Research Topics
Genomes and Genes | Struan F A GrantSummaryAffiliation: deCODE Genetics Country: Iceland Publications
| Collaborators
|
Detail Information
Publications
Linkage of osteoporosis to chromosome 20p12 and association to BMP2Unnur Styrkarsdottir
deCODE Genetics, Reykjavik, Iceland
PLoS Biol 1:E69. 2003....- Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNPStruan F A Grant
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
PLoS ONE 3:e1746. 2008..As such, variants in the FTO gene confer a similar magnitude of risk of obesity to children as to their adult counterparts and appear to have a global impact... 
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesStruan F A Grant
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 38:320-3. 2006..It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway...- Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolutionAgnar Helgason
deCODE Genetics, 101 Reykjavik, Iceland
Nat Genet 39:218-25. 2007.... - A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarctionAnna Helgadottir
deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
Nat Genet 38:68-74. 2006..Interactions with other genetic or environmental risk factors that are more common in African Americans are likely to account for the greater relative risk conferred by HapK in this group... - Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2Inga Reynisdottir
deCODE Genetics, Reykjavik, Iceland
Am J Hum Genet 73:323-35. 2003..Finally, we observed potential interactions between the 5q locus and two T2D susceptibility loci, previously mapped in other populations... - The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and strokeAnna Helgadottir
deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
Nat Genet 36:233-9. 2004..We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall... 
Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 geneStruan F A Grant
The Center for Applied Genomics and Division of Human Genetics, The Abramson Research Center of the Joseph Stokes Jr Research Institute, Department of Pediatrics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
Expert Rev Mol Diagn 8:199-207. 2008....- Association analysis of type 2 diabetes Loci in type 1 diabetesHui Qi Qu
Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
Diabetes 57:1983-6. 2008..To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L... - Chromosome 6p22 locus associated with clinically aggressive neuroblastomaJohn M Maris
Division of Oncology and the Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
N Engl J Med 358:2585-93. 2008..Neuroblastoma is a malignant condition of the developing sympathetic nervous system that most commonly affects young children and is often lethal. Its cause is not known... - Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritisEdward M Behrens
The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Arthritis Rheum 58:2206-7. 2008 - Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel diseaseSubra Kugathasan
Department of Pediatrics, Children s Research Institute and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Nat Genet 40:1211-5. 2008..30 x 10(-8) and 6.95 x 10(-8), respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 x 10(-8); OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively... - A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association studyHakon Hakonarson
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, PA 19104 4318, USA
Diabetes 57:1143-6. 2008..03 x 10(-10)) and confirmed in two additional cohorts. Here we describe the results of testing, in these additional cohorts, 23 loci that were next in rank of statistical significance... - A genome-wide association study identifies KIAA0350 as a type 1 diabetes geneHakon Hakonarson
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Nature 448:591-4. 2007..These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits... - Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's diseaseRobert N Baldassano
Gut 56:1171-3. 2007 - Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's diseaseRobert N Baldassano
Division of Gastroenterology and Nutrition, Abramson Research Center, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
Clin Gastroenterol Hepatol 5:972-6. 2007..We examined the effects of this and other previously reported SNPs at this locus with respect to CD in children... - PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping dataKai Wang
Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Genome Res 17:1665-74. 2007..3%. Our results demonstrate the feasibility of whole-genome fine-mapping of CNVs via high-density SNP genotyping... - Recent development in pharmacogenomics: from candidate genes to genome-wide association studiesStruan F A Grant
Center for Applied Genomics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
Expert Rev Mol Diagn 7:371-93. 2007.... - Microarray technology and applications in the arena of genome-wide associationStruan F A Grant
The Center for Applied Genomics and Division of Human Genetics, The Abramson Research Center of the Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
Clin Chem 54:1116-24. 2008..This has enabled large-scale genome-wide association (GWA) studies in complex diseases, such as diabetes, asthma, and inflammatory bowel disease, to be undertaken for the first time... - SNP genotyping on a genome-wide amplified DOP-PCR templateStruan F A Grant
LION bioscience AG, Im Neuenheimer Feld 515-517, 69120 Heidelberg, Germany
Nucleic Acids Res 30:e125. 2002..Adding carrier DNA to a final concentration of 10 ng/microl improved results. In conclusion, we have successfully used DOP-PCR to amplify our genomic DNA collection for subsequent SNP genotyping as a standard process...