Madhu G Tapadia


Affiliation: Banaras Hindu University
Country: India


  1. Singh S, Tapadia M. Molecular basis for efficacy of Guduchi and Madhuyashti feeding on different environmental stressors in Drosophila. Cell Stress Chaperones. 2019;: pubmed publisher
    ..However, neither of these formulations provided beneficial effects when grown under crowded conditions or when exposed to oxidative stressors. ..
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    Tapadia M, Gautam N. Non-apoptotic function of apoptotic proteins in the development of Malpighian tubules of Drosophila melanogaster. J Biosci. 2011;36:531-44 pubmed
    ..Strikingly, the localization of beta-tubulin, F-actin and Disclarge (Dlg) is also disrupted. These results suggest that the apoptotic proteins could be having non-apoptotic function in the development of Malpighian tubules. ..
  3. Verma P, Tapadia M. Immune response and anti-microbial peptides expression in Malpighian tubules of Drosophila melanogaster is under developmental regulation. PLoS ONE. 2012;7:e40714 pubmed publisher
    ..Expression of the NF-?B transcription factor, Relish, also coincides with activation of immune responsive genes in MT, demonstrating that immune regulation in MT is under developmental control and is governed by the Imd pathway. ..
  4. Gautam N, Verma P, Tapadia M. Ecdysone regulates morphogenesis and function of Malpighian tubules in Drosophila melanogaster through EcR-B2 isoform. Dev Biol. 2015;398:163-76 pubmed publisher
    ..B2 isoform of ecdysone receptor is critical for the development of Malpighian tubules and is expressed from early stages of its development. ..
  5. Verma P, Tapadia M. Early gene Broad complex plays a key role in regulating the immune response triggered by ecdysone in the Malpighian tubules of Drosophila melanogaster. Mol Immunol. 2015;66:325-39 pubmed publisher
    ..In the absence of ecdysone signaling the IMD pathway associated genes are down regulated and activation and translocation of transcription factor Relish is also affected. ..
  6. Yadav S, Tapadia M. Expression of polyQ aggregates in Malpighian tubules leads to degeneration in Drosophila melanogaster. Dev Biol. 2016;409:166-180 pubmed publisher
    ..Expression of resistance genes following polyQ expression was up regulated. The present study gives an insight into the effects of polyQ aggregates in non-neuronal tissues. ..
  7. Dubey S, Tapadia M. Yorkie Regulates Neurodegeneration Through Canonical Pathway and Innate Immune Response. Mol Neurobiol. 2018;55:1193-1207 pubmed publisher
    ..These studies strongly suggest a novel mechanism of suppression of PolyQ-mediated neurotoxicity by Yorkie through multiple channels. ..
  8. Gautam N, Verma P, Tapadia M. Drosophila Malpighian Tubules: A Model for Understanding Kidney Development, Function, and Disease. Results Probl Cell Differ. 2017;60:3-25 pubmed publisher