Sunil K Manna

Summary

Affiliation: Centre for DNA Fingerprinting and Diagnostics
Country: India

Publications

  1. ncbi request reprint Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis
    Audrey Varin
    Department of Virology and Institut d Etude et de Transfert de Gènes, Franche Comte University, F 25030 Besancon, France
    J Biol Chem 278:2219-27. 2003
  2. ncbi request reprint alpha-Melanocyte-stimulating hormone induces cell death in mast cells: involvement of NF-kappaB
    Abira Sarkar
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500 076, India
    FEBS Lett 549:87-93. 2003
  3. doi request reprint Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: suppression of serine/threonine and tyrosine kinases
    Sunil Kumar Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500001, India
    Biochem Pharmacol 83:1383-92. 2012
  4. pmc Novel derivative of benzofuran induces cell death mostly by G2/M cell cycle arrest through p53-dependent pathway but partially by inhibition of NF-kappaB
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500 001, India
    J Biol Chem 285:22318-27. 2010
  5. ncbi request reprint Inhibition of RelA phosphorylation sensitizes apoptosis in constitutive NF-kappaB-expressing and chemoresistant cells
    S K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    Cell Death Differ 14:158-70. 2007
  6. pmc Inhibiting TRAF2-mediated activation of NF-kappaB facilitates induction of AP-1
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500 001, India
    J Biol Chem 285:11617-27. 2010
  7. ncbi request reprint Alpha-melanocyte-stimulating hormone down-regulates CXC receptors through activation of neutrophil elastase
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad, India
    Eur J Immunol 36:754-69. 2006
  8. ncbi request reprint Cardiac glycoside inhibits IL-8-induced biological responses by downregulating IL-8 receptors through altering membrane fluidity
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad, India
    J Cell Physiol 207:195-207. 2006
  9. pmc Ras puts the brake on doxorubicin-mediated cell death in p53-expressing cells
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500 001, India
    J Biol Chem 286:7339-47. 2011
  10. pmc Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500 076, India
    J Biol Chem 280:7010-21. 2005

Collaborators

  • Bharat B Aggarwal
  • A Sarkar
  • Shyam S Biswal
  • Masahiro Higuchi
  • Georges Herbein
  • Pongali B Raghavendra
  • Maikho Thoh
  • Yashin Sreenivasan
  • Govindarajan T Ramesh
  • Charitha Gangadharan
  • Shubhashish Sarkar
  • Kimberly C Wise
  • Sidhartha K Mahali
  • Sidharth Mahali
  • Usha S Naik
  • Anil D Kulkarni
  • Vani Ramesh
  • Neil R Pellis
  • Renard L Thomas
  • Keiko Yamauchi
  • Bobby L Wilson
  • Kumar Felix
  • Paresh Manna
  • Audrey Varin
  • Niranjan Dasari
  • Kanakalatha Abbagani
  • Chitta Sureshkumar
  • Banaganapalli Babajan
  • Nune Raviprakash
  • Balakrishna Nagalla
  • Pankaj Kumar
  • Hampathalu A Nagarajaram
  • Niteen Pathak
  • A D Kulkarni
  • Kimberly Wise
  • Johnny Barr
  • Krishnan K Narang
  • Vincent Quivy
  • Anne Zelie Decrion
  • Carine Van Lint

