Research Topics
Genomes and Genes
| Agnar HelgasonSummaryAffiliation: deCODE Genetics Country: Iceland Publications
| Collaborators
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Detail Information
Publications
mtDNA variation in Inuit populations of Greenland and Canada: migration history and population structureAgnar Helgason
deCODE Genetics, Inc, 101 Reykjavik, Iceland
Am J Phys Anthropol 130:123-34. 2006....
An association between the kinship and fertility of human couplesAgnar Helgason
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Science 319:813-6. 2008....- A statistical approach to identify ancient template DNAAgnar Helgason
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
J Mol Evol 65:92-102. 2007..The proposed approach is likely to be of general use to researchers working with DNA from ancient tissues, particularly from human remains, where authentication of results has been most challenging... - Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolutionAgnar Helgason
deCODE Genetics, 101 Reykjavik, Iceland
Nat Genet 39:218-25. 2007.... - An Icelandic example of the impact of population structure on association studiesAgnar Helgason
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 37:90-5. 2005..Our results indicate that sampling strategies need to take account of substructure even in a relatively homogenous genetic isolate. This will probably be even more important in larger populations... 
Sequences from first settlers reveal rapid evolution in Icelandic mtDNA poolAgnar Helgason
deCODE Genetics, Reykjavik, Iceland
PLoS Genet 5:e1000343. 2009..These results demonstrate the inferential power gained in ancient DNA studies through the application of population genetics analyses to relatively large samples...- The past, present, and future of direct-to-consumer genetic testsAgnar Helgason
deCODE Genetics, Reykjavik, Iceland
Dialogues Clin Neurosci 12:61-8. 2010..In this paper, we review the current state and future prospects of such genetic tests, as scientists involved both in the discovery of disease associations and the development of genetic tests... - Two newly identified genetic determinants of pigmentation in EuropeansPatrick Sulem
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 40:835-7. 2008.... - Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traitsSimon N Stacey
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 40:1313-8. 2008..Approximately 1.6% of individuals of European ancestry are homozygous for both variants, and their estimated risk of BCC is 2.68 times that of noncarriers... - Fine-scale recombination rate differences between sexes, populations and individualsAugustine Kong
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nature 467:1099-103. 2010.... - ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinomaDaniel F Gudbjartsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 40:886-91. 2008..14, P = 6.1 x 10(-4)). An eye color variant in TYRP1 was associated with risk of CM (OR = 1.15, P = 4.6 x 10(-4)). The association of all three variants is robust with respect to adjustment for the effect of pigmentation... - Variants conferring risk of atrial fibrillation on chromosome 4q25Daniel F Gudbjartsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nature 448:353-7. 2007..42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart... - The BARD1 Cys557Ser variant and breast cancer risk in IcelandSimon N Stacey
deCODE Genetics, Reykjavik, Iceland
PLoS Med 3:e217. 2006..We then used a computerized genealogy of the Icelandic population to study the relationships between the Cys557Ser variant and familial clustering of breast cancer... - Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24Julius Gudmundsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:631-7. 2007..The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis... - Sequence variants in the RNF212 gene associate with genome-wide recombination rateAugustine Kong
deCODE Genetics Inc, 101 Reykjavik, Iceland
Science 319:1398-401. 2008..Consequently, if the frequency of the haplotype changes, the average recombination rate will increase for one sex and decrease for the other, but the sex-averaged recombination rate of the population can stay relatively constant... - Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetesJulius Gudmundsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:977-83. 2007..Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes... - Common variants near CAV1 and CAV2 are associated with primary open-angle glaucomaGudmar Thorleifsson
deCODE Genetics Inc, Reykjavik, Iceland
Nat Genet 42:906-9. 2010..42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG... - Rate of de novo mutations and the importance of father's age to disease riskAugustine Kong
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nature 488:471-5. 2012..These observations shed light on the importance of the father's age on the risk of diseases such as schizophrenia and autism... - Genetic determinants of hair, eye and skin pigmentation in EuropeansPatrick Sulem
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:1443-52. 2007..3 is associated with freckles. The fifth region provided refinements to a previously reported association in OCA2, and the sixth encompasses previously described variants in MC1R... - Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesStruan F A Grant
