Thorarinn Gudjonsson

Summary

Affiliation: Icelandic Cancer Society
Country: Iceland

Publications

  1. pmc Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia
    Thorarinn Gudjonsson
    Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    J Mammary Gland Biol Neoplasia 10:261-72. 2005
  2. ncbi request reprint Stem cell biology and the cellular pathways of carcinogenesis
    Thorarinn Gudjonsson
    Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, Reykjavik, Iceland
    APMIS 113:922-9. 2005
  3. ncbi request reprint Immortalization protocols used in cell culture models of human breast morphogenesis
    T Gudjonsson
    Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, P O Box 5420, 125, Reykjavik, Iceland
    Cell Mol Life Sci 61:2523-34. 2004
  4. ncbi request reprint Differentiation potential of a basal epithelial cell line established from human bronchial explant
    Skarphedinn Halldorsson
    Biology Institute, University of Iceland, Reykjavik, Iceland
    In Vitro Cell Dev Biol Anim 43:283-9. 2007
  5. doi request reprint Azithromycin maintains airway epithelial integrity during Pseudomonas aeruginosa infection
    Skarphedinn Halldorsson
    Institute of Biology, Biomedical Center, University of Iceland, Landspitali, Eiriksgata 5, Reykjavik, Iceland
    Am J Respir Cell Mol Biol 42:62-8. 2010
  6. pmc Expression and functional role of sprouty-2 in breast morphogenesis
    Valgardur Sigurdsson
    Stem Cell Research Unit, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    PLoS ONE 8:e60798. 2013
  7. doi request reprint Selection for EGFR gene amplification in a breast epithelial cell line with basal-like phenotype and hereditary background
    Saevar Ingthorsson
    Stem Cell Research Unit, Biomedical Center, University of Iceland and Department of Laboratory Hematology, Landspitali University Hospital, Reykjavik, Iceland
    In Vitro Cell Dev Biol Anim 47:139-48. 2011
  8. doi request reprint Drug delivery characteristics of the progenitor bronchial epithelial cell line VA10
    Berglind Eva Benediktsdóttir
    Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Hofsvallagata 53, 107, Reykjavik, Iceland
    Pharm Res 30:781-91. 2013
  9. ncbi request reprint Human breast microvascular endothelial cells retain phenotypic traits in long-term finite life span culture
    Valgardur Sigurdsson
    Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    In Vitro Cell Dev Biol Anim 42:332-40. 2006
  10. pmc Endothelial induced EMT in breast epithelial cells with stem cell properties
    Valgardur Sigurdsson
    Stem Cell Research Unit, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland
    PLoS ONE 6:e23833. 2011

