Subhash C Lakhotia

Summary

Affiliation: Banaras Hindu University
Country: India

Publications

  1. ncbi request reprint Male sterility associated with overexpression of the noncoding hsromega gene in cyst cells of testis of Drosophila melanogaster
    T K Rajendra
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Genet 80:97-110. 2001
  2. ncbi request reprint Heat shock genes - integrating cell survival and death
    Richa Arya
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    J Biosci 32:595-610. 2007
  3. pmc In vivo effects of traditional Ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications
    Vibha Dwivedi
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    PLoS ONE 7:e37113. 2012
  4. doi request reprint Long non-coding RNAs coordinate cellular responses to stress
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Wiley Interdiscip Rev RNA 3:779-96. 2012
  5. pmc Regulation of heat shock proteins, Hsp70 and Hsp64, in heat-shocked Malpighian tubules of Drosophila melanogaster larvae
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India
    Cell Stress Chaperones 7:347-56. 2002
  6. ncbi request reprint Epigenetics of heterochromatin
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Biosci 29:219-24. 2004
  7. ncbi request reprint Tissue- and development-specific induction and turnover of hsp70 transcripts from loci 87A and 87C after heat shock and during recovery in Drosophila melanogaster
    S C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Exp Biol 205:345-58. 2002
  8. doi request reprint The large noncoding hsrω-n transcripts are essential for thermotolerance and remobilization of hnRNPs, HP1 and RNA polymerase II during recovery from heat shock in Drosophila
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Chromosoma 121:49-70. 2012
  9. ncbi request reprint Forty years of the 93D puff of Drosophila melanogaster
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Biosci 36:399-423. 2011
  10. ncbi request reprint The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster
    Anand K Singh
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Biosci 37:659-78. 2012

Collaborators

  • Mousumi Mutsuddi
  • Sonali Sengupta
  • Caroline Jolly
  • Moushami Mallik
  • Richa Arya
  • Surajit Sarkar
  • Akanksha Verma
  • Vibha Dwivedi
  • Anand K Singh
  • - Akanksha
  • T K Rajendra
  • K V Prasanth
  • Madhu G Tapadia
  • E M Anandan
  • M S Valiathan
  • T S Muraleedharan
  • Rajesh S Mony
  • Roshan Fatima
  • A Sharma
  • A Mukherjee
  • A K Lal
  • J K Roy
  • B B Nath

