past Chairman of Researh American Academy of Otolaryngic Allergy
- The impact of atopy on neutrophil activity in middle ear effusion from children and adults with chronic otitis mediaDavid S Hurst
Department of Medical Sciences, Laboratory for Inflammation Research, University Hospital, Uppsala University, Sweden
Arch Otolaryngol Head Neck Surg 128:561-6. 2002..To identify the relationship of neutrophil activity to allergy as reflected by the level of myeloperoxidase (MPO) in ears of atopic patients with chronic otitis media with effusion (OME) by objective testing...
- Increased expression of major basic protein (MBP) and interleukin-5(IL-5) in middle ear biopsy specimens from atopic patients with persistent otitis media with effusionE D Wright
Meakins Christie Laboratories, and the Department of Otolaryngology, McGill University, Canada
Otolaryngol Head Neck Surg 123:533-8. 2000..Molecular biologic evidence to support an etiologic role for allergy in the pathogenesis of persistent otitis media with effusion (OME) is lacking...
- Evidence of eosinophil, neutrophil, and mast-cell mediators in the effusion of OME patients with and without atopyD S Hurst
Department of Medical Sciences, University Hospital, Uppsala, Sweden
Allergy 55:435-41. 2000..This study was designed to measure the involvement of eosinophils, neutrophils, and mast cells in the middle ear of patients with OME and to see whether that inflammatory response differed depending on whether or not the patient was atopic...
- Mast cells and tryptase in the middle ear of children with otitis media with effusionD S Hurst
Department of Medical Cell Biology, University of Uppsala, Sweden
Int J Pediatr Otorhinolaryngol 49:S315-9. 1999..This is the first report of the presence of tryptase, a reflection of mast cell activity, in chronic middle ear effusion of patients in whom atopic status was characterized...
- Evidence of possible localized specific immunoglobulin E production in middle ear fluid as demonstrated by ELISA testingD S Hurst
Otolaryngol Head Neck Surg 121:224-30. 1999..001), suggesting that IgE in middle ear effusion is not a transudate but more likely reflects an active localized process in atopic patients...
- Association of otitis media with effusion and allergy as demonstrated by intradermal skin testing and eosinophil cationic protein levels in both middle ear effusions and mucosal biopsiesD S Hurst
Department of Clinical Chemistry, Uppsala University, Sweden
Laryngoscope 106:1128-37. 1996....
- The presence of eosinophil cationic protein in middle ear effusionD S Hurst
Department of Clinical Chemistry, University Hospital, Uppsala, Sweden
Otolaryngol Head Neck Surg 108:711-22. 1993..0095). Mechanisms involving immune mediated disease in the middle ear, of which the eosinophil may be one participant, are presented...
- Allergy management of refractory serous otitis mediaD S Hurst
Otolaryngol Head Neck Surg 102:664-9. 1990..The history of chronic disease is defined. The pathophysiology of allergic mechanisms and studies attempting to prove or disprove an allergic effect on the middle ear and eustachian tube are reviewed...
- The importance of glycerin-containing negative control tests in allergy research studies that use intradermal skin testsDavid S Hurst
Tufts University, Boston, Massachusetts, USA
Otolaryngol Head Neck Surg 127:177-81. 2002..We sought to assess skin whealing with glycerin-containing control injections for intradermal skin tests...
- Efficacy of allergy immunotherapy as a treatment for patients with chronic otitis media with effusionDavid S Hurst
Tufts University, Boston, MA, United States
Int J Pediatr Otorhinolaryngol 72:1215-23. 2008....
- The role of allergy in otitis media with effusionDavid S Hurst
Tufts University, Department of Otolaryngology Head and Neck Surgery, Boston, MA 02111, USA
Otolaryngol Clin North Am 44:637-54, viii-ix. 2011....