Affiliation: Landspitali University Hospital
- Treatment of acid-related diseases in the elderly with emphasis on the use of proton pump inhibitorsBjarni Thjodleifsson
Department of Medicine, University Hospital, Reykjavik, Iceland
Drugs Aging 19:911-27. 2002..Drug clearance decreases with age independently of CYP2C19 status, exaggerating some of the differences between the PPIs and increasing the risk of drug interactions...
- A randomized, double-blind trial of the efficacy and safety of 10 or 20 mg rabeprazole compared with 20 mg omeprazole in the maintenance of gastro-oesophageal reflux disease over 5 yearsB Thjodleifsson
University Hospital, Reykjavik, Iceland
Aliment Pharmacol Ther 17:343-51. 2003..Proton pump inhibitors are the treatment of choice for both acute and maintenance treatment, but little is known from randomized controlled trials of their effects beyond 1 year...
- A common genetic background for inflammatory bowel disease and ankylosing spondylitis: a genealogic study in IcelandBjarni Thjodleifsson
Landspitali University Hospital, Hringbraut, Reykjavik IS 401, Iceland
Arthritis Rheum 56:2633-9. 2007..This study was undertaken to examine the familial occurrence and cosegregation of AS and inflammatory bowel disease (IBD) in order to determine whether there is a shared genetic risk factor in families...
- Review of rabeprazole in the treatment of gastro-oesophageal reflux diseaseBjarni Thjodleifsson
Landspitali University Hospital, Department of Gastroenterology, Hringbraut, Reykjavik, 101 Iceland
Expert Opin Pharmacother 5:137-49. 2004..This paper reviews the use of PPIs in the treatment of GERD with particular focus on one of the newer agents, rabeprazole...
- Infections and obesity: A multinational epidemiological studyBjarni Thjodleifsson
Department of Medicine, Landspitali University Hospital Hringbraut, IS 101, Reykjavik, Iceland
Scand J Infect Dis 40:381-6. 2008..The results suggest that infections with Chlamydia pneumoniae and Helicobacter pylori are both significantly and synergistically associated with overweight and this association is not related to indicators of systemic inflammation...
- [Epidemiological study of functional bowel disorders in Iceland]Linda B Olafsdóttir
Iceland University Hospital, Hringbraut, 101 Reykjavik, Iceland
Laeknabladid 91:329-33. 2005..The aim of the present study was to evaluate the prevalence of functional bowel disorders (FBD) in a population-based sample and to assess FBD-related health care seeking and medication in Iceland...
- Seroprevalence of Helicobacter pylori and cagA antibodies in Iceland, Estonia and SwedenBjarni Thjodleifsson
Medical Department, Landspitali University Hospital, Iceland
Scand J Infect Dis 39:683-9. 2007..Overall, socioeconomic development during the childhood period seems to be the most important factor for the prevalence of H. pylori infection. In adults, smoking may be a contributory factor...
- Natural history of functional gastrointestinal disorders: comparison of two longitudinal population-based studiesLinda Bjork Olafsdottir
Department of Gastroenterology, Landspitali, Reykjavik, Iceland
Dig Liver Dis 44:211-7. 2012..Functional gastrointestinal disorders are common but information on their natural history is limited...
- Natural history of heartburn: a 10-year population-based studyLinda Bjork Olafsdottir
Department of Gastroenterology, Landspitali University Hospitol, and The Social Science Research Institute, University of Iceland, 101 Reykjavik, Iceland
World J Gastroenterol 17:639-45. 2011..To study the natural history and prevalence of heartburn at a 10-year interval, and to study the effect of heartburn on various symptoms and activities...
- Irritable bowel syndrome: physicians' awareness and patients' experienceLinda Bjork Olafsdottir
Department of Gastroenterology, Landspitali, Faculty of Medicine, University of Iceland, Hringbraut, 101 Reykjavik, Iceland
World J Gastroenterol 18:3715-20. 2012..To study if and how physicians use the irritable bowel syndrome (IBS) diagnostic criteria and to assess treatment strategies in IBS patients...
- Natural history of functional dyspepsia: a 10-year population-based studyLinda Bjork Olafsdottir
Department of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland
Digestion 81:53-61. 2010..Functional dyspepsia (FD) is a common disorder, but information on its natural history is limited...
- Natural history of irritable bowel syndrome in women and dysmenorrhea: a 10-year follow-up studyLinda Bjork Olafsdottir
Department of Gastroenterology, Landspitali University Hospital, 101 Reykjavik, Iceland
Gastroenterol Res Pract 2012:534204. 2012..Conclusion. Women with IBS are more likely to experience dysmenorrhea than women without IBS which seems to be a part of the symptomatology in most women with IBS. IBS symptom severity seems to increase after menopause...
