews
    Department of Haematology, Christian Medical College and Hospital, Vellore 632004, India
    J Clin Oncol 28:3866-71. 2010
    ..Results in the low-risk group are comparable to that reported with conventional therapy while additional interventions would probably be required in high-risk cases...
  21. doi Impact of pretransplant splenectomy on patients with beta-thalassemia major undergoing a matched-related allogeneic stem cell transplantation
    Vikram Mathews
    Department of Haematology, Christian Medical College and Hospital, Vellore, India
    Pediatr Transplant 13:171-6. 2009
    ....
  22. doi Cellular immune reconstitution and its impact on clinical outcome in children with beta thalassemia major undergoing a matched related myeloablative allogeneic bone marrow transplant
    Reena Rajasekar
    Department of Haematology, Christian Medical College, Vellore, India
    Biol Blood Marrow Transplant 15:597-609. 2009
    ..On a multivariate analysis, patients with a day 28 NK cell count below the median value of 142/microL had a significantly higher rejection rate (hazard ratio [HR] = 11.1, P = .038) and a lower EFS (HR = 16.3, P = .034)...
  23. pmc Improved adeno-associated virus (AAV) serotype 1 and 5 vectors for gene therapy
    Dwaipayan Sen
    Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India
    Sci Rep 3:1832. 2013
    ..These studies demonstrate the feasibility of the use of these novel AAV1 and AAV5 vectors for potential gene therapy of diseases like hemophilia...
  24. doi Standardizing minimal residual disease by flow cytometry for precursor B lineage acute lymphoblastic leukemia in a developing country
    Nikhil Patkar
    Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India
    Cytometry B Clin Cytom 82:252-8. 2012
    ..In a first paper from India, we describe our experience in establishing a flow cytometry-based MRD assay for precursor B lineage ALL (BCP-ALL) with emphasis on the assay standardization and cost...
  25. doi Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy
    Ezhilarasi Chendamarai
    Department of Haematology, Christian Medical College, Vellore, India
    Blood 119:3413-9. 2012
    ..2%, respectively. High-risk group patients and those that remain RT-PCR positive at the end of induction are likely to benefit from serial MRD monitoring by RT-PCR for a period of 3 years from completion of therapy...
  26. doi Allogeneic hematopoietic stem cell transplantation is superior to immunosuppressive therapy in Indian children with aplastic anemia--a single-center analysis of 100 patients
    Biju George
    Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India
    Pediatr Hematol Oncol 27:122-31. 2010
    ..HSCT would be the treatment of choice in children with severe aplastic anemia who have a human leukocyte antigen (HLA)-matched related donor and is superior to IST in this series from India...
  27. doi Plasmacytoid dendritic cell count on day 28 in HLA-matched related allogeneic peripheral blood stem cell transplant predicts the incidence of acute and chronic GVHD
    Reena Rajasekar
    Department of Hematology, Christian Medical College, Vellore, India
    Biol Blood Marrow Transplant 14:344-50. 2008
    ..8, P = .008). These results suggest that the PC dendritic cell count in the peripheral blood on day 28 is a strong predictor for development of GVHD in recipients of an allogeneic matched related PBSCT...
  28. doi Management of hemophilia in patients with inhibitors: the perspective from developing countries
    Vikram Mathews
    Department of Hematology, Christian Medical College, Vellore, India
    Semin Thromb Hemost 35:820-6. 2009
    ..Even in resource-constrained environments, education and a policy of systematic screening of patients associated with judicious use of bypassing agents can significantly improve the care of PWH who develop inhibitors...
  29. ncbi Mutations in coagulation factor XIII A gene in eight unrelated Indians. Five novel mutations identified by a novel PCR-CSGE approach
    Giridhara R Jayandharan
    Department of Hematology, Christian Medical College, Vellore 632 004, India
    Thromb Haemost 95:551-6. 2006
    ..Apart from describing a significant number of novel mutations, this report is the first study from Southern India to describe FXIII A gene mutations...
  30. pmc A rapid & sensitive liquid chromatography- tandem mass spectrometry method for the quantitation of busulfan levels in plasma & application for routine therapeutic monitoring in haematopoietic stem cell transplantation
    Salamun Desire
    Department of Haematology, Christian Medical College, Vellore, India
    Indian J Med Res 137:777-84. 2013
    ..We report here a rapid and sensitive method to quantitate busulfan plasma levels in patients receiving busulfan as part of pre-transplant conditioning...
