H Hakonarson

Summary

Affiliation: deCODE Genetics
Country: Iceland

Publications

  1. ncbi request reprint The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 36:233-9. 2004
  2. pmc Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients
    Hakon Hakonarson
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Proc Natl Acad Sci U S A 102:14789-94. 2005
  3. ncbi request reprint Association between IL-1beta/TNF-alpha-induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle
    H Hakonarson
    deCODE Genetics, Reykjavik, Iceland
    Am J Respir Cell Mol Biol 25:761-71. 2001
  4. ncbi request reprint Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland
    H Hakonarson
    deCODE Genetics, Inc, Reykjavik, Iceland
    Am J Respir Crit Care Med 164:2036-44. 2001
  5. pmc A major susceptibility gene for asthma maps to chromosome 14q24
    Hakon Hakonarson
    deCODE Genetics, Inc, Reykjavik, Iceland
    Am J Hum Genet 71:483-91. 2002
  6. ncbi request reprint deCODE genetics, Inc
    Hakon Hakonarson
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Pharmacogenomics 4:209-15. 2003
  7. ncbi request reprint Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial
    Hakon Hakonarson
    deCODE Genetics Inc, Reykjavik, Iceland
    JAMA 293:2245-56. 2005
  8. pmc Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population
    A Helgadottir
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 76:505-9. 2005
  9. ncbi request reprint A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 38:68-74. 2006
  10. ncbi request reprint Advances in the development of genetic markers for the diagnosis of disease and drug response
    Eva Halapi
    Division of Inflammation and Pharmacogenomics, deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Expert Rev Mol Diagn 2:411-21. 2002

