Human umbilical cord blood-derived mononuclear cell transplantation: case series of 30 subjects with hereditary ataxiaWan Zhang Yang
Shenzhen Beike Cell Engineering Research Institution, Shenzhen, China
J Transl Med 9:65. 2011
..This open label treatment study used human umbilical cord blood-derived mononuclear cells (CBMC) combined with rehabilitation training as potential disease modulators...
- The King is Dead, Long Live the King: Entering A New Era of Stem Cell Research and Clinical Development
Thomas Ichim
Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
J Transl Med 9:218. 2011
..These events signal the entrance of the field of stem cells into a new era: an era where hype and misinformation no longer triumph over economic and medical realities...
- Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
Thomas E Ichim
Department of Orthomolecular Studies, Riordan Clinic, 3100 N Hillside, Wichita, Kansas 67210, USA
J Transl Med 9:25. 2011
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- Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for Creutzfeldt-Jakob disease
Alexia L McKnight
University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA
J Transl Med 8:125. 2010
..This study attempts to answer the questions "Could MRI detect prion diseases before clinical symptoms appear?, and if so, with what confidence?"..
- Circulating endothelial progenitor cells: a new approach to anti-aging medicine?
Nina A Mikirova
Bio Communications Research Institute, Wichita, Kansas, USA
J Transl Med 7:106. 2009
..We conclude by discussing several clinically-relevant approaches to EPC mobilization and provide preliminary data on a food supplement, Stem-Kine, which enhanced EPC mobilization in human subjects...
- Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia?
Michael P Murphy
Division of Vascular Surgery, Indiana University School of Medicine, Indiana, USA
J Transl Med 6:45. 2008
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- Anti-angiogenic effect of high doses of ascorbic acid
Nina A Mikirova
Bio Communications Research Institute, Wichita, Kansas, USA
J Transl Med 6:50. 2008
..Suppression of NO (nitric oxide) generation appeared to be one of the mechanisms by which AA mediated angiostatic effects. This study supports further investigation into non-cytotoxic antitumor activities of AA...
- Endometrial regenerative cells: a novel stem cell population
Xiaolong Meng
Bio Communications Research Institute, Wichita, USA
J Transl Med 5:57. 2007
..Given the ease of extraction and pluripotency of this cell population, we propose ERC as a novel alternative to current stem cells sources...
- RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis
Xiufen Zheng
Departments of Surgery, Pathology, Microbiology and Immunology, University of Western Ontario, 1393 Western Road, London, Ontario, N6G 1G9, Canada
Arthritis Res Ther 12:R13. 2010
..The current study evaluated a practical method of immune modulation through temporary systemic inhibition of the costimulatory molecule CD40...
- Exosomes as a tumor immune escape mechanism: possible therapeutic implications
Thomas E Ichim
Medistem Laboratories Inc, San Diego, USA
J Transl Med 6:37. 2008
..We conclude by discussing a novel therapeutic approach to cancer immune suppression by extracorporeal removal of exosomes using hollow fiber filtration technology...
Circulating endothelial progenitor cells and erectile dysfunction: possibility of nutritional intervention?T E Ichim
Department of Urology, Medistem Inc, San Diego, CA 92121, USA
Panminerva Med 52:75-80. 2010
..Interventions aimed at increasing circulating EPC may have potential in treatment of vascular ED...
- Stem cell therapy for autism
Thomas E Ichim
Medistem Laboratories Inc, Tempe, Arizona, USA
J Transl Med 5:30. 2007
..Additionally, anecdotal clinical cases have reported responses in autistic children receiving cord blood CD34+ cells. We propose the combined use of MSC and cord blood CD34+cells may be useful in the treatment of autism...
Autologous stromal vascular fraction cells: a tool for facilitating tolerance in rheumatic diseaseThomas E Ichim
Medistem Inc, San Diego, CA, USA
Cell Immunol 264:7-17. 2010
..We discuss the application of this autologous cell source in the context of rheumatoid arthritis, concluding with some practical examples of its applications...
- Combination stem cell therapy for heart failure
Thomas E Ichim
Medistem Inc, San Diego, USA
Int Arch Med 3:5. 2010
..We conclude by describing a case report of a heart failure patient treated with a combination stem cell protocol in an attempt to augment beneficial aspects of cord blood CD34 cells and mesenchymal-like stem cells...
- Safety evaluation of allogeneic umbilical cord blood mononuclear cell therapy for degenerative conditions
Wan Zhang Yang
Nanshan Affiliated Hospital of Guangdong Medical College, Shenzhen, China
J Transl Med 8:75. 2010
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- Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis
Neil H Riordan
Medistem Inc, San Diego, CA, USA
J Transl Med 7:29. 2009
..Based on this rationale and initial experiences, we propose controlled trials of autologous SVF in various inflammatory conditions...
- Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy
Thomas E Ichim
Medistem Inc, San Diego, CA 92122, USA
Cell Immunol 260:75-82. 2010
..We conclude by describing one practical scenario of stem cell therapy for DMD...
- Feasibility investigation of allogeneic endometrial regenerative cells
Zhaohui Zhong
Medistem Inc, San Diego, USA
J Transl Med 7:15. 2009
..These preliminary data suggest feasibility of clinical ERC administration and support further studies with this novel stem cell type...
- Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report
Thomas E Ichim
Medistem Inc, San Diego, USA
Int Arch Med 3:30. 2010
..Recovery of muscle, bowel and sexual function was noted, along with a decrease in ASIA score to "D". This case supports further investigation into allogeneic-based stem cell therapies for SCI...
- Exogenous endothelial cells as accelerators of hematopoietic reconstitution
J Christopher Mizer
Regen BioPharma Inc, San Diego, CA, USA
J Transl Med 10:231. 2012
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- Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects
Nina A Mikirova
Medistem Inc, San Diego, California, USA
J Transl Med 8:34. 2010
..These data suggest Stem-Kine supplementation may be useful as a stimulator of reparative processes associated with mobilization of hematopoietic and endothelial progenitors...
- Cord blood in regenerative medicine: do we need immune suppression?
Neil H Riordan
Medistem Laboratories Inc, Tempe, Arizona, USA
J Transl Med 5:8. 2007
..The previous use of unmatched cord blood in absence of any immune ablation, as well as potential steps for widespread clinical implementation of allogeneic cord blood grafts will also be discussed...
- Placental mesenchymal and cord blood stem cell therapy for dilated cardiomyopathy
Thomas E Ichim
Medistem Laboratories Inc, 2027 E Cedar Street Suite 102 Tempe, AZ 85281, USA
Reprod Biomed Online 16:898-905. 2008
..Presented here is case report of a patient with dilated cardiomyopathy treated with intravenous allogeneic mesenchymal stem cells and expanded umbilical cord blood CD34 cells who underwent a profound clinical improvement...
- Immunotherapy for melanoma: current status and perspectives
Doru T Alexandrescu
Division of Dermatology, University of California at San Diego, San Diego, CA, USA
J Immunother 33:570-90. 2010
..The need to engineer better immune interactions and to boost positive feedback loops appear crucial for the future of melanoma therapy, which ultimately resides in our understanding of the complexity of immune responses in this disease...
- Endometrial regenerative cells for treatment of heart failure: a new stem cell enters the clinic
Leo Bockeria
Bacoulev Institute for Cardiovascular Surgery, Moscow, Russia
J Transl Med 11:56. 2013
..The combined use of a novel "off the shelf" cell together with a minimally invasive 30 minute delivery method provides a potentially paradigm-shifting approach to cardiac regenerative therapy...
- Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma
Ray Chun Fai Chan
Department of Research and Development, Inovio Biomedical Corporation, San Diego, CA 92121 1318, USA
Oncol Rep 22:1197-203. 2009
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- Successful penile replantation with adjuvant hyperbaric oxygen treatment
Zhaohui Zhong
Department of Urology, The Second Xiangya Hospital of Central South University, Changsha, China
Urology 69:983.e3-5. 2007
..Of particular interest was the use of hyperbaric oxygen to accelerate the healing process. A review of the published data and future methods of increasing success of such surgical procedures is provided...
- Therapeutic use of Aldara in chronic myeloid leukemia
Annette M Marleau
Medistem Laboratories Inc, Tempe, Arizona, USA
J Transl Med 5:4. 2007
..The practical use of Aldara as a localized activator of DC in the context of present day leukemic therapeutics, as well as various properties of this unique immune modulator will be discussed...
- RNA interference: a potent tool for gene-specific therapeutics
Thomas E Ichim
Department of Surgery, Microbiology and Immunology, University of Western Ontario, ON, Canada
Am J Transplant 4:1227-36. 2004
..In this review we will present a brief history of RNAi, methods of inducing RNAi, application of RNAi in the therapeutic setting, and the possibilities of using this highly promising approach in the context of transplantation...
- Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis
Ashraf J Abusamra
London Health Science Centers, London, Ontario, Canada
Blood Cells Mol Dis 35:169-73. 2005
..Addition of anti-FasL antibody blocked the apoptosis induction by tumor exosomes. This study suggests that induction of T-cell apoptosis by tumor-derived exosomes appears to be a novel mechanism of tumor immune evasion...
- Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant
Dmitri Loukinov
National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
J Cell Biochem 98:1037-43. 2006
..This is the first report demonstrating the feasibility of vaccination with a cancer associated epigenetic regulator for the induction of tumor inhibition...
- Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine
Igor Popov
Department of Surgery, London Health Science Centre, London, Canada
Arthritis Res Ther 8:R141. 2006
..In conclusion, we demonstrate that in vitro-generated antigen-specific immature DC may have important potential as a tolerogenic vaccine for the treatment of autoimmune arthritis...
- Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites
Anahit Ghochikyan
Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA
J Immunol 178:566-73. 2007
..These cytolytic responses were observed across a wide range of different mouse cancers including mammary adenocarcinoma, glioma, leukemia, and mastocytoma...
- Antigen-specific therapy of rheumatoid arthritis
Thomas E Ichim
University of Western Ontario, Departments of Surgery, Pathology, Microbiology and Immunology, 339 Windermere Road, University Hospital C9 136, London, Ontario, N6A 5A5, Canada
Expert Opin Biol Ther 8:191-9. 2008
..Substantial advances have been made in recent years in terms of understanding basic immunological mechanisms of autoreactivity, as well as clinically implementing immune-based therapies that are antigen nonspecific...
- Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells
Wei Ping Min
Department of Surgery, University of Western Ontario, London, Ontario, Canada
Transplantation 75:1160-5. 2003
..This study addressed whether these two reagents act synergistically to inducing tolerance, and investigated associated cellular mechanisms...
