Niyaz Ahmed

Summary

Country: India

Publications

  1. pmc Helicobacter pylori--a seasoned pathogen by any other name
    Niyaz Ahmed
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India
    Gut Pathog 1:24. 2009
  2. doi request reprint Molecular epidemiology of tuberculosis in India: moving forward with a systems biology approach
    Niyaz Ahmed
    Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Hyderabad, India
    Tuberculosis (Edinb) 91:407-13. 2011
  3. doi request reprint Coevolution and adaptation of Helicobacter pylori and the case for 'functional molecular infection epidemiology'
    Niyaz Ahmed
    Pathogen Biology Laboratory, Department of Biotechnology, University of Hyderabad, Hyderabad, India
    Med Princ Pract 20:497-503. 2011
  4. pmc Microevolution of Helicobacter pylori type IV secretion systems in an ulcer disease patient over a ten-year period
    Ayesha Alvi
    Pathogen Evolution Lab, CDFD, Nacharam Gandipet, Hyderabad, India
    J Clin Microbiol 45:4039-43. 2007
  5. pmc Genomes of two chronological isolates (Helicobacter pylori 2017 and 2018) of the West African Helicobacter pylori strain 908 obtained from a single patient
    Tiruvayipati Suma Avasthi
    Department of Biotechnology, University of Hyderabad, Gachibowli, Hyderabad, India
    J Bacteriol 193:3385-6. 2011
  6. pmc Ancestral European roots of Helicobacter pylori in India
    S Manjulata Devi
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    BMC Genomics 8:184. 2007
  7. pmc Multiresistant uropathogenic Escherichia coli from a region in India where urinary tract infections are endemic: genotypic and phenotypic characteristics of sequence type 131 isolates of the CTX-M-15 extended-spectrum-β-lactamase-producing lineage
    Arif Hussain
    Department of Biotechnology, University of Hyderabad, Hyderabad, India
    Antimicrob Agents Chemother 56:6358-65. 2012
  8. ncbi request reprint High-resolution genome profiling differentiated Staphylococcus epidermidis isolated from patients with ocular infections and normal individuals
    Aparna Duggirala
    L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 48:3239-45. 2007
  9. pmc Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modern lineages and reveal a western type cag-pathogenicity island
    S Manjulata Devi
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    BMC Genomics 7:191. 2006
  10. pmc Mycobacterium tuberculosis DosR regulon gene Rv0079 encodes a putative, 'dormancy associated translation inhibitor (DATIN)'
    Ashutosh Kumar
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India
    PLoS ONE 7:e38709. 2012