Collaborators

Detail Information

Publications25

  1. pmc Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia
    Thorarinn Gudjonsson
    Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    J Mammary Gland Biol Neoplasia 10:261-72. 2005
    ..In this review we discuss data from our laboratories and from others regarding the cellular origin of human myoepithelial cells, their function in maintaining tissue polarity in the normal breast, and their role during neoplasia...
  2. ncbi request reprint Stem cell biology and the cellular pathways of carcinogenesis
    Thorarinn Gudjonsson
    Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, Reykjavik, Iceland
    APMIS 113:922-9. 2005
    ..In this review we discuss the concept of cancer stem cells and focus on examples where these cells have been identified...
  3. ncbi request reprint Immortalization protocols used in cell culture models of human breast morphogenesis
    T Gudjonsson
    Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, P O Box 5420, 125, Reykjavik, Iceland
    Cell Mol Life Sci 61:2523-34. 2004
    ..This review discusses various approaches to immortalization of breast-derived epithelial and stromal cells and the application of such cell lines for studies on human breast morphogenesis...
  4. ncbi request reprint Differentiation potential of a basal epithelial cell line established from human bronchial explant
    Skarphedinn Halldorsson
    Biology Institute, University of Iceland, Reykjavik, Iceland
    In Vitro Cell Dev Biol Anim 43:283-9. 2007
    ....
  5. doi request reprint Azithromycin maintains airway epithelial integrity during Pseudomonas aeruginosa infection
    Skarphedinn Halldorsson
    Institute of Biology, Biomedical Center, University of Iceland, Landspitali, Eiriksgata 5, Reykjavik, Iceland
    Am J Respir Cell Mol Biol 42:62-8. 2010
    ..These data suggest that azm protects the bronchial epithelium during P. aeruginosa infection independent of antimicrobial activity, and could explain in part the beneficial results seen in clinical trials of patients with CF...
  6. pmc Expression and functional role of sprouty-2 in breast morphogenesis
    Valgardur Sigurdsson
    Stem Cell Research Unit, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    PLoS ONE 8:e60798. 2013
    ..These data indicate that SPRY2 is an important regulator of branching morphogenesis and epithelial to mesenchymal transition in the mammary gland...
  7. doi request reprint Selection for EGFR gene amplification in a breast epithelial cell line with basal-like phenotype and hereditary background
    Saevar Ingthorsson
    Stem Cell Research Unit, Biomedical Center, University of Iceland and Department of Laboratory Hematology, Landspitali University Hospital, Reykjavik, Iceland
    In Vitro Cell Dev Biol Anim 47:139-48. 2011
    ..These cell lines may prove useful to understand molecular changes in breast cancer progression, in particular basal-like breast cancer subtype with bad prognosis and no current treatment options...
  8. doi request reprint Drug delivery characteristics of the progenitor bronchial epithelial cell line VA10
    Berglind Eva Benediktsdóttir
    Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Hofsvallagata 53, 107, Reykjavik, Iceland
    Pharm Res 30:781-91. 2013
    ..To determine the integrity and permeability properties of the immortalized human VA10 bronchial epithelial cell line for its suitability as an in vitro drug permeation model...
  9. ncbi request reprint Human breast microvascular endothelial cells retain phenotypic traits in long-term finite life span culture
    Valgardur Sigurdsson
    Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    In Vitro Cell Dev Biol Anim 42:332-40. 2006
    ..These cells will form the basis for studies on the role of endothelial cells in breast morphogenesis...
  10. pmc Endothelial induced EMT in breast epithelial cells with stem cell properties
    Valgardur Sigurdsson
    Stem Cell Research Unit, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland
    PLoS ONE 6:e23833. 2011
    ..We conclude that endothelial cells are potent inducers of EMT and may play a role in progression of basal-like breast cancer...
  11. doi request reprint Endothelial-rich microenvironment supports growth and branching morphogenesis of prostate epithelial cells
    Jon Thor Bergthorsson
    Stem Cell Research Unit, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland
    Prostate 73:884-96. 2013
    ..The aim of this study was to explore the morphogenic effect of endothelial cells on prostate epithelial cell lines in 3D culture and to establish an in vitro model for prostate branching morphogenesis...
  12. pmc Airway branching morphogenesis in three dimensional culture
    Sigrídur R Franzdóttir
    Stem Cell Research Unit, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland
    Respir Res 11:162. 2010
    ..The aim of this study was to recapitulate human lung morphogenesis in vitro by establishing a three dimensional (3D) co-culture model where lung epithelial cells were cultured in endothelial-rich stroma...
  13. doi request reprint Regioselective fluorescent labeling of N,N,N-trimethyl chitosan via oxime formation
    Berglind E Benediktsdóttir
    Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Hofsvallagata 53, IS 107 Reykjavik, Iceland
    Carbohydr Polym 90:1273-80. 2012
    ....
  14. pmc Novel effects of azithromycin on tight junction proteins in human airway epithelia
    Valthor Asgrimsson
    Faculty of Medicine, Landspitali University Hospital, Fossvogi E7, 108 Reykjavik, Iceland
    Antimicrob Agents Chemother 50:1805-12. 2006
    ..The results are novel and may help explain the beneficial effects of azithromycin in patients with cystic fibrosis, diffuse panbronchiolitis, and community-acquired pneumonia...
  15. ncbi request reprint Establishment of three human breast epithelial cell lines derived from carriers of the 999del5 BRCA2 Icelandic founder mutation
    Agla J Rubner Fridriksdottir
    Faculty of Medicine, University of Iceland, Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland
    In Vitro Cell Dev Biol Anim 41:337-42. 2005
    ..These cell lines form the basis for further studies on carcinogenesis and malignant progression of breast cancer on a defined genetic background...
  16. pmc Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia
    Ole William Petersen
    Structural Cell Biology Unit, Institute of Medical Anatomy, The Panum Institute, Copenhagen, Denmark
    Cell Prolif 36:33-44. 2003
    ..As more than 90% of breast cancers arise in TDLUs and more than 90% are also cytokeratin 19-positive, we suggest that this cell population contains a breast-cancer progenitor...
  17. pmc Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties
    Thorarinn Gudjonsson
    Structural Cell Biology Unit, Institute of Medical Anatomy, The Panum Institute, DK 2200 Copenhagen N, Denmark
    Genes Dev 16:693-706. 2002
    ..Thus, MUC(-)/ESA(+) epithelial cells within the luminal epithelial lineage may function as precursor cells of terminal duct lobular units in the human breast...
  18. ncbi request reprint [The application of stem cells for research and treatment of neurological disorders]
    Olafur A Sveinsson
    Taugalaekningadeild Karolinska sjúkrahúsins
    Laeknabladid 94:117-22. 2008
    ..Here we give an overview of neural stem cells and their possible future use in the treatment of neural diseases such as Parkinson s disease, motor neuron disease and spinal cord injury...
  19. pmc Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma
    Ole William Petersen
    Structural Cell Biology Unit, Department of Medical Anatomy, Section A, The Panum Institute, Copenhagen, Denmark
    Am J Pathol 162:391-402. 2003
    ..We conclude that breast cancer can generate its own nonmalignant stroma and that one function for this is that of a reciprocal interaction with epithelial tumor cells to facilitate tumor growth...
  20. pmc Evidence for a stem cell hierarchy in the adult human breast
    Rene Villadsen
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, and Zoophysiological Laboratory, University of Copenhagen, and Department of Pathology, State University Hospital, Copenhagen, Denmark
    J Cell Biol 177:87-101. 2007
    ..These findings identify an adult human breast ductal stem cell activity and its earliest descendants...
  21. pmc To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia
    Thorarinn Gudjonsson
    Structural Cell Biology Unit, Institute of Medical Anatomy, The Panum Institute, DK 2200, Copenhagen N, Denmark
    Methods 30:247-55. 2003
    ..Few if any of these observations would have been possible on two-dimensional tissue culture plastic...
  22. ncbi request reprint Maintenance of cell type diversification in the human breast
    Agla Jael Rubner Fridriksdottir
    Structural Cell Biology Unit, Institute of Medical Anatomy, The Panum Institute, Copenhagen, Denmark
    J Mammary Gland Biol Neoplasia 10:61-74. 2005
    ..The present review discusses the current approaches to address these issues and the measures taken to unravel and maintain cell type diversification for further investigation...
  23. ncbi request reprint Collagen gel contraction serves to rapidly distinguish epithelial- and mesenchymal-derived cells irrespective of alpha-smooth muscle actin expression
    Helga Lind Nielsen
    Structural Cell Biology Unit, Institute of Medical Anatomy, The Panum Institute, Copenhagen, Denmark
    In Vitro Cell Dev Biol Anim 39:297-303. 2003
    ..It is concluded that epithelial-derived mesenchymal-like cells are functionally defective within a connective tissue environment irrespective of an apparent contractile phenotype...
  24. pmc Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition
    Thorarinn Gudjonsson
    Structural Cell Biology Unit, Institute of Medical Anatomy, The Panum Institute, DK 2200 Copenhagen N, Denmark
    J Cell Sci 115:39-50. 2002
    ..These results have important implications for the role of myoepithelial cells in maintenance of polarity in normal breast and how they may function as structural tumor suppressors...
  25. ncbi request reprint Characterization of a novel breast carcinoma xenograft and cell line derived from a BRCA1 germ-line mutation carrier
    Oskar T Johannsson
    Departments of Oncology, University Hospital, Lund, Sweden
    Lab Invest 83:387-96. 2003
    ..We conclude that L56Br-X1 and L56Br-C1 are useful model systems for studies of the pathogenesis and new therapeutic modalities of BRCA1-induced human breast cancer...