Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathyIskandar Idris
John Peace Diabetes Centre, Kings Mill Hospital, Sherwood Hospitals NHS Trust, Sutton in Ashfield, Nottinghamshire, NG17 4JL, UK
Diab Vasc Dis Res 3:172-8. 2006
..Initial studies suggest that this agent decreased the development of sight-threatening macular oedema and the occurrence of visual loss. It did not, however, prevent the progression of diabetic retinopathy...
- Familial hyperinsulinaemia associated with epilepsy and mental retardation--a syndrome of familial insulin resistance
I Idris
Department of Diabetes, Endocrinology and Nutrition, Queens Medical Centre, Nottingham, UK
Diabet Med 21:628-31. 2004
..Whilst a variety of congenital syndromes of insulin resistance are identified by their characteristic clinical phenotypes, an association with epilepsy and mental retardation has not previously been reported...
- Maternal hypothyroidism in early and late gestation: effects on neonatal and obstetric outcome
Iskandar Idris
Department of Diabetes and Endocrinology, Nottingham City Hospital, UK
Clin Endocrinol (Oxf) 63:560-5. 2005
..The effects of thyroxine dose requirement during pregnancy and serum concentrations of TSH within such clinic settings are still not known...
- Effects of maternal hyperthyroidism during early gestation on neonatal and obstetric outcome
Iskandar Idris
Clin Endocrinol (Oxf) 65:133-5. 2006
Relation between age and coronary heart disease (CHD) risk in Asian Indian patients with diabetes: A cross-sectional and prospective cohort studyI Idris
Sherwood Forest Hospitals Foundation Trust and Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, UK
Diabetes Res Clin Pract 81:243-9. 2008
..We aimed to determine an age threshold above which patients develop a higher risk of CHD and would merit routine statin prescription...
- Responders to insulin therapy at 18 months in adults with newly diagnosed diabetes: which insulin regimen?
I Idris
School of Graduate Entry Medicine, University of Nottingham, Derby, UK
Diabet Med 30:e95-100. 2013
..To describe baseline characteristics of responders to insulin therapy (HbA(1c) targets < 58 mmol/mol, 7.5%) at 18 months among adults with newly diagnosed diabetes...
- Exenatide improves excessive daytime sleepiness and wakefulness in obese patients with type 2 diabetes without obstructive sleep apnoea
Iskandar Idris
Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
J Sleep Res 22:70-5. 2013
..These findings could form a basis for further studies to investigate the pathophysiological mechanisms of sleepiness in obese patients with type 2 diabetes...
- Association between thiazolidinedione treatment and risk of macular edema among patients with type 2 diabetes
Iskandar Idris
Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, England
Arch Intern Med 172:1005-11. 2012
..We evaluated, in patients with type 2 diabetes (T2D), the short-term and long-term risks of developing DME among users vs nonusers of thiazolidinediones...
- Diabetes mellitus and stroke
I Idris
John Pease Diabetes Centre, Sherwood Forest Hospitals NHS Trust, Nottinghamshire, UK
Int J Clin Pract 60:48-56. 2006
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- Does close glycaemic control promote healing in diabetic foot ulcers? Report of a feasibility study
I Idris
Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham, UK
Diabet Med 22:1060-3. 2005
..To undertake a pilot study to determine the feasibility of a definitive trial of the effect of close glycaemic control on healing of foot ulcers in diabetes...
- Sodium-glucose co-transporter-2 inhibitors: an emerging new class of oral antidiabetic drug
Iskandar Idris
Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
Diabetes Obes Metab 11:79-88. 2009
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- Obstructive sleep apnoea in patients with type 2 diabetes: aetiology and implications for clinical care
Iskandar Idris
Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
Diabetes Obes Metab 11:733-41. 2009
..The clinical implications are discussed...
- Discordance between non-HDL cholesterol and LDL cholesterol levels in patients with diabetes without previous cardiovascular events
I Idris
Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
Diabetes Metab 36:299-304. 2010
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- Concordance between plasma apolipoprotein B levels and cholesterol indices among patients receiving statins and nonstatin treatment: Post-hoc analyses from the U.K. InPractice study
Iskandar Idris
Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
J Clin Lipidol 5:316-23. 2011
..Current evidence has shown a degree of discordance between LDL-C with ApoB levels among patients not receiving lipid-lowering therapy. The extent of this discordance among patients receiving LDL-lowering therapies however is less clear...
