Cerebellar haemorrhage after repeated burr hole evacuation for chronic subdural haematomaJonathan A Hyam
Department of Neurosurgery, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, United Kingdom
J Clin Neurosci 14:83-6. 2007
..This complication should be considered among the differential diagnoses after neurological deterioration following CSDH evacuation...
Contrasting connectivity of the ventralis intermedius and ventralis oralis posterior nuclei of the motor thalamus demonstrated by probabilistic tractographyJonathan A Hyam
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
Neurosurgery 70:162-9; discussion 169. 2012
..Targeting of the motor thalamus for the treatment of tremor has traditionally been achieved by a combination of anatomical atlases and neuroimaging, intraoperative clinical assessment, and physiological recordings...
- Controlling the lungs via the brain: a novel neurosurgical method to improve lung function in humans
Jonathan A Hyam
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
Neurosurgery 70:469-77; discussion 477-8. 2012
..The supramedullary circuitry controlling respiratory airways is not well defined and has not been tested in humans...
- The autonomic effects of deep brain stimulation--a therapeutic opportunity
Jonathan A Hyam
Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Department of Psychiatry, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK
Nat Rev Neurol 8:391-400. 2012
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An examination of factors influencing the choice of therapy for patients with coronary artery diseaseShashivadan P Hirani
Health Psychology Unit, Centre for Behavioural and Social Sciences in Medicine University College London, Wolfson Building, 48 Riding House Street, London W1W 7EY, UK
BMC Cardiovasc Disord 6:31. 2006
..This study examined which of these factors differentiated patients receiving angioplasty from medication; bypass surgery from medication; and bypass surgery from angioplasty...
- Coma caused by spontaneous otogenic pneumocephalus
Jonathan A Hyam
Department of Neurosurgery, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom
Clin Neurol Neurosurg 110:62-4. 2008
..This case, however, establishes how it can cause a rapid decline towards coma...
- Comparison of contralateral pallidotomy vs. pallidal stimulation after prior unilateral pallidotomy for Parkinson's disease
Jonathan A Hyam
Department of Neurosurgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
Neuromodulation 14:117-22; discussion 122. 2011
..The aim of this study was to analyze which modality produced greater PD symptom improvement in patients with a prior pallidotomy and whether the chronological order of the pallidal surgery influenced the size of the improvement...
- Depiction of the neuroscientific principles of human motion 2 millennia ago by Lucretius
Jonathan A Hyam
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Neurology 77:1000-4. 2011
..Lucretius was the first commentator to introduce into Epicurean poetry the concept of such a mechanism consisting of a logical order of processes which are still consistent with modern concepts...
- Maintained deep brain stimulation for severe dystonia despite infection by using externalized electrodes and an extracorporeal pulse generator
Jonathan A Hyam
Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK
J Neurosurg 113:630-3. 2010
..The authors suggest that this prolonged extracorporeal stimulation should be considered by neurosurgeons in the face of this difficult clinical situation...
- Muslin granuloma presenting with speech disturbance diagnosed by endoscopic biopsy
Jonathan A Hyam
Department of Neurosurgery, Charing Cross Hospital, London, UK
Acta Neurochir (Wien) 151:565-7. 2009
..This is also the first case in which neuroendoscopy has been successfully employed to obtain tissue for diagnosis and to treat such a lesion...
- Expression of a latent ophthalmic artery collateral circulation after extracranial-intracranial bypass
Jonathan A Hyam
Department of Neurosurgery, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom
Clin Neurol Neurosurg 111:274-7. 2009
..The bulk of the right anterior circulation was derived retrogradely by latent collaterals from the internal carotid and ophthalmic arteries via small dural vessels which were not apparent prior to surgery...
- A spatiotemporal analysis of gait freezing and the impact of pedunculopontine nucleus stimulation
Wesley Thevathasan
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
Brain 135:1446-54. 2012
..Bilateral stimulation was more effective than unilateral...
