The operation of pattern separation and pattern completion processes associated with different attributes or domains of memoryMichael R Hunsaker
Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California, Davis Medical Center, 2805 50th Street, Room 1415, Sacramento, CA 95817, USA
Neurosci Biobehav Rev 37:36-58. 2013
..After these discussions, an optimal strategy for designing behavioral paradigms to evaluate pattern separation and pattern completion processes will be provided...
CGG trinucleotide repeat length modulates neural plasticity and spatiotemporal processing in a mouse model of the fragile X premutationMichael R Hunsaker
Department of Neurological Surgery, School of Medicine, University of California Davis, Davis, CA 95616, USA
Hippocampus 22:2260-75. 2012
..These data provide evidence for a neurocognitive endophenotype in the CGG KI mouse model of the premutation in which CGG repeat length negatively modulates plasticity and spatiotemporal attention...
- The importance of considering all attributes of memory in behavioral endophenotyping of mouse models of genetic disease
Michael R Hunsaker
Department of Neurological Surgery, University of California, Davis, CA 95616, USA
Behav Neurosci 126:371-80. 2012
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- Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders
Michael R Hunsaker
Department of Neurological Surgery, University of California, Davis, Davis, CA 95616, USA
Prog Neurobiol 96:220-41. 2012
..This approach emphasizes direct comparisons between the mouse and human that facilitate the development of neurobehavioral biomarkers or quantitative outcome measures for studies of genetic disorders across species...
- Motor deficits on a ladder rung task in male and female adolescent and adult CGG knock-in mice
Michael R Hunsaker
Department of Neurological Surgery, School of Medicine, University of California, Davis Davis, CA 95616, USA
Behav Brain Res 222:117-21. 2011
..The results demonstrate that both male and female CGG KI mice showed a greater number of foot slips as a function of increased CGG repeat length, independent of the age of the animal or general activity level...
- Temporal ordering deficits in female CGG KI mice heterozygous for the fragile X premutation
Michael R Hunsaker
Program in Neuroscience, University of California Davis, 1515 Newton Court, Davis, CA 95616, USA
Behav Brain Res 213:263-8. 2010
..No mice had any difficulty in detecting the presence of a novel object. These data suggest female CGG KI mice show a CGG repeat length-sensitive deficit for temporal ordering...
- Spatiotemporal processing deficits in female CGG KI mice modeling the fragile X premutation
Rachel M Borthwell
Department of Neurological Surgery, School of Medicine, University of California, Davis, Davis, CA 95616, USA
Behav Brain Res 233:29-34. 2012
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- Rare intranuclear inclusions in the brains of 3 older adult males with fragile x syndrome: implications for the spectrum of fragile x-associated disorders
Michael R Hunsaker
NeuroTherapeutics Research Institute and Department of Neurological Surgery, University of California, Davis School of Medicine, USA
J Neuropathol Exp Neurol 70:462-9. 2011
..The small numbers of inclusions and very low levels of both FMR1 RNA and protein suggest that the clinical course in these 3 subjects would not have been influenced by contributions from RNA toxicity...
- Progressive spatial processing deficits in a mouse model of the fragile X premutation
Michael R Hunsaker
Program in Neuroscience, University of California, Davis, Davis, CA 95616, USA
Behav Neurosci 123:1315-24. 2009
..At 48 weeks of age, CGG KI mice were unable to detect either change in object location. These data indicate that hippocampal-dependent impairments in spatial processing may occur prior to parietal cortex-dependent impairments in FXTAS...
- Distribution and frequency of intranuclear inclusions in female CGG KI mice modeling the fragile X premutation
Erik W Schluter
Department of Neurological Surgery, School of Medicine, University of California Davis, Davis, CA 95616, USA
Brain Res 1472:124-37. 2012
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- Widespread non-central nervous system organ pathology in fragile X premutation carriers with fragile X-associated tremor/ataxia syndrome and CGG knock-in mice
Michael R Hunsaker
Department of Neurological Surgery, University of California, Davis, Davis, CA, USA
Acta Neuropathol 122:467-79. 2011
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- Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation
Robert F Berman
Department of Neurological Surgery, School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616 8519, U S A
Epilepsia 53:150-60. 2012
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- Mouse models of the fragile x premutation and the fragile X associated tremor/ataxia syndrome
Michael R Hunsaker
Department of Neurological Surgery, University of California, Davis, CA, USA
Results Probl Cell Differ 54:255-69. 2012
..Behavioral, molecular, neuropathological, and endocrine features of the mouse models and their relation to human FXTAS are discussed...
- Ubiquitin-positive intranuclear inclusions in neuronal and glial cells in a mouse model of the fragile X premutation
H Jurgen Wenzel
Department of Neurological Surgery, University of California, Davis Davis, CA 95618, USA
Brain Res 1318:155-66. 2010
..This new finding of previously unreported pathology in astrocytes of CGG KI mice now provides an important mouse model to study astrocyte pathology in human FXTAS...
- Female CGG knock-in mice modeling the fragile X premutation are impaired on a skilled forelimb reaching task
Amanda A Diep
Department of Neurological Surgery, School of Medicine, University of California, Davis, Davis, CA 95616, USA
Neurobiol Learn Mem 97:229-34. 2012
..The results demonstrate that female CGG KI mice show deficits for learning a skilled forelimb reaching task compared to wildtype littermates, and that these deficits worsen with increasing CGG repeat lengths...
- Transecting the dorsal fornix results in novelty detection but not temporal ordering deficits in rats
Michael R Hunsaker
Program in Neuroscience, University of California, Newton Court, Davis, CA 95616, USA
Behav Brain Res 201:192-7. 2009
..The data also suggest that temporal processing and novelty detection may potentially be subserved by independent mechanisms in CA1...
- Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome
Claudia M Greco
MIND Institute, University of California Davis Medical Center, Sacramento, CA, USA
Mol Autism 2:2. 2011
..abstract:..
- Evaluation of metric, topological, and temporal ordering memory tasks after lateral fluid percussion injury
Gene G Gurkoff
Department of Neurological Surgery, University of California at Davis, Davis, California, USA
J Neurotrauma 30:292-300. 2013
..05) but not the CA1 of the hippocampus. These data demonstrate the utility of three object-based tasks to expand our understanding of how different neural memory systems are affected by TBI...
- The medial and lateral entorhinal cortex both contribute to contextual and item recognition memory: A test of the binding ofitems and context model
Michael R Hunsaker
MIND Institute, University of California, Davis Medical Center, Sacramento, California Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento, California
Hippocampus 23:380-91. 2013
..These data support the basic assumptions of the BIC model, but suggest that item and context information may interact in the entorhinal cortex. © 2013 Wiley Periodicals, Inc...
