Mahmoud Rezk Abdelwahed Hussein

Summary

Publications

  1. doi Analysis of hMSH2 mismatch repair protein expression in dysplasia, carcinoma in situ and invasive squamous cell carcinoma of the vocal folds
    Mahmoud Rezk A Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
    Cancer Invest 27:38-46. 2009
  2. doi Mucocutaneous Splendore-Hoeppli phenomenon
    Mahmoud R Hussein
    Department of Pathology, Assir Central Hospital, King Khalid University, Abha, Kingdom of Saudi Arabia
    J Cutan Pathol 35:979-88. 2008
  3. doi Phenotypic characterization of the infiltrating immune cells in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma
    Mahmoud Rezk A Hussein
    Departments of Pathology and Urology, Assir Central Hospital and King Khalid University, Abha, Saudi Arabia
    Exp Mol Pathol 86:108-13. 2009
  4. ncbi Primary peritoneal malignant mixed mesodermal (Müllerian) tumor
    Mahmoud R Hussein
    Department of Pathology, Assir Central Abha, KSA and Assuit University Hospitals, Assuit University, Assuit, Egypt
    Tumori 95:525-31. 2009
  5. doi Analysis of p53, BCL-2 and epidermal growth factor receptor protein expression in the partial and complete hydatidiform moles
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Exp Mol Pathol 87:63-9. 2009
  6. ncbi Calciphylaxis cutis: a case report and review of literature
    Mahmoud Rezk A Hussein
    Pathology Department, Assir Central Hospital, KSA, Saudi Arabia
    Exp Mol Pathol 86:134-5. 2009
  7. doi Skin-limited Langerhans' cell histiocytosis in children
    Mahmoud Rezk A Hussein
    Departments of Pathology, Assir Central Abha, KSA and Assuit University Hospitals, Assuit University, Assuit Eqypt
    Cancer Invest 27:504-11. 2009
  8. doi Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University and Assir Central Hospitals, Assuit, Egypt
    Pathol Oncol Res 14:321-8. 2008
  9. doi Decidual immune cell infiltrate in hydatidiform mole
    Mahmoud R Hussein
    Departments of Pathology, Assuit University Hospitals, Assuit University, Assuit, Egypt
    Cancer Invest 27:60-6. 2009
  10. doi Immune cell profile in invasive cholesteatomas: preliminary findings
    Mahmoud Rezk Abdelwahed Hussein
    Pathology Department, Assuit University Hospitals, Sohag University, Egypt
    Exp Mol Pathol 88:316-23. 2010

Collaborators

Detail Information

Publications49

  1. doi Analysis of hMSH2 mismatch repair protein expression in dysplasia, carcinoma in situ and invasive squamous cell carcinoma of the vocal folds
    Mahmoud Rezk A Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
    Cancer Invest 27:38-46. 2009
    ..Nor has the correlation between the hMSH2 protein expression and the clinicopathologic features of the vocal fold dysplasia and carcinoma been examined...
  2. doi Mucocutaneous Splendore-Hoeppli phenomenon
    Mahmoud R Hussein
    Department of Pathology, Assir Central Hospital, King Khalid University, Abha, Kingdom of Saudi Arabia
    J Cutan Pathol 35:979-88. 2008
    ..To conclude, Splendore-Hoeppli reaction is a tell tale of a spectrum of infections and reactive conditions. The molecular pathways involved in the development of this reaction are open for future investigations...
  3. doi Phenotypic characterization of the infiltrating immune cells in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma
    Mahmoud Rezk A Hussein
    Departments of Pathology and Urology, Assir Central Hospital and King Khalid University, Abha, Saudi Arabia
    Exp Mol Pathol 86:108-13. 2009
    ..This study elaborates on the cells of the immune system present in normal prostate, benign nodular prostatic hyperplasia and prostatic adenocarcinoma...
  4. ncbi Primary peritoneal malignant mixed mesodermal (Müllerian) tumor
    Mahmoud R Hussein
    Department of Pathology, Assir Central Abha, KSA and Assuit University Hospitals, Assuit University, Assuit, Egypt
    Tumori 95:525-31. 2009
    ..The neoplastic elements of extragenital MMMT presumably arise directly from the mesothelium or submesothelial stroma and hence parallel the biphasic pattern of the genital (uterine or ovarian) counterpart...
