Research Topics
Genomes and Genes
Species | Hilma HolmSummaryAffiliation: deCODE Genetics Country: Iceland Publications
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Detail Information
Publications
Several common variants modulate heart rate, PR interval and QRS durationHilma Holm
deCODE Genetics, Reykjavik, Iceland
Nat Genet 42:117-22. 2010..00032, respectively), between TBX5 and advanced atrioventricular block (P = 0.0067), and between SCN10A and pacemaker implantation (P = 0.0029). We also replicated previously described associations with the QT interval...
A rare variant in MYH6 is associated with high risk of sick sinus syndromeHilma Holm
deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
Nat Genet 43:316-20. 2011..53 and P = 1.5 × 10⁻²⁹. We show that the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant...- Discovery of common variants associated with low TSH levels and thyroid cancer riskJulius Gudmundsson
deCODE Genetics, Reykjavik, Iceland
Nat Genet 44:319-22. 2012..A strong association (P = 9.1 × 10(-91)) was observed between rs2439302 on 8p12 and expression of NRG1, which encodes the signaling protein neuregulin 1, in blood... - Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic strokeSolveig Gretarsdottir
deCODE Genetics, Reykjavik, Iceland
Ann Neurol 64:402-9. 2008..To find sequence variants that associate with the risk for ischemic stroke (IS), we performed a genome-wide association study... - Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolismAnna Helgadottir
Population Genomics, deCODE Genetics, Reykjavik, Iceland
J Am Coll Cardiol 60:722-9. 2012..The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components... - A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic strokeDaniel F Gudbjartsson
deCODE Genetics, Reykjavik, Iceland
Nat Genet 41:876-8. 2009..21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples... - New common variants affecting susceptibility to basal cell carcinomaSimon N Stacey
deCODE Genetics, Reykjavik, Iceland
Nat Genet 41:909-14. 2009..Finally, we report conclusive evidence that rs401681[C] in the TERT-CLPTM1L locus confers susceptibility to BCC but protects against melanoma... - Identification of low-frequency variants associated with gout and serum uric acid levelsPatrick Sulem
deCODE Genetics, Reykjavik, Iceland
Nat Genet 43:1127-30. 2011..This variant is close to a common variant previously associated with serum uric acid levels. This work illustrates how whole-genome sequencing data allow the detection of associations between low-frequency variants and complex traits... - Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseasesDaniel F Gudbjartsson
deCODE Genetics, Reykjavik, Iceland
PLoS Genet 6:e1001039. 2010..0064), and suggestively with gout. In contrast to CKD, the UMOD variant confers protection against kidney stones when studied in 3,617 Icelandic and Dutch kidney stone cases and 43,201 controls (OR = 0.88, P = 5.7 x 10(-5))... - Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumptionPatrick Sulem
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Hum Mol Genet 20:2071-7. 2011..AHR detects xenobiotics, such as polycyclic aryl hydrocarbons found in roasted coffee, and induces transcription of CYP1A1 and CYP1A2. The association of these SNPs with coffee consumption was present in both smokers and non-smokers... - Genetic correction of PSA values using sequence variants associated with PSA levelsJulius Gudmundsson
deCODE Genetics, IS 101 Reykjavik, Iceland
Sci Transl Med 2:62ra92. 2010..We propose that a personalized PSA cutoff value, based on genotype, should be used when deciding to perform a prostate biopsy... - Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysmSolveig Gretarsdottir
Population Genomics, deCODE Genetics, Reykjavik, Iceland
Nat Genet 42:692-7. 2010..Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival... - Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral densityGudmar Thorleifsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 41:926-30. 2009..The same variants were also found to associate with reduced bone mineral density at the hip (P = 0.00039) and spine (P = 0.0077)... 
Variants conferring risk of atrial fibrillation on chromosome 4q25Daniel F Gudbjartsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nature 448:353-7. 2007..42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart...- Genome-wide association study identifies sequence variants on 6q21 associated with age at menarchePatrick Sulem
deCODE Genetics, Reykjavik, Iceland
Nat Genet 41:734-8. 2009..Given the link between body fat and AAM, we also assessed 11 variants recently associated with higher body mass index (BMI) and 5 of those associated with earlier AAM... - Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populationsJulius Gudmundsson
deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
Nat Genet 41:460-4. 2009..33 allele is associated with low concentration of thyroxin (T(4)) and high concentration of triiodothyronine (T(3))...