Collaborators

Detail Information

Publications42

  1. pmc Helicobacter pylori--a seasoned pathogen by any other name
    Niyaz Ahmed
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India
    Gut Pathog 1:24. 2009
    ..Therefore, the powerful virulence properties and survival strategies of Helicobacter make it a seasoned pathogen; thus the efforts to portray it as a commensal or a (harmless) 'bacterial parasite' need rethinking...
  2. doi request reprint Molecular epidemiology of tuberculosis in India: moving forward with a systems biology approach
    Niyaz Ahmed
    Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Hyderabad, India
    Tuberculosis (Edinb) 91:407-13. 2011
    ....
  3. doi request reprint Coevolution and adaptation of Helicobacter pylori and the case for 'functional molecular infection epidemiology'
    Niyaz Ahmed
    Pathogen Biology Laboratory, Department of Biotechnology, University of Hyderabad, Hyderabad, India
    Med Princ Pract 20:497-503. 2011
    ..pylori and their discreet associations with serious clinical outcomes such as gastric cancer...
  4. pmc Microevolution of Helicobacter pylori type IV secretion systems in an ulcer disease patient over a ten-year period
    Ayesha Alvi
    Pathogen Evolution Lab, CDFD, Nacharam Gandipet, Hyderabad, India
    J Clin Microbiol 45:4039-43. 2007
    ..These results point to an obvious difficulty in correlating the continuously evolving virulence factors such as the cagPAI genes with disease characteristics that appear to remain stable...
  5. pmc Genomes of two chronological isolates (Helicobacter pylori 2017 and 2018) of the West African Helicobacter pylori strain 908 obtained from a single patient
    Tiruvayipati Suma Avasthi
    Department of Biotechnology, University of Hyderabad, Gachibowli, Hyderabad, India
    J Bacteriol 193:3385-6. 2011
    ..When compared with the genome of the parent strain, 908 (isolated from the antrum of the same patient in 1994), the genome sequences revealed genomic alterations relevant to virulence optimization or host-specific adaptation...
  6. pmc Ancestral European roots of Helicobacter pylori in India
    S Manjulata Devi
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    BMC Genomics 8:184. 2007
    ..pylori. We tried to address these issues through mapping genetic origins of present day H. pylori in India and their genomic comparison with hundreds of isolates from different geographic regions...
  7. pmc Multiresistant uropathogenic Escherichia coli from a region in India where urinary tract infections are endemic: genotypic and phenotypic characteristics of sequence type 131 isolates of the CTX-M-15 extended-spectrum-β-lactamase-producing lineage
    Arif Hussain
    Department of Biotechnology, University of Hyderabad, Hyderabad, India
    Antimicrob Agents Chemother 56:6358-65. 2012
    ....
  8. ncbi request reprint High-resolution genome profiling differentiated Staphylococcus epidermidis isolated from patients with ocular infections and normal individuals
    Aparna Duggirala
    L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 48:3239-45. 2007
    ....
  9. pmc Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modern lineages and reveal a western type cag-pathogenicity island
    S Manjulata Devi
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    BMC Genomics 7:191. 2006
    ..pylori of native Peruvians (of Amerindian ancestry) and their genomic comparison with isolates from Spain, and Japan...
  10. pmc Mycobacterium tuberculosis DosR regulon gene Rv0079 encodes a putative, 'dormancy associated translation inhibitor (DATIN)'
    Ashutosh Kumar
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India
    PLoS ONE 7:e38709. 2012
    ..We propose that the protein encoded by locus Rv0079 is a 'dormancy associated translation inhibitor' or DATIN...
  11. pmc Whole-genome sequences and comparative genomics of Salmonella enterica serovar Typhi isolates from patients with fatal and nonfatal typhoid fever in Papua New Guinea
    Ramani Baddam
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences Centre for Advanced Studies UGC SAP CAS I, University of Hyderabad, Gachibowli, Hyderabad, India
    J Bacteriol 194:5122-3. 2012
    ..The comparative genomics of these and other isolates would enable us to identify genetic rearrangements and mechanisms responsible for endemicity and the differential severity of pathogenic salmonellae in Papua New Guinea and elsewhere...
  12. pmc Concurrent proinflammatory and apoptotic activity of a Helicobacter pylori protein (HP986) points to its role in chronic persistence
    Ayesha Alvi
    Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, India
    PLoS ONE 6:e22530. 2011
    ....
  13. pmc Isocitrate dehydrogenase of Helicobacter pylori potentially induces humoral immune response in subjects with peptic ulcer disease and gastritis
    M Abid Hussain
    Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics CDFD, Hyderabad, India
    PLoS ONE 3:e1481. 2008
    ..We report immunogenic potentials of isocitrate dehydrogenase (ICD), an important house keeping protein of H. pylori...
  14. ncbi request reprint Genome scale portrait of cAMP-receptor protein (CRP) regulons in mycobacteria points to their role in pathogenesis
    Yusuf Akhter
    Laboratory of Molecular and Cellular Biology, CDFD, Hyderabad, India
    Gene 407:148-58. 2008
    ..The conservation of the CRP regulated genes in pathogenic mycobacteria, as opposed to non-pathogenic ones, highlights the importance of CRP-regulated genes in pathogenesis...
  15. ncbi request reprint genoBASE pylori: a genotype search tool and database of the human gastric pathogen Helicobacter pylori
    Niyaz Ahmed
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    Infect Genet Evol 7:463-8. 2007
    ..pylori. The database can be accessed through its website (http://www.cdfd.org.in/amplibase/HP)...