  5. doi Analysis of p53, BCL-2 and epidermal growth factor receptor protein expression in the partial and complete hydatidiform moles
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Exp Mol Pathol 87:63-9. 2009
    ..Epidermal growth factor receptor (EGF-R) is a transmembrane glycoprotein, which can bind and be activated by various ligands. It stimulates cell division and differentiation...
  6. ncbi Calciphylaxis cutis: a case report and review of literature
    Mahmoud Rezk A Hussein
    Pathology Department, Assir Central Hospital, KSA, Saudi Arabia
    Exp Mol Pathol 86:134-5. 2009
    ..Scand. J. Urol. Nephrol.1-3.). Here, we report a case of calciphylaxis in a 23-year-old female with past history of chronic renal failure, renal transplantation and intake of immunosuppressive drug. The relevant literature was discussed...
  7. doi Skin-limited Langerhans' cell histiocytosis in children
    Mahmoud Rezk A Hussein
    Departments of Pathology, Assir Central Abha, KSA and Assuit University Hospitals, Assuit University, Assuit Eqypt
    Cancer Invest 27:504-11. 2009
    ..Three types of histological pictures are seen: histiocytic, granulomatous (common) and xanthomatous (rare)...
  8. doi Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University and Assir Central Hospitals, Assuit, Egypt
    Pathol Oncol Res 14:321-8. 2008
    ..To conclude, the development of rheumatoid arthritis and osteoarthritis is associated with alteration of the levels of some cytokines. The assessment of these immunologic changes may have potential prognostic roles...
  9. doi Decidual immune cell infiltrate in hydatidiform mole
    Mahmoud R Hussein
    Departments of Pathology, Assuit University Hospitals, Assuit University, Assuit, Egypt
    Cancer Invest 27:60-6. 2009
    ..quot;..
  10. doi Immune cell profile in invasive cholesteatomas: preliminary findings
    Mahmoud Rezk Abdelwahed Hussein
    Pathology Department, Assuit University Hospitals, Sohag University, Egypt
    Exp Mol Pathol 88:316-23. 2010
    ..Cholesteatoma consists of keratinizing squamous epithelium, granulation tissue and keratin plugs. The pathogenesis of cholesteatoma may be related to alterations in the stromal immune cell infiltrate...
  11. doi Phenotypical characteristics of the immune cells in allergic contact dermatitis, atopic dermatitis and pityriasis rosea
    Mahmoud Rezk A Hussein
    Department of Pathology, Assuit University Hospitals, Assuit University, Assuit, Egypt
    Pathol Oncol Res 15:73-9. 2009
    ..The present data describe the profile of the immune cell infiltrate in AD, ACD and PR. The cell-mediated immunity seems to have critical role in the development of these lesions...
  12. doi Evaluation of the profile of the immune cell infiltrate in lichen planus, discoid lupus erythematosus, and chronic dermatitis
    Mahmoud Rezk A Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
    Pathology 40:682-93. 2008
    ..This investigation tries to test this hypothesis and to characterise immune cells in interface dermatitis...
  13. doi Steroid therapy is associated with decreased numbers of dendritic cells and fibroblasts, and increased numbers of satellite cells, in the dystrophic skeletal muscle
    Mahmoud Rezk A Hussein
    Department of Pathology, Faculty of Medicine, Assiut University, Assuit, Egypt
    J Clin Pathol 63:805-13. 2010
    ..In this investigation, it was hypothesised that steroid therapy is associated with morphological changes in the dystrophic muscle...
  14. doi Analysis of the vascular profile and CD99 protein expression in the partial and complete hydatidiform moles using quantitative CD34 immunohistochemistry
    Mahmoud Rezk Abdelwahed Hussein
    Departments of Pathology, Assuit University Hospitals, Assuit University, Assuit, Egypt
    Exp Mol Pathol 89:343-50. 2010
    ..The villous stroma of CHM is avascular or contains primitive endothelial-lined vascular elements. CD99 is a leukocyte antigen expressed in both normal and neoplastic tissue...
  15. doi Primary small cell neuroendocrine carcinoma of the urinary bladder: a clinicopathologic, immunohistochemical, and ultrastructural evaluation
    Mahmoud Rezk A Hussein
    Assir Central Hospital, Abha, Saudi Arabia
    Ultrastruct Pathol 34:232-5. 2010
    ..No metastasis was found at the time of diagnosis and the patient refused further chemotherapy or radiotherapy. The histogenesis, differential diagnosis, and prognosis of SCNEC of the urinary bladder were discussed...
