Vinay Kumar

Summary

Affiliation: Bhabha Atomic Research Centre
Country: India

Publications

  1. pmc Identification of nucleic acid binding sites on translin-associated factor X (TRAX) protein
    Gagan Deep Gupta
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, India
    PLoS ONE 7:e33035. 2012
  2. pmc Low-resolution structure of Drosophila translin
    Vinay Kumar
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    FEBS Open Bio 2:37-46. 2012
  3. ncbi request reprint Structural and mutational analyses reveal the functional role of active-site Lys-154 and Asp-173 of Salmonella typhimurium AphA protein
    Ravindra D Makde
    High Pressure Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Arch Biochem Biophys 464:70-9. 2007
  4. ncbi request reprint Crystal structures of Drosophila mutant translin and characterization of translin variants reveal the structural plasticity of translin proteins
    Gagan D Gupta
    High Pressure Physics Division, Bhabha Atomic Research Centre, Mumbai, India
    FEBS J 275:4235-49. 2008
  5. ncbi request reprint Interaction between mosquito-larvicidal Lysinibacillus sphaericus binary toxin components: analysis of complex formation
    Avinash Kale
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    Insect Biochem Mol Biol 43:1045-54. 2013
  6. ncbi request reprint Structure and mutational analysis of the PhoN protein of Salmonella typhimurium provide insight into mechanistic details
    Ravindra D Makde
    High Pressure Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Biochemistry 46:2079-90. 2007
  7. doi request reprint Molecular evolution of translin superfamily proteins within the genomes of eubacteria, archaea and eukaryotes
    Gagan D Gupta
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, India
    J Mol Evol 75:155-67. 2012
  8. ncbi request reprint Co-expressed recombinant human Translin-Trax complex binds DNA
    Gagan D Gupta
    Synchrotron Radiation Section, Bhabha Atomic Research Centre, Mumbai 400 085, India
    FEBS Lett 579:3141-6. 2005
  9. ncbi request reprint Protein engineering of class-A non-specific acid phosphatase (PhoN) of Salmonella typhimurium: modulation of the pH-activity profile
    Ravindra D Makde
    Synchrotron Radiation Section, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Biomol Eng 23:247-51. 2006
  10. pmc Membrane topology and predicted RNA-binding function of the 'early responsive to dehydration (ERD4)' plant protein
    Archana Rai
    Nuclear Agricultural and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai, India
    PLoS ONE 7:e32658. 2012

Collaborators

  • Gagan D Gupta
  • Ravindra D Makde
  • Ramesh S Hire
  • Avinash Kale
  • Stanislaus F D'Souza
  • Archana Rai
  • Ashok B Hadapad
  • Suresh K Mahajan
  • Penna Suprasanna
  • Tanaji K Dongre
  • Krati Dikshit

Detail Information

Publications11

  1. pmc Identification of nucleic acid binding sites on translin-associated factor X (TRAX) protein
    Gagan Deep Gupta
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, India
    PLoS ONE 7:e33035. 2012
    ..We suggest that both translin and TRAX are binding competent and contribute to the nucleic acid binding activity...
  2. pmc Low-resolution structure of Drosophila translin
    Vinay Kumar
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    FEBS Open Bio 2:37-46. 2012
    ..This study demonstrates clearly that low-resolution X-ray structure can be useful in understanding complex biological oligomers...
  3. ncbi request reprint Structural and mutational analyses reveal the functional role of active-site Lys-154 and Asp-173 of Salmonella typhimurium AphA protein
    Ravindra D Makde
    High Pressure Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Arch Biochem Biophys 464:70-9. 2007
    ..Nearly 10,000-fold increase in the K(d) value for dissociation of the cofactor Mg(II) observed for the D173N mutant correlates well with theoretically estimated change in the binding free energy of Mg(II)...
  4. ncbi request reprint Crystal structures of Drosophila mutant translin and characterization of translin variants reveal the structural plasticity of translin proteins
    Gagan D Gupta
    High Pressure Physics Division, Bhabha Atomic Research Centre, Mumbai, India
    FEBS J 275:4235-49. 2008
    ..The present studies suggest that the oligomeric status of translin critically influences the DNA binding properties of translin proteins...
  5. ncbi request reprint Interaction between mosquito-larvicidal Lysinibacillus sphaericus binary toxin components: analysis of complex formation
    Avinash Kale
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    Insect Biochem Mol Biol 43:1045-54. 2013
    ..59 ng mL(-1)) reported so far for combination of BinA/BinB components, and thus is an attractive option for development of new bio-pesticides for control of mosquito borne vector diseases...
  6. ncbi request reprint Structure and mutational analysis of the PhoN protein of Salmonella typhimurium provide insight into mechanistic details
    Ravindra D Makde
    High Pressure Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Biochemistry 46:2079-90. 2007
    ....
  7. doi request reprint Molecular evolution of translin superfamily proteins within the genomes of eubacteria, archaea and eukaryotes
    Gagan D Gupta
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, India
    J Mol Evol 75:155-67. 2012
    ..Since Chloroflexi has been debated to be near the last universal common ancestor, the present analysis indicates that TRAX may be useful to understand the tree of life...
  8. ncbi request reprint Co-expressed recombinant human Translin-Trax complex binds DNA
    Gagan D Gupta
    Synchrotron Radiation Section, Bhabha Atomic Research Centre, Mumbai 400 085, India
    FEBS Lett 579:3141-6. 2005
    ..The complex binds single-stranded/double-stranded DNA. ssDNA gel-shifted complex shows both proteins at nearly equimolar ratio, suggesting that Translin "chaperones" Trax and forms heteromeric complex that is DNA binding competent...
  9. ncbi request reprint Protein engineering of class-A non-specific acid phosphatase (PhoN) of Salmonella typhimurium: modulation of the pH-activity profile
    Ravindra D Makde
    Synchrotron Radiation Section, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Biomol Eng 23:247-51. 2006
    ..Nonetheless, the active site scaffold in I78H mutant may not be disturbed, as similar steady-state kinetic parameters are observed for both I78H mutant and wild-type PhoN at their respective pH optima...
  10. pmc Membrane topology and predicted RNA-binding function of the 'early responsive to dehydration (ERD4)' plant protein
    Archana Rai
    Nuclear Agricultural and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai, India
    PLoS ONE 7:e32658. 2012
    ..This is the first functional annotation of ERD4 family of proteins that can be useful in designing experiments to unravel crucial aspects of stress tolerance mechanism...
  11. doi request reprint Purification and characterization of mosquitocidal Bacillus sphaericus BinA protein
    Ramesh S Hire
    Bhabha Atomic Research Centre, Mumbai, India
    J Invertebr Pathol 101:106-11. 2009
    ..This is the first report of large-scale purification and accurate toxicity estimation of soluble B. sphaericus BinA. This can help in design and synthesis of improved bacterial insecticide...