  16. doi request reprint Dormancy Associated Translation Inhibitor (DATIN/Rv0079) of Mycobacterium tuberculosis interacts with TLR2 and induces proinflammatory cytokine expression
    Ashutosh Kumar
    Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India
    Cytokine 64:258-64. 2013
    ..The cytokine profiles dissected herein point to a possible role of DATIN in maintenance of latency with the help of the proinflammatory responses...
  17. pmc Next-generation sequencing and de novo assembly, genome organization, and comparative genomic analyses of the genomes of two Helicobacter pylori isolates from duodenal ulcer patients in India
    Narender Kumar
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India
    J Bacteriol 194:5963-4. 2012
    ..pylori genotypes, and this will be helpful in solving the so-called Indian enigma, by which high infection rates do not corroborate the minuscule number of serious outcomes observed, including gastric cancer...
  18. pmc Rapid identification of Mycobacterium tuberculosis Beijing genotypes on the basis of the mycobacterial interspersed repetitive unit locus 26 signature
    K Rajender Rao
    Pathogen Evolution Group, Laboratory of Molecular and Cell Biology, Centre for DNA Fingerprinting and Diagnostics CDFD, Nacharam, Hyderabad, India
    J Clin Microbiol 44:274-7. 2006
    ..The test can also be adopted for direct application on clinical samples to save time on culturing bacilli for genotyping...
  19. doi request reprint Ancestral Mycobacterium tuberculosis genotypes in India: implications for TB control programmes
    Niyaz Ahmed
    Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad, India
    Infect Genet Evol 9:142-6. 2009
    ..It appears that despite a hypothetical 'ancestral advantage', future dynamics of tubercle bacilli in the back drop of surging HIV and diabetes incidences may pose a major healthcare problem in India in the years to come...
  20. pmc Genetic affinities within a large global collection of pathogenic Leptospira: implications for strain identification and molecular epidemiology
    Kishore Nalam
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India
    PLoS ONE 5:e12637. 2010
    ....
  21. pmc Molecular analysis of a leprosy immunotherapeutic bacillus provides insights into Mycobacterium evolution
    Niyaz Ahmed
    Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    PLoS ONE 2:e968. 2007
    ..Thus a comprehensive analysis of MIP vis-à-vis evolutionary path, underpinning its immanent immunomodulating properties is of the highest desiderata...
  22. pmc Comparative genomics of Helicobacter pylori isolates recovered from ulcer disease patients in England
    Farhana Kauser
    Pathogen Evolution Group, Laboratory of Molecular and Cell Biology, Centre for DNA Fingerprinting and Diagnostics CDFD, Hyderabad, India
    BMC Microbiol 5:32. 2005
    ..Phylogenetic analysis was carried out based on various high-resolution genotyping techniques...
  23. pmc Novel protein antigen (JHP940) from the genomic plasticity region of Helicobacter pylori induces tumor necrosis factor alpha and interleukin-8 secretion by human macrophages
    Mohammed Rizwan
    Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    J Bacteriol 190:1146-51. 2008
    ..The induction of the proinflammatory cytokines by JHP940, therefore, points to its putative role in chronic gastric inflammation and, possibly, the various other outcomes of H. pylori infection, including gastric cancer...
  24. doi request reprint Helicobacter pylori Antigen HP0986 (TieA) Interacts with Cultured Gastric Epithelial Cells and Induces IL8 Secretion via NF-κB Mediated Pathway
    Savita Devi
    Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, 500046, India
    Helicobacter 19:26-36. 2014
    ..Also, we studied antigenic role of HP0986 in altering cytokine responses of human gastric epithelial (AGS) cells including its interaction with and localization within the AGS cells...
  25. pmc Genome sequencing and analysis of Salmonella enterica serovar Typhi strain CR0063 representing a carrier individual during an outbreak of typhoid fever in Kelantan, Malaysia
    Ramani Baddam
    Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India
    Gut Pathog 4:20. 2012
    ..Putative genomic coordinates relevant in pathogenesis and persistence of this carrier strain are identified and discussed...
  26. pmc Genetic fine structure of a Salmonella enterica serovar Typhi strain associated with the 2005 outbreak of typhoid fever in Kelantan, Malaysia
    Ramani Baddam
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India
    J Bacteriol 194:3565-6. 2012
    ..The whole-genome sequence and comparative genomics of this strain should enable us to understand the virulence mechanisms and evolutionary dynamics of this pathogen in Malaysia and elsewhere...
  27. pmc Modern and ancestral genotypes of Mycobacterium tuberculosis from Andhra Pradesh, India
    Shirly K Thomas
    Institute of Life Sciences, University of Hyderabad Campus, Hyderabad, India
    PLoS ONE 6:e27584. 2011
    ..tuberculosis from the Indian state of Andhra Pradesh and provides a much needed snapshot of the strain diversity that will be helpful in devising effective TB control programs in this part of the world...
  28. pmc High-resolution genotyping of Pseudomonas aeruginosa strains linked to acute post cataract surgery endophthalmitis outbreaks in India
    Prashanth Kenchappa
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics CDFD, Nacharam, Hyderabad, India
    Ann Clin Microbiol Antimicrob 4:19. 2005
    ..Investigation of two independent outbreaks of post cataract surgery endophthalmitis identified the reservoir of epidemic strains of P. aeruginosa...
  29. doi request reprint Diagnostic potential of an iron-regulated hemin-binding protein HbpA that is widely conserved in Leptospira interrogans
    Velineni Sridhar