  16. doi Primary meningioma of the nasal septum: a case report and review of literature
    Ali Hassan Alzarae
    Department of Otorhinolaryngology Head and Neck Surgery, Asser Central Hospital, Abha, Kingdom of Saudi Arabia
    Appl Immunohistochem Mol Morphol 18:296-8. 2010
    ..The clinicopathologic features and pathogenesis of the primary nasal meningioma is briefly discussed...
  17. doi Skin metastasis: a pathologist's perspective
    Mahmoud Rezk Abdelwahed Hussein
    Department of Pathology, Assir Central Hospital, Kingdom of Saudi Arabia
    J Cutan Pathol 37:e1-20. 2010
    ..Metastasis to the skin is often a pre-terminal event that heralds poor outcome...
  18. ncbi Immunohistological evaluation of immune cell infiltrate in cutaneous Kaposi's sarcoma
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Assiut, Egypt
    Cell Biol Int 32:157-62. 2008
    ..However, these issues should be tested by further studies...
  19. ncbi Analysis of p53 and bcl-2 protein expression in the non-tumorigenic, pretumorigenic, and tumorigenic keratinocytic hyperproliferative lesions
    Mahmoud R Hussein
    Department of Pathology, Faculties of Medicine, Assuit and South Valley Universities, Assuit, Egypt
    J Cutan Pathol 31:643-51. 2004
    ..The aim of this work was to examine the expression patterns of apoptosis-linked molecules (bcl-2 and p53) in these lesions...
  20. ncbi Alterations of p53, Bcl-2, and hMSH2 protein expression in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas in the upper Egypt
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University, Assuit, Egypt
    Cancer Biol Ther 3:983-8. 2004
    ..We hypothesized that mammary carcinogenesis involves interactions among p53, Bcl-2 and hMSh2 proteins. In the Upper Egypt, the clinicopathologic features and genetic changes during mammary carcinogenesis are unknown...
  21. pmc Immunohistological analysis of immune cells in blistering skin lesions
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assiut University Hospitals, Assiut University, Assiut, Egypt
    J Clin Pathol 60:62-71. 2007
    ..Bullous skin lesions are characterised by the presence of intraepidermal or subepidermal bullae. Although inflammatory cell infiltrate is a constant feature in these lesions, their immunophenotypic characterisation is still incomplete...
  22. ncbi The TP53 tumor suppressor gene and melanoma tumorigenesis: is there a relationship?
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit City, Egypt
    Tumour Biol 25:200-7. 2004
    ....
  23. ncbi Analysis of the mononuclear inflammatory cell infiltrate in the non-tumorigenic, pre-tumorigenic and tumorigenic keratinocytic hyperproliferative lesions of the skin
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Egypt
    Cancer Biol Ther 4:819-21. 2005
    ..This study tries to test this hypothesis and to characterize MICs in these lesions...
  24. doi Atypical lymphoid proliferations: the pathologist's viewpoint
    Mahmoud Rezk Abdelwahed Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt
    Expert Rev Hematol 6:139-53. 2013
    ..In the author's opinion, the use of this descriptive term AtLP may obviate the need to force some lymphoid proliferations (equivocal lesions or mimickers of lymphomas) into either the benign or malignant categories...
  25. doi Evaluation of Langerhans' cells in normal and eczematous dermatitis skin by CD1a protein immunohistochemistry: preliminary findings
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit University, Assuit, Egypt
    J Cutan Pathol 35:554-8. 2008
    ..Langerhans' cells (CD1a positive, bone marrow-derived cells), are the antigen presenting cells of the skin. Our knowledge about the status of these cells in eczematous dermatitis is incomplete...
  26. doi Cutaneous and lymphadenopathic Kaposi's sarcoma: a case report and review of literature
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit University, Egypt
    J Cutan Pathol 35:575-8. 2008
    ..The vascular nature of the lesion was supported by positive staining for CD31 and CD34. This study examines the clinicopathologic features of KS in children and summarizes the relevant literature...
  27. ncbi Primary cutaneous meningioma of the scalp: a case report and review of literature
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Egypt
    J Cutan Pathol 34:26-8. 2007
    ..Immunostains for cytokeratin, S-100 protein, vascular (CD34 and CD31) and muscle markers (Desmin and smooth muscle actin) were negative. The diagnosis of cutaneous meningioma was established. A review of literature was presented...