- Age threshold for vascular prophylaxis by aspirin in patients without diabetes
U Bulugahapitiya
Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, UK
Heart 94:1429-32. 2008
..To determine an appropriate age threshold at which to prescribe aspirin for primary cardiovascular disease (CVD) prevention among men and women without diabetes...
- Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes
I Idris
School of Medical and Surgical Sciences, University of Nottingham, Royal Infirmary, Derby, UK
Diabetologia 44:659-73. 2001
..Thus, a greater understanding of the functional diversity and pathophysiological regulation of PKC isozymes is likely to have important clinical and therapeutic benefits...
Obstructive sleep apnoea is independently associated with the metabolic syndrome but not insulin resistance stateA Gruber
Sherwood Forest Hospitals NHS Trust, Nottinghamshire, Mansfield, UK
Cardiovasc Diabetol 5:22. 2006
..Appropriate pharmacological intervention targeting these independent factors is important in reducing the increased CV risks among patients with OSA...
- Increased skeletal muscle expression of PKC-theta but not PKC-alpha mRNA in type 2 diabetes: inverse relationship with in-vivo insulin sensitivity
S Gray
School of Medical and Surgical Sciences, Centre for Integrated Systems Biology and Medicine, University of Nottingham, Derby, UK
Eur J Clin Invest 33:983-7. 2003
..The results indicate that transcriptional up-regulation of PKC-theta may at least partly contribute to the increased muscle PKC-theta signalling in T2DM, and that PKC-theta mRNA may be inversely related to in-vivo insulin sensitivity...
- Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research
R Donnelly
School of Medical and Surgical Sciences, University of Nottingham, Derbyshire Royal Infirmary, Derby DE1 2QY, UK
Br J Ophthalmol 88:145-51. 2004
..TRANSLATIONAL RESEARCH IN PRACTICE: a PKC-beta inhibitor for diabetic retinopathy..
- Cardiovascular and metabolic risk profiles in young and old patients with type 2 diabetes
W Gunathilake
Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
QJM 103:881-4. 2010
..Young patients (aged < 40 years) with type 2 diabetes (T2D) have a high lifetime risk of developing cardiovascular disease (CVD). However, little is known about the CVD risk profile of this cohort in the UK primary care setting...
- Predictors of responders to insulin therapy at 1 year among adults with type 2 diabetes
V Owen
East Midlands Research Support Unit, University of Nottingham, University Park, Nottingham, UK
Diabetes Obes Metab 12:865-70. 2010
..This study aims to determine baseline parameters including body mass index (BMI) threshold that might predict responders to insulin therapy...
- Tissue- and time-dependent effects of endothelin-1 on insulin-stimulated glucose uptake
I Idris
School of Medical and Surgical Sciences, University of Nottingham, Derby, UK
Biochem Pharmacol 62:1705-8. 2001
..It is therefore unlikely that chronic hyperendothelinaemia has a direct insulin-antagonist effect contributing to peripheral (ie muscle/fat) insulin resistance in vivo...
- Is diabetes a coronary risk equivalent? Systematic review and meta-analysis
U Bulugahapitiya
Sherwood Forest Hospitals Foundation Trust and Academic Unit of Diabetes, Endocrinology and Metabolism, University of Sheffield, Sheffield, UK
Diabet Med 26:142-8. 2009
..To determine whether patients with diabetes without prior myocardial infarction (MI) have the same risk of total coronary heart disease (CHD) events as non-diabetic patients with previous myocardial infarction...
- Serum urea and total cholesterol independently predict re-hospitalisation with a cardiac-related event following an acute ST-elevation myocardial infarction
A Gruber
Sherwood Forest Hospitals NHS Trust, Nottinghamshire, UK
Eur J Intern Med 18:531-4. 2007
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- Rosiglitazone and pulmonary oedema: an acute dose-dependent effect on human endothelial cell permeability
I Idris
School of Medical and Surgical Sciences, University of Nottingham, UK
Diabetologia 46:288-90. 2003
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- Erythromelia, or Mitchell's syndrome--new names for unexplained signs of inflammation in distal symmetrical neuropathy in diabetes
W J Jeffcoate
Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham, UK
Diabet Med 21:1334-8. 2004
..The vasodilation was associated with swelling and stiffness, but was painless and self-limiting...