Detail Information

Publications33

  1. ncbi request reprint Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesis
    Audrey Varin
    Department of Virology and Institut d Etude et de Transfert de Gènes, Franche Comte University, F 25030 Besancon, France
    J Biol Chem 278:2219-27. 2003
    ..Therefore, our results suggest that exogenous Nef could fuel the progression of the disease via stimulation of HIV-1 provirus present in such cellular reservoirs as mononuclear phagocytes in HIV-infected patients...
  2. ncbi request reprint alpha-Melanocyte-stimulating hormone induces cell death in mast cells: involvement of NF-kappaB
    Abira Sarkar
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500 076, India
    FEBS Lett 549:87-93. 2003
    ..Overall, our results suggest that NF-kappaB is the key molecule involved in alpha-MSH-mediated cell death and this may help to regulate mast cell-mediated inflammation...
  3. doi request reprint Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: suppression of serine/threonine and tyrosine kinases
    Sunil Kumar Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500001, India
    Biochem Pharmacol 83:1383-92. 2012
    ..Thus, the double-edged sword effect of inhibition of NF-κB via inhibition of both serine/threonine kinase and PTK by biochanin might show useful therapeutic value against activities of cells that lead to tumorigenesis and inflammation...
  4. pmc Novel derivative of benzofuran induces cell death mostly by G2/M cell cycle arrest through p53-dependent pathway but partially by inhibition of NF-kappaB
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500 001, India
    J Biol Chem 285:22318-27. 2010
    ..Thus, this novel benzofuran lignan derivative can be effective chemopreventive or chemotherapeutic agent against malignant T-cells...
  5. ncbi request reprint Inhibition of RelA phosphorylation sensitizes apoptosis in constitutive NF-kappaB-expressing and chemoresistant cells
    S K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    Cell Death Differ 14:158-70. 2007
    ..These results suggest novel approaches for designing of anticancer drugs for combination chemotherapy...
  6. pmc Inhibiting TRAF2-mediated activation of NF-kappaB facilitates induction of AP-1
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500 001, India
    J Biol Chem 285:11617-27. 2010
    ..These results suggest novel approaches to design of P(3)-25 as an anti-cancer/inflammatory drug for therapy through regulation of the TRAF2 pathway...
  7. ncbi request reprint Alpha-melanocyte-stimulating hormone down-regulates CXC receptors through activation of neutrophil elastase
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad, India
    Eur J Immunol 36:754-69. 2006
    ..These studies suggest that alpha-MSH inhibits IL-8-mediated biological responses by down-regulating CXCR through induction of serine protease and that alpha-MSH acts as a potent immunomodulator in neutrophil-driven inflammatory distress...
  8. ncbi request reprint Cardiac glycoside inhibits IL-8-induced biological responses by downregulating IL-8 receptors through altering membrane fluidity
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad, India
    J Cell Physiol 207:195-207. 2006
    ..The study might help to regulate IL-8-mediated biological responses involved in inflammation, metastasis, and neovascularization...
  9. pmc Ras puts the brake on doxorubicin-mediated cell death in p53-expressing cells
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500 001, India
    J Biol Chem 286:7339-47. 2011
    ..High basal expression of Fas might be an important determinant in doxorubicin-mediated cell death in p53-negative cells...
  10. pmc Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500 076, India
    J Biol Chem 280:7010-21. 2005
    ..This is the first report that IL-8 induces NF-kappaB in a distinct pathway, and activation of NF-kappaB and its dependent genes may be one of the pathways of IL-8-induced inflammation and angiogenesis...
  11. doi request reprint Decrease in RelA phosphorylation by inhibiting protein kinase A induces cell death in NF-kappaB-expressing and drug-resistant tumor cells
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500076, India
    Mol Immunol 46:1340-50. 2009
    ..The study might help to understand the mechanism of P(3)-25-mediated apoptosis and to design it as new chemotherapeutic drug for tumor therapy...
  12. ncbi request reprint beta-D-Glucoside suppresses tumor necrosis factor-induced activation of nuclear transcription factor kappaB but potentiates apoptosis
