I Idris

Summary

Publications

  1. ncbi request reprint Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathy
    Iskandar Idris
    John Peace Diabetes Centre, Kings Mill Hospital, Sherwood Hospitals NHS Trust, Sutton in Ashfield, Nottinghamshire, NG17 4JL, UK
    Diab Vasc Dis Res 3:172-8. 2006
  2. ncbi request reprint Familial hyperinsulinaemia associated with epilepsy and mental retardation--a syndrome of familial insulin resistance
    I Idris
    Department of Diabetes, Endocrinology and Nutrition, Queens Medical Centre, Nottingham, UK
    Diabet Med 21:628-31. 2004
  3. ncbi request reprint Maternal hypothyroidism in early and late gestation: effects on neonatal and obstetric outcome
    Iskandar Idris
    Department of Diabetes and Endocrinology, Nottingham City Hospital, UK
    Clin Endocrinol (Oxf) 63:560-5. 2005
  4. ncbi request reprint Effects of maternal hyperthyroidism during early gestation on neonatal and obstetric outcome
    Iskandar Idris
    Clin Endocrinol (Oxf) 65:133-5. 2006
  5. doi request reprint Relation between age and coronary heart disease (CHD) risk in Asian Indian patients with diabetes: A cross-sectional and prospective cohort study
    I Idris
    Sherwood Forest Hospitals Foundation Trust and Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, UK
    Diabetes Res Clin Pract 81:243-9. 2008
  6. ncbi request reprint Responders to insulin therapy at 18 months in adults with newly diagnosed diabetes: which insulin regimen?
    I Idris
    School of Graduate Entry Medicine, University of Nottingham, Derby, UK
    Diabet Med 30:e95-100. 2013
  7. doi request reprint Exenatide improves excessive daytime sleepiness and wakefulness in obese patients with type 2 diabetes without obstructive sleep apnoea
    Iskandar Idris
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    J Sleep Res 22:70-5. 2013
  8. doi request reprint Association between thiazolidinedione treatment and risk of macular edema among patients with type 2 diabetes
    Iskandar Idris
    Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, England
    Arch Intern Med 172:1005-11. 2012
  9. ncbi request reprint Diabetes mellitus and stroke
    I Idris
    John Pease Diabetes Centre, Sherwood Forest Hospitals NHS Trust, Nottinghamshire, UK
    Int J Clin Pract 60:48-56. 2006
  10. doi request reprint Obstructive sleep apnoea in patients with type 2 diabetes: aetiology and implications for clinical care
    Iskandar Idris
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    Diabetes Obes Metab 11:733-41. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathy
    Iskandar Idris
    John Peace Diabetes Centre, Kings Mill Hospital, Sherwood Hospitals NHS Trust, Sutton in Ashfield, Nottinghamshire, NG17 4JL, UK
    Diab Vasc Dis Res 3:172-8. 2006
    ..Initial studies suggest that this agent decreased the development of sight-threatening macular oedema and the occurrence of visual loss. It did not, however, prevent the progression of diabetic retinopathy...
  2. ncbi request reprint Familial hyperinsulinaemia associated with epilepsy and mental retardation--a syndrome of familial insulin resistance
    I Idris
    Department of Diabetes, Endocrinology and Nutrition, Queens Medical Centre, Nottingham, UK
    Diabet Med 21:628-31. 2004
    ..Whilst a variety of congenital syndromes of insulin resistance are identified by their characteristic clinical phenotypes, an association with epilepsy and mental retardation has not previously been reported...
  3. ncbi request reprint Maternal hypothyroidism in early and late gestation: effects on neonatal and obstetric outcome
    Iskandar Idris
    Department of Diabetes and Endocrinology, Nottingham City Hospital, UK
    Clin Endocrinol (Oxf) 63:560-5. 2005
    ..The effects of thyroxine dose requirement during pregnancy and serum concentrations of TSH within such clinic settings are still not known...
