Laufey Tryggvadottir

Summary

Affiliation: Icelandic Cancer Society
Country: Iceland

Publications

  1. doi request reprint Tumour diploidy and survival in breast cancer patients with BRCA2 mutations
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Icelandic Cancer Society, Skogarhlid 8, P O Box 5420, 125, Reykjavik, Iceland
    Breast Cancer Res Treat 140:375-84. 2013
  2. ncbi request reprint Breastfeeding and reduced risk of breast cancer in an Icelandic cohort study
    L Tryggvadottir
    Epidemiological Unit, Icelandic Cancer Society, Skogarhlid 8, P O Box 5420, IS 125 Reykjavik, Iceland
    Am J Epidemiol 154:37-42. 2001
  3. doi request reprint Trends in the survival of patients diagnosed with malignant melanoma of the skin in the Nordic countries 1964-2003 followed up to the end of 2006
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
    Acta Oncol 49:665-72. 2010
  4. doi request reprint Trends in the survival of patients diagnosed with breast cancer in the Nordic countries 1964-2003 followed up to the end of 2006
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
    Acta Oncol 49:624-31. 2010
  5. ncbi request reprint Prostate cancer progression and survival in BRCA2 mutation carriers
    Laufey Tryggvadottir
    Icelandic Cancer Registry, PO Box 5420, Iceland
    J Natl Cancer Inst 99:929-35. 2007
  6. ncbi request reprint Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation carriers, 1920-2000
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Skógarhlío 8, Reykjavik, Iceland
    J Natl Cancer Inst 98:116-22. 2006
  7. ncbi request reprint Breast cancer risk factors and age at diagnosis: an Icelandic cohort study
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
    Int J Cancer 98:604-8. 2002
  8. pmc BRCA2 mutation carriers, reproductive factors and breast cancer risk
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Reykjavik, Iceland
    Breast Cancer Res 5:R121-8. 2003
  9. pmc Consumption of fish products across the lifespan and prostate cancer risk
    Johanna E Torfadottir
    Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland
    PLoS ONE 8:e59799. 2013
  10. pmc A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer
    Julius Gudmundsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 44:1326-9. 2012

