Agnar Helgason

Summary

Affiliation: University of Iceland
Country: Iceland

Publications

  1. pmc A populationwide coalescent analysis of Icelandic matrilineal and patrilineal genealogies: evidence for a faster evolutionary rate of mtDNA lineages than Y chromosomes
    Agnar Helgason
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 72:1370-88. 2003
  2. ncbi request reprint A reassessment of genetic diversity in Icelanders: strong evidence from multiple loci for relative homogeneity caused by genetic drift
    A Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Ann Hum Genet 67:281-97. 2003
  3. doi request reprint Two newly identified genetic determinants of pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:835-7. 2008
  4. doi request reprint Fine-scale recombination rate differences between sexes, populations and individuals
    Augustine Kong
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 467:1099-103. 2010
  5. doi request reprint Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits
    Simon N Stacey
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:1313-8. 2008
  6. ncbi request reprint Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:977-83. 2007
  7. doi request reprint ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:886-91. 2008
  8. ncbi request reprint Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:631-7. 2007
  9. ncbi request reprint Variants conferring risk of atrial fibrillation on chromosome 4q25
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 448:353-7. 2007
  10. ncbi request reprint Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    Agnar Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 39:218-25. 2007

Detail Information

Publications36

  1. pmc A populationwide coalescent analysis of Icelandic matrilineal and patrilineal genealogies: evidence for a faster evolutionary rate of mtDNA lineages than Y chromosomes
    Agnar Helgason
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 72:1370-88. 2003
    ..These findings may have implications for coalescent date estimates based on mtDNA and Y chromosomes...
  2. ncbi request reprint A reassessment of genetic diversity in Icelanders: strong evidence from multiple loci for relative homogeneity caused by genetic drift
    A Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Ann Hum Genet 67:281-97. 2003
    ..Overall, our analyses strongly indicate that the Icelandic gene pool is less heterogeneous than those of most other European populations...
  3. doi request reprint Two newly identified genetic determinants of pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:835-7. 2008
    ....
  4. doi request reprint Fine-scale recombination rate differences between sexes, populations and individuals
    Augustine Kong
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 467:1099-103. 2010
    ....
  5. doi request reprint Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits
    Simon N Stacey
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:1313-8. 2008
    ..Approximately 1.6% of individuals of European ancestry are homozygous for both variants, and their estimated risk of BCC is 2.68 times that of noncarriers...
  6. ncbi request reprint Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:977-83. 2007
    ..Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes...
  7. doi request reprint ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:886-91. 2008
    ..14, P = 6.1 x 10(-4)). An eye color variant in TYRP1 was associated with risk of CM (OR = 1.15, P = 4.6 x 10(-4)). The association of all three variants is robust with respect to adjustment for the effect of pigmentation...
  8. ncbi request reprint Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:631-7. 2007
    ..The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis...
  9. ncbi request reprint Variants conferring risk of atrial fibrillation on chromosome 4q25
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 448:353-7. 2007
    ..42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart...
  10. ncbi request reprint Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    Agnar Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 39:218-25. 2007
    ....
  11. doi request reprint Sequence variants in the RNF212 gene associate with genome-wide recombination rate
    Augustine Kong
    deCODE Genetics Inc, 101 Reykjavik, Iceland
    Science 319:1398-401. 2008
    ..Consequently, if the frequency of the haplotype changes, the average recombination rate will increase for one sex and decrease for the other, but the sex-averaged recombination rate of the population can stay relatively constant...
  12. pmc Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma
    Gudmar Thorleifsson
    deCODE Genetics Inc, Reykjavik, Iceland
    Nat Genet 42:906-9. 2010
    ..42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG...
  13. pmc The BARD1 Cys557Ser variant and breast cancer risk in Iceland
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    PLoS Med 3:e217. 2006
    ..We then used a computerized genealogy of the Icelandic population to study the relationships between the Cys557Ser variant and familial clustering of breast cancer...
  14. ncbi request reprint mtDNA variation in Inuit populations of Greenland and Canada: migration history and population structure
    Agnar Helgason
    deCODE Genetics, Inc, 101 Reykjavik, Iceland
    Am J Phys Anthropol 130:123-34. 2006
    ....
  15. ncbi request reprint Genetic determinants of hair, eye and skin pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:1443-52. 2007
    ..3 is associated with freckles. The fifth region provided refinements to a previously reported association in OCA2, and the sixth encompasses previously described variants in MC1R...
  16. pmc Rate of de novo mutations and the importance of father's age to disease risk
    Augustine Kong
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 488:471-5. 2012
    ..These observations shed light on the importance of the father's age on the risk of diseases such as schizophrenia and autism...
  17. ncbi request reprint Evaluating differences in linkage disequilibrium between populations
