David J Hunter

Summary

Publications

  1. pmc A randomized trial of patellofemoral bracing for treatment of patellofemoral osteoarthritis
    D J Hunter
    New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Osteoarthritis Cartilage 19:792-800. 2011
  2. doi Osteoarthritis
    David J Hunter
    Rheumatology Department, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, NSW, Australia
    Best Pract Res Clin Rheumatol 25:801-14. 2011
  3. ncbi The effect of anterior cruciate ligament injury on bone curvature: exploratory analysis in the KANON trial
    D J Hunter
    Rheumatology Department, Royal North Shore Hospital and Kolling Institute, University of Sydney, Sydney, NSW, Australia Electronic address
    Osteoarthritis Cartilage 22:959-68. 2014
  4. ncbi Biomarkers for osteoarthritis: current position and steps towards further validation
    David J Hunter
    Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, Kolling Institute, University of Sydney, Reserve Road, St Leonards, Sydney, NSW 2065, Australia Electronic address
    Best Pract Res Clin Rheumatol 28:61-71. 2014
  5. pmc Addition of telephone coaching to a physiotherapist-delivered physical activity program in people with knee osteoarthritis: a randomised controlled trial protocol
    Kim L Bennell
    Department of Physiotherapy, School of Health Sciences, The University of Melbourne, Centre for Health, Exercise and Sports Medicine, Melbourne, Vic, Australia
    BMC Musculoskelet Disord 13:246. 2012
  6. doi Structural correlates of pain in joints with osteoarthritis
    D J Hunter
    Kolling Institute, University of Sydney, Sydney, Australia
    Osteoarthritis Cartilage 21:1170-8. 2013
  7. pmc Imaging biomarker validation and qualification report: sixth OARSI Workshop on Imaging in Osteoarthritis combined with third OA Biomarkers Workshop
    D J Hunter
    Kolling Institute, University of Sydney, Royal North Shore Hospital, Sydney, Australia
    Osteoarthritis Cartilage 21:939-42. 2013
  8. ncbi Realignment treatment for medial tibiofemoral osteoarthritis: randomised trial
    David Hunter
    Department of Rheumatology, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2066, Australia
    Ann Rheum Dis 71:1658-65. 2012
  9. pmc Bias in the physical examination of patients with lumbar radiculopathy
    Pradeep Suri
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA
    BMC Musculoskelet Disord 11:275. 2010
  10. doi Pharmacologic therapy for osteoarthritis--the era of disease modification
    David J Hunter
    Rheumatology Department and Northern Clinical School, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Nat Rev Rheumatol 7:13-22. 2011

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. pmc A randomized trial of patellofemoral bracing for treatment of patellofemoral osteoarthritis
    D J Hunter
    New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, USA
    Osteoarthritis Cartilage 19:792-800. 2011
    ..The objective of this study was to determine the efficacy of a realigning patellofemoral (PF) brace in improving pain and function among persons with symptomatic lateral PF OA...
  2. doi Osteoarthritis
    David J Hunter
    Rheumatology Department, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, NSW, Australia
    Best Pract Res Clin Rheumatol 25:801-14. 2011
    ..Greater therapeutic attention to the important role of mechanical factors, joint injury and obesity in OA etiopathogenesis, is required if we are to find ways of reducing the public health impact of this condition...
  3. ncbi The effect of anterior cruciate ligament injury on bone curvature: exploratory analysis in the KANON trial
    D J Hunter
    Rheumatology Department, Royal North Shore Hospital and Kolling Institute, University of Sydney, Sydney, NSW, Australia Electronic address
    Osteoarthritis Cartilage 22:959-68. 2014
    ..Investigate the 5-year longitudinal changes in bone curvature after acute anterior cruciate ligament (ACL) injury, and identify predictors of such changes...
  4. ncbi Biomarkers for osteoarthritis: current position and steps towards further validation
    David J Hunter
    Department of Rheumatology, Royal North Shore Hospital and Northern Clinical School, Kolling Institute, University of Sydney, Reserve Road, St Leonards, Sydney, NSW 2065, Australia Electronic address
    Best Pract Res Clin Rheumatol 28:61-71. 2014
    ..With this approach we endeavor to identify, develop, and qualify biological markers (biomarkers) to support new drug development, preventive medicine, and medical diagnostics for osteoarthritis. ..