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 38:320-3. 2006..It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway... - Evaluating differences in linkage disequilibrium between populationsBirgir Hrafnkelsson
deCODE Genetics, 101 Reykjavik, Iceland
Ann Hum Genet 74:233-47. 2010.... - Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locusSimon N Stacey
deCODE Genetics, Reykjavik, Iceland
PLoS Genet 6:e1001029. 2010..These studies demonstrate that shifting the analysis among ancestral populations can provide valuable resolution in association mapping... - A common inversion under selection in EuropeansHreinn Stefansson
deCODE Genetics, Sturlugata 8, , Iceland
Nat Genet 37:129-37. 2005..Here we show that the H2 lineage is undergoing positive selection in the Icelandic population, such that carrier females have more children and have higher recombination rates than noncarriers... - A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarctionAnna Helgadottir
deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
Nat Genet 38:68-74. 2006..Interactions with other genetic or environmental risk factors that are more common in African Americans are likely to account for the greater relative risk conferred by HapK in this group... - Genetics of gene expression and its effect on diseaseValur Emilsson
deCODE Genetics, 101 Reykjavik, Iceland
Nature 452:423-8. 2008..A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits... - A new subclade of mtDNA haplogroup C1 found in Icelanders: evidence of pre-Columbian contact?Sigríður Sunna Ebenesersdóttir
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Am J Phys Anthropol 144:92-9. 2011..Rather, it is presently the only known member of a new subclade, C1e. While a Native American origin seems most likely for C1e, an Asian or European origin cannot be ruled out... - A rare variant in MYH6 is associated with high risk of sick sinus syndromeHilma Holm
deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
Nat Genet 43:316-20. 2011..53 and P = 1.5 × 10⁻²⁹. We show that the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant... - A drastic reduction in the life span of cystatin C L68Q carriers due to life-style changes during the last two centuriesAstridur Palsdottir
Institute for Experimental Pathology, University of Iceland, Keldur, Reykjavik, Iceland
PLoS Genet 4:e1000099. 2008.... - Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancerSimon N Stacey
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:865-9. 2007..rs3803662 is near the 5' end of TNRC9 , a high mobility group chromatin-associated protein whose expression is implicated in breast cancer metastasis to bone... - A populationwide coalescent analysis of Icelandic matrilineal and patrilineal genealogies: evidence for a faster evolutionary rate of mtDNA lineages than Y chromosomesAgnar Helgason
deCODE Genetics, Reykjavik, Iceland
Am J Hum Genet 72:1370-88. 2003..These findings may have implications for coalescent date estimates based on mtDNA and Y chromosomes... - Blondes, lost and found: representations of genes, identity, and historyGisli Palsson
Department of Anthropology, Oddi, University of Iceland, 101 Reykjavik, Iceland
Dev World Bioeth 3:159-69. 2003.... - A common variant associated with prostate cancer in European and African populationsLaufey T Amundadottir
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 38:652-8. 2006..This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry... - Identification of low-frequency variants associated with gout and serum uric acid levelsPatrick Sulem
deCODE Genetics, Reykjavik, Iceland
Nat Genet 43:1127-30. 2011..This variant is close to a common variant previously associated with serum uric acid levels. This work illustrates how whole-genome sequencing data allow the detection of associations between low-frequency variants and complex traits... - Prion susceptibility and protective alleles exhibit marked geographic differencesMarta Soldevila
Unitat de Biologia Evolutiva, , Universitat Pompeu Fabra, Barcelona, Spain
Hum Mutat 22:104-5. 2003..The protective 219L allele was restricted to Asian and Pacific populations. Susceptibility alleles exhibit marked geographic differences in frequency, and thus, differences in probability to develop prion diseases... - Assessing the signatures of selection in PRNP from polymorphism data: results support Kreitman and Di Rienzo's opinionMarta Soldevila
Trends Genet 21:389-91. 2005 - Lessons from the past: familial aggregation analysis of fatal pandemic influenza (Spanish flu) in Iceland in 1918Magnus Gottfredsson
Landspitali University Hospital, 108 Reykjavik, Iceland
Proc Natl Acad Sci U S A 105:1303-8. 2008..Our data do not provide conclusive evidence for the role of genetic factors in susceptibility to the Spanish flu... - Y-chromosomal DNA variation in PakistanRaheel Qamar
Biomedical and Genetic Engineering Division, Dr. A. Q. Khan Research Laboratories, Islamabad, Pakistan
Am J Hum Genet 70:1107-24. 2002.... - Erroneous claims about the impact of mitochondrial DNA sequence database errorsAgnar Helgason
Am J Hum Genet 73:974-5. 2003