Collaborators

Detail Information

Publications38

  1. ncbi request reprint The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 36:233-9. 2004
    ..We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall...
  2. pmc Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients
    Hakon Hakonarson
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Proc Natl Acad Sci U S A 102:14789-94. 2005
    ..Upon validation in an independent study, these results support the development of a diagnostic test to guide GC therapy in asthma patients...
  3. ncbi request reprint Association between IL-1beta/TNF-alpha-induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle
    H Hakonarson
    deCODE Genetics, Reykjavik, Iceland
    Am J Respir Cell Mol Biol 25:761-71. 2001
    ..We speculate that glucocorticoid-sensitive, cytokine-induced pathways involved in ASM cell signaling represent important targets for new therapeutic interventions...
  4. ncbi request reprint Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland
    H Hakonarson
    deCODE Genetics, Inc, Reykjavik, Iceland
    Am J Respir Crit Care Med 164:2036-44. 2001
    ....
  5. pmc A major susceptibility gene for asthma maps to chromosome 14q24
    Hakon Hakonarson
    deCODE Genetics, Inc, Reykjavik, Iceland
    Am J Hum Genet 71:483-91. 2002
    ..2 cM, the LOD score rose to 4.00. We designate this locus "asthma locus one" (AS1). Taken together, these results provide evidence of a novel susceptibility gene for asthma on chromosome 14q24...
  6. ncbi request reprint deCODE genetics, Inc
    Hakon Hakonarson
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Pharmacogenomics 4:209-15. 2003
    ....
  7. ncbi request reprint Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial
    Hakon Hakonarson
    deCODE Genetics Inc, Reykjavik, Iceland
    JAMA 293:2245-56. 2005
    ..Myocardial infarction (MI) is the leading cause of death in the world. Variants in the 5-lipoxygenase-activating protein (FLAP) gene are associated with risk of MI...
  8. pmc Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population
    A Helgadottir
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 76:505-9. 2005
    ..However, we observed that HapB was overrepresented in male patients. This replication of haplotype association with stroke in a population outside Iceland further supports a role for ALOX5AP in cardiovascular diseases...
  9. ncbi request reprint A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 38:68-74. 2006
    ..Interactions with other genetic or environmental risk factors that are more common in African Americans are likely to account for the greater relative risk conferred by HapK in this group...
  10. ncbi request reprint Advances in the development of genetic markers for the diagnosis of disease and drug response
    Eva Halapi
    Division of Inflammation and Pharmacogenomics, deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Expert Rev Mol Diagn 2:411-21. 2002
    ..This review addresses recent advances in the development of genetic markers that can be used to diagnose disease or drug response...
  11. ncbi request reprint Genetic approaches to assessing evidence for a T helper type 1 cytokine defect in adult asthma
    Illugi F Birkisson
    The Medical University of Iceland, Reykjavik, Iceland
    Am J Respir Crit Care Med 169:1007-13. 2004
    ..We conclude that decrease in Th1 type cytokine response is unlikely to present a primary event in asthma...
  12. ncbi request reprint Current concepts on the genetics of asthma
    H Hakonarson
    deCODE Genetics, Inc, Reykjavik, Iceland
    Curr Opin Pediatr 13:267-77. 2001
    ....
  13. ncbi request reprint Familial aggregation of atrial fibrillation in Iceland
    David O Arnar
    Department of Medicine, Landspitali University Hospital, Hringbraut, Reykjavik, Iceland
    Eur Heart J 27:708-12. 2006
    ..AF is a disorder with a high prevalence, which has been known to cluster in families, but the heritability of the common form has not been well defined...
  14. ncbi request reprint Population genomics of drug response
    Eva Halapi
    deCODE Genetics, Inc, Reykjavik, Iceland
    Am J Pharmacogenomics 4:73-82. 2004
    ..Collectively, these studies support the value of leveraging information available within population-based data systems to map and isolate genes for common complex disease and drug response...
  15. ncbi request reprint Recent development in genomic and proteomic research for asthma
    Eva Halapi
    Division of Respiratory and Pharmacogenomic Research, deCODE Genetics, Inc, Reykjavik, Iceland
    Curr Opin Pulm Med 10:22-30. 2004
    ..Asthma is a complex genetic disorder with a heterogeneous phenotype attributed to the interactions among many genes and the environment. This review highlights recent developments in asthma genomic and proteomic research...
  16. ncbi request reprint Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland
    Jürgen Laufs
    deCODE Genetics, Sturlugata 8, Reykjavik 101, Iceland
    Am J Pharmacogenomics 4:63-8. 2004
    ..The objective of this study was to examine the association of VDBP to different subtypes of COPD...
  17. ncbi request reprint Genetic analyses in asthma: current concepts and future directions
    Hakon Hakonarson
    Division of Respiratory and Pharmacogenomics Research, deCODE Genetics, Inc, Reykjavik, Iceland
    Am J Pharmacogenomics 2:155-66. 2002
    ....
  18. ncbi request reprint A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
    Hakon Hakonarson
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 448:591-4. 2007
    ..These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits...
  19. doi request reprint A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study
    Hakon Hakonarson
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Diabetes 57:1143-6. 2008
