Manisha Madkaikar

Summary

Affiliation: National Institute of Immunohaematology
Location: Mumbai, India
Summary:
at present working as scientist E/ Deputy Director and head of the Department of Paediatric Immunology and Leukocyte Biology at NIIH. She has been working in the area of Haematopietic Stem cells, Haematological malignancies, Bone Marrow failure Syndromes and Primary Immunodeficiency Disorders
Publications:
Advances in Autoimmune Lymphoproliferative Syndromes (ALPS).

Madkaikar M, Mhatre S, Gupta M, Ghosh K.

Eur J Haematol. 2011 Mar 29. doi: 10.1111/j.1600-0609.2011.01617.x. [Epub ahead of print]

PMID:

[PubMed - as supplied by publisher]

Related citations
2.

Hemolytic anemia and distal renal tubular acidosis in two Indian patients homozygous for SLC4A1/AE1 mutation A858D.

Shmukler BE, Kedar PS, Warang P, Desai M, Madkaikar M, Ghosh K, Colah RB, Alper SL.

Am J Hematol. 2010 Oct;85(10):824-8.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
3.

Novel immunophenotypic and morphologic presentation in acute myeloid leukemia (AML) with JAK2 V617F mutation.

Swaminathan S, Madkaikar M, Ghosh K, Vundinti BR, Kerketta L, Gupta M.

Eur J Haematol. 2010 Feb 1;84(2):180-2. Epub 2009 Oct 12. No abstract available.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
4.

Paroxysmal nocturnal haemoglobinuria: diagnostic tests, advantages, & limitations.

Madkaikar M, Gupta M, Jijina F, Ghosh K.

Eur J Haematol. 2009 Dec 1;83(6):503-11. Epub 2009 Aug 17. Review.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
5.

Reproducible methodology for the isolation of mesenchymal stem cells from human umbilical cord and its potential for cardiomyocyte generation.

Pereira WC, Khushnooma I, Madkaikar M, Ghosh K.

J Tissue Eng Regen Med. 2008 Oct;2(7):394-9.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
6.

Report of proceedings of the national meeting on "Guidelines for Immunophenotyping of Hematolymphoid Neoplasms by Flow Cytometry".

Gujral S, Subramanian PG, Patkar N, Badrinath Y, Kumar A, Tembhare P, Vazifdar A, Khodaiji S, Madkaikar M, Ghosh K, Yargop M, Dasgupta A.

Indian J Pathol Microbiol. 2008 Apr-Jun;51(2):161-6.

PMID:

[PubMed - indexed for MEDLINE]

Free Article

Related citations
7.

Three way translocation in a new variant of t(8;21) acute myeloid leukemia involving Xp22.

Vundinti BR, Kerketta L, Madkaikar M, Jijina F, Ghosh K.

Indian J Cancer. 2008 Jan-Mar;45(1):30-2.

PMID:

[PubMed - indexed for MEDLINE]

Free Article

Related citations
8.

Twin pregnancy in a patient of chronic myeloid leukemia on imatinib therapy.

Meera V, Jijina F, Shrikande M, Madkaikar M, Ghosh K.

Leuk Res. 2008 Oct;32(10):1620-2. Epub 2008 Apr 16.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
9.

Spontaneous resolution of severe aplastic anemia following thymic hemorrhage.

Ghosh K, Madkaikar M, Jijina F.

Acta Haematol. 2008;119(2):69-72. Epub 2008 Feb 20.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
10.

Optimising methods of red cell sedimentation from cord blood to maximise nucleated cell recovery prior to cryopreservation.

Madkaikar M, Gupta M, Ghosh K, Swaminathan S, Sonawane L, Mohanty D.

Br J Biomed Sci. 2007;64(4):157-9.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
11.

Ex vivo expansion of umbilical cord blood stem cells using different combinations of cytokines and stromal cells.

Madkaikar M, Ghosh K, Gupta M, Swaminathan S, Mohanty D.

Acta Haematol. 2007;118(3):153-9. Epub 2007 Sep 20.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
12.

Fractures of long bones in severe haemophilia.

Ghosh K, Madkaikar M, Jijina F, Shetty S.

Haemophilia. 2007 May;13(3):337-9. No abstract available.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
13.

Osteoporosis in young haemophiliacs from western India.

Nair AP, Jijina F, Ghosh K, Madkaikar M, Shrikhande M, Nema M.

Am J Hematol. 2007 Jun;82(6):453-7.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
14.

Hybrid cytogenetics of chronic lymphocytic leukemia and follicular cell lymphoma in a case of non-Hodgkins lymphoma.

