R Mahesh

Summary

Affiliation: Birla Institute of Technology and Science
Country: India

Publications

  1. ncbi request reprint Microwave assisted synthesis of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile as a new class of serotonin 5-HT3 receptor antagonists
    Radhakrishnan Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India
    Bioorg Med Chem Lett 14:5179-81. 2004
  2. ncbi request reprint Microwave-assisted solvent-free synthesis of 3-[(4-substituted piperazin-1-yl)alkyl] imidazo[2,1-b][1,3]benzothiazol-2(3H)-ones as serotonin3 (5-HT3) receptor antagonists
    R Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, India
    Pharmazie 60:411-4. 2005
  3. ncbi request reprint Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin3 (5-HT3) receptor antagonist
    Radhakrishnan Mahesh
    Pharmacy Group, Birla Institute of Technology and Science Pilani 333 031, India
    Biol Pharm Bull 27:1403-5. 2004
  4. ncbi request reprint Cancer chemotherapy-induced nausea and vomiting: role of mediators, development of drugs and treatment methods
    R Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, India
    Pharmazie 60:83-96. 2005
  5. ncbi request reprint Effect of acute and chronic treatment with QCF-3 (4-benzylpiperazin-1-yl) (quinoxalin-2-yl) methanone, a novel 5-HT(3) receptor antagonist, in animal models of depression
    Thangaraj Devadoss
    Pharmacy Group, FD III, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India
    Pharmacol Rep 62:245-57. 2010
  6. ncbi request reprint Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models
    R Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, Rajasthan, India
    Pharmazie 62:919-24. 2007
  7. pmc Assessing the Neuronal Serotonergic Target-based Antidepressant Stratagem: Impact of In Vivo Interaction Studies and Knockout Models
    R Rajkumar
    Pharmacy Group, FD III, Vidya Vihar, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India
    Curr Neuropharmacol 6:215-34. 2008
  8. doi request reprint The auspicious role of the 5-HT3 receptor in depression: a probable neuronal target?
    Ramamoorthy Rajkumar
    Pharmacy Group, Birla Institute of Technology and Science, Rajasthan, India
    J Psychopharmacol 24:455-69. 2010
  9. doi request reprint A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants
    Dilip Kumar Pandey
    Pharmacy Group, FD III, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India
    Pharmacol Biochem Behav 94:363-73. 2010
  10. doi request reprint 1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT(2A) receptors: proposal of a modified rodent antidepressant assay
    Ramamoorthy Rajkumar
    Pharmacy Group, FD III, Birla Institute of Technology and Science, Pilani, Rajasthan, India
    Eur J Pharmacol 608:32-41. 2009

Collaborators

  • Ramamoorthy Rajkumar
  • Dilip Kumar Pandey
  • Thangaraj Devadoss
  • Ramachandran Venkatesha Perumal
  • Shushil K Yadav
  • Akutota Ashok Kumar
  • Dilip K Pandey
  • V Sambasiva Rao
  • Muralidharan Arjun
  • Raghuraman Radha