  31. ncbi Surgery for hemophilia in developing countries
    Vikram Mathews
    Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India
    Semin Thromb Hemost 31:538-43. 2005
    ..We hope that this experience will form a framework on which guidelines can be established for developing countries...
  32. doi Polymorphisms in the immunoregulatory genes are associated with hematopoietic recovery and increased susceptibility to bacterial infections in patients with thalassaemia major undergoing matched related hematopoietic stem cell transplantation
    Shanmugaapriya Sellathamby
    Department of Hematology, Christian Medical College, Vellore, India
    Biol Blood Marrow Transplant 18:1219-26. 2012
    ..8; 95% CI, 1.06-2.93; P = .028). These data suggest that outcome after allogeneic stem cell transplantation could be affected by many factors. The mechanisms by which they bring about such impact needs further evaluation...
  33. doi Cytogenetic analysis of acute myeloid leukemia with t(8;21) from a tertiary care center in India with correlation between clinicopathologic characteristics and molecular analysis
    Mayur Parihar
    Cytogenetics Unit, Christian Medical College, Vellore, Tamil Nadu, India
    Leuk Lymphoma 53:103-9. 2012
    ..One patient had a granulocytic sarcoma. Complete remission was achieved in 96% of the 26 newly diagnosed patients after first induction. The median follow-up was 25 months (range 4-68). The overall survival was 69% at 31 months...
  34. doi Treatment of children with acute lymphoblastic leukemia in India using a BFM protocol
    Ashish Bajel
    Department of Haematology, Christian Medical College, Vellore, Tamil Nadu 632004, India
    Pediatr Blood Cancer 51:621-5. 2008
    ..Limited data exists on the long-term treatment outcome and prognosis of childhood ALL in India...
  35. doi Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia
    Savitha Varatharajan
    Department of Haematology, Christian Medical College, Vellore, 632004, India
    Eur J Clin Pharmacol 68:1577-86. 2012
    ....
  36. ncbi Infections in children undergoing allogeneic bone marrow transplantation in India
    Biju George
    Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India
    Pediatr Transplant 10:48-54. 2006
    ..The profile and mortality of infections in this series from India is not significantly different from reports from the West...
  37. ncbi A new stratification strategy that identifies a subset of class III patients with an adverse prognosis among children with beta thalassemia major undergoing a matched related allogeneic stem cell transplantation
    Vikram Mathews
    Department of Haematology, Christian Medical College and Hospital, Vellore, India
    Biol Blood Marrow Transplant 13:889-94. 2007
    ..Patients in this high-risk group would probably benefit from novel therapeutic approaches...
  38. ncbi Rapid detection of beta-globin gene mutations and polymorphisms by temporal temperature gradient gel electrophoresis
    Ramachandran V Shaji
    Department of Haematology, Christian Medical College, Vellore 632004, India
    Clin Chem 49:777-81. 2003
    ..Prevention programs based on molecular diagnosis of heterozygous carriers and/or patients require the use of reliable mutation scanning methods in at-risk populations...
  39. ncbi Hb Lepore in the Indian population
    Ramachandran V Shaji
    Department of Hematology, Christian Medical College, Vellore, India
    Hemoglobin 27:7-14. 2003
    ..We also describe a possible misdiagnosis in the heterozygous state of Hb Lepore, as Hb Lepore and Hb A2 are not distinctly separated by cation exchange high performance liquid chromatography...
  40. doi Fluorescence in situ hybridization patterns of BCR/ABL1 fusion in chronic myelogenous leukemia at diagnosis
    Poonam P Jain
    Cytogenetics Unit, Christian Medical College, Vellore, Tamilnadu, India
    Indian J Pathol Microbiol 55:347-51. 2012
    ..FISH analysis at presentation is used to determine the number of cells with BCR/ABL1 fusion and establish whether the patterns are typical or atypical. Response to therapy can then be monitored by serial testing...
  41. doi Clinicopathological features of hepatosplenic T cell lymphoma: a single centre experience from India
    Nikhil Patkar
    Department of Haematology, Christian Medical College, Vellore, India
    Leuk Lymphoma 53:609-15. 2012
    ..In our series, HSTCL was characterized by typical clinical and variable immunophenotypic features and a dismal clinical outcome...
  42. ncbi Hyperbilirubinemia in homozygous HbE disease is associated with the UGT1A1 gene polymorphism
    Eunice Sindhuvi Edison
    Department of Haematology, Christian Medical College, Vellore, India
    Hemoglobin 29:189-95. 2005
    ..A study of the UGT1A1 gene polymorphism shows that the variant TA7 in the promoter region of the UGT1A1 gene is associated with hyperbilirubinemia in homozygous HbE patients...