Babu Rao V, Kerketta L, Madkaikar M, Farah J, Ghosh K.

Acta Haematol. 2006;116(2):150-2. No abstract available.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
15.

Intracranial haemorrhage in severe haemophilia: prevalence and outcome in a developing country.

Ghosh K, Nair AP, Jijina F, Madkaikar M, Shetty S, Mohanty D.

Haemophilia. 2005 Sep;11(5):459-62.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
16.

Congenital methemoglobinemia caused by Hb-MRatnagiri (beta-63CAT-->TAT, His-->Tyr) in an Indian family.

Kedar PS, Nadkarni AH, Phanasgoankar S, Madkaikar M, Ghosh K, Gorakshakar AC, Colah RB, Mohanty D.

Am J Hematol. 2005 Jun;79(2):168-70.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
17.

Immunotherapy in benzene-induced aplastic anemia using a biotherapeutic approach--is it durable?

Madkaikar M, Ghosh K.

Stem Cells Dev. 2004 Apr;13(2):161-2; author reply 162-3. No abstract available.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
18.

Treating patients of myelodysplastic syndrome with antithymocytic globulin--should we be more selective?

Madkaikar M, Ghosh K.

Blood. 2003 Nov 15;102(10):3851-2; author reply 3852. No abstract available.

PMID:

[PubMed - indexed for MEDLINE]

Free Article

Related citations
19.

Severe megakaryocytic dysplasia in a case of myelodysplasia progressing to acute megakaryocytic leukemia presenting with dic(1;16)(q21;p13.3) and t(1;22)(p13;q13).

Ghosh K, Vundinti BR, Kerketta L, Madkaikar M, Mohanty D, Jijina F.

Cancer Genet Cytogenet. 2003 Oct 15;146(2):176-8. No abstract available.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
20.

Virological, serological and haemopoietic colony studies and its correlation with the outcome of severe aplastic anemia.

Ghosh K, Iyer Y, Basu A, Madkaikar M, Jijina F, Shankarkumar U, Mohanty D.

Hematol J. 2003;4(4):292-4. No abstract available.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
A novel translocation der(4)t(1;4)(q21;q35) and a marker chromosome in a case of myelodysplastic syndrome.

Vundinti BR, Madkaikar M, Kerketta L, Jijina F, Ghosh K, Mohanty D, Jijina F.

Cancer Genet Cytogenet. 2003 Jul 15;144(2):175-6. No abstract available.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
22.

Open heart surgery with mitral valve replacement--ordeal of an undiagnosed haemophilia patient.

Ghosh K, Madkaikar M, Jijina F, Gandhi S, Shetty S, Mohanty D.

Clin Lab Haematol. 2003 Apr;25(2):131-3. No abstract available.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
23.

First-time development of FVIII inhibitor in haemophilia patients during the postoperative period.

Ghosh K, Jijina F, Shetty S, Madkaikar M, Mohanty D.

Haemophilia. 2002 Nov;8(6):776-80.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
24.

Tuberculosis and immune thrombocytopenia.

Madkaikar M, Ghosh K, Jijina F, Gupta M, Rajpurkar M, Mohanty D.

Haematologica. 2002 Aug;87(8):ELT38. No abstract available.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
25.

Low cost autologous peripheral blood stem cell transplantation performed in a municipal hospital for a patient with plasma cell leukaemia.

Ghosh K, Gosavi S, Pathare A, Madkaikar M, Rao VB, Mohanty D.

Clin Lab Haematol. 2002 Jun;24(3):187-90.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
26.

Systemic capillary leak syndrome preceding plasma cell leukaemia.

Ghosh K, Madkaikar M, Iyer Y, Pathare A, Jijina F, Mohanty D.

Acta Haematol. 2001;106(3):118-21.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
27.

Ophthalmic surgery in haemophilia.

Jijina F, Ghosh K, Madkaikar M, Mohanty D.

Haemophilia. 2001 Sep;7(5):464-7.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
28.

Venous thromboembolism in young patients from western India: a study.

Ghosh K, Shetty S, Madkaikar M, Pawar A, Nair S, Khare A, Pathare A, Jijina F, Mohanty D.

Clin Appl Thromb Hemost. 2001 Apr;7(2):158-65.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
29.

Transfusion transmitted diseases in haemophilics from western India.

Ghosh K, Joshi SH, Shetty S, Pawar A, Chipkar S, Pujari V, Madkaikar M, Pathare AV, Jijina F, Mohanty D.