- HbA1c during pregnancy: its relationship to meal related glycaemia and neonatal birth weight in patients with diabetes
R A Gandhi
Department of Diabetes and Endocrinology, Nottingham City Hospital, Nottingham, UK
Eur J Obstet Gynecol Reprod Biol 138:45-8. 2008
..We therefore aimed to establish the strength of the association between mean HBG profiles and HbA1c in diabetic pregnancies and whether HbA1c levels and glycaemic variability affects neonatal birth weight (NBW)...
- Protein kinase C-beta inhibition and diabetic microangiopathy: effects on endothelial permeability responses in vitro
Iskandar Idris
Centre for Integrated Systems Biology and Medicine, School of Medical and Surgical Sciences, University of Nottingham, Nottingham, UK
Eur J Pharmacol 485:141-4. 2004
..Thus, two major pathways involved in vascular leakage in diabetic microangiopathy are amenable to therapeutic blockade by PKC-beta inhibition...
- Combining population health and baseline risk strategy by determining an age cutoff for initiating statins in patients with diabetes: a population-based study
Sajith Siyambalapitiya
Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Mansfield Road, Nottinghamshire NG17 4JL UK
Diabetes Care 30:2025-9. 2007
..By considering different strategies, we also aim to assess the effectiveness and efficiency of different strategies to reduce CVD events...
- Coexistence of smoking and metabolic syndrome among middle-aged patients with diabetes in the UK: a cross-sectional analysis
Uditha Bulugahapitiya
Diab Vasc Dis Res 4:241-2. 2007
- Safety of very tight glucose control in type 2 diabetes in question
Iskandar Idris
Sherwood Forest Hospitals Foundation Trust, UK
Diabetes Obes Metab 10:438. 2008
- National Institute of Clinical Excellence provides an update on the clinical management of patients with type 2 diabetes
Iskandar Idris
Diabetes Obes Metab 10:605-6. 2008
- Insulin action in skeletal muscle: isozyme-specific effects of protein kinase C
Iskandar Idris
Division of Vascular Medicine, School of Medical and Surgical Sciences, University of Nottingham, Derbyshire Royal Infirmary, United Kingdom
Ann N Y Acad Sci 967:176-82. 2002
..Hence, pharmacological therapies targeting specific PKC isoforms could enhance insulin action and improve glycemic control in patients with impaired glucose tolerance and overt diabetes...
- Exendin-4 increases insulin sensitivity via a PI-3-kinase-dependent mechanism: contrasting effects of GLP-1
Iskandar Idris
Division of Vascular Medicine, School of Medical and Surgical Sciences, University of Nottingham, Derbyshire Royal Infirmary, DE1 2QY, Derby, UK
Biochem Pharmacol 63:993-6. 2002
..Furthermore, the contrasting responses of exendin and GLP-1 in 3T3-adipocytes suggest that the peripheral insulin-sensitizing effect of exendin-4 (in contrast to the insulinotropic effect) does not involve the GLP-1 receptor pathway...
- Dipeptidyl peptidase-IV inhibitors: a major new class of oral antidiabetic drug
Iskandar Idris
Department of Diabetes and Endocrinology, Sherwood Forest Hospitals NHS Trust, Mansfield, UK
Diabetes Obes Metab 9:153-65. 2007
..DPP-IV inhibitors represent a major new class of oral antidiabetic drug and their metabolic profile offers a number of unique clinical advantages for the management of type 2 diabetes...
- Improving patients' knowledge on the relationship between HbA1c and mean plasma glucose improves glycaemic control among persons with poorly controlled diabetes
Nosheen Iqbal
Department of Diabetes and Endocrinology, Sherwood Forest Hospitals Foundation Trust, Nottinghamshire, UK
Ann Clin Biochem 45:504-7. 2008
..Recent recommendation advocates the reporting of HbA1c in terms of mean plasma glucose. We examined the impact of improving patients' interpretation of a given HbA1c value on glycaemic control...