Detail Information

Publications24

  1. doi request reprint Tumour diploidy and survival in breast cancer patients with BRCA2 mutations
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Icelandic Cancer Society, Skogarhlid 8, P O Box 5420, 125, Reykjavik, Iceland
    Breast Cancer Res Treat 140:375-84. 2013
    ..Breast cancer patients who carry the Icelandic founder BRCA2 mutation have inferior long-term survival than noncarriers, but the adverse prognosis is restricted to mutation carriers with diploid, slowly proliferating tumours. ..
  2. ncbi request reprint Breastfeeding and reduced risk of breast cancer in an Icelandic cohort study
    L Tryggvadottir
    Epidemiological Unit, Icelandic Cancer Society, Skogarhlid 8, P O Box 5420, IS 125 Reykjavik, Iceland
    Am J Epidemiol 154:37-42. 2001
    ..33 (95% confidence interval: 0.19, 0.56) for women diagnosed at all ages. This is the first cohort study to indicate a negative association between breastfeeding and breast cancer...
  3. doi request reprint Trends in the survival of patients diagnosed with malignant melanoma of the skin in the Nordic countries 1964-2003 followed up to the end of 2006
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
    Acta Oncol 49:665-72. 2010
    ..A previous Nordic study showed a marked and steady increase in the age-adjusted 5-year relative survival of skin melanoma patients diagnosed during the period 1958 through 1987. Males had considerably poorer survival than females...
  4. doi request reprint Trends in the survival of patients diagnosed with breast cancer in the Nordic countries 1964-2003 followed up to the end of 2006
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
    Acta Oncol 49:624-31. 2010
    ..European patients have generally high 5-year relative survival ratios, and the Nordic countries, except for Denmark, have ratios among the highest...
  5. ncbi request reprint Prostate cancer progression and survival in BRCA2 mutation carriers
    Laufey Tryggvadottir
    Icelandic Cancer Registry, PO Box 5420, Iceland
    J Natl Cancer Inst 99:929-35. 2007
    ..We compared prostate cancer-specific survival, disease stage, and tumor grade between prostate cancer patients carrying the Icelandic BRCA2 999del5 founder mutation and noncarriers...
  6. ncbi request reprint Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation carriers, 1920-2000
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Skógarhlío 8, Reykjavik, Iceland
    J Natl Cancer Inst 98:116-22. 2006
    ..We examined the cumulative breast cancer incidence and mortality before age 70 over a diagnosis period of 80 years in Icelandic women who carried the BRCA2 founder mutation 999del5...
  7. ncbi request reprint Breast cancer risk factors and age at diagnosis: an Icelandic cohort study
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
    Int J Cancer 98:604-8. 2002
    ..The results confirm that age at diagnosis should be taken into account when studying the effects of breast cancer risk factors...
  8. pmc BRCA2 mutation carriers, reproductive factors and breast cancer risk
    Laufey Tryggvadottir
    Icelandic Cancer Registry, Reykjavik, Iceland
    Breast Cancer Res 5:R121-8. 2003
    ..In the general population, breast cancer risk is affected by age at menarche, by age at first birth, by the number of births and by the duration of breast feeding. Whether this is true for mutation carriers is not clear...
  9. pmc Consumption of fish products across the lifespan and prostate cancer risk
    Johanna E Torfadottir
    Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland
    PLoS ONE 8:e59799. 2013
    ..To examine whether fish and fish oil consumption across the lifespan is associated with a lower risk of prostate cancer...
  10. pmc A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer
    Julius Gudmundsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 44:1326-9. 2012
    ..26 years younger than non-carriers (P = 0.0059). We also report results for a previously described HOXB13 variant (rs138213197[T]), confirming it as a prostate cancer risk variant in populations from across Europe...
  11. doi request reprint Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche
    Patrick Sulem
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:734-8. 2009
    ..Given the link between body fat and AAM, we also assessed 11 variants recently associated with higher body mass index (BMI) and 5 of those associated with earlier AAM...
  12. pmc Discovery of common variants associated with low TSH levels and thyroid cancer risk
    Julius Gudmundsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 44:319-22. 2012
    ..A strong association (P = 9.1 × 10(-91)) was observed between rs2439302 on 8p12 and expression of NRG1, which encodes the signaling protein neuregulin 1, in blood...
  13. doi request reprint Data quality at the Icelandic Cancer Registry: comparability, validity, timeliness and completeness
    Lara Gudrun Sigurdardottir
    Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
    Acta Oncol 51:880-9. 2012
    ..In this paper we report the first formal evaluation of the comparability, validity, timeliness and completeness of the ICR...
  14. doi request reprint Colon cancer: association of histopathological parameters and patients' survival with clinical presentation
    Kristin K Alexiusdottir
    Faculty of Medicine, University of Iceland, Reykjavik, Iceland Oncology Research Center, Landspitali University Hospital, Reykjavik, Iceland The Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
    APMIS 121:901-7. 2013
    ..Anemia, general symptoms, changes in bowel habits, acute symptoms, and abdominal pain correlate with more aggressive tumor characteristics and adverse outcome for patients...
  15. doi request reprint Mutations in BRIP1 confer high risk of ovarian cancer
    Thorunn Rafnar
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 43:1104-7. 2011
    ..0079). Ovarian tumors from heterozygous carriers of the Icelandic mutation show loss of the wild-type allele, indicating that BRIP1 behaves like a classical tumor suppressor gene in ovarian cancer...
  16. ncbi request reprint Breast cancer risk associated with AURKA 91T -->A polymorphism in relation to BRCA mutations
    Linda Vidarsdottir
    Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, Skogarhlid 8, 105 Reykjavik, Iceland
    Cancer Lett 250:206-12. 2007
    ..This may throw light on previously conflicting results...
  17. doi request reprint Cancer risk by education in Iceland; a census-based cohort study
    Halldora Vidarsdottir
    Icelandic Cancer Registry, Icelandic Cancer Society, Reykjavik, Iceland
    Acta Oncol 47:385-90. 2008
    ..The relationship between education and cancer risk has not been studied in the small, but ethnically homogenous, Icelandic population postulated to be outstanding as regards social equity...
  18. doi request reprint Employment participation and work experience of male cancer survivors: a NOCWO study
    Holmfridur K Gunnarsdottir
    Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland
    Work 46:385-93. 2013
    ....
  19. pmc Rye bread consumption in early life and reduced risk of advanced prostate cancer
    Johanna E Torfadottir
    Centre of Public Health Sciences, University of Iceland, Stapi v Hringbraut 101, Reykjavik, Iceland
    Cancer Causes Control 23:941-50. 2012
    ..To determine whether consumption of whole-grain rye bread, oatmeal, and whole-wheat bread, during different periods of life, is associated with risk of prostate cancer (PCa)...
  20. pmc A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 43:1098-103. 2011
    ..35, P = 1.0 × 10(-5)) and colorectal adenoma (OR = 1.39, P = 1.6 × 10(-4)). However, we observed no effect for breast cancer, a common Li-Fraumeni syndrome tumor (OR = 1.06, P = 0.57, 95% confidence interval 0.88-1.27)...
  21. pmc The use of genealogy databases for risk assessment in genetic health service: a systematic review
    Vigdis Stefansdottir
    Department of Genetics and Molecular Medicine, Landspitali, The National Univ Hosp of Iceland, Reykjavik, Iceland
    J Community Genet 4:1-7. 2013
    ..While authors of the four papers described the potential use of genealogy databases in clinical genetic services, such use has not been adequately investigated and further research is required...
  22. ncbi request reprint Eligibility and willingness of young Icelandic women to participate in a HPV vaccination trial
    Thorbjorg Gudmundsdottir
    The Icelandic Directorate of Health, Division of Infectious Disease Control, Reykjavik, Iceland
    Acta Obstet Gynecol Scand 82:345-50. 2003
    ..The aim of this study was to analyze the eligibility and willingness of 18-23-year-old Icelandic women to participate in a vaccination trial to prevent HPV infection and to assess knowledge of HPV...
  23. doi request reprint Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
    ..6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity...
  24. ncbi request reprint Positive association between DNA strand breaks in peripheral blood mononuclear cells and polyunsaturated fatty acids in red blood cells from women
    Audur Y Thorlaksdottir
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    Nutr Cancer 59:21-8. 2007
    ....