Indian J Med Res. 2000 Aug;112:61-4.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
30.

Combined factor V and VIII deficiency in Indian population.

Shetty S, Madkaikar M, Nair S, Pawar A, Baindur S, Pathare A, Ghosh K, Mohanty D.

Haemophilia. 2000 Sep;6(5):504-7.

PMID:

[PubMed - indexed for MEDLINE]

Related citations
31.

Modulation of prolactin release by a 25 kD peptide of human seminal plasma.

Arbatti NJ, Madkaikar VP, Kadam MS, Bandivdekar AH, Gopalkrishnan K, Sheth AR.

Arch Androl. 1989;22(2):173-82.

PMID:
2502085
[PubMed - indexed for MEDLINE]

Publications

  1. ncbi Venous thromboembolism in young patients from western India: a study
    K Ghosh
    Institute of Immunohaematology (Indian Council of Medical Research) KEM Hospital Campus, Parel, Mumbai, India
    Clin Appl Thromb Hemost 7:158-65. 2001
  2. ncbi Osteoporosis in young haemophiliacs from western India
    Anish P Nair
    J C Patel Department of Haematology, KEM Hospital, Parel, Mumbai, India
    Am J Hematol 82:453-7. 2007
  3. ncbi Fractures of long bones in severe haemophilia
    K Ghosh
    Haemophilia 13:337-9. 2007
  4. ncbi Ex vivo expansion of umbilical cord blood stem cells using different combinations of cytokines and stromal cells
    Manisha Madkaikar
    Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Acta Haematol 118:153-9. 2007
  5. ncbi Optimising methods of red cell sedimentation from cord blood to maximise nucleated cell recovery prior to cryopreservation
    M Madkaikar
    Institute of Immunohaematology, K E M Hospital, Parel, Mumbai, India
    Br J Biomed Sci 64:157-9. 2007
  6. ncbi Spontaneous resolution of severe aplastic anemia following thymic hemorrhage
    Kanjaksha Ghosh
    Institute of Immunohaematology, KEM Hospital, Mumbai, India
    Acta Haematol 119:69-72. 2008
  7. ncbi Twin pregnancy in a patient of chronic myeloid leukemia on imatinib therapy
    V Meera
    JC Patel Department of Hematology, KEM Hospital, Mumbai, India
    Leuk Res 32:1620-2. 2008
  8. ncbi Three way translocation in a new variant of t(8;21) acute myeloid leukemia involving Xp22
    B R Vundinti
    Institute of Immunohaematology ICMR, 13th Floor, New Multistoryed Building, KEM Hospital Campus, Parel, Mumbai 400 012, Maharashtra, India
    Indian J Cancer 45:30-2. 2008
  9. ncbi Report of proceedings of the national meeting on "Guidelines for Immunophenotyping of Hematolymphoid Neoplasms by Flow Cytometry"
    Sumeet Gujral
    Department of Pathology, Tata Memorial Hospital, Mumbai, India
    Indian J Pathol Microbiol 51:161-6. 2008
  10. doi Reproducible methodology for the isolation of mesenchymal stem cells from human umbilical cord and its potential for cardiomyocyte generation
    Winston Costa Pereira
    R and D, LifeCell International Pvt Ltd, 26, Vandalur Kelambakkam Main Road, Keelakottaiyur, Chennai 600048, India
    J Tissue Eng Regen Med 2:394-9. 2008

