Arun Sharma

Summary

Affiliation: Centre for Research in Medical Entomology
Country: India

Publications

  1. ncbi request reprint Malarial protease inhibitors: potential new chemotherapeutic agents
    Arun Sharma
    Indian Council of Medical Research, National Institute of Malaria Research, 22 Sham Nath Marg, Delhi 110 054, India
    Curr Opin Investig Drugs 8:642-52. 2007
  2. ncbi request reprint Purification and characterization of a hemoglobin degrading aspartic protease from the malarial parasite Plasmodium vivax
    Arun Sharma
    Malaria Research Centre, 22 Sham Nath Marg, Delhi 110 054, India
    J Biochem 138:71-8. 2005
  3. ncbi request reprint Stage-specific cytosolic protein kinase C-like activity in human malarial parasite Plasmodium falciparum
    Arun Sharma
    Department of Protein Biochemistry, Malaria Research Centre, 22 Sham Nath Marg, Delhi 110 054, India
    Indian J Biochem Biophys 42:145-51. 2005
  4. doi request reprint Salivary gland transcriptome analysis in response to sugar feeding in malaria vector Anopheles stephensi
    Rajnikant Dixit
    Host Parasite Interaction Biology Group, National Institute of Malaria Research, Sector 8, Dwarka, Delhi, India
    J Insect Physiol 57:1399-406. 2011
  5. doi request reprint High proportion of mixed-species Plasmodium infections in India revealed by PCR diagnostic assay
    Bhavna Gupta
    National Institute of Malaria Research, Dwarka, New Delhi, India
    Trop Med Int Health 15:819-24. 2010
  6. pmc Determination of nitric oxide metabolites, nitrate and nitrite, in Anopheles culicifacies mosquito midgut and haemolymph by anion exchange high-performance liquid chromatography: plausible mechanism of refractoriness
    Arun Sharma
    Protein Biochemistry Laboratory, National Institute of Malaria Research ICMR, 22 Sham Nath Marg, Delhi 110 054, India
    Malar J 7:71. 2008
  7. ncbi request reprint Parasite killing in Plasmodium vivax malaria by nitric oxide: implication of aspartic protease inhibition
    Arun Sharma
    Malaria Research Centre, 22 Sham Nath Marg, Delhi 110 054, India
    J Biochem 136:329-34. 2004
  8. doi request reprint Sequence homology and structural analysis of plasmepsin 4 isolated from Indian Plasmodium vivax isolates
    Manmeet Rawat
    Protein Biochemistry and Structural Biology Laboratory, National Institute of Malaria Research, Sector 8, Dwarka, New Delhi, India
    Infect Genet Evol 11:924-33. 2011

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Malarial protease inhibitors: potential new chemotherapeutic agents
    Arun Sharma
    Indian Council of Medical Research, National Institute of Malaria Research, 22 Sham Nath Marg, Delhi 110 054, India
    Curr Opin Investig Drugs 8:642-52. 2007
    ..This review summarizes experimental evidence to support the rational design and development of protease inhibitors as potential new antimalarial drugs...
  2. ncbi request reprint Purification and characterization of a hemoglobin degrading aspartic protease from the malarial parasite Plasmodium vivax
    Arun Sharma
    Malaria Research Centre, 22 Sham Nath Marg, Delhi 110 054, India
    J Biochem 138:71-8. 2005
    ..Ca2+ and Mg2+ ions enhance the protease activity, whereas Cu2+ and Hg2+ ions were found to be inhibitory. The pivotal role of aspartic protease in initiating hemoglobin degradation in P. vivax malaria parasite is also demonstrated...
  3. ncbi request reprint Stage-specific cytosolic protein kinase C-like activity in human malarial parasite Plasmodium falciparum
    Arun Sharma
    Department of Protein Biochemistry, Malaria Research Centre, 22 Sham Nath Marg, Delhi 110 054, India
    Indian J Biochem Biophys 42:145-51. 2005
    ..The results suggest that the PKC-like activity is developmentally expressed during the parasitic survival and development...
  4. doi request reprint Salivary gland transcriptome analysis in response to sugar feeding in malaria vector Anopheles stephensi
    Rajnikant Dixit
    Host Parasite Interaction Biology Group, National Institute of Malaria Research, Sector 8, Dwarka, Delhi, India
    J Insect Physiol 57:1399-406. 2011
    ..Further functional characterization of theses putative transcripts is under investigation to examine their role in the mosquito salivary glands...
  5. doi request reprint High proportion of mixed-species Plasmodium infections in India revealed by PCR diagnostic assay
    Bhavna Gupta
    National Institute of Malaria Research, Dwarka, New Delhi, India
    Trop Med Int Health 15:819-24. 2010
    ..An unusually high proportion of mixed infections was detected, signifying the sensitivity of PCR assay over traditional microscopic diagnosis...
  6. pmc Determination of nitric oxide metabolites, nitrate and nitrite, in Anopheles culicifacies mosquito midgut and haemolymph by anion exchange high-performance liquid chromatography: plausible mechanism of refractoriness
    Arun Sharma
    Protein Biochemistry Laboratory, National Institute of Malaria Research ICMR, 22 Sham Nath Marg, Delhi 110 054, India
    Malar J 7:71. 2008
    ..NO metabolites, nitrite (NO2-) and nitrate (NO3-) are produced by the action of an inducible Anopheles culicifacies NO synthase (AcNOS) in mosquito mid-guts and may be central to anti-parasitic arsenal of these mosquitoes...
  7. ncbi request reprint Parasite killing in Plasmodium vivax malaria by nitric oxide: implication of aspartic protease inhibition
    Arun Sharma
    Malaria Research Centre, 22 Sham Nath Marg, Delhi 110 054, India
    J Biochem 136:329-34. 2004
    ..vivax infections for antimalarial chemotherapy and also biochemical adaptations of the malaria parasite for survival in the host erythrocytes with a better understanding of the protease substrate interactions...
  8. doi request reprint Sequence homology and structural analysis of plasmepsin 4 isolated from Indian Plasmodium vivax isolates
    Manmeet Rawat
    Protein Biochemistry and Structural Biology Laboratory, National Institute of Malaria Research, Sector 8, Dwarka, New Delhi, India
    Infect Genet Evol 11:924-33. 2011
    ..vivax plasmepsins (PvPMs) from different geographical regions are of utmost importance for drugs and vaccine designs for anti-malarial strategies...