Shailendra K Saxena

Summary

Affiliation: CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007 (AP), India.
Location: Hyderabad , India
Grants:
1R37-DA025576 ; 1R01-MH085259
Publications:
1: Saxena SK, Gupta A, Bhagyashree K, Saxena R, Arora N, Banerjee AK, Tripathi AK, Chandrasekar MJ, Gandhi N, Nair MP.
Targeting strategies for Human immunodeficiency virus: a combinatorial approach.
Mini Rev Med Chem. 2012 Mar;12(3):236-54.
PubMed PMID: .


2: Saiyed ZM, Gandhi N, Agudelo M, Napuri J, Samikkannu T, Reddy PV, Khatavkar P, Yndart A, Saxena SK, Nair MP.
HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated
neurocognitive disorder (HAND).
Neurochem Int. 2011 May;58(6):656-64.
PubMed PMID: ;
PubMed Central PMCID: PMC3085929.


3: Gandhi N, Saiyed ZM, Napuri J, Samikkannu T, Reddy PV, Agudelo M, Khatavkar P, Saxena SK, Nair MP.
Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier
dysfunction: implications for HIV-1-associated neurocognitive disorder.
J Neurovirol. 2010 Jul;16(4):294-305.
PubMed PMID: .


4: Samikkannu T, Rao KV, Gandhi N, Saxena SK, Nair MP.
Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase
and serotonin in immature dendritic cells: Implications for neuroAIDS.
J Neurovirol. 2010 Jul;16(4):255-63.
PubMed PMID: .


5: Saxena SK, Mishra N, Saxena R, Swamy ML, Sahgal P, Saxena S, Tiwari S, Mathur A, Nair MP.
Structural and antigenic variance between novel influenza A/H1N1/2009 and influenza A/H1N1/2008 viruses.
J Infect Dev Ctries. 2009 Nov 26;4(1):1-6.
PubMed PMID: .


6: Saxena SK, Mishra N, Saxena R, Saxena S.
Swine flu: influenza A/H1N1 2009: the unseen and unsaid.
Future Microbiol. 2009 Oct;4(8):945-7.
PubMed PMID: .


7: Saxena SK, Mishra N, Saxena R, Singh M, Mathur A.
Trend of Japanese encephalitis in North India: evidence from thirty-eight acute encephalitis cases and appraisal of niceties.
J Infect Dev Ctries. 2009 Aug 30;3(7):517-30.
PubMed PMID: .


8: Saxena SK. Controversial role of smallpox on historical positive selection at the CCR5 chemokine gene (CCR5-Delta 32).
J Infect Dev Ctries. 2009 May 1;3(4):324-6.
PubMed PMID: .


9: Saxena SK, Singh M, Mishra N, Lakshmi V.
Resurgence of chikungunya virus in India: an emerging threat.
Euro Surveill. 2006 Aug 10;11(8):E060810.2.
PubMed PMID: .


10: Sundaravaradan V, Saxena SK, Ramakrishnan R, Yedavalli VR, Harris DT, Ahmad N.
Differential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expression.
Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11701-6.
PubMed PMID: ;
PubMed Central PMCID: PMC1544233.


11: Saxena SK, Mathur A, Srivastava RC.
Inhibition of Japanese encephalitis virus infection by diethyldithiocarbamate is independent of its antioxidant potential.
Antivir Chem Chemother. 2003 Mar;14(2):91-8.
PubMed PMID: .


12: Tandon A, Singh A, Atrishi E, Saxena SK, Mathur A.
Alteration in plasma glucose levels in Japanese encephalitis patients.
Int J Exp Pathol. 2002 Feb;83(1):39-46.
PubMed PMID: ;
PubMed Central PMCID: PMC2517666.


13: Saxena SK, Mathur A, Srivastava RC.
Induction of nitric oxide synthase during Japanese encephalitis virus infection: evidence of protective role.
Arch Biochem Biophys. 2001 Jul 1;391(1):1-7.
PubMed PMID: .


14: Saxena SK, Singh A, Mathur A.
Antiviral effect of nitric oxide during Japanese encephalitis virus infection.
Int J Exp Pathol. 2000 Apr;81(2):165-72.
PubMed PMID: ;
PubMed Central PMCID: PMC2517721.