    Birgir Hrafnkelsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Ann Hum Genet 74:233-47. 2010
    ....
  18. ncbi request reprint Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer
    Simon N Stacey
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:865-9. 2007
    ..rs3803662 is near the 5' end of TNRC9 , a high mobility group chromatin-associated protein whose expression is implicated in breast cancer metastasis to bone...
  19. doi request reprint Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits
    Unnur Styrkarsdottir
    deCODE Genetics Amgen, 101 Reykjavik, Iceland
    Nature 497:517-20. 2013
    ..Interestingly, the phenotype of carriers of the c.376C>T mutation overlaps that of Lgr4 mutant mice...
  20. pmc Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    PLoS Genet 6:e1001029. 2010
    ..These studies demonstrate that shifting the analysis among ancestral populations can provide valuable resolution in association mapping...
  21. doi request reprint Genetics of gene expression and its effect on disease
    Valur Emilsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:423-8. 2008
    ..A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits...
  22. pmc A rare variant in MYH6 is associated with high risk of sick sinus syndrome
    Hilma Holm
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 43:316-20. 2011
    ..53 and P = 1.5 × 10⁻²⁹. We show that the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant...
  23. pmc Sequences from first settlers reveal rapid evolution in Icelandic mtDNA pool
    Agnar Helgason
    deCODE Genetics, Reykjavik, Iceland
    PLoS Genet 5:e1000343. 2009
    ..These results demonstrate the inferential power gained in ancient DNA studies through the application of population genetics analyses to relatively large samples...
  24. doi request reprint A new subclade of mtDNA haplogroup C1 found in Icelanders: evidence of pre-Columbian contact?
    Sigríður Sunna Ebenesersdóttir
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Am J Phys Anthropol 144:92-9. 2011
    ..Rather, it is presently the only known member of a new subclade, C1e. While a Native American origin seems most likely for C1e, an Asian or European origin cannot be ruled out...
  25. ncbi request reprint Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes
    Valgerdur Steinthorsdottir
    deCODE Genetics Amgen, Inc, Reykjavik, Iceland
    Nat Genet 46:294-8. 2014
    ..23, P = 3.9 × 10(-10) and OR = 1.47, P = 1.7 × 10(-5), respectively), and a rare (0.20%) frameshift variant in PDX1, encoding p.Gly218Alafs*12, associates with high risk of T2D (OR = 2.27, P = 7.3 × 10(-7)). ..
  26. pmc A drastic reduction in the life span of cystatin C L68Q carriers due to life-style changes during the last two centuries
    Astridur Palsdottir
    Institute for Experimental Pathology, University of Iceland, Keldur, Reykjavik, Iceland
    PLoS Genet 4:e1000099. 2008
    ....
  27. ncbi request reprint A common variant associated with prostate cancer in European and African populations
    Laufey T Amundadottir
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 38:652-8. 2006
    ..This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry...
  28. ncbi request reprint Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    Struan F A Grant
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 38:320-3. 2006
    ..It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway...
  29. pmc The past, present, and future of direct-to-consumer genetic tests
    Agnar Helgason
    deCODE Genetics, Reykjavik, Iceland
    Dialogues Clin Neurosci 12:61-8. 2010
    ..In this paper, we review the current state and future prospects of such genetic tests, as scientists involved both in the discovery of disease associations and the development of genetic tests...
  30. doi request reprint Identification of low-frequency variants associated with gout and serum uric acid levels
    Patrick Sulem
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 43:1127-30. 2011
    ..This variant is close to a common variant previously associated with serum uric acid levels. This work illustrates how whole-genome sequencing data allow the detection of associations between low-frequency variants and complex traits...
  31. ncbi request reprint A statistical approach to identify ancient template DNA
    Agnar Helgason
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    J Mol Evol 65:92-102. 2007
    ..The proposed approach is likely to be of general use to researchers working with DNA from ancient tissues, particularly from human remains, where authentication of results has been most challenging...
  32. ncbi request reprint An Icelandic example of the impact of population structure on association studies
    Agnar Helgason
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 37:90-5. 2005
    ..Our results indicate that sampling strategies need to take account of substructure even in a relatively homogenous genetic isolate. This will probably be even more important in larger populations...
  33. ncbi request reprint A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 38:68-74. 2006
    ..Interactions with other genetic or environmental risk factors that are more common in African Americans are likely to account for the greater relative risk conferred by HapK in this group...
  34. ncbi request reprint A common inversion under selection in Europeans
    Hreinn Stefansson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 37:129-37. 2005
    ..Here we show that the H2 lineage is undergoing positive selection in the Icelandic population, such that carrier females have more children and have higher recombination rates than noncarriers...
  35. doi request reprint An association between the kinship and fertility of human couples
    Agnar Helgason
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Science 319:813-6. 2008
    ....
  36. ncbi request reprint Blondes, lost and found: representations of genes, identity, and history
    Gisli Palsson
    Department of Anthropology, Oddi, University of Iceland, 101 Reykjavik, Iceland
    Dev World Bioeth 3:159-69. 2003
    ....