  4. ncbi request reprint Effects of maternal hyperthyroidism during early gestation on neonatal and obstetric outcome
    Iskandar Idris
    Clin Endocrinol (Oxf) 65:133-5. 2006
  5. doi request reprint Relation between age and coronary heart disease (CHD) risk in Asian Indian patients with diabetes: A cross-sectional and prospective cohort study
    I Idris
    Sherwood Forest Hospitals Foundation Trust and Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, UK
    Diabetes Res Clin Pract 81:243-9. 2008
    ..We aimed to determine an age threshold above which patients develop a higher risk of CHD and would merit routine statin prescription...
  6. ncbi request reprint Responders to insulin therapy at 18 months in adults with newly diagnosed diabetes: which insulin regimen?
    I Idris
    School of Graduate Entry Medicine, University of Nottingham, Derby, UK
    Diabet Med 30:e95-100. 2013
    ..To describe baseline characteristics of responders to insulin therapy (HbA(1c) targets < 58 mmol/mol, 7.5%) at 18 months among adults with newly diagnosed diabetes...
  7. doi request reprint Exenatide improves excessive daytime sleepiness and wakefulness in obese patients with type 2 diabetes without obstructive sleep apnoea
    Iskandar Idris
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    J Sleep Res 22:70-5. 2013
    ..These findings could form a basis for further studies to investigate the pathophysiological mechanisms of sleepiness in obese patients with type 2 diabetes...
  8. doi request reprint Association between thiazolidinedione treatment and risk of macular edema among patients with type 2 diabetes
    Iskandar Idris
    Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, England
    Arch Intern Med 172:1005-11. 2012
    ..We evaluated, in patients with type 2 diabetes (T2D), the short-term and long-term risks of developing DME among users vs nonusers of thiazolidinediones...
  9. ncbi request reprint Diabetes mellitus and stroke
    I Idris
    John Pease Diabetes Centre, Sherwood Forest Hospitals NHS Trust, Nottinghamshire, UK
    Int J Clin Pract 60:48-56. 2006
    ....
  10. doi request reprint Obstructive sleep apnoea in patients with type 2 diabetes: aetiology and implications for clinical care
    Iskandar Idris
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    Diabetes Obes Metab 11:733-41. 2009
    ..The clinical implications are discussed...
  11. doi request reprint Sodium-glucose co-transporter-2 inhibitors: an emerging new class of oral antidiabetic drug
    Iskandar Idris
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    Diabetes Obes Metab 11:79-88. 2009
    ....
  12. ncbi request reprint Does close glycaemic control promote healing in diabetic foot ulcers? Report of a feasibility study
    I Idris
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham, UK
    Diabet Med 22:1060-3. 2005
    ..To undertake a pilot study to determine the feasibility of a definitive trial of the effect of close glycaemic control on healing of foot ulcers in diabetes...
  13. doi request reprint Discordance between non-HDL cholesterol and LDL cholesterol levels in patients with diabetes without previous cardiovascular events
    I Idris
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    Diabetes Metab 36:299-304. 2010
    ....
  14. doi request reprint Concordance between plasma apolipoprotein B levels and cholesterol indices among patients receiving statins and nonstatin treatment: Post-hoc analyses from the U.K. InPractice study
    Iskandar Idris
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    J Clin Lipidol 5:316-23. 2011
    ..Current evidence has shown a degree of discordance between LDL-C with ApoB levels among patients not receiving lipid-lowering therapy. The extent of this discordance among patients receiving LDL-lowering therapies however is less clear...
  15. doi request reprint Age threshold for vascular prophylaxis by aspirin in patients without diabetes
    U Bulugahapitiya
    Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, UK
    Heart 94:1429-32. 2008
    ..To determine an appropriate age threshold at which to prescribe aspirin for primary cardiovascular disease (CVD) prevention among men and women without diabetes...
  16. ncbi request reprint Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes
    I Idris
    School of Medical and Surgical Sciences, University of Nottingham, Royal Infirmary, Derby, UK
    Diabetologia 44:659-73. 2001
    ..Thus, a greater understanding of the functional diversity and pathophysiological regulation of PKC isozymes is likely to have important clinical and therapeutic benefits...