15: Srivastava S, Khanna N, Saxena SK, Singh A, Mathur A, Dhole TN.
Degradation of Japanese encephalitis virus by neutrophils.
Int J Exp Pathol. 1999 Feb;80(1):17-24.
PubMed PMID: ;
PubMed Central PMCID: PMC2517752.


16: Saxena SK, Gravell M, Wu YN, Mikulski SM, Shogen K, Ardelt W, Youle RJ.
Inhibition of HIV-1 production and selective degradation of viral RNA by an amphibian ribonuclease.
J Biol Chem. 1996 Aug 23;271(34):20783-8.
PubMed PMID: 8702832.

17. Reddy PV, Kanthikeel SP, Saxena SK, Saiyed ZM, Nair MP.
Interactive effects of morphine on HIV infection: Role in HIV-associated neurocognitive disorder.
AIDS Res Treat. 2012, Article ID 953678,
(DOI: 10.1155/2012/953678)

18. Saxena SK, Shrivastava G, Tiwari S, Nair MPN.
HIV-1 Nef: hacker of the host cell.
Fut. Virol. 2012. 7(2): 117-120.
(DOI: 10.2217/fvl.11.146).

19. Saxena SK, Swamy MLA, Verma SK, Saxena R.
The intolerable burden of chikungunya: whats new, whats needed?
Proc. Natl. Acad. Sci. Sect B. Biol. Sci. 2012 (Springer) 82(1): 153-165
(DOI 10.1007/s40011-011-0012-y).

20. Singh A., Saxena S.K., Srivastava A.K., Mathur A.
Japanese Encephalitis: A Persistent Threat.
Proc. Natl. Acad. Sci. Sect B. Biol. Sci. 2012 (Springer) 82(1): 55-68
(DOI 10.1007/s40011-011-0005-x).

Publications

  1. pmc HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND)
    Zainulabedin M Saiyed
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA
    Neurochem Int 58:656-64. 2011
  2. doi request reprint Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: implications for HIV-1-associated neurocognitive disorder
    Nimisha Gandhi
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA
    J Neurovirol 16:294-305. 2010
  3. doi request reprint Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS
    Thangavel Samikkannu
    Department of Immunology, Institute of Neuroimmune Pharmacology, College of Medicine, Florida International University, Miami, Florida 33199, USA
    J Neurovirol 16:255-63. 2010
  4. ncbi request reprint Structural and antigenic variance between novel influenza A/H1N1/2009 and influenza A/H1N1/2008 viruses
    Shailendra K Saxena
    Centre for Cellular and Molecular Biology, Hyderabad 500 007, India
    J Infect Dev Ctries 4:1-6. 2010
  5. ncbi request reprint Trend of Japanese encephalitis in North India: evidence from thirty-eight acute encephalitis cases and appraisal of niceties
    Shailendra K Saxena
    Laboratory of Infectious Diseases and Molecular Virology, Centre for Cellular and Molecular Biology CSIR, Uppal Road, Hyderabad 500007, India
    J Infect Dev Ctries 3:517-30. 2009
  6. ncbi request reprint Resurgence of chikungunya virus in India: an emerging threat
    S K Saxena
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Euro Surveill 11:E060810.2. 2006
  7. pmc Differential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expression
    Vasudha Sundaravaradan
    Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 103:11701-6. 2006
  8. ncbi request reprint Inhibition of Japanese encephalitis virus infection by diethyldithiocarbamate is independent of its antioxidant potential
    Shailendra Kumar Saxena
    Postgraduate Department of Microbiology, King George s Medical College, Lucknow, India
    Antivir Chem Chemother 14:91-8. 2003
  9. pmc Alteration in plasma glucose levels in Japanese encephalitis patients
    Apurva Tandon
    Post Graduate Department of Microbiology, King George s Medical College, C11 7, River Bank Colony, Lucknow 226001, India
    Int J Exp Pathol 83:39-46. 2002
  10. ncbi request reprint Induction of nitric oxide synthase during Japanese encephalitis virus infection: evidence of protective role
    S K Saxena
    Postgraduate Department of Microbiology, King George's Medical College, Lucknow 226003, India
    Arch Biochem Biophys 391:1-7. 2001