    Abira Sarkar
    Centre for DNA Fingerprinting and Diagnostics, Laboratory of Immunology, Nacharam, Hyderabad 500 076, India
    J Biol Chem 279:33768-81. 2004
    ..Mangiferin-mediated down-regulation of NF-kappaB also potentiates chemotherapeutic agent-mediated cell death, suggesting a role in combination therapy for cancer...
  13. pmc Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases
    Pongali B Raghavendra
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad, 500076, India
    Apoptosis 12:307-18. 2007
    ..Overall, our data suggest that oleandrin might be important therapeutic molecule in case of tumors where cell death pathway occurs due to deregulation of caspase-mediated pathway...
  14. ncbi request reprint alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced biological responses by downregulating CD14 from macrophages
    Abira Sarkar
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, 500 076 Hyderabad, India
    FEBS Lett 553:286-94. 2003
    ..Overall, our results suggest that alpha-MSH exerts its anti-inflammatory effect by a novel mechanism in macrophages through downregulating of the endotoxin receptor CD14...
  15. pmc Azadirachtin interacts with retinoic acid receptors and inhibits retinoic acid-mediated biological responses
    Maikho Thoh
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500001, India
    J Biol Chem 286:4690-702. 2011
    ..Thus, azadirachtin exerts anti-inflammatory and anti-metastatic responses by a novel pathway that would be beneficial for further anti-inflammatory and anti-cancer therapies...
  16. pmc Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses
    Maikho Thoh
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500 001, India
    J Biol Chem 285:5888-95. 2010
    ..Thus, azadirachtin exerts an anti-inflammatory response by a novel pathway, which may be beneficial for anti-inflammatory therapy...
  17. pmc Advanced glycation end products (AGEs) induce apoptosis via a novel pathway: involvement of Ca2+ mediated by interleukin-8 protein
    Sidharth Mahali
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500 001, India
    J Biol Chem 286:34903-13. 2011
    ..Thus, this study may be important in several age-related neuronal diseases where AGE-induced apoptosis is observed because of high amounts of AGE...
  18. ncbi request reprint Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells
    Yashin Sreenivasan
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics CDFD, ECIL Road, Nacharam, Hyderabad, 500076, India
    J Clin Immunol 26:308-22. 2006
    ..Overall, these results suggest that oleandrin mediates apoptosis in tumor cells by inducing Fas but not in primary cells indicating its potential anti-cancer property with no or slight side effect...
  19. ncbi request reprint Oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity
    Pongali B Raghavendra
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500076, India
    Mol Immunol 44:2292-302. 2007
    ....
  20. doi request reprint Inhibition of constitutive activity of nuclear transcription factor kappaB sensitizes doxorubicin-resistant cells to apoptosis
    Charitha Gangadharan
    Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad, India
    J Cell Biochem 107:203-13. 2009
    ..This study indicates that NF-kappaB plays an important role in chemoresistance and establishes the fact that inhibition of NF-kappaB will be a novel approach in chemotherapy...
  21. doi request reprint Novel role of thiadiazolidine derivatives in inducing cell death through Myc-Max, Akt, FKHR, and FasL pathway
    Pongali B Raghavendra
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500001, India
    Biochem Pharmacol 78:495-503. 2009
    ..Our results suggest that P(3)-25 derivative exerts anti-tumor activities by decreasing Myc-mediated response and increasing FasL expression, which may help in designing drugs for tumor therapy...
  22. ncbi request reprint Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation
    Yashin Sreenivasan
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500 076, India
    Oncogene 22:4356-69. 2003
    ..These observations collectively suggest that araC induces apoptosis in NF-kappaB-expressing cells by dephosphorylating the p65 subunit of NF-kappaB...
  23. doi request reprint Beta-D-glucoside protects against advanced glycation end products (AGEs)-mediated diabetic responses by suppressing ERK and inducing PPAR gamma DNA binding
    Sidhartha K Mahali
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500001, India