  17. pmc Obstructive sleep apnoea is independently associated with the metabolic syndrome but not insulin resistance state
    A Gruber
    Sherwood Forest Hospitals NHS Trust, Nottinghamshire, Mansfield, UK
    Cardiovasc Diabetol 5:22. 2006
    ..Appropriate pharmacological intervention targeting these independent factors is important in reducing the increased CV risks among patients with OSA...
  18. pmc Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research
    R Donnelly
    School of Medical and Surgical Sciences, University of Nottingham, Derbyshire Royal Infirmary, Derby DE1 2QY, UK
    Br J Ophthalmol 88:145-51. 2004
    ..TRANSLATIONAL RESEARCH IN PRACTICE: a PKC-beta inhibitor for diabetic retinopathy..
  19. ncbi request reprint Increased skeletal muscle expression of PKC-theta but not PKC-alpha mRNA in type 2 diabetes: inverse relationship with in-vivo insulin sensitivity
    S Gray
    School of Medical and Surgical Sciences, Centre for Integrated Systems Biology and Medicine, University of Nottingham, Derby, UK
    Eur J Clin Invest 33:983-7. 2003
    ....
  20. doi request reprint Cardiovascular and metabolic risk profiles in young and old patients with type 2 diabetes
    W Gunathilake
    Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    QJM 103:881-4. 2010
    ..Young patients (aged < 40 years) with type 2 diabetes (T2D) have a high lifetime risk of developing cardiovascular disease (CVD). However, little is known about the CVD risk profile of this cohort in the UK primary care setting...
  21. ncbi request reprint The use of U-500 regular insulin in the management of patients with obesity and insulin resistance
    P Jones
    Department of Diabetes and Endocrinology, Nottingham University Hospitals, Nottingham, UK
    Diabetes Obes Metab 15:882-7. 2013
    ..To prevent insulin dosing and administration errors, great care must be taken in providing staff and patient education, and in developing policies for the management of patients on U-500 insulin who are admitted to hospital. ..
  22. doi request reprint Predictors of responders to insulin therapy at 1 year among adults with type 2 diabetes
    V Owen
    East Midlands Research Support Unit, University of Nottingham, University Park, Nottingham, UK
    Diabetes Obes Metab 12:865-70. 2010
    ..This study aims to determine baseline parameters including body mass index (BMI) threshold that might predict responders to insulin therapy...
  23. ncbi request reprint Tissue- and time-dependent effects of endothelin-1 on insulin-stimulated glucose uptake
    I Idris
    School of Medical and Surgical Sciences, University of Nottingham, Derby, UK
    Biochem Pharmacol 62:1705-8. 2001
    ..It is therefore unlikely that chronic hyperendothelinaemia has a direct insulin-antagonist effect contributing to peripheral (ie muscle/fat) insulin resistance in vivo...
  24. ncbi request reprint Serum urea and total cholesterol independently predict re-hospitalisation with a cardiac-related event following an acute ST-elevation myocardial infarction
    A Gruber
    Sherwood Forest Hospitals NHS Trust, Nottinghamshire, UK
    Eur J Intern Med 18:531-4. 2007
    ....
  25. ncbi request reprint Is diabetes a coronary risk equivalent? Systematic review and meta-analysis
    U Bulugahapitiya
    Sherwood Forest Hospitals Foundation Trust and Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, UK
    Diabet Med 26:142-8. 2009
    ..To determine whether patients with diabetes without prior myocardial infarction (MI) have the same risk of total coronary heart disease (CHD) events as non-diabetic patients with previous myocardial infarction...
  26. ncbi request reprint Rosiglitazone and pulmonary oedema: an acute dose-dependent effect on human endothelial cell permeability
    I Idris
    School of Medical and Surgical Sciences, University of Nottingham, UK
    Diabetologia 46:288-90. 2003
    ....
  27. ncbi request reprint Erythromelia, or Mitchell's syndrome--new names for unexplained signs of inflammation in distal symmetrical neuropathy in diabetes
    W J Jeffcoate
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham, UK
    Diabet Med 21:1334-8. 2004
    ..The vasodilation was associated with swelling and stiffness, but was painless and self-limiting...
