Hilma Holm

Summary

Affiliation: deCODE Genetics
Country: Iceland

Publications

  1. doi Several common variants modulate heart rate, PR interval and QRS duration
    Hilma Holm
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 42:117-22. 2010
  2. pmc A rare variant in MYH6 is associated with high risk of sick sinus syndrome
    Hilma Holm
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 43:316-20. 2011
  3. pmc Discovery of common variants associated with low TSH levels and thyroid cancer risk
    Julius Gudmundsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 44:319-22. 2012
  4. doi Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke
    Solveig Gretarsdottir
    deCODE Genetics, Reykjavik, Iceland
    Ann Neurol 64:402-9. 2008
  5. ncbi Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism
    Anna Helgadottir
    Population Genomics, deCODE Genetics, Reykjavik, Iceland
    J Am Coll Cardiol 60:722-9. 2012
  6. pmc A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
    Daniel F Gudbjartsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:876-8. 2009
  7. pmc New common variants affecting susceptibility to basal cell carcinoma
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:909-14. 2009
  8. doi Identification of low-frequency variants associated with gout and serum uric acid levels
    Patrick Sulem
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 43:1127-30. 2011
  9. pmc Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases
    Daniel F Gudbjartsson
    deCODE Genetics, Reykjavik, Iceland
    PLoS Genet 6:e1001039. 2010
  10. pmc Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Hum Mol Genet 20:2071-7. 2011

Detail Information

Publications16

  1. doi Several common variants modulate heart rate, PR interval and QRS duration
    Hilma Holm
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 42:117-22. 2010
    ..00032, respectively), between TBX5 and advanced atrioventricular block (P = 0.0067), and between SCN10A and pacemaker implantation (P = 0.0029). We also replicated previously described associations with the QT interval...
  2. pmc A rare variant in MYH6 is associated with high risk of sick sinus syndrome
    Hilma Holm
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 43:316-20. 2011
    ..53 and P = 1.5 × 10⁻²⁹. We show that the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant...
  3. pmc Discovery of common variants associated with low TSH levels and thyroid cancer risk
    Julius Gudmundsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 44:319-22. 2012
    ..A strong association (P = 9.1 × 10(-91)) was observed between rs2439302 on 8p12 and expression of NRG1, which encodes the signaling protein neuregulin 1, in blood...
  4. doi Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke
    Solveig Gretarsdottir
    deCODE Genetics, Reykjavik, Iceland
    Ann Neurol 64:402-9. 2008
    ..To find sequence variants that associate with the risk for ischemic stroke (IS), we performed a genome-wide association study...
  5. ncbi Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism
    Anna Helgadottir
    Population Genomics, deCODE Genetics, Reykjavik, Iceland
    J Am Coll Cardiol 60:722-9. 2012
    ..The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components...
  6. pmc A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
    Daniel F Gudbjartsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:876-8. 2009
    ..21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples...
  7. pmc New common variants affecting susceptibility to basal cell carcinoma
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:909-14. 2009
    ..Finally, we report conclusive evidence that rs401681[C] in the TERT-CLPTM1L locus confers susceptibility to BCC but protects against melanoma...
  8. doi Identification of low-frequency variants associated with gout and serum uric acid levels
    Patrick Sulem
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 43:1127-30. 2011
    ..This variant is close to a common variant previously associated with serum uric acid levels. This work illustrates how whole-genome sequencing data allow the detection of associations between low-frequency variants and complex traits...
  9. pmc Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases
    Daniel F Gudbjartsson
    deCODE Genetics, Reykjavik, Iceland
    PLoS Genet 6:e1001039. 2010
    ..0064), and suggestively with gout. In contrast to CKD, the UMOD variant confers protection against kidney stones when studied in 3,617 Icelandic and Dutch kidney stone cases and 43,201 controls (OR = 0.88, P = 5.7 x 10(-5))...
  10. pmc Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Hum Mol Genet 20:2071-7. 2011
    ..AHR detects xenobiotics, such as polycyclic aryl hydrocarbons found in roasted coffee, and induces transcription of CYP1A1 and CYP1A2. The association of these SNPs with coffee consumption was present in both smokers and non-smokers...
  11. pmc Genetic correction of PSA values using sequence variants associated with PSA levels
    Julius Gudmundsson
    deCODE Genetics, IS 101 Reykjavik, Iceland
    Sci Transl Med 2:62ra92. 2010
    ..We propose that a personalized PSA cutoff value, based on genotype, should be used when deciding to perform a prostate biopsy...
  12. ncbi Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
    Solveig Gretarsdottir
    Population Genomics, deCODE Genetics, Reykjavik, Iceland
    Nat Genet 42:692-7. 2010
    ..Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival...
  13. ncbi Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density
    Gudmar Thorleifsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 41:926-30. 2009
    ..The same variants were also found to associate with reduced bone mineral density at the hip (P = 0.00039) and spine (P = 0.0077)...
  14. ncbi Variants conferring risk of atrial fibrillation on chromosome 4q25
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 448:353-7. 2007
    ..42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart...
  15. doi Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche
    Patrick Sulem
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:734-8. 2009
    ..Given the link between body fat and AAM, we also assessed 11 variants recently associated with higher body mass index (BMI) and 5 of those associated with earlier AAM...
  16. pmc Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 41:460-4. 2009
    ..33 allele is associated with low concentration of thyroxin (T(4)) and high concentration of triiodothyronine (T(3))...