Collaborators

Detail Information

Publications28

  1. ncbi Venous thromboembolism in young patients from western India: a study
    K Ghosh
    Institute of Immunohaematology (Indian Council of Medical Research) KEM Hospital Campus, Parel, Mumbai, India
    Clin Appl Thromb Hemost 7:158-65. 2001
    ..8% of the patients had homozygosity for the MTHFR C677T polymorphism...
  2. ncbi Osteoporosis in young haemophiliacs from western India
    Anish P Nair
    J C Patel Department of Haematology, KEM Hospital, Parel, Mumbai, India
    Am J Hematol 82:453-7. 2007
    ....
  3. ncbi Fractures of long bones in severe haemophilia
    K Ghosh
    Haemophilia 13:337-9. 2007
  4. ncbi Ex vivo expansion of umbilical cord blood stem cells using different combinations of cytokines and stromal cells
    Manisha Madkaikar
    Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Acta Haematol 118:153-9. 2007
    ..Even if there was some doubt about the long-term repopulating capacity of the expanded cells part of the collected umbilical cord cells (25%) could be expanded till day 12 after transplanting the major part (75%) of the collection...
  5. ncbi Optimising methods of red cell sedimentation from cord blood to maximise nucleated cell recovery prior to cryopreservation
    M Madkaikar
    Institute of Immunohaematology, K E M Hospital, Parel, Mumbai, India
    Br J Biomed Sci 64:157-9. 2007
    ..may reduce RBC sedimentation and thus reduce NC recovery. While diluting cord blood with an equal volume of PBS is a simple method to improve the NC recovery, it does involve an additional processing step...
  6. ncbi Spontaneous resolution of severe aplastic anemia following thymic hemorrhage
    Kanjaksha Ghosh
    Institute of Immunohaematology, KEM Hospital, Mumbai, India
    Acta Haematol 119:69-72. 2008
    ..These cases show possible ways to manipulate the thymus gland as a management strategy for this disease...
  7. ncbi Twin pregnancy in a patient of chronic myeloid leukemia on imatinib therapy
    V Meera
    JC Patel Department of Hematology, KEM Hospital, Mumbai, India
    Leuk Res 32:1620-2. 2008
    ..We report here the birth of normal mono-ovular mono-chorionic twin while the patient is on imatinib during conception and early pregnancy for chronic myeloid leukaemia...
  8. ncbi Three way translocation in a new variant of t(8;21) acute myeloid leukemia involving Xp22
    B R Vundinti
    Institute of Immunohaematology ICMR, 13th Floor, New Multistoryed Building, KEM Hospital Campus, Parel, Mumbai 400 012, Maharashtra, India
    Indian J Cancer 45:30-2. 2008
    ..The patient did not respond to therapy and follow-up of cytogenetics revealed same chromosome abnormality. Hence, this three way translocation involving X chromosome might be associated with poor prognosis...
  9. ncbi Report of proceedings of the national meeting on "Guidelines for Immunophenotyping of Hematolymphoid Neoplasms by Flow Cytometry"
    Sumeet Gujral
    Department of Pathology, Tata Memorial Hospital, Mumbai, India
    Indian J Pathol Microbiol 51:161-6. 2008
    ..The first national meeting on "Guidelines for Immunophenotyping of Hematolymphoid Neoplasms by Flow Cytometry" was held on 14 March 2008 in Mumbai, India...
  10. doi Reproducible methodology for the isolation of mesenchymal stem cells from human umbilical cord and its potential for cardiomyocyte generation
    Winston Costa Pereira
    R and D, LifeCell International Pvt Ltd, 26, Vandalur Kelambakkam Main Road, Keelakottaiyur, Chennai 600048, India
    J Tissue Eng Regen Med 2:394-9. 2008
    ..When these MSCs were subjected to cardiomyocyte differentiation, we observed a change in the morphological characteristics, which was accompanied by the formation of myotube structures and spontaneous beating after 21 days...
  11. doi Paroxysmal nocturnal haemoglobinuria: diagnostic tests, advantages, & limitations
    Manisha Madkaikar
    National Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India
    Eur J Haematol 83:503-11. 2009
    ..This review is aimed to focus mainly on the different methods available for the detection of PNH clone and the recent advances and recommendations for the flowcytometric diagnosis of PNH...
  12. ncbi Intracranial haemorrhage in severe haemophilia: prevalence and outcome in a developing country
    K Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital Campus, Parel, Mumbia, India
    Haemophilia 11:459-62. 2005
    ..8%) similar to that of the western countries and almost no morbidity. Surgery was not required in any of these patients except in one elderly patient with HIV infection on antiretroviral therapy...
  13. ncbi Congenital methemoglobinemia caused by Hb-MRatnagiri (beta-63CAT-->TAT, His-->Tyr) in an Indian family
    Prabhakar S Kedar
    Institute of Immunohaematology, Indian Council of Medical Research, K E M Hospital, Parel, Mumbai 400012, India
    Am J Hematol 79:168-70. 2005