Detail Information

Publications36

  1. ncbi request reprint Male sterility associated with overexpression of the noncoding hsromega gene in cyst cells of testis of Drosophila melanogaster
    T K Rajendra
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Genet 80:97-110. 2001
    ....
  2. ncbi request reprint Heat shock genes - integrating cell survival and death
    Richa Arya
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    J Biosci 32:595-610. 2007
    ..The heat shock genes obviously do much more than merely help cells survive stress...
  3. pmc In vivo effects of traditional Ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications
    Vibha Dwivedi
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    PLoS ONE 7:e37113. 2012
    ..It is necessary to examine effects of the whole Ayurvedic formulations rather than their "active" components as is done in most current studies...
  4. doi request reprint Long non-coding RNAs coordinate cellular responses to stress
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Wiley Interdiscip Rev RNA 3:779-96. 2012
    ..Thus the stress-related lncRNAs act as hubs in the cellular networks to coordinate activities of the members within and between different networks to maintain cellular homeostasis for survival or to trigger cell death...
  5. pmc Regulation of heat shock proteins, Hsp70 and Hsp64, in heat-shocked Malpighian tubules of Drosophila melanogaster larvae
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India
    Cell Stress Chaperones 7:347-56. 2002
    ....
  6. ncbi request reprint Epigenetics of heterochromatin
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Biosci 29:219-24. 2004
  7. ncbi request reprint Tissue- and development-specific induction and turnover of hsp70 transcripts from loci 87A and 87C after heat shock and during recovery in Drosophila melanogaster
    S C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Exp Biol 205:345-58. 2002
    ....
  8. doi request reprint The large noncoding hsrω-n transcripts are essential for thermotolerance and remobilization of hnRNPs, HP1 and RNA polymerase II during recovery from heat shock in Drosophila
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Chromosoma 121:49-70. 2012
    ..In the absence of their relocation to pre-stress chromosome sites, normal developmental gene activity fails to be restored, which finally results in delayed organismal death...
  9. ncbi request reprint Forty years of the 93D puff of Drosophila melanogaster
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Biosci 36:399-423. 2011
    ....
  10. ncbi request reprint The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster
    Anand K Singh
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Biosci 37:659-78. 2012
    ..Therefore, in spite of the functional redundancy provided by Hrp38, Hrp36 is essential for normal development and for survival under conditions of stress...
  11. pmc Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models
    Moushami Mallik
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    Genetics 184:927-45. 2010
    ..reinforce the view that the noncoding hsromega RNA functions as a "hub" in cellular networks to maintain homeostasis by coordinating the functional availability of crucial cellular regulatory proteins...
  12. doi request reprint DNApol-ϵ gene is indispensable for the survival and growth of Drosophila melanogaster
    Akanksha Verma
    Department of Zoology, Cytogenetics Laboratory, Banaras Hindu University, Varanasi, India
    Genesis 50:86-101. 2012
    ..The first mutant allele of the DNApol-ϵ gene will facilitate functional characterization of this enzyme in the genetically tractable Drosophila model...
  13. ncbi request reprint RNAi for the large non-coding hsromega transcripts suppresses polyglutamine pathogenesis in Drosophila models
    Moushami Mallik
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    RNA Biol 6:464-78. 2009
    ..Functional analogues of the large non-coding hsromega transcripts in human thus appear to be promising candidates as therapeutic targets for the polyQ-mediated neurodegenerative diseases...
  14. pmc The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila
    Moushami Mallik
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    Genetics 183:831-52. 2009
    ..These observations add to the diversity of regulatory functions that the large noncoding RNAs carry out in the cells' life...
  15. ncbi request reprint Pleiotropic consequences of misexpression of the developmentally active and stress-inducible non-coding hsrω gene in Drosophila
    Moushami Mallik
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    J Biosci 36:265-80. 2011
    ....
  16. ncbi request reprint In situ quantification of hsp70 and alpha-beta transcripts at 87A and 87C loci in relation to hsr-omega gene activity in polytene cells of Drosophila melanogaster
    A Sharma
    Department of Zoology, Banaras Hindu University, Varanasi, India
    Chromosome Res 3:386-93. 1995
    ..abstract truncated at 250 words)..
  17. ncbi request reprint Altered expressions of the noncoding hsromega gene enhances poly-Q-induced neurotoxicity in Drosophila
    Sonali Sengupta
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    RNA Biol 3:28-35. 2006
    ....
  18. ncbi request reprint Gelatin as a blocking agent in Southern blot and chromosomal in situ hybridizations
    S C Lakhotia
    Department of Zoology, Banaras Hindu University, Varanasi, India
    Trends Genet 9:261. 1993
  19. ncbi request reprint The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility
    Surajit Sarkar
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Genet 84:265-81. 2005
    ....
  20. ncbi request reprint Mutations affecting beta-alanine metabolism influence inducibility of the 93D puff by heat shock in Drosophila melanogaster
    S C Lakhotia
    Department of Zoology, Banaras Hindu University, Varanasi, India
    Chromosoma 99:296-305. 1990
    ..The selective inducibility of the 93D puff by benzamide was not affected by ebony or black mutations or by excess beta-alanine in wild-type larvae...
  21. ncbi request reprint Modifiers and mechanisms of multi-system polyglutamine neurodegenerative disorders: lessons from fly models
    Moushami Mallik
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Genet 89:497-526. 2010
    ..Such network effects pose a major challenge for therapeutic applications...
  22. pmc Expression of mdr49 and mdr65 multidrug resistance genes in larval tissues of Drosophila melanogaster under normal and stress conditions
    Madhu G Tapadia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Cell Stress Chaperones 10:7-11. 2005
    ....
  23. ncbi request reprint Developmental regulation and complex organization of the promoter of the non-coding hsr(omega) gene of Drosophila melanogaster
    S C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Biosci 26:25-38. 2001
    ....
  24. ncbi request reprint RNA metabolism in situ at the 93D heat shock locus in polytene nuclei of Drosophila melanogaster after various treatments
    S C Lakhotia
    Department of Zoology, Banaras Hindu University, Varanasi, India
    Chromosome Res 3:151-61. 1995
    ..We suggest that the different 93D transcripts have roles in turnover and/or transport of RNA in nucleus as well as some role in cytoplasmic translation...
  25. pmc Hsp60D is essential for caspase-mediated induced apoptosis in Drosophila melanogaster
    Richa Arya
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    Cell Stress Chaperones 13:509-26. 2008
    ..Depletion of either of these proteins disrupts the granular distribution of the other. We suggest that in the absence of Hsp60D, DIAP1 is unable to dissociate from effecter and executioner caspases, which thus remain inactive...
  26. ncbi request reprint Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila
    K V Prasanth
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Cell Sci 113:3485-97. 2000
    ....
  27. ncbi request reprint The 93D heat shock locus of Drosophila melanogaster: modulation by genetic and developmental factors
    S C Lakhotia
    Department of Zoology, Banaras Hindu University, Varanasi, India
    Genome 31:677-83. 1989
    ..abstract truncated at 250 words)..
  28. ncbi request reprint 1(2)gl gene regulates late expression of segment polarity genes in Drosophila
    A Mukherjee
    Department of Zoology, Banaras Hindu University, Varanasi, India
    Mech Dev 51:227-34. 1995
    ..We suggest that 1(2)gl is involved in regulating post embryonic expression of segment polarity genes...
  29. ncbi request reprint The hsromega(05241) allele of the noncoding hsromega gene of Drosophila melanogaster is not responsible for male sterility as reported earlier
    - Akanksha
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Genet 87:87-90. 2008
  30. doi request reprint Hsp60C is required in follicle as well as germline cells during oogenesis in Drosophila melanogaster
    Surajit Sarkar
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    Dev Dyn 237:1334-47. 2008
    ..Our results provide the first evidence for an essential role of Hsp60C in Drosophila oogenesis, especially in organization and maintenance of cytoskeletal and cell adhesion components...
  31. ncbi request reprint Search for a Drosophila-93D-like locus in Chironomus and Anopheles
    B B Nath
    Department of Zoology, Banaras Hindu University, Varanasi, India
    Cytobios 65:7-13. 1991
    ..The existence of a possible 'functional counterpart' of the 93D locus in Chironomus and Anopheles genomes cannot be eliminated...
  32. ncbi request reprint Genetic mapping of the amide response element(s) of the hsr omega locus of Drosophila melanogaster
    S C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    Chromosoma 107:127-35. 1998
    ..The Df(3R)eP and Df(3R)eR-1 deletions also abolished dosage compensation at the 93D locus as well as the effect of beta-alanine levels on its heat shock inducibility...
  33. ncbi request reprint The 93D (hsr-omega) locus of Drosophila: non-coding gene with house-keeping functions
    S C Lakhotia
    Department of Zoology, Banaras Hindu University, Varanasi, India
    Genetica 97:339-48. 1996
    ..melanogaster. It appears that the hsr-omega locus has important house-keeping functions in transport and turnover of some transcripts and in monitoring the 'health' of the translational machinery of the cell...
  34. ncbi request reprint Spatial expression of the hsr-omega (93D) gene in different tissues of Drosophila melanogaster and identification of promoter elements controlling its developmental expression
    M Mutsuddi
    Department of Zoology, Banaras Hindu University, Varanasi, India
    Dev Genet 17:303-11. 1995
    ..The widespread expression in most tissue types and the known lethality associated with its homozygous deletion, suggest that the variety of non-protein coding transcripts of the hsr-omega gene have vital "house-keeping" functions...
  35. pmc Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells
    Caroline Jolly
    INSERM U309, La Tronche, F 38700, France
    Nucleic Acids Res 34:5508-14. 2006
    ....