V Steinthorsdottir

Summary

Affiliation: deCODE Genetics
Country: Iceland

Publications

  1. ncbi Clostridium perfringens beta-toxin forms multimeric transmembrane pores in human endothelial cells
    V Steinthorsdottir
    Institute for Experimental Pathology, University of Iceland, Reykjavik, Keldur, 112, Iceland
    Microb Pathog 28:45-50. 2000
  2. ncbi Multiple novel transcription initiation sites for NRG1
    Valgerdur Steinthorsdottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Gene 342:97-105. 2004
  3. ncbi A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    Valgerdur Steinthorsdottir
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:770-5. 2007
  4. ncbi Genetic factors contribute to the risk of developing endometriosis
    H Stefansson
    deCODE Genetics, Lynghals 1, Reykjavik, IS 110, Iceland
    Hum Reprod 17:555-9. 2002
  5. ncbi Site-directed mutagenesis of Clostridium perfringens beta-toxin: expression of wild-type and mutant toxins in Bacillus subtilis
    V Steinthorsdottir
    Institute for Experimental Pathology, University of Iceland, Reykjavik, Iceland
    FEMS Microbiol Lett 158:17-23. 1998
  6. ncbi Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
  7. ncbi The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 40:217-24. 2008
  8. ncbi Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:977-83. 2007
  9. ncbi Many sequence variants affecting diversity of adult human height
    Daniel F Gudbjartsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 40:609-15. 2008
  10. ncbi Neuregulin 1 and schizophrenia
    Hreinn Stefansson
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Ann Med 36:62-71. 2004

Detail Information

Publications14

  1. ncbi Clostridium perfringens beta-toxin forms multimeric transmembrane pores in human endothelial cells
    V Steinthorsdottir
    Institute for Experimental Pathology, University of Iceland, Reykjavik, Keldur, 112, Iceland
    Microb Pathog 28:45-50. 2000
    ..Multimer formation was not observed on other cell types tested. We conclude that beta-toxin is a cell specific pore-forming toxin, structurally and functionally related to alpha-toxin of Staphylococcus aureus...
  2. ncbi Multiple novel transcription initiation sites for NRG1
    Valgerdur Steinthorsdottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Gene 342:97-105. 2004
    ....
  3. ncbi A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    Valgerdur Steinthorsdottir
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:770-5. 2007
    ..The insulin response for homozygotes was approximately 20% lower than for heterozygotes or noncarriers, suggesting that this variant confers risk of T2D through reduced insulin secretion...
  4. ncbi Genetic factors contribute to the risk of developing endometriosis
    H Stefansson
    deCODE Genetics, Lynghals 1, Reykjavik, IS 110, Iceland
    Hum Reprod 17:555-9. 2002
    ..Endometriosis is known to cluster within nuclear families. The extent of familial clustering can be evaluated in Iceland with its large population-based genealogical database...
  5. ncbi Site-directed mutagenesis of Clostridium perfringens beta-toxin: expression of wild-type and mutant toxins in Bacillus subtilis
    V Steinthorsdottir
    Institute for Experimental Pathology, University of Iceland, Reykjavik, Iceland
    FEMS Microbiol Lett 158:17-23. 1998
    ..Both residues have counterparts in the membrane binding region of alpha-toxin. Alteration of the single cysteine residue did not affect protein function, contrary to previous suggestions...
  6. ncbi Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  7. ncbi The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 40:217-24. 2008
    ..These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases...
  8. ncbi Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:977-83. 2007
    ..Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes...
  9. ncbi Many sequence variants affecting diversity of adult human height
    Daniel F Gudbjartsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 40:609-15. 2008
    ..Association to three previously reported loci are replicated in our analyses, and the strongest association was with SNPs in the ZBTB38 gene...
  10. ncbi Neuregulin 1 and schizophrenia
    Hreinn Stefansson
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Ann Med 36:62-71. 2004
    ....
  11. ncbi Association of neuregulin 1 with schizophrenia confirmed in a Scottish population
    Hreinn Stefansson
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 72:83-7. 2003
    ..000064 to .0021 for the allele contributing to the at-risk haplotype. This direct replication of haplotype association in a second population further implicates NRG1 as a factor that contributes to the etiology of schizophrenia...
  12. ncbi Neuregulin 1 and susceptibility to schizophrenia
    Hreinn Stefansson
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 71:877-92. 2002
    ..We also demonstrate that the behavioral phenotypes of the NRG1 hypomorphs are partially reversible with clozapine, an atypical antipsychotic drug used to treat schizophrenia...
  13. ncbi Genetics of gene expression and its effect on disease
    Valur Emilsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:423-8. 2008
    ..A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits...
  14. ncbi A common inversion under selection in Europeans
    Hreinn Stefansson
    deCODE Genetics, Sturlugata 8, , Iceland
    Nat Genet 37:129-37. 2005
    ..Here we show that the H2 lineage is undergoing positive selection in the Icelandic population, such that carrier females have more children and have higher recombination rates than noncarriers...