    School of Life Sciences, University of Hyderabad, Hyderabad, India
    Infect Genet Evol 8:772-6. 2008
    ..In addition, we detected anti-HbpA antibodies in the serum of patients with leptospirosis. PCR-based detection of hbpA in clinical isolates of serovars and the in vivo expression of HbpA reflects the diagnostic potential of this antigen...
  30. doi request reprint Helicobacter pylori and type 1 diabetes mellitus: possibility of modifying chronic disease susceptibility with vaccinomics at the anvil
    Tiruvayipati Suma Avasthi
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India
    OMICS 15:589-96. 2011
    ..Given this, the present review attempts to analyze and examine the confounding association of H. pylori and T1DM and the approaches to tackle them, and how the emerging field of vaccinomics might help in this pursuit...
  31. pmc Genome of multidrug-resistant uropathogenic Escherichia coli strain NA114 from India
    Tiruvayipati Suma Avasthi
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Professor CR Rao Road, Gachibowli, Hyderabad 500 046, India
    J Bacteriol 193:4272-3. 2011
    ..The genome sequence and comparative genomics emanating from it will be significant in under-standing the genetic makeup of diverse UPEC strains and in boosting the development of new diagnostics/vaccines...
  32. pmc Genome of Helicobacter pylori strain 908
    Singamaneni Haritha Devi
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India
    J Bacteriol 192:6488-9. 2010
    ..Comparative and functional genomics of HP908 and its subclones will be important in understanding genomic plasticity and the capacity to colonize and persist in a changing host environment...
  33. doi request reprint Treatment end point determinants for pulmonary tuberculosis: human resistin as a surrogate biomarker
    Nasreen Z Ehtesham
    Institute of Life Sciences, University of Hyderabad Campus, Prof C R Rao Road, Hyderabad, India
    Tuberculosis (Edinb) 91:293-9. 2011
    ..001) of treatment inversely correlated with resistin levels. Our data suggest resistin could be a surrogate marker for TB treatment in addition to its utility as an early prognostic biomarker for monitoring TB disease onset...
  34. pmc Iron-dependent RNA-binding activity of Mycobacterium tuberculosis aconitase
    Sharmistha Banerjee
    Centre for DNA Fingerprinting and Diagnostics, Hyderabad, 500076, India
    J Bacteriol 189:4046-52. 2007
    ..tuberculosis Acn are mutually exclusive. Our results demonstrate the bifunctional nature of M. tuberculosis Acn, pointing to its likely role in iron homeostasis...
  35. pmc Helicobacter pylori and gastroduodenal pathology: new threats of the old friend
    Niyaz Ahmed
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    Ann Clin Microbiol Antimicrob 4:1. 2005
    ..The contribution of comparative genomics to our understanding of the genome organisation and diversity of H. pylori and its pathophysiological importance to human healthcare is exemplified in this review...
  36. pmc Genome of a novel isolate of Paracoccus denitrificans capable of degrading N,N-dimethylformamide
    Dayananda Siddavattam
    Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Professor CR Rao Road, Gachibowli, Hyderabad 500 046, India
    J Bacteriol 193:5598-9. 2011
    ..The genome sequence and biological circuitry revealed thereupon will be invaluable in understanding the metabolic capabilities, functioning, and evolution of this important bacterial organism...
  37. doi request reprint Mycobacterial Hsp65 potentially cross-reacts with autoantibodies of diabetes sera and also induces (in vitro) cytokine responses relevant to diabetes mellitus
    Pittu Sandhya Rani
    Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India
    Mol Biosyst 9:2932-41. 2013
    ..Taken together, these findings point towards a dual role for mycobacterial Hsp65: in inducing autoimmunity and in inflammation, the two cardinal features of diabetes mellitus. ..
  38. pmc In vitro cytokine profiles and viability of different human cells treated with whole cell lysate of Mycobacterium avium subsp. paratuberculosis
    Pittu Sandhya Rani
    Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India
    Gut Pathog 4:10. 2012
    ..We also found that MAP lysate induced cytotoxicity in PANC-1cells. Collectively, these results provide a much needed base-line data set of cytokines broadly signifying a MAP induced cellular response by human cells...
  39. doi request reprint Helicobacter pylori in 2013: multiplying genomes, emerging insights
    Niyaz Ahmed
    Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, 500046, India Institute of Biological Sciences, University of Malaya, Kuala Lumpur, 50603, Malaysia
    Helicobacter 18:1-4. 2013
    ..As the magnitude of diversity in the H. pylori gene pool becomes more and more clear, geographic and demographic factors should be brought to analysis while identifying disease-specific biomarkers and defining new virulence mechanisms. ..
  40. pmc Mycobacterium avium subsp. paratuberculosis as a trigger of type-1 diabetes: destination Sardinia, or beyond?
    Pittu Sandhya Rani
    Pathogen Biology Laboratory, School of Life Sciences, University of Hyderabad, Hyderabad, India
    Gut Pathog 2:1. 2010
    ..Systematic mechanistic insights are needed to prove this link. Unfortunately, no easy animal model(s) or in-vitro systems are available to decipher the complex immunological network that is triggered in MAP infection leading to T1DM...
  41. pmc Disease-causing mutations in proteins: structural analysis of the CYP1B1 mutations causing primary congenital glaucoma in humans
    Malkaram S Achary
    Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    Biophys J 91:4329-39. 2006
    ....
  42. ncbi request reprint Leptospirosis
    Seyed E Hasnain
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    Lancet Infect Dis 4:543; discussion 544. 2004