- Persistent Chlamydia Pneumoniae serology is related to decline in lung function in women but not in men. Effect of persistent Chlamydia pneumoniae infection on lung functionThorarinn Gislason
University of Iceland, Faculty of Medicine, Reykjavik, Iceland
BMC Pulm Med 10:44. 2010..Chlamydia pneumoniae (C pn) infection causes an acute inflammation in the respiratory system that may become persistent, but little is known about the long-term respiratory effects of C pn infections...
- Trends in peptic ulcer morbidity and mortality in IcelandHildur Thors
Department of Gastroenterology, National University Hospital, 101 Reykjavik, Iceland
J Clin Epidemiol 55:681-6. 2002..These were the generations with the highest prevalence of H. pylori antibodies, the subjects born after the turn of the century at a time of maximum crowding and poor hygiene in Iceland due to the industrial revolution...
- Colonic adenomas found via colonoscopy: yield and risk factors for high-grade dysplasiaSjofn Kristjansdottir
Speglun ehf, Reykjavik, Iceland
Digestion 82:252-7. 2010..The adenoma-carcinoma sequence is the model for colorectal carcinoma (CRC) developing through high-grade dysplasia (HGD) to CRC. The aim was to assess prevalence and location of adenomas found during colonoscopy and risk factors for HGD...
- Subclinical intestinal inflammation: an inherited abnormality in Crohn's disease relatives?Bjarni Thjodleifsson
Department of Medicine, Iceland University Hospital, Reykjavik, Iceland
Gastroenterology 124:1728-37. 2003..We assessed the possible presence, prevalence, and inheritance pattern of subclinical intestinal inflammation in apparently healthy relatives of patients with Crohn's disease...
- Effects of 5 years of treatment with rabeprazole or omeprazole on the gastric mucosaGuido Rindi
University of Parma, Parma, Italy bDepartment of Pathology, University of Genoa, Italy
Eur J Gastroenterol Hepatol 17:559-66. 2005..The objective was to determine the effects of 5 years of treatment with rabeprazole or omeprazole on the gastric mucosa...
- A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopyLaurence Maiden
Department of Medicine, Guy s, King s, St Thomas Medical School, London, England
Gastroenterology 128:1172-8. 2005..We used wireless capsule enteroscopy to quantitate and assess the nature of the small bowel damage caused by nonsteroidal anti-inflammatory drugs when taken on a short-term basis...
- The effect of infectious burden on the prevalence of atopy and respiratory allergies in Iceland, Estonia, and SwedenChrister Janson
Respiratory Medicine and Allergology, Akademiska sjukhuset, Uppsala, Sweden
J Allergy Clin Immunol 120:673-9. 2007..Epidemiologic reports on the effect of microbe exposure on the development of atopy and allergic asthma are inconsistent...
- Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel diseaseKen Takeuchi
Department of Internal Medicine, Guy s, King s, St Thomas Medical School, London, United Kingdom
Clin Gastroenterol Hepatol 4:196-202. 2006..We assessed the effect of these drugs in patients with inflammatory bowel disease (n = 209) and the possible mechanisms...
- Seroprevalence of Toxoplasma gondii in Sweden, Estonia and IcelandAlda Birgisdottir
Faculty of Medicine, University of Iceland
Scand J Infect Dis 38:625-31. 2006..We concluded that risk factors for T. gondii infection suggested that soil exposure was 1 of the mechanisms in all 3 countries and a meat-associated infection route is a risk in Sweden...
- The murky world of the COX-2-selective agentsIngvar Bjarnason
Department of Medicine, Guy s, King s, St Thomas Medical School, Bessemer Road, London SE5 9PJ, UK
Inflammopharmacology 13:381-93. 2005
- [Cirrhosis hepatis, viral hepatitis C and alcohol consumption in Iceland]Bjarni Thjodleifsson
Laeknabladid 94:7. 2008
- Subclinical intestinal inflammation and sacroiliac changes in relatives of patients with ankylosing spondylitisIngvar Bjarnason
Department of Medicine, Guy s, King s, St Thomas Medical School, London, England
Gastroenterology 125:1598-605. 2003..The relationship between this inflammation and the subjects' HLA-B27 genotype as well as computerized tomographic sacroiliac abnormalities was also assessed...
- Granulomatous ileitis in a patient with ankylosing spondylitisDanielle Adebayo
Nat Clin Pract Gastroenterol Hepatol 4:347-51. 2007..A 21-year-old white male with a 3-year history of back pain presented with a 6-month history of weight loss (without significant gastrointestinal symptoms), lethargy and left hip pain, and diarrhea that had lasted 4 days...
- Long-term effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective agents on the small bowel: a cross-sectional capsule enteroscopy studyLaurence Maiden
Department of Medicine, King s College Hospital, London, United Kingdom
Clin Gastroenterol Hepatol 5:1040-5. 2007..We used capsule enteroscopy to study small-bowel damage in patients on long-term NSAIDs and COX-2-selective agents...