    ..03 x 10(-10)) and confirmed in two additional cohorts. Here we describe the results of testing, in these additional cohorts, 23 loci that were next in rank of statistical significance...
  20. doi request reprint Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 gene
    Struan F A Grant
    The Center for Applied Genomics and Division of Human Genetics, The Abramson Research Center of the Joseph Stokes Jr Research Institute, Department of Pediatrics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Expert Rev Mol Diagn 8:199-207. 2008
    ....
  21. pmc Association analysis of type 2 diabetes Loci in type 1 diabetes
    Hui Qi Qu
    Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1983-6. 2008
    ..To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L...
  22. pmc Chromosome 6p22 locus associated with clinically aggressive neuroblastoma
    John M Maris
    Division of Oncology and the Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    N Engl J Med 358:2585-93. 2008
    ..Neuroblastoma is a malignant condition of the developing sympathetic nervous system that most commonly affects young children and is often lethal. Its cause is not known...
  23. doi request reprint Microarray technology and applications in the arena of genome-wide association
    Struan F A Grant
    The Center for Applied Genomics and Division of Human Genetics, The Abramson Research Center of the Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Clin Chem 54:1116-24. 2008
    ..This has enabled large-scale genome-wide association (GWA) studies in complex diseases, such as diabetes, asthma, and inflammatory bowel disease, to be undertaken for the first time...
  24. pmc Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease
    Robert N Baldassano
    Gut 56:1171-3. 2007
  25. ncbi request reprint Recent development in pharmacogenomics: from candidate genes to genome-wide association studies
    Struan F A Grant
    Center for Applied Genomics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Expert Rev Mol Diagn 7:371-93. 2007
    ....
  26. pmc Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
    Subra Kugathasan
    Department of Pediatrics, Children s Research Institute and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nat Genet 40:1211-5. 2008
    ..30 x 10(-8) and 6.95 x 10(-8), respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 x 10(-8); OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively...
  27. ncbi request reprint Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review
    Ammarin Thakkinstian
    Clinical Epidemiology Unit, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Am J Epidemiol 162:201-11. 2005
    ..001). Haplotype analysis suggests that there may be an interaction between the two sites, with a lower risk of asthma associated with the Glu27 allele (compared with Gln27), and that this risk is modified by the allele at position 16...
  28. ncbi request reprint Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome
    Thorarinn Gislason
    Department of Pulmonary Medicine, Vifilsstadir, Gardabaer, Iceland
    Am J Respir Crit Care Med 166:833-8. 2002
    ..Collectively, these results demonstrate a strong familial component in OSAS and suggest that infants who died of SIDS may have shared some of the same susceptibility factors with OSAS...
  29. ncbi request reprint Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease
    Robert N Baldassano
    Division of Gastroenterology and Nutrition, Abramson Research Center, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Gastroenterol Hepatol 5:972-6. 2007
    ..We examined the effects of this and other previously reported SNPs at this locus with respect to CD in children...
  30. pmc Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 3:e1746. 2008
    ..As such, variants in the FTO gene confer a similar magnitude of risk of obesity to children as to their adult counterparts and appear to have a global impact...
  31. pmc Identification of ALK as a major familial neuroblastoma predisposition gene
    Yael P Mosse
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 455:930-5. 2008
    ....
  32. pmc Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection
    Rakesh Sindhi
    Hillman Center for Pediatric Transplantation, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Gastroenterology 135:830-9, 839.e1-10. 2008
    ....
  33. doi request reprint Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis
    Edward M Behrens
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Arthritis Rheum 58:2206-7. 2008
  34. pmc Complex management of a patient with a contiguous Xp11.4 gene deletion involving ornithine transcarbamylase: a role for detailed molecular analysis in complex presentations of classical diseases
    Matthew A Deardorff
    Division of Metabolic Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Genet Metab 94:498-502. 2008
    ....
  35. ncbi request reprint Linkage to apnea-hypopnea index across the life-span: is this a viable strategy?
    Allan I Pack
    Am J Respir Crit Care Med 170:1260; author reply 1260-1. 2004
  36. pmc PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data
    Kai Wang
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Res 17:1665-74. 2007
    ..3%. Our results demonstrate the feasibility of whole-genome fine-mapping of CNVs via high-density SNP genotyping...
  37. ncbi request reprint T lymphocyte-mediated changes in airway smooth muscle responsiveness are attributed to induced autocrine release and actions of IL-5 and IL-1beta
    Hakon Hakonarson
    Division of Pulmonary Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 110:624-33. 2002
    ....
  38. ncbi request reprint Autocrine regulation of airway smooth muscle responsiveness
    Hakon Hakonarson
    Division of Pulmonary Medicine, Research Institute, Abramson s Pediatric Research Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Respir Physiol Neurobiol 137:263-76. 2003
    ....