  5. pmc Addition of telephone coaching to a physiotherapist-delivered physical activity program in people with knee osteoarthritis: a randomised controlled trial protocol
    Kim L Bennell
    Department of Physiotherapy, School of Health Sciences, The University of Melbourne, Centre for Health, Exercise and Sports Medicine, Melbourne, Vic, Australia
    BMC Musculoskelet Disord 13:246. 2012
    ..This pragmatic randomised controlled trial will investigate the clinical- and cost-effectiveness of adding telephone coaching to a physiotherapist-delivered physical activity intervention for people with knee OA...
  6. doi Structural correlates of pain in joints with osteoarthritis
    D J Hunter
    Kolling Institute, University of Sydney, Sydney, Australia
    Osteoarthritis Cartilage 21:1170-8. 2013
    ..To describe the insights on the epidemiology of pain-structure association and the ramifications of these studies for clinical trials...
  7. pmc Imaging biomarker validation and qualification report: sixth OARSI Workshop on Imaging in Osteoarthritis combined with third OA Biomarkers Workshop
    D J Hunter
    Kolling Institute, University of Sydney, Royal North Shore Hospital, Sydney, Australia
    Osteoarthritis Cartilage 21:939-42. 2013
    ....
  8. ncbi Realignment treatment for medial tibiofemoral osteoarthritis: randomised trial
    David Hunter
    Department of Rheumatology, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2066, Australia
    Ann Rheum Dis 71:1658-65. 2012
    ..The objective of this 30-week randomised crossover trial was to determine whether a multi-modal realignment treatmentwould be successful in relieving pain and improving function among persons with medial tibiofemoral osteoarthritis (OA)...
  9. pmc Bias in the physical examination of patients with lumbar radiculopathy
    Pradeep Suri
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA
    BMC Musculoskelet Disord 11:275. 2010
    ..The objective of this study was to assess the effects of bias due to prior knowledge of lumbar spine magnetic resonance imaging findings (MRI) on perceived diagnostic accuracy of the physical examination for lumbar radiculopathy...
  10. doi Pharmacologic therapy for osteoarthritis--the era of disease modification
    David J Hunter
    Rheumatology Department and Northern Clinical School, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Nat Rev Rheumatol 7:13-22. 2011
    ..A research agenda with respect to disease modification in OA is also provided, and some of the future challenges we face in this field are discussed...
  11. pmc Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis
    David J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA 02120, US
    BMC Musculoskelet Disord 11:232. 2010
    ..The secondary objectives were to determine the effect on symptomatic responses through 24 weeks...
  12. doi Quality of osteoarthritis care for community-dwelling older adults
    David J Hunter
    Department of Rheumatology, University of Sydney, Australia
    Clin Geriatr Med 26:401-17. 2010
    ..Future efforts to guide management of OA of the hip or knee are better directed towards implementing practices known to be effective in a context-dependent manner to optimize health care quality...
  13. doi Lower extremity osteoarthritis management needs a paradigm shift
    David J Hunter
    Rheumatology Department, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney 2065, New South Wales, Australia
    Br J Sports Med 45:283-8. 2011
    ..Similarly, current palliation should shift towards coordinated conservative management with reorganisation of the delivery of health services...
  14. pmc Systematic review of the concurrent and predictive validity of MRI biomarkers in OA
    D J Hunter
    Rheumatology Department, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, NSW, Australia
    Osteoarthritis Cartilage 19:557-88. 2011
    ..To summarize literature on the concurrent and predictive validity of MRI-based measures of osteoarthritis (OA) structural change...
  15. pmc Definition of osteoarthritis on MRI: results of a Delphi exercise
    D J Hunter
    Rheumatology Department, Royal North Shore Hospital and Northern Clinical School, University of Sydney, NSW 2066, Australia
    Osteoarthritis Cartilage 19:963-9. 2011
    ..The objective of our research was to develop an MRI definition of structural OA...
  16. pmc Responsiveness and reliability of MRI in knee osteoarthritis: a meta-analysis of published evidence
    D J Hunter
    Rheumatology Department, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, NSW, Australia
    Osteoarthritis Cartilage 19:589-605. 2011
    ..To summarize literature on the responsiveness and reliability of MRI-based measures of knee osteoarthritis (OA) structural change...
