Thomas E Ichim

Summary

Publications

  1. pmc Human umbilical cord blood-derived mononuclear cell transplantation: case series of 30 subjects with hereditary ataxia
    Wan Zhang Yang
    Shenzhen Beike Cell Engineering Research Institution, Shenzhen, China
    J Transl Med 9:65. 2011
  2. pmc Comparison of endometrial regenerative cells and bone marrow stromal cells
    Huan Wang
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Transl Med 10:207. 2012
  3. pmc Intracavernous administration of bone marrow mononuclear cells: a new method of treating erectile dysfunction?
    Thomas E Ichim
    Institute for Molecular Medicine, Huntington Beach, CA, USA
    J Transl Med 11:139. 2013
  4. pmc The King is Dead, Long Live the King: Entering A New Era of Stem Cell Research and Clinical Development
    Thomas Ichim
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Transl Med 9:218. 2011
  5. pmc Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
    Thomas E Ichim
    Department of Orthomolecular Studies, Riordan Clinic, 3100 N Hillside, Wichita, Kansas 67210, USA
    J Transl Med 9:25. 2011
  6. pmc Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for Creutzfeldt-Jakob disease
    Alexia L McKnight
    University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA
    J Transl Med 8:125. 2010
  7. pmc Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia?
    Michael P Murphy
    Division of Vascular Surgery, Indiana University School of Medicine, Indiana, USA
    J Transl Med 6:45. 2008
  8. pmc Endometrial regenerative cells: a novel stem cell population
    Xiaolong Meng
    Bio Communications Research Institute, Wichita, USA
    J Transl Med 5:57. 2007
  9. pmc RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis
    Xiufen Zheng
    Departments of Surgery, Pathology, Microbiology and Immunology, University of Western Ontario, 1393 Western Road, London, Ontario, N6G 1G9, Canada
    Arthritis Res Ther 12:R13. 2010
  10. pmc Exosomes as a tumor immune escape mechanism: possible therapeutic implications
    Thomas E Ichim
    Medistem Laboratories Inc, San Diego, USA
    J Transl Med 6:37. 2008

