Eirikur Steingrimsson

Summary

Affiliation: University of Iceland
Country: Iceland

Publications

  1. ncbi Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Proc Natl Acad Sci U S A 99:4477-82. 2002
  2. ncbi Mouse coat color mutations: from fancy mice to functional genomics
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, University of Iceland, Reykjavik, Iceland
    Dev Dyn 235:2401-11. 2006
  3. ncbi Melanocytes and the microphthalmia transcription factor network
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, University of Iceland, 101 Reykjavik, Iceland
    Annu Rev Genet 38:365-411. 2004
  4. ncbi Interpretation of complex phenotypes: lessons from the Mitf gene
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology and BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Pigment Cell Melanoma Res 23:736-40. 2010
  5. ncbi Interallelic complementation at the mouse Mitf locus
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genetics 163:267-76. 2003
  6. ncbi Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains
    Jón Hallsteinn Hallsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Pigment Cell Res 20:185-200. 2007
  7. ncbi The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue
    Georg L Bauer
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Genetics 183:581-94. 2009
  8. ncbi Melanocyte stem cell maintenance and hair graying
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Cell 121:9-12. 2005
  9. ncbi The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression
    Alexander Schepsky
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Mol Cell Biol 26:8914-27. 2006
  10. ncbi The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development
    Jón H Hallsson
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genetics 167:233-41. 2004

Collaborators

  • Neal G Copeland
  • Heinz Arnheiter
  • Martin Hrabe de Angelis
  • Ling Hou
  • Colin R Goding
  • Andreas Hecht
  • Bernhard Ø Palsson
  • Ines Thiele
  • Benedikta S Haflidadóttir
  • Alexander Schepsky
  • Jón H Hallsson
  • Martin I Sigurdsson
  • Kristin Bergsteinsdottir
  • Christian Praetorius
  • Georg L Bauer
  • Jón Hallsteinn Hallsson
  • Adalheidur Gígja Hansdottir
  • Anna Möller
  • Neema Jamshidi
  • Julien Debbache
  • Søren Warming
  • Bryndís K Gísladóttir
  • T Norene O'Sullivan
  • Keren Bismuth
  • Deborah A Swing
  • Colin Fletcher
  • Nancy A Jenkins
  • Gunnar J Gunnarsson
  • Jane Goodall
  • Katja Bruser
  • Helmut Fuchs
  • Ward Odenwald
  • Chad Stivers
  • John Favor
  • Karen Pálsdóttir
  • Angelika Neuhäuser-Klaus
  • Thor Eysteinsson
  • Francesca Pignoni

Detail Information

Publications14

  1. ncbi Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Proc Natl Acad Sci U S A 99:4477-82. 2002
    ..These results suggest that heterodimeric interactions are not essential for Mitf-Tfe function in contrast to other bHLH-Zip families like Myc/Max/Mad, where heterodimeric interactions seem to be essential...
  2. ncbi Mouse coat color mutations: from fancy mice to functional genomics
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, University of Iceland, Reykjavik, Iceland
    Dev Dyn 235:2401-11. 2006
    ..The usefulness of coat color mutations has just begun to emerge...
  3. ncbi Melanocytes and the microphthalmia transcription factor network
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, University of Iceland, 101 Reykjavik, Iceland
    Annu Rev Genet 38:365-411. 2004
    ....
  4. ncbi Interpretation of complex phenotypes: lessons from the Mitf gene
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology and BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Pigment Cell Melanoma Res 23:736-40. 2010
    ..Here, the molecular, genetic, and phenotypic properties of this mutation are reviewed and an attempt made to explain the underlying biochemical reason for its observed effects...
  5. ncbi Interallelic complementation at the mouse Mitf locus
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genetics 163:267-76. 2003
    ..Our analysis suggests that Mitf(Mi-wh)-associated interallelic complementation is due to the unique biochemical nature of this mutation...
  6. ncbi Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains
    Jón Hallsteinn Hallsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Pigment Cell Res 20:185-200. 2007
    ..Our analysis sheds new light on the conservation of the Mitf gene and protein and opens the door for further functional analysis...
  7. ncbi The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue
    Georg L Bauer
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Genetics 183:581-94. 2009
    ..Furthermore, as MITF and signaling mechanisms have been shown to play an important role in melanomas, our findings may lead to novel insights into this resilient disease...
  8. ncbi Melanocyte stem cell maintenance and hair graying
    Eirikur Steingrimsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Cell 121:9-12. 2005
    ....
  9. ncbi The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression
    Alexander Schepsky
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Mol Cell Biol 26:8914-27. 2006
    ..Our results reveal a novel mechanism by which Wnt signaling and beta-catenin activate gene expression, with significant implications for our understanding of both melanocyte development and melanoma...
  10. ncbi The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development
    Jón H Hallsson
    Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genetics 167:233-41. 2004
    ..These findings further support the common origin of the vertebrate and invertebrate eyes...
  11. ncbi miR-148 regulates Mitf in melanoma cells
    Benedikta S Haflidadóttir
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    PLoS ONE 5:e11574. 2010
    ..Loss of this regulation, either by mutations or by shortening of the 3'UTR sequence, is therefore a likely factor in melanoma formation and/or progression...
  12. ncbi The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins
    Adalheidur Gígja Hansdottir
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Iceland, 101 Reykjavik, Iceland
    Genomics 83:932-5. 2004
    ..The novel mutations are phenotypically distinct from previously known Mitf mutations...
  13. ncbi Electroretinographic assessment of retinal function in microphthalmia mutant mice
    Anna Möller
    Department of Physiology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Exp Eye Res 78:837-48. 2004
    ..The reduced scotopic c-wave in Mitf(mi-bws)/Mitf(mi-bws) mice, without reduction in the scotopic a-wave indicates an RPE defect without photoreceptor involvement in these mice...
  14. ncbi A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1
    Martin I Sigurdsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    BMC Syst Biol 4:140. 2010
    ..Detailed metabolic reconstructions of mammals have recently emerged, including human reconstructions. They raise the question if the various successful applications of microbial reconstructions can be replicated in complex organisms...