A Venkateswarlu

Summary

Affiliation: Bollaram Road
Country: India

Publications

  1. ncbi request reprint Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure-activity relationship
    Vedula M Sharma
    Discovery Chemistry Natural Products, Dr Reddy s Research Foundation, Miyapur, Hyderabad, India
    Bioorg Med Chem Lett 12:2303-7. 2002
  2. ncbi request reprint Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents
    Vedula M Sharma
    Discovery Chemistry, Dr Reddy s Laboratories, Discovery Research, Miyapur, Hyderabad, 500 050, India
    Bioorg Med Chem Lett 13:1679-82. 2003
  3. ncbi request reprint Synthesis and biological evaluation of [4-(2-phenylethenesulfonylmethyl)phenyl]-quinazolin-4-yl-amines as orally active anti-cancer agents
    Vedula M Sharma
    Discovery Chemistry, Dr Reddy s Laboratories, Discovery Research, Miyapur, Hyderabad 500 049, India
    Bioorg Med Chem Lett 14:67-71. 2004
  4. ncbi request reprint Biological investigation and structure-activity relationship studies on azadirone from Azadirachta indica A. Juss
    Srinivas Nanduri
    Discovery Chemistry, Dr Reddy s Laboratories Ltd, Discovery Research, Bollaram Road, Miyapur, Hyderabad 500 050, India
    Bioorg Med Chem Lett 13:4111-5. 2003
  5. ncbi request reprint Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors
    Sunil K Singh
    Discovery Chemistry, Discovery Research Dr Reddy s Laboratories Ltd, Bollaram Road, 500 049, Miyapur, Hyderabad, India
    Bioorg Med Chem Lett 14:499-504. 2004
  6. ncbi request reprint Novel C-ring analogues of 20(S)-camptothecin. Part 3: synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues
    D Subrahmanyam
    Natural Products Division, Dr Reddy s Research Foundation, Hyderabad, AP, India
    Bioorg Med Chem Lett 10:369-71. 2000

Collaborators

  • Sunil K Singh
  • Braj B Lohray
  • Vedula M Sharma
  • Sriram Rajagopal
  • K V Adi Seshu
  • R Ajaykumar
  • R Rajagopalan
  • Dhanvanthri S Deevi
  • V Chandra Sekhar
  • C Vamsee Krishna
  • P Aravind Babu
  • Srinivas Nanduri
  • N V S Rao Mamidi
  • P Prasanna
  • D Subrahmanyam
  • V Ravi Krishna
  • B Vishnu
  • J Sreenu
  • T Sravan Kumar
  • Sachin Madan
  • Vijay Kumar Nyavanandi
  • Siva Sanjeeva Rao Thunuguntla
  • R Ajaya Kumar
  • Sridevi Kasu
  • P Sai Ram
  • P Mahesh Kumar
  • G Sunil Kumar
  • C Seshagiri Rao
  • C V Laxman Rao
  • R C Puranik
  • K B Sunil Kumar
  • D Subramanyam
  • B Renuka
  • C Prasad Narasimhulu
  • T V Sastry
  • M J Babu
  • V M Sarma
  • C V Krishna
  • D S Deevi
  • A S Srinivas
  • S A Kumar
  • N K Damodaran

Detail Information

Publications6

  1. ncbi request reprint Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure-activity relationship
    Vedula M Sharma
    Discovery Chemistry Natural Products, Dr Reddy s Research Foundation, Miyapur, Hyderabad, India
    Bioorg Med Chem Lett 12:2303-7. 2002
    ..The results indicate that these compounds may constitute a new class of anticancer agents...
  2. ncbi request reprint Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents
    Vedula M Sharma
    Discovery Chemistry, Dr Reddy s Laboratories, Discovery Research, Miyapur, Hyderabad, 500 050, India
    Bioorg Med Chem Lett 13:1679-82. 2003
    ..1-8.1 microM concentration. Among these, compounds 21 and 28 exhibited good pharmacokinetic properties. These compounds were further evaluated for their in vivo efficacy in modified hollow fibre assay (HFA)...
  3. ncbi request reprint Synthesis and biological evaluation of [4-(2-phenylethenesulfonylmethyl)phenyl]-quinazolin-4-yl-amines as orally active anti-cancer agents
    Vedula M Sharma
    Discovery Chemistry, Dr Reddy s Laboratories, Discovery Research, Miyapur, Hyderabad 500 049, India
    Bioorg Med Chem Lett 14:67-71. 2004
    ..Compound 9 exhibited promising activity in this model. Dose-response studies for this compound against HT-29 human colon adeno carcinoma xenografts at 100, 200 and 400mg/kg doses were performed...
  4. ncbi request reprint Biological investigation and structure-activity relationship studies on azadirone from Azadirachta indica A. Juss
    Srinivas Nanduri
    Discovery Chemistry, Dr Reddy s Laboratories Ltd, Discovery Research, Bollaram Road, Miyapur, Hyderabad 500 050, India
    Bioorg Med Chem Lett 13:4111-5. 2003
    ..Compound 1 and two of the semi-synthetic analogues 10 and 13 were found to possess good in vivo antitumor activity in modified hollow fiber animal models...
  5. ncbi request reprint Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors
    Sunil K Singh
    Discovery Chemistry, Discovery Research Dr Reddy s Laboratories Ltd, Bollaram Road, 500 049, Miyapur, Hyderabad, India
    Bioorg Med Chem Lett 14:499-504. 2004
    ..The series with a hydroxymethyl group adjacent to the sulfonamide was found to be the most potent modification that yielded many compounds selectively active against COX-2 enzyme in vitro...
  6. ncbi request reprint Novel C-ring analogues of 20(S)-camptothecin. Part 3: synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues
    D Subrahmanyam
    Natural Products Division, Dr Reddy s Research Foundation, Hyderabad, AP, India
    Bioorg Med Chem Lett 10:369-71. 2000
    ..Most of these compounds were found to exhibit potent anti-cancer activity based on their in vitro cytotoxicity data obtained against human tumor cell lines...