  28. ncbi request reprint HbA1c during pregnancy: its relationship to meal related glycaemia and neonatal birth weight in patients with diabetes
    R A Gandhi
    Department of Diabetes and Endocrinology, Nottingham City Hospital, Nottingham, UK
    Eur J Obstet Gynecol Reprod Biol 138:45-8. 2008
    ..We therefore aimed to establish the strength of the association between mean HBG profiles and HbA1c in diabetic pregnancies and whether HbA1c levels and glycaemic variability affects neonatal birth weight (NBW)...
  29. ncbi request reprint Protein kinase C-beta inhibition and diabetic microangiopathy: effects on endothelial permeability responses in vitro
    Iskandar Idris
    Centre for Integrated Systems Biology and Medicine, School of Medical and Surgical Sciences, University of Nottingham, Nottingham, UK
    Eur J Pharmacol 485:141-4. 2004
    ..Thus, two major pathways involved in vascular leakage in diabetic microangiopathy are amenable to therapeutic blockade by PKC-beta inhibition...
  30. ncbi request reprint Combining population health and baseline risk strategy by determining an age cutoff for initiating statins in patients with diabetes: a population-based study
    Sajith Siyambalapitiya
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Mansfield Road, Nottinghamshire NG17 4JL UK
    Diabetes Care 30:2025-9. 2007
    ..By considering different strategies, we also aim to assess the effectiveness and efficiency of different strategies to reduce CVD events...
  31. ncbi request reprint Dipeptidyl peptidase-IV inhibitors: a major new class of oral antidiabetic drug
    Iskandar Idris
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals NHS Trust, Mansfield, UK
    Diabetes Obes Metab 9:153-65. 2007
    ..DPP-IV inhibitors represent a major new class of oral antidiabetic drug and their metabolic profile offers a number of unique clinical advantages for the management of type 2 diabetes...
  32. ncbi request reprint Improving patients' knowledge on the relationship between HbA1c and mean plasma glucose improves glycaemic control among persons with poorly controlled diabetes
    Nosheen Iqbal
    Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
    Ann Clin Biochem 45:504-7. 2008
    ..Recent recommendation advocates the reporting of HbA1c in terms of mean plasma glucose. We examined the impact of improving patients' interpretation of a given HbA1c value on glycaemic control...
  33. doi request reprint National Institute of Clinical Excellence provides an update on the clinical management of patients with type 2 diabetes
    Iskandar Idris
    Diabetes Obes Metab 10:605-6. 2008
  34. ncbi request reprint Insulin action in skeletal muscle: isozyme-specific effects of protein kinase C
    Iskandar Idris
    Division of Vascular Medicine, School of Medical and Surgical Sciences, University of Nottingham, Derbyshire Royal Infirmary, United Kingdom
    Ann N Y Acad Sci 967:176-82. 2002
    ..Hence, pharmacological therapies targeting specific PKC isoforms could enhance insulin action and improve glycemic control in patients with impaired glucose tolerance and overt diabetes...
  35. ncbi request reprint Exendin-4 increases insulin sensitivity via a PI-3-kinase-dependent mechanism: contrasting effects of GLP-1
    Iskandar Idris
    Division of Vascular Medicine, School of Medical and Surgical Sciences, University of Nottingham, Derbyshire Royal Infirmary, DE1 2QY, Derby, UK
    Biochem Pharmacol 63:993-6. 2002
    ..Furthermore, the contrasting responses of exendin and GLP-1 in 3T3-adipocytes suggest that the peripheral insulin-sensitizing effect of exendin-4 (in contrast to the insulinotropic effect) does not involve the GLP-1 receptor pathway...
  36. ncbi request reprint Safety of very tight glucose control in type 2 diabetes in question
    Iskandar Idris
    Sherwood Forest Hospitals Foundation Trust, UK
    Diabetes Obes Metab 10:438. 2008
  37. ncbi request reprint Coexistence of smoking and metabolic syndrome among middle-aged patients with diabetes in the UK: a cross-sectional analysis
    Uditha Bulugahapitiya
    Diab Vasc Dis Res 4:241-2. 2007