- MEG can map short and long-term changes in brain activity following deep brain stimulation for chronic pain
Hamid R Mohseni
University Department of Psychiatry, University of Oxford, Oxford, United Kingdom
PLoS ONE 7:e37993. 2012
..These results broaden our understanding of the underlying mechanisms of DBS in the human brain...
- Identifying cardiovascular neurocircuitry involved in the exercise pressor reflex in humans using functional neurosurgery
Shanika D Basnayake
Dept of Physiology, Anatomy and Genetics, Univ of Oxford, Oxford OX1 3PT, UK
J Appl Physiol 110:881-91. 2011
..No significant changes were seen in the activity of other nuclei during occlusion. These electrophysiological data provide direct evidence for a role of the PAG in the integrating neurocircuitry of the exercise pressor reflex in humans...
- Pedunculopontine nucleus stimulation improves gait freezing in Parkinson disease
Wesley Thevathasan
Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom
Neurosurgery 69:1248-53; discussion 1254. 2011
..However, controversies remain regarding the clinical application of this new therapy, including patient selection, electrode positioning, and how best to assess outcomes...
- Application of a null-beamformer to source localisation in MEG data of deep brain stimulation
Hamid R Mohseni
Institute of Biomedical Engineering, School of Engineering Science, University of Oxford, UK
Conf Proc IEEE Eng Med Biol Soc 2010:4120-3. 2010
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- Ventral periaqueductal grey stimulation alters heart rate variability in humans with chronic pain
Erlick A C Pereira
Nuffield Department of Surgery, University of Oxford, Oxford, UK
Exp Neurol 223:574-81. 2010
..Heart rate variability (HRV) is an established measure of cardiovascular regulation, and an index of autonomic function...
- A block to pre-prepared movement in gait freezing, relieved by pedunculopontine nucleus stimulation
Wesley Thevathasan
Department of Clinical Neurology, University of Oxford, UK
Brain 134:2085-95. 2011
..These findings suggest a relative block to triggered, pre-prepared movement in gait freezing and postural instability, relieved by pedunculopontine nucleus stimulation...
- Intra-operative deep brain stimulation of the periaqueductal grey matter modulates blood pressure and heart rate variability in humans
Alexander L Green
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK and Department of Anaesthesia, John Radcliffe Hospital, Oxford, UK
Neuromodulation 13:174-81. 2010
..Understanding of the mechanisms by which this therapy causes cardiovascular modulation will inform future innovation in this field with the aim of improving the efficacy and safety of patient treatment options...
- Post-deep brain stimulation--gradual non-stimulation dependent decrease in strength with attenuation of multiple sclerosis tremor
Jonathan A Hyam
Department of Neurosurgery, West London Neurosciences Centre Charing Cross Hospital, London, UK
J Neurol 254:854-60. 2007
..There was also a significant correlation (0.699; p = 0.0359) between decreasing upper limb strength and decreasing intention tremor severity for the upper limbs of patients that had undergone contralateral DBS...
- Impact of emotion on consciousness: positive stimuli enhance conscious reportability
Kristine Rømer Thomsen
Department of Psychiatry, University of Oxford, Oxford, United Kingdom
PLoS ONE 6:e18686. 2011
..In line with previous studies, the data indicate a key role of the ACC, but goes beyond earlier work by providing the first direct evidence of interaction between emotion and conscious experience in the human ACC...
- Case mix, outcomes and comparison of risk prediction models for admissions to adult, general and specialist critical care units for head injury: a secondary analysis of the ICNARC Case Mix Programme Database
Jonathan A Hyam
Department of Neurosurgery, Charing Cross Hospital, London, UK
Crit Care 10:S2. 2006
..Non-survivors have a short length of ICU and hospital stay. APACHE II and III have poorer calibration and discrimination than SAPS II, MPM II and the ICNARC model in traumatic brain injury; however, no model had perfect calibration...
