Mustapha Umar Imam


Affiliation: Universiti Putra Malaysia
Location: Serdang, Malaysia
Nutrigenomics, Preventive medicine, Diabetes, antioxidants, Oxidative stress
Antidiabetic properties of germinated brown rice (GBR), 2009, BERNAS Sdn Bhd Malaysia


  1. Ismail N, Ismail M, Fathy S, Musa S, Imam M, Foo J, et al. Neuroprotective effects of germinated brown rice against hydrogen peroxide induced cell death in human SH-SY5Y cells. Int J Mol Sci. 2012;13:9692-708 pubmed publisher
    ..Therefore, GBR could be developed as a value added functional food to prevent neurodegenerative diseases caused by oxidative stress and apoptosis. ..
  2. Imam M, Ismail M. Effects of brown rice and white rice on expression of xenobiotic metabolism genes in type 2 diabetic rats. Int J Mol Sci. 2012;13:8597-608 pubmed publisher
    ..These results may have profound implications for rice eating populations, constituting half the world's population. ..
  3. Isa T, Zakaria Z, Rukayadi Y, Mohd Hezmee M, Jaji A, Imam M, et al. Antibacterial Activity of Ciprofloxacin-Encapsulated Cockle Shells Calcium Carbonate (Aragonite) Nanoparticles and Its Biocompatability in Macrophage J774A.1. Int J Mol Sci. 2016;17: pubmed publisher
    ..The results indicated that ciprofloxacin-nanoparticles enhanced the antibacterial efficacy of the antibiotic, and could act as a suitable delivery system against intracellular infections. ..
  4. Waziri P, Abdullah R, Yeap S, Omar A, Abdul A, Kassim N, et al. Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway. J Ethnopharmacol. 2016;194:549-558 pubmed publisher
    ..f. is an anti-hepG2 cell compound as shown by its ability to induce apoptosis through the mitochondrial pathway of apoptosis. Clausenidin can potentially be developed into an anticancer compound. ..
  5. Yida Z, Imam M, Ismail M, Ismail N, Ideris A, Abdullah M. High fat diet-induced inflammation and oxidative stress are attenuated by N-acetylneuraminic acid in rats. J Biomed Sci. 2015;22:96 pubmed publisher
    ..However, the translational implications of these findings can only be determined after long-term effects are established. Hence, the use of Neu5Ac on obesity-related diseases requires additional attention. ..
  6. Yida Z, Imam M, Ismail M, Wong W, Abdullah M, Ideris A, et al. N-Acetylneuraminic acid attenuates hypercoagulation on high fat diet-induced hyperlipidemic rats. Food Nutr Res. 2015;59:29046 pubmed publisher
    ..The implications of the present findings are that Neu5Ac may be used to prevent coagulation-related cardiovascular events in hyperlipidemic conditions. These findings are worth studying further. ..
  7. Adamu H, Imam M, Ooi D, Esa N, Rosli R, Ismail M. Perinatal exposure to germinated brown rice and its gamma amino-butyric acid-rich extract prevents high fat diet-induced insulin resistance in first generation rat offspring. Food Nutr Res. 2016;60:30209 pubmed publisher
    ..These results showed that intrauterine exposure to GBR-influenced metabolic outcomes in offspring of rats with underlying epigenetic changes and transcriptional implications that led to improved glucose homeostasis. ..
  8. Ismail N, Ismail M, Imam M, Azmi N, Fathy S, Foo J, et al. Mechanistic basis for protection of differentiated SH-SY5Y cells by oryzanol-rich fraction against hydrogen peroxide-induced neurotoxicity. BMC Complement Altern Med. 2014;14:467 pubmed publisher
    ..These findings suggest ORF may be an effective antioxidant that could prevent oxidative stress-induced neurodegenerative disorders. ..
  9. Yida Z, Imam M, Ismail M, Hou Z, Abdullah M, Ideris A, et al. Edible Bird's Nest attenuates high fat diet-induced oxidative stress and inflammation via regulation of hepatic antioxidant and inflammatory genes. BMC Complement Altern Med. 2015;15:310 pubmed publisher
    ..These promising results can open up opportunities for translating the benefits of EBN to humans. ..

Detail Information


  1. Sarega N, Imam M, Esa N, Zawawi N, Ismail M. Effects of phenolic-rich extracts of Clinacanthus nutans on high fat and high cholesterol diet-induced insulin resistance. BMC Complement Altern Med. 2016;16:88 pubmed publisher
    ..nutans, on the other hand, attenuated the metabolic effects and transcriptional changes induced by the HFHC diet. The results suggested that C.nutans may be a good source of functional ingredient for the prevention of insulin resistance. ..
  2. Wong W, Ismail M, Imam M, Zhang Y. Modulation of platelet functions by crude rice (Oryza sativa) bran policosanol extract. BMC Complement Altern Med. 2016;16:252 pubmed publisher
    ..These findings serve as a scientific platform to further explore alternative therapies in cardiovascular diseases related to platelet malfunction. ..
  3. Adamu H, Imam M, Ooi D, Esa N, Rosli R, Ismail M. In utero exposure to germinated brown rice and its oryzanol-rich extract attenuated high fat diet-induced insulin resistance in F1 generation of rats. BMC Complement Altern Med. 2017;17:67 pubmed publisher
    ..However, dams and offsprings of the GBR and OE groups had higher hepatic H3 acetylation. GBR and OE can be used as functional ingredients for the amelioration of HFD-induced epigeneticallymediated insulin resistance. ..
  4. Imam M, Zhang S, Ma J, Wang H, Wang F. Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress. Nutrients. 2017;9: pubmed publisher
  5. Azmi N, Ismail N, Imam M, Ismail M. Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuroblastoma cells: role of anti-apoptotic, pro-survival and antioxidant genes. BMC Complement Altern Med. 2013;13:177 pubmed publisher
    ..In view of the rich antioxidant content of GBR, we studied its potential to modulate processes leading up to AD...