Eirikur Steingrimsson

Summary

Affiliation: University of Iceland
Country: Iceland

Publications

  1. ncbi request reprint Mouse coat color mutations: from fancy mice to functional genomics
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, University of Iceland, Reykjavik, Iceland
    Dev Dyn 235:2401-11. 2006
  2. ncbi request reprint Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains
    Jón Hallsteinn Hallsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Pigment Cell Res 20:185-200. 2007
  3. pmc Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Proc Natl Acad Sci U S A 99:4477-82. 2002
  4. pmc Interallelic complementation at the mouse Mitf locus
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genetics 163:267-76. 2003
  5. ncbi request reprint Interpretation of complex phenotypes: lessons from the Mitf gene
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology and BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Pigment Cell Melanoma Res 23:736-40. 2010
  6. ncbi request reprint Melanocytes and the microphthalmia transcription factor network
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, University of Iceland, 101 Reykjavik, Iceland
    Annu Rev Genet 38:365-411. 2004
  7. pmc The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue
    Georg L Bauer
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Genetics 183:581-94. 2009
  8. pmc The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development
    Jón H Hallsson
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genetics 167:233-41. 2004
  9. ncbi request reprint Melanocyte stem cell maintenance and hair graying
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Cell 121:9-12. 2005
  10. pmc The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression
    Alexander Schepsky
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Mol Cell Biol 26:8914-27. 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Mouse coat color mutations: from fancy mice to functional genomics
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, University of Iceland, Reykjavik, Iceland
    Dev Dyn 235:2401-11. 2006
    ..The usefulness of coat color mutations has just begun to emerge...
  2. ncbi request reprint Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains
    Jón Hallsteinn Hallsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Pigment Cell Res 20:185-200. 2007
    ..Our analysis sheds new light on the conservation of the Mitf gene and protein and opens the door for further functional analysis...
  3. pmc Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Proc Natl Acad Sci U S A 99:4477-82. 2002
    ..These results suggest that heterodimeric interactions are not essential for Mitf-Tfe function in contrast to other bHLH-Zip families like Myc/Max/Mad, where heterodimeric interactions seem to be essential...
  4. pmc Interallelic complementation at the mouse Mitf locus
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genetics 163:267-76. 2003
    ..Our analysis suggests that Mitf(Mi-wh)-associated interallelic complementation is due to the unique biochemical nature of this mutation...
  5. ncbi request reprint Interpretation of complex phenotypes: lessons from the Mitf gene
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology and BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Pigment Cell Melanoma Res 23:736-40. 2010
    ..Here, the molecular, genetic, and phenotypic properties of this mutation are reviewed and an attempt made to explain the underlying biochemical reason for its observed effects...
  6. ncbi request reprint Melanocytes and the microphthalmia transcription factor network
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, University of Iceland, 101 Reykjavik, Iceland
    Annu Rev Genet 38:365-411. 2004
    ....
  7. pmc The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue
    Georg L Bauer
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Genetics 183:581-94. 2009
    ..Furthermore, as MITF and signaling mechanisms have been shown to play an important role in melanomas, our findings may lead to novel insights into this resilient disease...
  8. pmc The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development
    Jón H Hallsson
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genetics 167:233-41. 2004
    ..These findings further support the common origin of the vertebrate and invertebrate eyes...
  9. ncbi request reprint Melanocyte stem cell maintenance and hair graying
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Cell 121:9-12. 2005
    ....
  10. pmc The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression
    Alexander Schepsky
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Mol Cell Biol 26:8914-27. 2006
    ..Our results reveal a novel mechanism by which Wnt signaling and beta-catenin activate gene expression, with significant implications for our understanding of both melanocyte development and melanoma...
  11. pmc miR-148 regulates Mitf in melanoma cells
    Benedikta S Haflidadóttir
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    PLoS ONE 5:e11574. 2010
    ..Loss of this regulation, either by mutations or by shortening of the 3'UTR sequence, is therefore a likely factor in melanoma formation and/or progression...
  12. pmc A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway
    Christian Praetorius
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Cell 155:1022-33. 2013
    ..Our findings provide a clear example of a noncoding polymorphism that affects a phenotype by modulating a developmental gene regulatory network. ..
  13. pmc MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function
    Christine Grill
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, 101 Reykjavik, Iceland
    Hum Mol Genet 22:4357-67. 2013
    ..Our results provide molecular insights into how mutations in a single gene can lead to such different phenotypes. ..
  14. ncbi request reprint The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins
    Adalheidur Gígja Hansdottir
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genomics 83:932-5. 2004
    ..The novel mutations are phenotypically distinct from previously known Mitf mutations...
  15. ncbi request reprint Electroretinographic assessment of retinal function in microphthalmia mutant mice
    Anna Möller
    Department of Physiology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Exp Eye Res 78:837-48. 2004
    ..The reduced scotopic c-wave in Mitf(mi-bws)/Mitf(mi-bws) mice, without reduction in the scotopic a-wave indicates an RPE defect without photoreceptor involvement in these mice...
  16. ncbi request reprint Sun-induced freckling: ephelides and solar lentigines
    Christian Praetorius
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Pigment Cell Melanoma Res 27:339-50. 2014
    ..However, despite being commonly observed, we know very little about them. Here, we review the current status of knowledge about freckles and propose a model for their formation...
  17. pmc Expression and functional role of sprouty-2 in breast morphogenesis
    Valgardur Sigurdsson
    Stem Cell Research Unit, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    PLoS ONE 8:e60798. 2013
    ..These data indicate that SPRY2 is an important regulator of branching morphogenesis and epithelial to mesenchymal transition in the mammary gland...
  18. pmc A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1
    Martin I Sigurdsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    BMC Syst Biol 4:140. 2010
    ..Detailed metabolic reconstructions of mammals have recently emerged, including human reconstructions. They raise the question if the various successful applications of microbial reconstructions can be replicated in complex organisms...