Rakesh K Mishra

Summary

Affiliation: Centre for Cellular and Molecular Biology
Country: India

Publications

  1. Srivastava S, Avvaru A, Sowpati D, Mishra R. Patterns of microsatellite distribution across eukaryotic genomes. BMC Genomics. 2019;20:153 pubmed publisher
    ..The microsatellite dataset generated in this work provides a large number of candidates for functional analysis and for studying their roles across the evolutionary landscape. ..
  2. Sureka R, Wadhwa R, Thakur S, Pathak R, Mishra R. Comparison of Nuclear Matrix and Mitotic Chromosome Scaffold Proteins in Drosophila S2 Cells-Transmission of Hallmarks of Nuclear Organization Through Mitosis. Mol Cell Proteomics. 2018;17:1965-1978 pubmed publisher
  3. Srivastava S, Puri D, Garapati H, Dhawan J, Mishra R. Vertebrate GAGA factor associated insulator elements demarcate homeotic genes in the HOX clusters. Epigenetics Chromatin. 2013;6:8 pubmed publisher
    ..Our findings thus provide new insights into the regulatory processes and evolutionarily conserved epigenetic mechanisms that control homeotic gene expression. ..
  4. Singh N, Mishra R. Specific combinations of boundary element and Polycomb response element are required for the regulation of the Hox genes in Drosophila melanogaster. Mech Dev. 2015;138 Pt 2:141-150 pubmed publisher
    ..Our results demonstrate the functional relevance of the closely associated BE and PRE combinations in regulation of Hox genes. ..
  5. Sowpati D, Ramamoorthy S, Mishra R. Expansion of the polycomb system and evolution of complexity. Mech Dev. 2015;138 Pt 2:97-112 pubmed publisher
  6. Dewari P, Ajani F, Kushawah G, Kumar D, Mishra R. Reversible loss of reproductive fitness in zebrafish on chronic alcohol exposure. Alcohol. 2016;50:83-9 pubmed publisher
    ..Our results highlight the adverse effects of chronic alcohol exposure on the reproductive capacity of both males and females, and underscore the utility of the zebrafish model system to understand the biology of chronic alcoholism. ..
  7. Saha P, Sowpati D, Mishra R. Epigenomic and genomic landscape of Drosophila melanogaster heterochromatic genes. Genomics. 2019;111:177-185 pubmed publisher
  8. Ramamoorthy S, Garapati H, Mishra R. Length and sequence dependent accumulation of simple sequence repeats in vertebrates: potential role in genome organization and regulation. Gene. 2014;551:167-75 pubmed publisher
    ..Taken together, these results suggest that SSRs are functionally relevant with potential regulatory role. We propose that such repeats are evolving under positive selection pressure like any other functional element in the genome. ..
  9. Sabarinadh C, Subramanian S, Tripathi A, Mishra R. Extreme conservation of noncoding DNA near HoxD complex of vertebrates. BMC Genomics. 2004;5:75 pubmed
    ..We suggest that such sequences are likely to provide molecular handle to gain insight into the evolution and mechanism of regulation of associated gene complexes. ..

More Information

Publications17

  1. Senthilkumar R, Mishra R. Novel motifs distinguish multiple homologues of Polycomb in vertebrates: expansion and diversification of the epigenetic toolkit. BMC Genomics. 2009;10:549 pubmed publisher
    ..The signature motifs of PC homologues and insect specific motif identified in this study pave the way to understand the molecular basis of epigenetic mechanisms. ..
  2. Sreesankar E, Senthilkumar R, Bharathi V, Mishra R, Mishra K. Functional diversification of yeast telomere associated protein, Rif1, in higher eukaryotes. BMC Genomics. 2012;13:255 pubmed publisher
    ..Functional studies show that dRif1 responds differently to DNA damage, implying that dRif1 may have a different function and this may be conserved in other organisms as well. ..
  3. Pathak R, Srinivasan A, Mishra R. Genome-wide mapping of matrix attachment regions in Drosophila melanogaster. BMC Genomics. 2014;15:1022 pubmed publisher
    ..We also identified sequence motifs and repeats that constitute MARs. Our data reveal the contact points of genome to the nuclear architecture and provide a link between nuclear functions and genomic packaging. ..
  4. Krishnan J, Athar F, Rani T, Mishra R. Simple sequence repeats showing 'length preference' have regulatory functions in humans. Gene. 2017;628:156-161 pubmed publisher
    ..The results of our functional assays propose cis-gene regulatory roles for these specific length enriched SSRs and opens avenues for further investigations. ..
  5. Saha P, Verma S, Pathak R, Mishra R. Long Noncoding RNAs in Mammalian Development and Diseases. Adv Exp Med Biol. 2017;1008:155-198 pubmed publisher
    ..This chapter presents an account on a class of such noncoding transcripts that are longer than 200 nucleotides (long noncoding RNA-lncRNA) in mammalian development and diseases. ..
  6. Srivastava A, Kumar A, Mishra R. Vertebrate GAF/ThPOK: emerging functions in chromatin architecture and transcriptional regulation. Cell Mol Life Sci. 2018;75:623-633 pubmed publisher
    ..We also discuss the underlying mechanisms which aid in the diverse and context-dependent functions of this protein. ..
  7. Sowpati D, Srivastava S, Dhawan J, Mishra R. C-State: an interactive web app for simultaneous multi-gene visualization and comparative epigenetic pattern search. BMC Bioinformatics. 2017;18:392 pubmed publisher
    ..It allows for powerful GUI-based pattern searching and visualization. We include a case study to demonstrate its potential for identifying user-defined epigenetic trends in context of gene expression profiles. ..
  8. Dasari V, Srivastava S, Khan S, Mishra R. Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster. Biogerontology. 2018;19:33-45 pubmed publisher
    ..Our observations highlight the role of global epigenetic regulators in determining life span. ..