  17. doi From joint anatomy to clinical outcomes in osteoarthritis and cartilage repair: summary of the fifth annual osteoarthritis imaging workshop
    D J Hunter
    Rheumatology Department, Royal North Shore Hospital and Northern Clinical School, University of Sydney, Sydney, NSW, Australia
    Osteoarthritis Cartilage 19:1263-9. 2011
    ..This white paper constitutes an overview of presentations and discussions from the fifth Annual Workshop on Imaging in Osteoarthritis (OA) held in Salzburg June eighth to eleventh 2011...
  18. ncbi Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score)
    D J Hunter
    Rheumatology Department, Royal North Shore Hospital, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia
    Osteoarthritis Cartilage 19:990-1002. 2011
    ..The purpose of this report is to describe the instrument and its reliability...
  19. pmc Fat, protein, and meat consumption and renal cell cancer risk: a pooled analysis of 13 prospective studies
    Jung Eun Lee
    Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 100:1695-706. 2008
    ....
  20. pmc Haplotypes of the estrogen receptor beta gene and breast cancer risk
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 122:387-92. 2008
    ..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women...
  21. pmc Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies
    Yikyung Park
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 21:1745-57. 2010
    ..To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer...
  22. pmc Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Breast Cancer Res Treat 115:613-22. 2009
    ..We comprehensively evaluated genetic variants in DNA repair genes with premenopausal breast cancer risk...
  23. pmc A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Sara Lindstrom
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 95:E121-7. 2010
    ..A long-standing hypothesis has been that inherited variation in the androgen receptor (AR) gene plays a role in prostate cancer initiation. However, studies to date have been inconclusive and often suffered from small sample sizes...
  24. pmc Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer
    Fangyi Gu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:2877-87. 2010
    ..Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins...
  25. pmc +331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 125:1685-91. 2009
    ..This finding adds to the evidence that the PR has an important etiologic role in breast cancer and should be evaluated in future studies...
  26. pmc Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Mol Cancer 9:125. 2010
    ..Thus, it is of particular interest to examine whether its wide variation can be attributed to clinical, pathologic or molecular features...
  27. pmc Biochemical markers of bone turnover and their association with bone marrow lesions
    David J Hunter
    Department of Epidemiology and Biostatistics, Boston University School of Medicine, Albany Street, Boston, Massachusetts 02118, USA
    Arthritis Res Ther 10:R102. 2008
    ..Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs)...
  28. pmc Dietary acrylamide intake and risk of premenopausal breast cancer
    Kathryn M Wilson
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 169:954-61. 2009
    ..They found no evidence that acrylamide intake, within the range of US diets, is associated with increased risk of premenopausal breast cancer...
  29. pmc Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:3551-7. 2008
    ..No associations were found for other SNPs with skin cancer risk. This study provides evidence for the contribution of the MMP9 Arg668Gln to SCC development...
  30. ncbi Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up
    Davaasambuu Ganmaa
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 122:2071-6. 2008
    ..However, our results suggested a weak inverse association between caffeine-containing beverages and risk of postmenopausal breast cancer...
  31. ncbi Fruits, vegetables, and colon cancer risk in a pooled analysis of 14 cohort studies
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 99:1471-83. 2007
    ..Statistical power to examine associations by colon site has been limited in previous studies...
  32. pmc Genome-wide association study of tanning phenotype in a population of European ancestry
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2250-7. 2009
    ..Overall, these tanning ability-related loci are similar to the hair color-related loci previously reported in the GWAS of hair color...
  33. ncbi Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Yen Ching Chen
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1973-81. 2007
    ..Estrogen receptor beta (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis...
  34. pmc Predictors and consequences of anaemia among antiretroviral-naïve HIV-infected and HIV-uninfected children in Tanzania
    Anirban Chatterjee
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Public Health Nutr 13:289-96. 2010
    ..The aims of the present study were to identify maternal and child predictors of anaemia among children born to HIV-infected women and to study the association between childhood anaemia and mortality...
  35. ncbi Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:917-26. 2005
    ..We assessed dietary iron intake and genetic and biochemical markers of iron status in a prospective, nested case-control study of women enrolled in the Nurses' Health Study...