Detail Information

Publications13

  1. ncbi request reprint Microwave assisted synthesis of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile as a new class of serotonin 5-HT3 receptor antagonists
    Radhakrishnan Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India
    Bioorg Med Chem Lett 14:5179-81. 2004
    ..Among the compounds tested, 2-(4-allylpiperazin-1-yl)-1,8-naphthyridine-3-carbonitrile 6d showed most favorable 5-HT3 receptor antagonism in the Guinea pig ileum...
  2. ncbi request reprint Microwave-assisted solvent-free synthesis of 3-[(4-substituted piperazin-1-yl)alkyl] imidazo[2,1-b][1,3]benzothiazol-2(3H)-ones as serotonin3 (5-HT3) receptor antagonists
    R Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, India
    Pharmazie 60:411-4. 2005
    ..Among the test compounds, 3-[2-(4-methylpiperazin-1-yl)ethyl]imidazo[2,1-b][1,3]benzothiazol-2(3H)-one (3b) showed most favorable 5-hydroxytryptamine3 antagonism (pA2 6.7) in the isolated guinea pig ileum...
  3. ncbi request reprint Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin3 (5-HT3) receptor antagonist
    Radhakrishnan Mahesh
    Pharmacy Group, Birla Institute of Technology and Science Pilani 333 031, India
    Biol Pharm Bull 27:1403-5. 2004
    ..Compound 3g exhibited comparable 5-HT(3) antagonistic activity (pA(2) 6.4) to that of standard antagonist Ondansetron (pA(2) 6.9), while the other compounds exhibited mild to moderate 5-HT(3) antagonistic activities...
  4. ncbi request reprint Cancer chemotherapy-induced nausea and vomiting: role of mediators, development of drugs and treatment methods
    R Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, India
    Pharmazie 60:83-96. 2005
    ..So there is a need of further research in this field to get economically useful methods for the treatment of acute and delayed chemotherapy-induced nausea and vomiting...
  5. ncbi request reprint Effect of acute and chronic treatment with QCF-3 (4-benzylpiperazin-1-yl) (quinoxalin-2-yl) methanone, a novel 5-HT(3) receptor antagonist, in animal models of depression
    Thangaraj Devadoss
    Pharmacy Group, FD III, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India
    Pharmacol Rep 62:245-57. 2010
    ..In conclusion, this behavioral study describes an antidepressant-like effect of QCF-3 in rodent behavioral models of depression...
  6. ncbi request reprint Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models
    R Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, Rajasthan, India
    Pharmazie 62:919-24. 2007
    ..This preliminary study points to a serotonergic mechanism behind the antidepressant-like effects of NA-2 and invigorates further investigation of analogous compounds in various other models of depression...
  7. pmc Assessing the Neuronal Serotonergic Target-based Antidepressant Stratagem: Impact of In Vivo Interaction Studies and Knockout Models
    R Rajkumar
    Pharmacy Group, FD III, Vidya Vihar, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India
    Curr Neuropharmacol 6:215-34. 2008
    ..In conclusion, 5-HT based multi-targeted antidepressant drug discovery supported by in vivo interaction studies and knockout models is advocated as a strategy to provide classic molecules for clinical trials...
  8. doi request reprint The auspicious role of the 5-HT3 receptor in depression: a probable neuronal target?
    Ramamoorthy Rajkumar
    Pharmacy Group, Birla Institute of Technology and Science, Rajasthan, India
    J Psychopharmacol 24:455-69. 2010
    ..Finally, this critical review commended the serotonin type-3 receptor as a candidate neuronal antidepressant drug target...
  9. doi request reprint A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants
    Dilip Kumar Pandey
    Pharmacy Group, FD III, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India
    Pharmacol Biochem Behav 94:363-73. 2010
    ..Finally, we propound the combination of 5-HT(2A) receptor antagonists and tricyclic antidepressants as a likely strategy to achieve an early-onset of antidepressant action...
  10. doi request reprint 1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT(2A) receptors: proposal of a modified rodent antidepressant assay
    Ramamoorthy Rajkumar
    Pharmacy Group, FD III, Birla Institute of Technology and Science, Pilani, Rajasthan, India
    Eur J Pharmacol 608:32-41. 2009
    ..Finally, the mCPP induced depression-like behaviour in rodents is envisaged as a modified antidepressant assay to identify novel serotonergic antidepressants...
  11. doi request reprint Depressant-like effects of parthenolide in a rodent behavioural antidepressant test battery
    Dilip Kumar Pandey
    Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India
    J Pharm Pharmacol 60:1643-50. 2008
    ..This study depicts the severe depressogenic potential of PTL (in its pure form) plausibly mediated by platelet/neuronal hypo-serotonergic effects...
  12. ncbi request reprint Effect of anti-depressants on neuro-behavioural consequences following impact accelerated traumatic brain injury in rats
    Radhakrishnan Mahesh
    Department of Pharmacy, FD III, Birla Institute of Technology and Science, Pilani 333 031, India
    Indian J Exp Biol 48:466-73. 2010
    ..The results showed a quantitative battery of neuro-behavioural functional assessments that correlates with neuronal damage following traumatic brain injury...
  13. ncbi request reprint Synthesis and biological evaluation of a novel structural type of serotonin 5-HT3 receptor antagonists
    Ramachandran Venkatesha Perumal
    Department of Pharmaceutical Chemistry, Periyar College of Pharmaceutical Sciences for Girls, Trichirappalli 620 021, Tamil Nadu, India
    Bioorg Med Chem Lett 16:2769-72. 2006
    ..Among the test compounds, N-{3-[(4-methylpiperazin-1-yl)methyl]-4-hydroxyphenyl}-3-methoxyquinoxalin-2-carboxamide 4e showed most favorable 5-HT(3) receptor antagonism...