  28. pmc Alterations of p53, BCL-2, and hMSH2 protein expression in the normal brain tissues, gliosis, and gliomas
    Mahmoud R Hussein
    Faculty of Medicine, Assuit University Hospitals, Assuit University, Assuit, Egypt
    Int J Exp Pathol 87:297-306. 2006
    ..07, P > 0.05) and between p53 and hMSH2 (r = -0.08, P > 0.05) protein expression. Alterations of the p53, BCL-2, and hMSH2 proteins occur during the development of these tumors...
  29. ncbi Alterations of p53, Bcl-2, and hMSH2 protein expression in the cirrhotic, macroregenerative, dysplastic nodules and hepatocellular carcinomas in Upper Egypt
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University, Assuit, Egypt
    Liver Int 24:552-60. 2004
    ..In Upper Egypt, the clinicopathologic and genetic changes during hepatocarcinogensis (cirrhotic nodules (CN); macroregenerative nodules (MRN) and dysplastic nodules (DN) are unknown...
  30. ncbi Apoptosis in the ovary: molecular mechanisms
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Assiut, Egypt
    Hum Reprod Update 11:162-77. 2005
    ..It also presents the existing literature and assesses the gaps in our knowledge...
  31. doi Extracutaneous malignant melanomas
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
    Cancer Invest 26:516-34. 2008
    ..Special staining and immunohistochemistry should be resorted to establish the diagnosis...
  32. pmc Enhancement of the repair of meniscal wounds in the red-white zone (middle third) by the injection of bone marrow cells in canine animal model
    Mohammed Abdel-Hamid
    Department of Orthopedics, Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
    Int J Exp Pathol 86:117-23. 2005
    ..Whether this improvement occurs through BMSC differentiation into cells operational in the repair process, the release of certain mediator or other unknown mechanisms mandates further investigations...
  33. ncbi Clinicopathological features of melanocytic skin lesions in Egypt
    Mahmoud R Hussein
    Department of Pathology, Assuit University Hospitals, Faculty of Medicine, Assuit University, Assuit, Egypt
    Eur J Cancer Prev 15:64-8. 2006
    ..Another key difference from the West is the 'sun-bed' culture of the West and the desire to have suntans. This is the first study that reports the clinicopathologic features of melanocytic skin lesions in Egypt...
  34. ncbi Ultraviolet radiation and skin cancer: molecular mechanisms
    Mahmoud R Hussein
    Pathology Department, Assuit University Hospitals, Assuit University, Assuit, Egypt
    J Cutan Pathol 32:191-205. 2005
    ..This review presents background information about the skin optics, UV radiation, and molecular events involved in photocarcinogenesis...
  35. ncbi Analysis of the Bcl-2 and p53 protein expression in the lymphoproliferative lesions in the upper Egypt
    Mahmoud R Hussein
    Pathology Departments, School of Medicine and South Egypt Cancer Institute, Assuit University, Assuit, Egypt
    Cancer Biol Ther 4:324-8. 2005
    ..In the Upper Egypt, the clinicopathologic and genetic characteristics (p53 and Bcl-2) of the lymphoproliferative lesions (reactive hyperplasia, RH; Non-Hodgkin's lymphoma, NHL and Hodgkin's disease, HD) is unknown...
  36. ncbi Dendritic cells and melanoma tumorigenesis: an insight
    Mahmoud R Hussein
    Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Assiut, Egypt
    Cancer Biol Ther 4:501-5. 2005
    ..This review provides insights into DCs status in the skin, and their roles in melanoma. It also sheds light on the possible use of DCs in melanoma therapy...
  37. ncbi Microsatellite instability and alterations of mismatch repair protein expression in choroidal melanomas
    Mahmoud R Hussein
    Department of Pathology, Faculty of Medicine, Assuit University, Assuit University Hospitals, Assuit, Egypt
    Arch Ophthalmol 123:1705-11. 2005
    ....
  38. ncbi Analysis of apoptotic cell death, Bcl-2, and p53 protein expression in freshly fixed and cryopreserved ovarian tissue after exposure to warm ischemia
    Mahmoud R Hussein
    Department of Pathology, Assiut University School of Medicine, Assiut, Egypt
    Fertil Steril 85:1082-92. 2006
    ..To evaluate the effect of ischemia time on the expression of Bcl-2 and p53 proteins on freshly fixed and cryopreserved-thawed ovarian tissue...