Collaborators

Detail Information

Publications16

  1. pmc HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND)
    Zainulabedin M Saiyed
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA
    Neurochem Int 58:656-64. 2011
    ..Therefore, use of HDAC2 specific inhibitor in combination with HAART may be of therapeutic value in treatment of neurocognitive disorders observed in HIV-1 infected individuals...
  2. doi request reprint Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: implications for HIV-1-associated neurocognitive disorder
    Nimisha Gandhi
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, USA
    J Neurovirol 16:294-305. 2010
    ..Thus, these results for the first time delineate the differential role of Tat B and Tat C and/or cocaine in BBB dysfunction, which may be correlated with the clade-specific differences observed in HIV-1-associated neurological disorders...
  3. doi request reprint Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS
    Thangavel Samikkannu
    Department of Immunology, Institute of Neuroimmune Pharmacology, College of Medicine, Florida International University, Miami, Florida 33199, USA
    J Neurovirol 16:255-63. 2010
    ..These studies suggest that HIV-1 clade B and C Tat proteins may play a differential role in the neuropathogenesis of HIV-associated dementia (HAD) or HIV-associated neurocognitive disorder (HAND)...
  4. ncbi request reprint Structural and antigenic variance between novel influenza A/H1N1/2009 and influenza A/H1N1/2008 viruses
    Shailendra K Saxena
    Centre for Cellular and Molecular Biology, Hyderabad 500 007, India
    J Infect Dev Ctries 4:1-6. 2010
    ....
  5. ncbi request reprint Trend of Japanese encephalitis in North India: evidence from thirty-eight acute encephalitis cases and appraisal of niceties
    Shailendra K Saxena
    Laboratory of Infectious Diseases and Molecular Virology, Centre for Cellular and Molecular Biology CSIR, Uppal Road, Hyderabad 500007, India
    J Infect Dev Ctries 3:517-30. 2009
    ..The present study was planned to reconfirm the circulation of JE in the area and to assess the trend of the disease to slow down the burden of JE...
  6. ncbi request reprint Resurgence of chikungunya virus in India: an emerging threat
    S K Saxena
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Euro Surveill 11:E060810.2. 2006
  7. pmc Differential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expression
    Vasudha Sundaravaradan
    Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 103:11701-6. 2006
    ....
  8. ncbi request reprint Inhibition of Japanese encephalitis virus infection by diethyldithiocarbamate is independent of its antioxidant potential
    Shailendra Kumar Saxena
    Postgraduate Department of Microbiology, King George s Medical College, Lucknow, India
    Antivir Chem Chemother 14:91-8. 2003
    ..Interestingly, DDTC alone did not stimulate iNOS and TNF-alpha in mock-infected normal mice. These results show that DDTC may have a possible therapeutic role during JEV infection...
  9. pmc Alteration in plasma glucose levels in Japanese encephalitis patients
    Apurva Tandon
    Post Graduate Department of Microbiology, King George s Medical College, C11 7, River Bank Colony, Lucknow 226001, India
    Int J Exp Pathol 83:39-46. 2002
    ..We conclude that during the convalescent stage of JEV infection, a unique factor, hTCHF, is secreted by activated CD8+ T cells from patients and that this is responsible for the development of hypoglycaemia...
  10. ncbi request reprint Induction of nitric oxide synthase during Japanese encephalitis virus infection: evidence of protective role
    S K Saxena
    Postgraduate Department of Microbiology, King George's Medical College, Lucknow 226003, India
    Arch Biochem Biophys 391:1-7. 2001
    ..These observations thus provide evidence of the protective role of iNOS during JEV infection and indicate that iNOS may be a key mediator in host innate immune response to infection...
  11. ncbi request reprint Targeting strategies for Human immunodeficiency virus: a combinatorial approach
    S K Saxena
    Centre for Cellular and Molecular Biology CSIR, Uppal Road, Hyderabad 500007 AP, India
    Mini Rev Med Chem 12:236-54. 2012
    ....