Collaborators

Detail Information

Publications39

  1. pmc Human umbilical cord blood-derived mononuclear cell transplantation: case series of 30 subjects with hereditary ataxia
    Wan Zhang Yang
    Shenzhen Beike Cell Engineering Research Institution, Shenzhen, China
    J Transl Med 9:65. 2011
    ..This open label treatment study used human umbilical cord blood-derived mononuclear cells (CBMC) combined with rehabilitation training as potential disease modulators...
  2. pmc Comparison of endometrial regenerative cells and bone marrow stromal cells
    Huan Wang
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Transl Med 10:207. 2012
    ..Endometrial regenerative cells (ERC) and bone marrow stromal cells (BMSC) are being used in clinical trials. While they have been reported to have similar characteristics, they have not been directly compared...
  3. pmc Intracavernous administration of bone marrow mononuclear cells: a new method of treating erectile dysfunction?
    Thomas E Ichim
    Institute for Molecular Medicine, Huntington Beach, CA, USA
    J Transl Med 11:139. 2013
    ..Here we outline the rationale for use of autologous BMMC in patients with ED, as well as provide early safety data on the first use of this procedure clinically. ..
  4. pmc The King is Dead, Long Live the King: Entering A New Era of Stem Cell Research and Clinical Development
    Thomas Ichim
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Transl Med 9:218. 2011
    ..These events signal the entrance of the field of stem cells into a new era: an era where hype and misinformation no longer triumph over economic and medical realities...
  5. pmc Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?
    Thomas E Ichim
    Department of Orthomolecular Studies, Riordan Clinic, 3100 N Hillside, Wichita, Kansas 67210, USA
    J Transl Med 9:25. 2011
    ....
  6. pmc Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for Creutzfeldt-Jakob disease
    Alexia L McKnight
    University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square, PA 19348, USA
    J Transl Med 8:125. 2010
    ..This study attempts to answer the questions "Could MRI detect prion diseases before clinical symptoms appear?, and if so, with what confidence?"..
  7. pmc Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia?
    Michael P Murphy
    Division of Vascular Surgery, Indiana University School of Medicine, Indiana, USA
    J Transl Med 6:45. 2008
    ....
  8. pmc Endometrial regenerative cells: a novel stem cell population
    Xiaolong Meng
    Bio Communications Research Institute, Wichita, USA
    J Transl Med 5:57. 2007
    ..Given the ease of extraction and pluripotency of this cell population, we propose ERC as a novel alternative to current stem cells sources...
  9. pmc RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis
    Xiufen Zheng
    Departments of Surgery, Pathology, Microbiology and Immunology, University of Western Ontario, 1393 Western Road, London, Ontario, N6G 1G9, Canada
    Arthritis Res Ther 12:R13. 2010
    ..The current study evaluated a practical method of immune modulation through temporary systemic inhibition of the costimulatory molecule CD40...
  10. pmc Exosomes as a tumor immune escape mechanism: possible therapeutic implications
    Thomas E Ichim
    Medistem Laboratories Inc, San Diego, USA
    J Transl Med 6:37. 2008
    ..We conclude by discussing a novel therapeutic approach to cancer immune suppression by extracorporeal removal of exosomes using hollow fiber filtration technology...
  11. pmc Stem cell therapy for autism
    Thomas E Ichim
    Medistem Laboratories Inc, Tempe, Arizona, USA
    J Transl Med 5:30. 2007
    ..Additionally, anecdotal clinical cases have reported responses in autistic children receiving cord blood CD34+ cells. We propose the combined use of MSC and cord blood CD34+cells may be useful in the treatment of autism...
  12. pmc Combination stem cell therapy for heart failure
    Thomas E Ichim
    Medistem Inc, San Diego, USA
    Int Arch Med 3:5. 2010
    ..We conclude by describing a case report of a heart failure patient treated with a combination stem cell protocol in an attempt to augment beneficial aspects of cord blood CD34 cells and mesenchymal-like stem cells...
  13. doi request reprint Autologous stromal vascular fraction cells: a tool for facilitating tolerance in rheumatic disease
    Thomas E Ichim
    Medistem Inc, San Diego, CA, USA
    Cell Immunol 264:7-17. 2010
    ..We discuss the application of this autologous cell source in the context of rheumatoid arthritis, concluding with some practical examples of its applications...
  14. ncbi request reprint Circulating endothelial progenitor cells and erectile dysfunction: possibility of nutritional intervention?
    T E Ichim
    Department of Urology, Medistem Inc, San Diego, CA 92121, USA
    Panminerva Med 52:75-80. 2010
    ..Interventions aimed at increasing circulating EPC may have potential in treatment of vascular ED...
  15. pmc Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects
    Nina A Mikirova
    Medistem Inc, San Diego, California, USA
    J Transl Med 8:34. 2010
    ..These data suggest Stem-Kine supplementation may be useful as a stimulator of reparative processes associated with mobilization of hematopoietic and endothelial progenitors...
  16. pmc Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis
    Neil H Riordan
    Medistem Inc, San Diego, CA, USA
    J Transl Med 7:29. 2009
    ..Based on this rationale and initial experiences, we propose controlled trials of autologous SVF in various inflammatory conditions...
  17. pmc Safety evaluation of allogeneic umbilical cord blood mononuclear cell therapy for degenerative conditions
    Wan Zhang Yang
    Nanshan Affiliated Hospital of Guangdong Medical College, Shenzhen, China
    J Transl Med 8:75. 2010
    ....
  18. pmc Circulating endothelial progenitor cells: a new approach to anti-aging medicine?
    Nina A Mikirova
    Bio Communications Research Institute, Wichita, Kansas, USA
    J Transl Med 7:106. 2009
    ..We conclude by discussing several clinically-relevant approaches to EPC mobilization and provide preliminary data on a food supplement, Stem-Kine, which enhanced EPC mobilization in human subjects...
  19. doi request reprint Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy
    Thomas E Ichim
    Medistem Inc, San Diego, CA 92122, USA
    Cell Immunol 260:75-82. 2010
    ..We conclude by describing one practical scenario of stem cell therapy for DMD...
  20. pmc Exogenous endothelial cells as accelerators of hematopoietic reconstitution
    J Christopher Mizer
    Regen BioPharma Inc, San Diego, CA, USA
    J Transl Med 10:231. 2012
    ....
  21. pmc Feasibility investigation of allogeneic endometrial regenerative cells
    Zhaohui Zhong
    Medistem Inc, San Diego, USA
    J Transl Med 7:15. 2009
    ..These preliminary data suggest feasibility of clinical ERC administration and support further studies with this novel stem cell type...