  36. pmc Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:3140-9. 2010
    ..We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk...
  37. pmc Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians
    Hongmei Nan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 125:909-17. 2009
    ..Our study provides evidence for the contribution of pigmentation genetic variants, in addition to the MC1R variants, to variation in human pigmentary phenotypes and possibly the development of skin cancer...
  38. doi Large-scale evaluation of genetic variants in candidate genes for colorectal cancer risk in the Nurses' Health Study and the Health Professionals' Follow-up Study
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:311-9. 2008
    ..00003). The SNP500Cancer database and the Illumina GoldenGate Assay allowed us to test a larger number of SNPs than previously possible. We identified several SNPs worthy of investigation in larger studies...
  39. pmc Facet orientation and tropism: associations with spondylolysis
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    J Spinal Disord Tech 23:101-5. 2010
    ..Cross-sectional study...
  40. ncbi Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies
    Jeanine M Genkinger
    Department of Nutrition, Harvard School of Public Health, Room 339, Building 2, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:364-72. 2006
    ..Although case-control studies have reported conflicting results for dairy foods and lactose, several cohort studies have shown positive associations between skim milk, lactose, and ovarian cancer...
  41. pmc The accuracy of the physical examination for the diagnosis of midlumbar and low lumbar nerve root impingement
    Pradeep Suri
    Division of Research, New England Baptist Hospital, Boston, MA, USA
    Spine (Phila Pa 1976) 36:63-73. 2011
    ....
  42. pmc Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:282-8. 2009
    ..Nonetheless, the data are consistent with the hypothesis that IGF-1- and IL-6-related gene variation influences susceptibility to multiple myeloma and warrant confirmation in larger populations...
  43. pmc Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 21:331-45. 2010
    ..Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer...
  44. pmc Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
    Chunyan He
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 41:724-8. 2009
    ..42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L). These newly identified loci might expand understanding of the biological pathways regulating these two traits...
  45. pmc Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 18:4677-87. 2009
    ..40 x 10(-15)). Genome-wide significant loci were not identified for plasma folate. These data reveal new biological candidates and confirm prior candidate genes for plasma homocysteine, plasma vitamin B12 and plasma PLP...
  46. pmc ABO blood group and the risk of pancreatic cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Natl Cancer Inst 101:424-31. 2009
    ..ABO blood type is an inherited characteristic that in previous small studies has been associated with the risk of gastrointestinal malignancies...
  47. ncbi Knee alignment does not predict incident osteoarthritis: the Framingham osteoarthritis study
    David J Hunter
    Boston University School of Medicine, Clinical Epidemiology Research and Training Unit, and Brigham and Women s Hospital, Boston, Massachusetts 02118, USA
    Arthritis Rheum 56:1212-8. 2007
    ....
  48. ncbi Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: a pooled analysis of 8 prospective studies
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 118:970-8. 2006
    ..The results generally did not differ across studies or by sex, smoking habits and lung cancer cell type. In conclusion, these data do not support the hypothesis that intakes of vitamins A, C and E and folate reduce lung cancer risk...
  49. ncbi The p53 codon 72 polymorphism, sunburns, and risk of skin cancer in US Caucasian women
    Jiali Han
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Carcinog 45:694-700. 2006
    ..This study suggests that the Arg72Pro polymorphism may play a role in skin carcinogenesis...
  50. pmc Computed tomography-evaluated features of spinal degeneration: prevalence, intercorrelation, and association with self-reported low back pain
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Spine J 10:200-8. 2010
    ..Although the role of radiographic abnormalities in the etiology of nonspecific low back pain (LBP) is unclear, the frequent identification of these features on radiologic studies continues to influence medical decision making...
  51. pmc Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 20:2673-9. 2011
    ..5 × 10(-6)) and in primary melanoma (P = 4.6 × 10(-4)) compared with the normal skin...
  52. pmc Vitamin A and vitamin B-12 concentrations in relation to mortality and morbidity among children born to HIV-infected women
    Anirban Chatterjee
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Trop Pediatr 56:27-35. 2010
    ..Higher vitamin A concentrations in plasma are protective against mortality in children born to HIV-infected women...