  43. ncbi Compound heterozygosity for Hb E and Hb Lepore-Hollandia in India; first report and potential diagnostic pitfalls
    Eunice Sindhuvi Edison
    Department of Haematology, Christian Medical College, Vellore, India
    Hemoglobin 29:221-4. 2005
    ..This study shows that cases of Hb E/Lepore may remain undetected unless family studies and/or detailed DNA analyses in patients diagnosed to have Hb E-beta-thal are performed...
  44. doi Frequency of TPMT alleles in Indian patients with acute lymphatic leukemia and effect on the dose of 6-mercaptopurine
    Salamun Desire
    Department of Haematology, Christian Medical College, Vellore, India
    Med Oncol 27:1046-9. 2010
    ..Other novel variants in TPMT or variations in the genes involved in transport and biotransformation of 6-MP need to be evaluated in the Indian population...
  45. doi The t(6;9)(p22;q34) in myeloid neoplasms: a retrospective study of 16 cases
    Monika Gupta
    Cytogenetics Unit, Christian Medical College, Ida Scudder Road, Vellore 632004, India
    Cancer Genet Cytogenet 203:297-302. 2010
    ..The response to chemotherapy was poor in the remaining patients. The only patients who survived were three out of the four who had allogeneic hematopoietic stem cell transplantation (HSCT)...
  46. ncbi Coexistence of a novel beta-globin gene deletion (codons 81-87) with the codon 30 (G-->C) mutation in an Indian patient with beta0-thalassemia
    Ramachandran V Shaji
    Department of Haematology, Christian Medical College Hospital, Vellore, India
    Hemoglobin 26:237-43. 2002
    ..Direct and inverted repeat sequences present in the deleted region might be involved in the origin of this mutation. The patient had moderate anemia and did not require blood transfusions (thalassemia intermedia)...
  47. ncbi Hb Showa-Yakushiji [beta110(G12)Leu-->Pro] in four unrelated patients from west Bengal
    Eunice S Edison
    Department of Haematology, Christian Medical College, Vellore, India
    Hemoglobin 29:19-25. 2005
    ..The mutation producing this abnormal hemoglobin (Hb) was found on the same haplotype in all these patients but differed from the Japanese haplotype, indicating its independent origin in India...
  48. ncbi Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them
    Sangeetha Hareendran
    Centre for Stem Cell Research, Christian Medical College, Vellore, Tamil Nadu, India
    Rev Med Virol 23:399-413. 2013
    ..In this review, we have summarised the nature of the immune response documented against AAV in various pre-clinical and clinical settings and have further discussed the strategies to evade them...
  49. doi International reporting scale of BCR-ABL1 fusion transcript in chronic myeloid leukemia: first report from India
    Poonkuzhali Balasubramanian
    Department of Haematology, Christian Medical College, Vellore, India
    Acta Haematol 127:135-42. 2012
    ..In this report, we explain the process and steps involved in obtaining a valid lab-specific conversion factor for expressing BCR-ABL1 transcript levels in the IS...
  50. doi The phenotypic heterogeneity of severe hemophilia
    Giridhara Rao Jayandharan
    Department of Hematology, Christian Medical College, Vellore, India
    Semin Thromb Hemost 34:128-41. 2008
    ..A detailed understanding of all factors that may contribute to joint damage in severe hemophilia could help us in tailoring therapy for these individuals...
  51. ncbi Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide regimen
    Vikram Mathews
    Department of Haematology, Christian Medical College, Vellore, 632004 India
    Haematologica 92:994-5. 2007
    ..012) and a delay in achieving a molecular remission (p=0.022). Neither FLT3 activating mutations nor secondary cytogenetic changes had an impact on clinical outcome...
  52. doi The use of a fludarabine-based conditioning regimen in patients with severe aplastic anemia--a retrospective analysis from three Indian centers
    Biju George
    Department of Haematology, Christian Medical College Vellore, Vellore, India
    Clin Transplant 27:923-9. 2013
    ..6 ± 3.1% in the low-risk group (n = 45) and 64.0 ± 5.6% in the high-risk group (n = 76). Conditioning with fludarabine and cyclophosphamide is associated with very good long-term survival in patients undergoing HSCT for SAA...
  53. pmc Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo
    Nishanth Gabriel
    Department of Hematology, Christian Medical College, Vellore 632004, Tamil Nadu, India
    Hum Gene Ther Methods 24:80-93. 2013
    ..One of the mutant vectors, S489A, generated ~8-fold fewer antibodies that could be cross-neutralized by AAV2-WT. This study thus demonstrates the feasibility of the use of these novel AAV2 capsid mutant vectors in hepatic gene therapy...