  39. pmc Tumour-associated macrophages and melanoma tumourigenesis: integrating the complexity
    Mahmoud R Hussein
    Department of Histopathology, Assuit University Hospitals, Faculty of Medicine, Assuit University, Assuit, Egypt
    Int J Exp Pathol 87:163-76. 2006
    ..To date, little is available in the literature about the interactions between TAMs and melanoma cells. This viewpoint not only tries to examine these interactions but also provides relevant speculations...
  40. pmc The effects of glucocorticoid therapy on the inflammatory and dendritic cells in muscular dystrophies
    Mahmoud R Hussein
    Department of Pathology, Assiut University, Assiut, Egypt
    Int J Exp Pathol 87:451-61. 2006
    ..In DMD/BMD, prednisone therapeutic effect was associated with reduced MICs and DCs numbers. Whether this therapeutic effect reflects targeting of the deleterious immune response produced by these cells mandates further investigations...
  41. ncbi Primary renal lymphoma
    Hyder A Omer
    Department of Medicine, College of Medicine, King Khalid University, Nephrology Section, Assir Central Hospital, Abha, Kingdom of Saudi Arabia
    Nephrology (Carlton) 12:314-5. 2007
  42. ncbi Evaluation of angiogenesis in normal and lichen planus skin by CD34 protein immunohistochemistry: preliminary findings
    Mahmoud R Hussein
    Departments of Pathology, Assuit University Hospitals and Faculty of Medicine, Assuit University, Assuit, Egypt
    Cell Biol Int 31:1292-5. 2007
    ..These results provide a morphological evidence of potent angiogenic activity in cutaneous lichen planus, indicating that the local microvasculature may undergo an intense process of inflammation-dependent angiogenesis...
  43. ncbi Microsatellite instability and its relevance to cutaneous tumorigenesis
    Mahmoud R Hussein
    The Department of Medicine Dermatology, University of Wisconsin and William S Middleton Memorial Veteran Hospital, Madison, WI 53705, USA
    J Cutan Pathol 29:257-67. 2002
    ..Thus far, MSI is considered to be a distinct tumorigenic pathway that reveals surprising versatility. The ramifications for cutaneous neoplasms warrant further investigation...
  44. ncbi Apoptosis and melanoma: molecular mechanisms
    Mahmoud R Hussein
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Pathol 199:275-88. 2003
    ..This review summarizes the state of current knowledge about the key molecular components and mechanisms of apoptosis in melanoma, discusses potential therapeutic ramifications, and provides directions for future research...
  45. ncbi Identification of novel deletion Loci at 1p36 and 9p22-21 in melanocytic dysplastic nevi and cutaneous malignant melanomas
    Mahmoud R Hussein
    Arch Dermatol 139:816-7. 2003
  46. ncbi hMLH1 and hMSH2 gene mutations are present in radial growth-phase cutaneous malignant melanoma cell lines and can be induced further by ultraviolet-B irradiation
    Mahmoud R Hussein
    Department of Dermatology, University of Wisconsin, William S Middleton Veteran Hospital, Madison, WI 53705, USA
    Exp Dermatol 12:872-5. 2003
    ..Further investigation will be needed to determine whether mutations such as these contribute to the development of microsatellite instability in melanoma...
  47. ncbi Building bridges in cancer: mismatch repair and microsatellite instability
    Mahmoud R Hussein
    Department of Medicine Dermatology, University of Wisconsin and William S Middleton Memorial Veteran Hospital, Madison, Wisconsin 53705, USA
    Am J Dermatopathol 24:76-81. 2002
    ....
  48. ncbi Skin cancer in Egypt: a word in your ear
    Mahmoud R Hussein
    University of Wisconsin Medical School and William S Middleton Memorial Veteran Hospital, Madison, WI 53705 USA
    Cancer Biol Ther 4:593-5. 2005
    ..In Egypt, the clinicopathologic features of skin cancer are still unknown...
  49. ncbi Microsatellite instability in human melanocytic skin tumors: an incidental finding or a pathogenetic mechanism?
    Mahmoud R Hussein
    The Department of Medicine Dermatology, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Cutan Pathol 29:1-4. 2002