  53. pmc Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk
    Bahar Mikhak
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:2335-40. 2008
    ..On the other hand, some epidemiologic studies suggest that the Ala allele is associated with a higher risk of cancer, including prostate cancer...
  54. pmc Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma
    Fangyi Gu
    Department of aEpidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Melanoma Res 18:330-5. 2008
    ..93 to 1.03. We did not find significant results for the SNPs in the other four genes. These data suggest the involvement of IL-6R in melanoma development. Further studies are needed to confirm these findings...
  55. ncbi MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Carcinogenesis 28:1985-90. 2007
    ..56C>T) of the MGMT promoter and promoter methylation/silencing of MGMT in colorectal cancer. Our data provide compelling evidence for common susceptibility for MGMT promoter CpG island methylation...
  56. pmc Acute low back pain is marked by variability: An internet-based pilot study
    Pradeep Suri
    Division of PM and R, VA Boston Healthcare System, Boston, USA
    BMC Musculoskelet Disord 12:220. 2011
    ....
  57. pmc Does lumbar spinal degeneration begin with the anterior structures? A study of the observed epidemiology in a community-based population
    Pradeep Suri
    Division of PM and R, VA Boston Healthcare System, Boston, USA
    BMC Musculoskelet Disord 12:202. 2011
    ..We conducted a study to examine whether the view that spinal degeneration begins with the anterior spinal structures is supported by epidemiologic observations of degeneration in a community-based population...
  58. pmc Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    BMC Cancer 6:217. 2006
    ..We investigated whether variants at both polymorphisms, while not independently associated with breast cancer risk, could influence breast cancer risk when considered together...
  59. ncbi Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 119:2148-54. 2006
    ..These results suggest that consumption of the major carotenoids during adulthood does not play a major role in the incidence of ovarian cancer...
  60. ncbi Manganese superoxide dismutase polymorphism and risk of skin cancer (United States)
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA, 02115, USA
    Cancer Causes Control 18:79-89. 2007
    ..We assessed whether the functional V16A polymorphism in the MnSOD gene is associated with skin cancer risk...
  61. pmc Spondylolysis and spondylolisthesis: prevalence and association with low back pain in the adult community-based population
    Leonid Kalichman
    Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA
    Spine (Phila Pa 1976) 34:199-205. 2009
    ..Cross-sectional study...
  62. pmc Pattern of joint damage in persons with knee osteoarthritis and concomitant ACL tears
    Verena Stein
    Division of Research, New England Baptist Hospital, Boston, MA, USA
    Rheumatol Int 32:1197-208. 2012
    ....
  63. pmc Use of tanning beds and incidence of skin cancer
    Mingfeng Zhang
    Brigham and Women s Hospital, Boston, MA, USA
    J Clin Oncol 30:1588-93. 2012
    ..We sought to evaluate the risk effect of tanning bed use on skin cancers among teenage and young adults. We also expected to determine whether a dose-response relationship was evident...
  64. pmc Recurrence of radicular pain or back pain after nonsurgical treatment of symptomatic lumbar disk herniation
    Pradeep Suri
    Veterans Affairs Boston Healthcare System, Boston, MA, USA
    Arch Phys Med Rehabil 93:690-5. 2012
    ..To determine recurrence rates of lower-extremity radicular pain after nonsurgical treatment of acute symptomatic lumbar disk herniation (LDH), and to identify predictors of recurrence...
  65. pmc Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Mol Genet 19:1856-62. 2010
    ..Our findings indicate that the genetic variants at ABO locus affect plasma sE-selectin levels and diabetes risk. The genetic associations with diabetes risk were independent of sE-selectin levels...
  66. pmc Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk
    Genevieve M Monsees
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Breast Cancer Res Treat 125:207-14. 2011
    ..85. Common variation alone in DNA repair genes plays at most a small role in determining postmenopausal breast cancer risk among women of European ancestry...
  67. doi Association between age, sex, BMI and CT-evaluated spinal degeneration features
    Leonid Kalichman
    Division of Research, New England Baptist Hospital, Boston, MA 02120, USA
    J Back Musculoskelet Rehabil 22:189-95. 2009
    ..The aim of our study was to evaluate the association between age, sex and body mass index (BMI) and lumbar spine degeneration features evaluated on computed tomography (CT) in a community-based sample...