  54. doi Cytidine deaminase genetic variants influence RNA expression and cytarabine cytotoxicity in acute myeloid leukemia
    Ajay Abraham
    Christian Medical College, Vellore 632004, India
    Pharmacogenomics 13:269-82. 2012
    ..We evaluated factors influencing variation in CDA mRNA expression in adult AML patients and normal controls, and how they contributed to Ara-C cytotoxicity in AML cells...
  55. ncbi Fludarabine based reduced intensity conditioning regimens in children undergoing allogeneic stem cell transplantation for severe aplastic anemia
    Biju George
    Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India
    Pediatr Transplant 12:14-9. 2008
    ..36.3%; p = 0.133) and improved event free (85.7 vs. 54.5%; p = 0.177) and overall survival (85.7 vs. 63.6%; p = 0.350). Flu with Cy +/- ATG reduces rejection and improves overall and event free survival in children with aplastic anemia...
  56. doi Diagnosis and management of von Willebrand disease: a developing country perspective
    Sukesh Chandran Nair
    Department of Clinical Pathology and Blood Bank, Vellore, India
    Semin Thromb Hemost 37:587-94. 2011
    ..We have also shown that modest doses of intermediate purity FVIII (Koate DVI; Talecris Biotherapeutics, Raleigh, NC, USA) at 35 IU/kg preoperatively and 10 to 20 IU/kg after that are sufficient for surgical hemostasis in these patients...
  57. ncbi A novel beta-thalassemia mutation in an Asian Indian
    Ramachandran V Shaji
    Department of Haematology, Christian Medical College Hospital, Vellore, India
    Hemoglobin 26:49-57. 2002
    ..A slipped strand mispairing during DNA replication repair is proposed as the potential mechanism in generating this small deletion...
  58. pmc Treatment of acute promyelocytic leukemia with single-agent arsenic trioxide
    Vikram Mathews
    Department of Haematology, Christian Medical College and Hospital, Vellore, India
    Mediterr J Hematol Infect Dis 3:e2011056. 2011
    ..In this review we focus on the use of single agent ATO for the treatment of APL and summarize our experience and review the literature...
  59. ncbi Molecular basis of hereditary factor VII deficiency in India: five novel mutations including a double missense mutation (Ala191Glu; Trp364Cys) in 11 unrelated patients
    Giridhara Rao Jayandharan
    Department of Hematology, Christian Medical College, Vellore, India
    Haematologica 92:1002-3. 2007
    ..These mutations were considered to be causative of disease because of their nature, evolutionary conservation and molecular modeling. This is the first report of mutations in patients with FVII deficiency from southern India...
  60. ncbi Identification of rare and novel deletions that cause (δβ)0-thalassaemia and hereditary persistence of foetal haemoglobin in Indian population
    Thiyagaraj Mayuranathan
    Department of Haematology, Christian Medical College, Vellore, India
    Eur J Haematol 92:514-20. 2014
    ..Molecular characterization of these deletions is important for accurate molecular diagnosis, and they will also provide the information on the cis-acting genetic regulatory elements present in the β-globin cluster...
  61. ncbi Etiology of diarrhea in patients undergoing allogeneic bone marrow transplantation in South India
    Gagandeep Kang
    Department of Gastrointestinal Sciences and Haematology, Christian Medical College and Hospital, Vellore 632004, India
    Transplantation 73:1247-51. 2002
    ..No studies so far have examined enteric infections in patients undergoing bone marrow transplantation (BMT) in developing countries where asymptomatic carriage and colonization with enteric pathogens is frequent...
  62. ncbi Arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: a single center experience
    Vikram Mathews
    Department of Haematology, Christian Medical College and Hospital, Vellore, India
    Am J Hematol 70:292-9. 2002
    ..In our experience, arsenic trioxide is effective in inducing and maintaining remission in patients with APML with minimal side effects. The optimal regimen and total dose required need to be defined...
  63. pmc Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors
    Balaji Balakrishnan
    Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India
    PLoS ONE 8:e53845. 2013
    ..8 fold increase in transgene expression. Collectively, these data suggest that AAV vectors activate the cellular UPR pathways and their selective inhibition may be beneficial during AAV mediated gene transfer...