    ..This leads to a substitution of histidine (CAT) by tyrosine (TAT) at the beta 63 (E7) position, similar to Hb-M Saskatoon. We have named this variant as Hb-M(Ratnagiri)...
  14. ncbi Immunotherapy in benzene-induced aplastic anemia using a biotherapeutic approach--is it durable?
    Manisha Madkaikar
    Stem Cells Dev 13:161-2; author reply 162-3. 2004
  15. ncbi Ophthalmic surgery in haemophilia
    F Jijina
    JC Patel Department of Haematology, KEM Hospital, Mumbai, India
    Haemophilia 7:464-7. 2001
    ..Thus, satisfactory eye surgery in patients with haemophilia is possible with a restricted amount of factor concentrates with gratifying results...
  16. ncbi Systemic capillary leak syndrome preceding plasma cell leukaemia
    K Ghosh
    Institute of Immunohaematology Indian Council of Medical Research, KEM Hospital Campus, Parel, Mumbai, India
    Acta Haematol 106:118-21. 2001
    ..His disease relapsed without recurrence of the capillary leak. He died 15 months after PBSCT and 20 months after the diagnosis of plasma cell leukaemia...
  17. ncbi Low cost autologous peripheral blood stem cell transplantation performed in a municipal hospital for a patient with plasma cell leukaemia
    K Ghosh
    Institute of Immunohaematology, Indian Council of Medical Research, KEM Hospital Campus, Parel, Mumbai, India
    Clin Lab Haematol 24:187-90. 2002
    ..The patient remained in remission for 7 months, after which he relapsed and was treated with chemotherapy and electron beam radiation to the skin...
  18. ncbi Tuberculosis and immune thrombocytopenia
    Manisha Madkaikar
    Institute of Immunohaematology, 13th Floor, New Multistoreyed Bldg, KEM Hospital Campus, Parel, Mumbai 400 012, India
    Haematologica 87:ELT38. 2002
  19. ncbi First-time development of FVIII inhibitor in haemophilia patients during the postoperative period
    K Ghosh
    Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Haemophilia 8:776-80. 2002
    ....
  20. ncbi Open heart surgery with mitral valve replacement--ordeal of an undiagnosed haemophilia patient
    K Ghosh
    Comprehensive haemophilia care centre, Institute of Immunohaematology, 13th flr, K E M Hospital, Parel, Mumbai 400012, India
    Clin Lab Haematol 25:131-3. 2003
  21. ncbi A novel translocation der(4)t(1;4)(q21;q35) and a marker chromosome in a case of myelodysplastic syndrome
    Babu Rao Vundinti
    Cancer Genet Cytogenet 144:175-6. 2003
  22. ncbi Virological, serological and haemopoietic colony studies and its correlation with the outcome of severe aplastic anemia
    Kanjaksha Ghosh
    Hematol J 4:292-4. 2003
  23. ncbi Severe megakaryocytic dysplasia in a case of myelodysplasia progressing to acute megakaryocytic leukemia presenting with dic(1;16)(q21;p13.3) and t(1;22)(p13;q13)
    Kanjaksha Ghosh
    Cancer Genet Cytogenet 146:176-8. 2003
  24. ncbi Treating patients of myelodysplastic syndrome with antithymocytic globulin--should we be more selective?
    Manisha Madkaikar
    Blood 102:3851-2; author reply 3852. 2003
  25. ncbi X-linked hyper IgM syndrome: Clinical, immunological and molecular features in patients from India
    Manisha Madkaikar
    National Institute of Immunohaematology, KEM Hospital, 13th Floor, Parel, Mumbai 400012, India Electronic address
    Blood Cells Mol Dis 53:99-104. 2014
    ..Confirmation of diagnosis with identification of underlying molecular defect is important for the initiation of appropriate therapeutic interventions, including immunoglobulin replacement, antibiotics and bone marrow transplantation...
  26. doi Comprehensive report of primary immunodeficiency disorders from a tertiary care center in India
    Manisha Madkaikar
    Department of Paediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology, 13th Floor, NMS Bldg, KEM Hospital, Parel, Mumbai, 400012, India
    J Clin Immunol 33:507-12. 2013
    ..Here we describe the frequency of different primary immunodeficiency disorders, their clinical features and disease complications of 159 patients with PID diagnosed in a tertiary care center from India over the last 3 years...
  27. doi Prenatal diagnosis of LAD-I on cord blood by flowcytometry
    Manisha Rajan Madkaikar
    National Institute of Immunohematlogy, Pediatric Immunology and Leukocyte Biology, 13th flr, KEM Hospital, Parel, Mumbai, Maharashtra, 400012, India
    Indian J Pediatr 79:1605-9. 2012
    ..To optimize a simple flowcytometric technique for Prenatal diagnosis (PND) for Leukocyte adhesions defect (LAD-I) on cordocentesis sample at 18 wk gestation...
  28. doi Advances in autoimmune lymphoproliferative syndromes
    Manisha Madkaikar
    National Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India
    Eur J Haematol 87:1-9. 2011
    ..This review describes the clinical and laboratory manifestations found in patients with ALPS, as well as the molecular basis for the disease and new advances in treatment...