  68. pmc Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations
    Margaret A Gates
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 124:729-33. 2009
    ..16-1.18 per allele at the alpha=0.05 level in the pooled analysis. Our results do not provide strong support for an association between these breast cancer susceptibility alleles and epithelial ovarian cancer risk...
  69. ncbi Lack of associations of selected variants in genes involved in cell cycle and apoptosis with skin cancer risk
    Jiali Han
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:592-3. 2006
  70. pmc A prospective study of telomere length and the risk of skin cancer
    Jiali Han
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Invest Dermatol 129:415-21. 2009
    ..85 (95% CI, 0.94-3.62) (P, trend=0.09). The opposing associations observed should be interpreted with caution, and further research is needed to confirm these possible associations...
  71. pmc Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  72. pmc Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 19:1846-55. 2010
    ..These data provide novel evidence revealing the role of polymorphisms in LEPR in modulating plasma levels of sOB-R and may further our understanding of the complex relationships among leptin, leptin receptor and diabetes-related traits...
  73. pmc Breast cancer susceptibility loci and mammographic density
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
    Breast Cancer Res 10:R66. 2008
    ....
  74. pmc Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 20:3718-24. 2011
    ..21 (1.02-1.44); P= 0.03], were associated with an increased risk of SCC. These two variants were not associated with melanoma risk. We conclude that 6p25 and 13q32 are novel loci conferring susceptibility to non-melanoma skin cancer...
  75. pmc A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 90:1623-31. 2009
    ..Evidence from observational studies suggests that inadequate folate status enhances colorectal carcinogenesis, but results from some randomized trials do not support this hypothesis...
  76. ncbi Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer
    Anita Koushik
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2408-17. 2006
    ..Our results corroborate previous findings for MTHFR Ala(222)Val and suggest that other genes involved in one-carbon metabolism, particularly those that affect DNA methylation, may be associated with colorectal cancer risk...
  77. ncbi Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study
    Aditi Hazra
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 28:1510-9. 2007
    ..Further investigation is required to validate the association of the polymorphisms in the one-carbon metabolic genes and risk of colorectal adenoma...
  78. pmc Intakes of fruit, vegetables, and carotenoids and renal cell cancer risk: a pooled analysis of 13 prospective studies
    Jung Eun Lee
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:1730-9. 2009
    ..13 (0.95-1.34) for lycopene. In conclusion, increasing fruit and vegetable consumption is associated with decreasing risk of renal cell cancer; carotenoids present in fruit and vegetables may partly contribute to this protection...
  79. pmc Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:885-90. 2010
    ..We sought to identify the common genetic variants associated with IL-18 levels...
  80. ncbi Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mol Carcinog 44:21-30. 2005
    ..Our results indicate that individuals exposed to tobacco carcinogens were at increased risk of colorectal cancer and that overall risk is related to mEH and CYP2C9 genotype, although the results were not consistent between men and women...
  81. pmc Facet joint osteoarthritis and low back pain in the community-based population
    Leonid Kalichman
    Boston University School of Medicine, Boston, MA, USA
    Spine (Phila Pa 1976) 33:2560-5. 2008
    ..Cross-sectional study...
  82. pmc Facet orientation and tropism: associations with facet joint osteoarthritis and degeneratives
    Leonid Kalichman
    Boston University School of Medicine, Boston, MA, USA
    Spine (Phila Pa 1976) 34:E579-85. 2009
    ..Cross-sectional study...
  83. doi Beyond odds ratios--communicating disease risk based on genetic profiles
    Peter Kraft
    Harvard School of Public Health, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Genet 10:264-9. 2009
    ..We argue that other measures--such as sensitivity, specificity, and positive and negative predictive values--are more useful when proposing a genetic profile for risk prediction...
  84. pmc A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk
    Chunyan He
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Breast Cancer Res Treat 113:585-94. 2009
    ..Further research is needed to confirm these possible associations...
  85. pmc Prospective study of common variants in the retinoic acid receptor-related orphan receptor α gene and risk of neovascular age-related macular degeneration
    Debra A Schaumberg
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Arch Ophthalmol 128:1462-71. 2010
    ..We aimed to determine if common variants in RORA predict future risk of neovascular AMD...