  64. doi Role of molecular genetics in hemophilia: from diagnosis to therapy
    Giridhara Rao Jayandharan
    Department of Hematology Centre for Stem Cell Research, Christian Medical College, Vellore, India
    Semin Thromb Hemost 38:64-78. 2012
    ..This article reviews the applications of molecular genetics in hemophilia, in general, and how such techniques can be useful for optimizing patient care, in particular...
  65. doi Non-Hodgkin lymphoma in childhood and adolescence: frequency and distribution of immunomorphological types from a tertiary care center in South India
    Marie Therese Manipadam
    Department of Pathology, Christian Medical College, Vellore, India
    World J Pediatr 7:318-25. 2011
    ..A review of pediatric NHL statistics from population-based cancer registries was included in this study...
  66. ncbi External quality assessment scheme for hemostasis in India
    Joy Mammen
    Department of Clinical Pathology and Blood Bank, Christian Medical College, Vellore, India
    Semin Thromb Hemost 33:265-72. 2007
    ..The challenges ahead are to increase participation, improve reporting of results, and provide individualized support to laboratories to improve performance when necessary...
  67. ncbi Functional assessment of arthropathy--an international perspective
    Pradeep M Poonnoose
    Department of Orthopaedics, Christian Medical College, Vellore, India
    Semin Hematol 43:S27-32. 2006
    ..Such improved understanding should assist with the development of contextually relevant guidelines for the management of hemophilia...
  68. doi Intralesional mesenchymal stromal cell transplant in a rodent model of cortical cryoinjury
    Ranjith K Moorthy
    Department of Neurological Sciences, Christian Medical College, Vellore, Tamilnadu, India
    Neurol India 59:573-8. 2011
    ..The effect of intralesional mesenchymal stromal cell (MSC) transplant in the subacute phase of brain injury has not been studied...
  69. ncbi A complex karyotype involving chromosomes 3, 6, 11, 12, and 22 in adult acute lymphoblastic leukemia
    Subramaniyam Shivakumar
    Department of Hematology, Christian Medical College Hospital, Vellore, Tamil Nadu, India
    Leuk Lymphoma 43:1673-7. 2002
    ....
  70. ncbi Molecular characterization of factor IX gene mutations in 53 patients with haemophilia B in India
    Giridhara Rao Jayandharan
    Thromb Haemost 94:883-6. 2005
  71. ncbi Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of alphaIIbbeta3 integrin (ITGA2B, ITGB3)
    Hava Peretz
    Clinical Biochemistry Laboratory, Sourasky Medical Center, Tel Aviv, Israel
    Hum Mutat 27:359-69. 2006
    ....
  72. ncbi Molecular defects in type 3 von Willebrand disease: updated results from 40 multiethnic patients
    Luciano Baronciani
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milan, Italy
    Blood Cells Mol Dis 30:264-70. 2003
    ..This study extend our previous finding that mutations responsible for type 3 VWD are scattered throughout the entire VWF gene and that there is no founder effect in these three populations studied...
  73. doi Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation
    Camille Vassord
    INSERM, U763 Hôpital Robert Debré, Paris, France
    Eur J Haematol 80:299-302. 2008
    ..We demonstrate that endothelial cells, contrary to hepatic cells do not express GST alpha either at mRNA or protein levels and hence are potentially susceptible to busulfan-mediated cytotoxic damage...
  74. ncbi Molecular remission with arsenic trioxide in patients with newly diagnosed acute promyelocytic leukemia
    Biju George
    Haematologica 89:1266-7. 2004
    ..Though only 5.5% achieved molecular remission at induction remission, 94.5% became negative during consolidation. At 20 months follow-up, 85% remain in remission but longer follow up studies are needed to monitor late relapses...
  75. ncbi Stem cell research in India: from hype and hope to reality
    Alok Srivastava
    Natl Med J India 19:243-5. 2006
  76. ncbi Successful surgical hemostasis in patients with von Willebrand disease following infusion of KoateDVI
    Alok Srivastava
    Thromb Haemost 87:541-3. 2002
  77. ncbi An overview of an indoor radon study carried out in dwellings in India and Bangladesh during the last decade using solid state nuclear track detectors
    Alok Srivastava
    Department of Chemistry, Panjab University, Chandigarh 160014, India
    J Environ Radioact 78:113-21. 2005
    ..The mean value for indoor radon level given in the report of UNSCEAR 2000 for India needs to be revised...
  78. ncbi Imatinib-induced erythroderma
    Teena Mathew
    Australas J Dermatol 48:193-4. 2007
  79. pmc General transcription factor specified global gene regulation in archaea
    Marc T Facciotti
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98121, USA
    Proc Natl Acad Sci U S A 104:4630-5. 2007
    ....