  22. pmc Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report
    Thomas E Ichim
    Medistem Inc, San Diego, USA
    Int Arch Med 3:30. 2010
    ..Recovery of muscle, bowel and sexual function was noted, along with a decrease in ASIA score to "D". This case supports further investigation into allogeneic-based stem cell therapies for SCI...
  23. pmc Anti-angiogenic effect of high doses of ascorbic acid
    Nina A Mikirova
    Bio Communications Research Institute, Wichita, Kansas, USA
    J Transl Med 6:50. 2008
    ..Suppression of NO (nitric oxide) generation appeared to be one of the mechanisms by which AA mediated angiostatic effects. This study supports further investigation into non-cytotoxic antitumor activities of AA...
  24. pmc Cord blood in regenerative medicine: do we need immune suppression?
    Neil H Riordan
    Medistem Laboratories Inc, Tempe, Arizona, USA
    J Transl Med 5:8. 2007
    ..The previous use of unmatched cord blood in absence of any immune ablation, as well as potential steps for widespread clinical implementation of allogeneic cord blood grafts will also be discussed...
  25. pmc Immunotherapy for melanoma: current status and perspectives
    Doru T Alexandrescu
    Division of Dermatology, University of California at San Diego, San Diego, CA, USA
    J Immunother 33:570-90. 2010
    ..The need to engineer better immune interactions and to boost positive feedback loops appear crucial for the future of melanoma therapy, which ultimately resides in our understanding of the complexity of immune responses in this disease...
  26. ncbi request reprint Placental mesenchymal and cord blood stem cell therapy for dilated cardiomyopathy
    Thomas E Ichim
    Medistem Laboratories Inc, 2027 E Cedar Street Suite 102 Tempe, AZ 85281, USA
    Reprod Biomed Online 16:898-905. 2008
    ..Presented here is case report of a patient with dilated cardiomyopathy treated with intravenous allogeneic mesenchymal stem cells and expanded umbilical cord blood CD34 cells who underwent a profound clinical improvement...
  27. ncbi request reprint Inhibition of intracranial glioma growth by endometrial regenerative cells
    Xiaodi Han
    Bio Communications Research Institute, Wichita, Kansas, USA
    Cell Cycle 8:606-10. 2009
    ..Further studies are needed to determine the qualitative differences between physiological angiogenesis, which seems to be supported by ERC and tumor angiogenesis which appeared to be inhibited...
  28. ncbi request reprint Enhancement of DNA cancer vaccine efficacy by combination with anti-angiogenesis in regression of established subcutaneous B16 melanoma
    Ray Chun Fai Chan
    Department of Research and Development, Inovio Biomedical Corporation, San Diego, CA 92121 1318, USA
    Oncol Rep 22:1197-203. 2009
    ....
  29. pmc Endometrial regenerative cells for treatment of heart failure: a new stem cell enters the clinic
    Leo Bockeria
    Bacoulev Institute for Cardiovascular Surgery, Moscow, Russia
    J Transl Med 11:56. 2013
    ..The combined use of a novel "off the shelf" cell together with a minimally invasive 30 minute delivery method provides a potentially paradigm-shifting approach to cardiac regenerative therapy...
  30. pmc Therapeutic use of Aldara in chronic myeloid leukemia
    Annette M Marleau
    Medistem Laboratories Inc, Tempe, Arizona, USA
    J Transl Med 5:4. 2007
    ..The practical use of Aldara as a localized activator of DC in the context of present day leukemic therapeutics, as well as various properties of this unique immune modulator will be discussed...
  31. ncbi request reprint Successful penile replantation with adjuvant hyperbaric oxygen treatment
    Zhaohui Zhong
    Department of Urology, The Second Xiangya Hospital of Central South University, Changsha, China
    Urology 69:983.e3-5. 2007
    ..Of particular interest was the use of hyperbaric oxygen to accelerate the healing process. A review of the published data and future methods of increasing success of such surgical procedures is provided...
  32. pmc Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites
    Anahit Ghochikyan
    Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA
    J Immunol 178:566-73. 2007
    ..These cytolytic responses were observed across a wide range of different mouse cancers including mammary adenocarcinoma, glioma, leukemia, and mastocytoma...
  33. pmc Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine
    Igor Popov
    Department of Surgery, London Health Science Centre, London, Canada
    Arthritis Res Ther 8:R141. 2006
    ..In conclusion, we demonstrate that in vitro-generated antigen-specific immature DC may have important potential as a tolerogenic vaccine for the treatment of autoimmune arthritis...
  34. ncbi request reprint Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant
    Dmitri Loukinov
    National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    J Cell Biochem 98:1037-43. 2006
    ..This is the first report demonstrating the feasibility of vaccination with a cancer associated epigenetic regulator for the induction of tumor inhibition...
  35. ncbi request reprint Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis
    Ashraf J Abusamra
    London Health Science Centers, London, Ontario, Canada
    Blood Cells Mol Dis 35:169-73. 2005
    ..Addition of anti-FasL antibody blocked the apoptosis induction by tumor exosomes. This study suggests that induction of T-cell apoptosis by tumor-derived exosomes appears to be a novel mechanism of tumor immune evasion...
  36. ncbi request reprint RNA interference: a potent tool for gene-specific therapeutics
    Thomas E Ichim
    Department of Surgery, Microbiology and Immunology, University of Western Ontario, ON, Canada
    Am J Transplant 4:1227-36. 2004
    ..In this review we will present a brief history of RNAi, methods of inducing RNAi, application of RNAi in the therapeutic setting, and the possibilities of using this highly promising approach in the context of transplantation...
  37. ncbi request reprint Antigen-specific therapy of rheumatoid arthritis
    Thomas E Ichim
    University of Western Ontario, Departments of Surgery, Pathology, Microbiology and Immunology, 339 Windermere Road, University Hospital C9 136, London, Ontario, N6A 5A5, Canada
    Expert Opin Biol Ther 8:191-9. 2008
    ..Substantial advances have been made in recent years in terms of understanding basic immunological mechanisms of autoreactivity, as well as clinically implementing immune-based therapies that are antigen nonspecific...
  38. ncbi request reprint Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells
    Wei Ping Min
    Department of Surgery, University of Western Ontario, London, Ontario, Canada
    Transplantation 75:1160-5. 2003
    ..This study addressed whether these two reagents act synergistically to inducing tolerance, and investigated associated cellular mechanisms...