  86. pmc Changes in paraspinal muscles and their association with low back pain and spinal degeneration: CT study
    Leonid Kalichman
    Boston University School of Medicine, Boston, MA, USA
    Eur Spine J 19:1136-44. 2010
    ..We conclude that the paraspinal muscle density decreases with age, and increases BMI. It is associated with at some levels FJOA, spondylolisthesis and disc narrowing at the same level, but not associated with occurrence of LBP...
  87. pmc Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells
    Natsumi Irahara
    Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115, USA
    J Mol Diagn 12:177-83. 2010
    ..9) in leukocyte DNA. In conclusion, bisulfite conversion and PCR-pyrosequencing assay can measure LINE-1 methylation in macrodissected colon cancer, normal colon, and blood DNA, and may be useful in clinical and research settings...
  88. pmc A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Cancer Causes Control 20:171-9. 2009
    ..05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07). These results provide evidence for the potential involvement of MDM2 SNP309 in pigmentary traits...
  89. pmc Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 70:1015-23. 2010
    ..68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk...
  90. pmc The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA02115, USA
    Hum Mol Genet 17:3502-8. 2008
    ..In addition, the SNP was related to greater long-term weight change and increased risk of diabetes in women...
  91. pmc Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Cancer 9:172. 2009
    ..Overexpression of the FGFR4 protein has been linked to cutaneous melanoma progression. Previous studies reported associations between genetic variants in the FGFR2 and FGFR4 genes and development of various cancers...
  92. pmc A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 3:604-10. 2010
    ..Additionally, the association of selenium with PCa mortality was modified by a variant, suggesting the possibility that some men with PCa may benefit more from selenium than others, depending on their genotype...
  93. pmc Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis
    Catherine L Hill
    Boston University School of Medicine, A203, 80 E Concord Street, Boston, MA 02118, USA
    Ann Rheum Dis 66:1599-603. 2007
    ..To examine the relationship between longitudinal fluctuations in synovitis with change in pain and cartilage in knee osteoarthritis...
  94. pmc Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies
    Sara Lindstrom
    Department of Epidemiology, Harvard School of Public Health, Building 2, Room 249B, 655 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:873-6. 2010
    ..Genetic variation in two members of the Toll-like receptor family, TLR4 and the gene cluster TLR6-1-10, has been implicated in prostate cancer in several studies but the associated alleles have not been consistent across reports...
  95. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  96. pmc Common variants of FUT2 are associated with plasma vitamin B12 levels
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Program in Molecular and Genetic Epidemiology, Boston, Massachusetts 02115, USA
    Nat Genet 40:1160-2. 2008
    ..This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels...
  97. doi The management of osteoarthritis: an overview and call to appropriate conservative treatment
    David J Hunter
    Division of Research, New England Baptist Hospital, 125 Parker Hill Avenue, Boston, MA 02120, USA
    Med Clin North Am 93:127-43, xi. 2009
    ..The authors encourage active clinician involvement and instilling self-management strategies in patients to further promote effective long-term treatment of this pervasive disease...
  98. ncbi Chopstick arthropathy: the Beijing Osteoarthritis Study
    David J Hunter
    Boston University Arthritis Center, BU School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Arthritis Rheum 50:1495-500. 2004
    ..We conducted a population-based survey among elderly Chinese individuals living in Beijing, to explore whether chopsticks use is associated with prevalent hand OA...
  99. ncbi Imaging outcomes and their role in determining outcomes in osteoarthritis and rheumatoid arthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, and the Department of Medicine at Boston Medical Center, Boston, Massachussetts 02118, USA
    Curr Opin Rheumatol 18:157-62. 2006
    ..This review describes the advances in knowledge of outcomes that have occurred recently as a result of imaging research in both osteoarthritis and rheumatoid arthritis...
  100. doi Pharmacologic intervention for osteoarthritis in older adults
    William F Harvey
    Tufts Medical Center, Boston, MA 02111, USA
    Clin Geriatr Med 26:503-15. 2010
    ..Acetaminophen and nonsteroidal antiinflammatory drugs are the mainstay of pharmacologic therapy, but there are numerous adjunctive or alternative medications that may provide some benefit to patients with osteoarthritis...
  101. pmc Osteoarthritis
    David J Hunter
    Boston University Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
    BMJ 332:639-42. 2006