    Biochem Pharmacol 84:1681-90. 2012
    ..With these dual effects, mangiferin can be a likely candidate for developing therapeutic drug against diabetes...
  24. pmc A study of nuclear transcription factor-kappa B in childhood autism
    Usha S Naik
    Department of Psychiatry, Osmania Medical College, Hyderabad, India
    PLoS ONE 6:e19488. 2011
    ..On this hypothesis, it was proposed to determine NF-κB in children with autism...
  25. ncbi request reprint Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents
    Sunil K Manna
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
    Cancer Lett 190:171-82. 2003
    ..Overall our results indicate that calagualine inhibits activation of NF-kappaB and this may provide a molecular basis for calagualine's ability to suppress inflammation and tumorigenesis...
  26. ncbi request reprint 1,2,4-Thiadiazolidine derivative inhibits nuclear transcription factor-kappaB and its dependent genes activation but induces apoptosis
    Paresh Manna
    Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India
    Int J Cancer 113:549-60. 2005
    ..Overall our results suggest that P(3)-25 derivative exerts anti-inflammatory and anti-tumor activities, which may have a role in designing such drugs...
  27. pmc Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis
    Sunil K Manna
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Cente, Houston, TX 77030, USA
    Clin Cancer Res 13:2290-7. 2007
    ....
  28. ncbi request reprint Regulation of the activation of nuclear factor kappaB by mitochondrial respiratory function: evidence for the reactive oxygen species-dependent and -independent pathways
    Masahiro Higuchi
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Antioxid Redox Signal 4:945-55. 2002
    ..Our results thus demonstrate the involvement of mitochondrial respiratory function in the activation of reactive oxygen species-dependent and -independent pathways for NF-kappaB activation...
  29. pmc Low levels of arsenite activates nuclear factor-kappaB and activator protein-1 in immortalized mesencephalic cells
    Kumar Felix
    Molecular Neurotoxicology Laboratory, Department of Biology, Texas Southern University, Houston, TX 77004, USA
    J Biochem Mol Toxicol 19:67-77. 2005
    ..These results suggest that arsenite, at low and subcytoxic concentrations, appears to induce oxidative stress leading to activation of early transcription factors whereas addition of antioxidant inhibited the activation of these factors...
  30. ncbi request reprint Activation of nuclear transcription factor-kappaB in mouse brain induced by a simulated microgravity environment
    Kimberly C Wise
    Molecular Neurotoxicology Laboratory, Department of Biology, Texas Southern University, Houston, Texas 77004, USA
    In Vitro Cell Dev Biol Anim 41:118-23. 2005
    ..These results suggest that exposure of brain to simulated microgravity can induce expression of certain transcription factors, and these have been earlier argued to be oxidative stress dependent...
  31. pmc Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-kappaB in human keratinocytes
    Sunil K Manna
    Molecular Neurotoxicology Laboratory, Department of Biology, Texas Southern University, Houston, Texas 77004, USA
    Nano Lett 5:1676-84. 2005
    ..Further, the mechanism of activation of NF-kappaB was due to the activation of stress-related kinases by SWCNT particles in keratinocytes. In conclusion, these studies show the mechanism of toxicity induced by SWCNT particles...
  32. pmc Long term environmental tobacco smoke activates nuclear transcription factor-kappa B, activator protein-1, and stress responsive kinases in mouse brain
    Sunil K Manna
    Molecular Neurotoxicology Laboratory, Department of Biology, Texas Southern University, Houston, TX 77004, USA
    Biochem Pharmacol 71:1602-9. 2006
    ..Overall our results indicate that exposure to long-term cigarette smoke induces oxidative stress leading to activation of stress induced kinases and activation of proinflammatory transcription factors...
  33. pmc Activation of activator protein-1 in mouse brain regions exposed to simulated microgravity
    Shubhashish Sarkar
    Molecular Neurotoxicology Laboratory Proteomics, Department of Biology, Texas Southern University, Houston, Texas 77004, USA
    In Vitro Cell Dev Biol Anim 42:96-9. 2006
    ..The activation of the AP-1 is dependent upon the increased kinase activity of c-Jun NH-terminal2 kinase-1. These results suggest that microgravity stress in the brain can elicit AP-1 activity...